• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.322-331
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• 2013

The purpose of the present study was to develop a convergent education contents for dementia prevention, operating on the web network applying modern information technology(IT). At the preparation stage, local and worldwide literatures related to dementia were analyzed followed by surveying industry demands, based on which the program was designed and developed. In the following enhancement stage, the program was modified as much as possible by advices obtained from experts in various fields. Development results of the present program are summarized as follows. Firstly, 645 intellect development model to prevent dementia was established through peer review and verification of convergent education theories by expert groups. This model was named as "Garisani" meaning "cognition capable of judging objects" in the Korean language. Secondly, 'Find a way' and 'Connect a line' modules were developed in the numeric field as well as 'Identify a letter(I, II)' modules, in the language field for web-based left brain training program. Thirdly, 'Find my car' and 'Vision training' modules in the attention field and 'Object inference' and 'Compare pictures' modules in the cognition field were developed for web-based right brain training program. Fourth, 'Pentomino' and 'BQmaze'(Brain Quotient and maze) modules in the space perception field and 'Visual training' in the memory field were developed for web-based left and right brains training. Fifth, all results were integrated leading to a 52 week Garisani convergent education program for dementia prevention.

• Journal of Genetic Medicine
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• v.17 no.2
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• pp.79-82
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• 2020

In epilepsy-aphasia spectrum (EAS) disorders, mutations in the glutamate receptor ionotropic N-methyl-D-aspartate type subunit 2A (GRIN2A) have become important for screening the disease. Research into the phenotypic variability of several types of neurologic impairment involving these mutations is in progress. However, the non-neurological problems related to these mutations are poorly understood. EAS disorders usually have epileptic, cognitive, or behavioral manifestations. In this case report, we present a female patient with epilepsy, delay in expressive language and social development, and intellectual disability with low intelligence quotient and memory quotient, but normal motor development. Through genetic analysis, she was found to have a missense and a nonsense mutation in GRIN2A (c.1770A>C; p.Lys509Asn and c.3187G>T; p.Glu1063∗, respectively) and we consider the nonsense mutation as 'pathogenic variant'. She was also discovered to have congenital hypothyroidism, growth hormone deficiency and Rathke's cleft cyst in the brain, which were previously unknown features of GRIN2A mutation. Our findings should widen understanding of the spectrum of GRIN2A phenotypes, and emphasize the need for more research into the association between GRIN2A mutations and non-neurologic clinical presentations.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.9
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• pp.3897-3903
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• 2011

This study was to examine the effectiveness of neurofeedback training by observing the pre and post brainwave measurement results of about 39(experimental group 25, comparative group 14) student who have shown emotional. The study was examined at S city M dong A hearing impairments student, from Mar. 2009 and to Feb. 2010. The training took place two times a week, for about 40 minutes per session. The tool used to meas ure the psychological reaction was POMS (Profile of Mood State). First, the result confirmed the differences of both attention quotient(L R) and resistance stress quotient(L R). Second,, the results of the analysis show mood state. Therefore, the result of the study shows that there is possibility that NeuroFeedback technique might be positively affecting emotional of the hearing impairments student.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.4
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• pp.129-136
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• 2021

Objectives: To investigate the relationship between brain structure and empathy in early adolescents with attention-deficit/hyperactivity disorder (ADHD). Methods: Nineteen early adolescents with ADHD and 20 healthy controls underwent 3T MRI. All the participants were assessed for different aspects of empathy using measures including the Interpersonal Reactivity Index and Empathy Quotient. Cortical thickness and subcortical structural volume based on T1-weighted scans were analyzed using FreeSurfer. Results: Cognitive empathy (t=-2.52, p=0.016) and perspective taking (t=-2.10, p=0.043) were impaired in the ADHD group compared with the control group. The cluster encompassing the left posterior insular, supramarginal, and transverse temporal cortices [cluster-wise p-value (CWP)=0.001], which are associated with emotional empathy, was significantly smaller in the ADHD group, and the volume of the left nucleus accumbens was greater than that of the control group (F=10.12, p=0.003, effect size=0.22). In the control group, the left superior temporal (CWP=0.002) and lingual cortical (CWP=0.035) thicknesses were positively associated with cognitive empathy, while the right amygdala volume was positively associated with empathic concern (Coef=14.26, t=3.92, p=0.001). However, there was no significant correlation between empathy and brain structure in the ADHD group. Conclusion: The ADHD group had a smaller volume of the cortical area associated with emotional empathy than the control group, and there was no brain region showing significant correlation with empathy, unlike in the control group.

• Korean Journal of Biological Psychiatry
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• v.22 no.2
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• pp.78-86
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• 2015

Objectives Although ginseng has been reported to protect neuronal cells and improve various cognitive functions, relationship between ginseng supplementation and response inhibition, one of the important cognitive domains has not been explored. In addition, effects of ginseng on in vivo human brain have not been investigated using the diffusion tensor imaging (DTI). The purpose of the current study is to investigate changes in intrusion errors and white matter microstructure after Korean Red Ginseng supplementation using standardized neuropsychological tests and DTI. Methods Fifty-one healthy participants were randomly allocated to the Korean Red Ginseng (n = 26) or placebo (n = 25) groups for 8 weeks. The California Verbal Learning Test was used to assess the number of intrusion errors. Intelligence quotient (IQ) was measured with the Korean Wechsler Adult Intelligence Scale. Depressive and anxiety symptoms were evaluated using Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, and Hopkins Symptom Checklist-25. The fractional anisotropy (FA) was measured from the brain DTI data. Results After the 8-week intervention, Korean Red Ginseng supplementation significantly reduced intrusion errors after adjusting age, sex, IQ, and baseline score of the intrusion errors (p for interaction = 0.005). Change in FA values in the left anterior corona radiata was greater in the Korean Red Ginseng group compared to the placebo group (t = 4.29, p = 0.04). Conclusions Korean Red Ginseng supplementation may be efficacious for improving response inhibition and white matter microstructure integrity in the prefrontal cortex.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.7
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• pp.2949-2954
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• 2012

This study was to examine the correlation between the brain function of adult suffering from obesity and the level of their obesity based on brainwave measurements. Based on the result of Body Composition Analysis (BCA) examination, population of 651 overweight pupils was chosen from June 2011 to December of 2012 in S city, I hospital. These patients were measured by timeseries linear analysis for their brain function and observed via brainwave activities. The results have been thus far; first, as their BMI (Body Mass Index) and level of obesity (body fat percentage) were higher, degree of mental stress and resistant to stress marked lower. These results prove that by managing the stress resistant ability and attention ability, self-controlling ability, one can expect a positive effect on finding a methods to ease the obese-related problems.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2655-2661
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• 2014

This study is analized with how Dance as a healing art influence to elderly women's brain function measured by 2 channel system EEG(Electroencephalogram). The objects in this study are 60 aged over 65years in K city. The study started from March to July in 2013. The treatment was conducted by ones a week, 60minutes a time for 16 weeks. Participants are 30 of the experimental group and 30 of the control group checked by EEG before and after treatment. The result in experimental group is indicated as followed. The Basic Rhythm Quotient Lt(79.11/89.56, p<.015), wave length Rt((8.33/9.37, p<.003), amplitude Lt(39.87/47.19, p<.006), amplitude Rt(40.09/49.87, p<.000) did show statistically higher score after treatment. Therefore, dance as a healing art is to be proved the value and efficiency of the practical use for activating elderly women's brain function.

• Journal of the Korean Society of School Health
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• v.34 no.2
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• pp.107-114
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• 2021

Purpose: The aim of this study was to investigate the factors influencing eating attitudes in female nursing students. Methods: A cross-sectional study was conducted on 121 university students in 2016. Data was collected using self reported questionnaires asking about circadian rhythm (Morningness-Eveningness Questionnaire), daytime sleepiness (Epworth Sleepiness Scale), sleep quality (Pittsburgh Sleep Quality Index), and eating attitudes (Eating Attitudes Test-26). Stress resistance was measured with a brain quotient test. The data were analyzed with a t-test, ANOVA, Pearson's correlation analysis and linear regression using SPSS 22.0. Results: Eating attitudes were associated with daytime sleepiness, sleep quality, and stress resistance of the right hemisphere. Among these, daytime sleepiness and sleep quality had a significant effect on eating attitudes. Conclusion: The results of this study suggest that sleep should be taken into account when developing interventions for preventing eating disorders in female nursing students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.6
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• pp.2072-2077
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• 2010

This study is focused on the effects of elder's blood type on determining awareness and emotional character of the elderly, by comparing each individual's brain wave. Observed records are from thoes elder's who volunteered for KRIJUS( Korea Research Institute of Jungshin Science)'s brain wave measurement from September 2008 to June 2009. The whole 762 elder group consists of 311 female and 451 male. Blood types are A>B>O>AB dominately ordered. The result shown no relations between the blood types and their emotional character among elderly female, while elderly men shown meaningful difference; type B and O had higher rate on negative aspects. When it comes to awareness categories, both emotional(p=.001) and active(right)(p=.040) index shown meaningful differences. Type A had highest rate on emotional index and AB had it on active index. This study revealed meaningful relation between blood types and emotional character among several categories, while suggesting follow-up researches figuring out more detailed explanations for its effect and genetic role.

• Journal of The Korean Association For Science Education
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• v.32 no.3
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• pp.524-531
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• 2012

Categorization is an important human function used to process different stimuli. It is also one of the most important factors affecting measurement of a person's classification ability. Explicit categorization, the representative system by which categorization ability is measured, can verbally describe the categorization rule. The purpose of this study was to develop a prediction model for categorization ability as it relates to the classification process of living organisms using fMRI. Fifty-five participants were divided into two groups: a model generation group, comprised of twenty-seven subjects, and a model verification group, made up of twenty-eight subjects. During prediction model generation, functional connectivity was used to analyze temporal correlations between brain activation regions. A classification ability quotient (CQ) was calculated to identify the verbal categorization ability distribution of each subject. Additionally, the connectivity coefficient (CC) was calculated to quantify the functional connectivity for each subject. Hence, it was possible to generate a prediction model through regression analysis based on participants' CQ and CC values. The resultant categorization ability regression model predictor was statistically significant; however, researchers proceeded to verify its predictive ability power. In order to verify the predictive power of the developed regression model, researchers used the regression model and subjects' CC values to predict CQ values for twenty-eight subjects. Correlation between the predicted CQ values and the observed CQ values was confirmed. Results of this study suggested that explicit categorization ability differs at the brain network level of individuals. Also, the finding suggested that differences in functional connectivity between individuals reflect differences in categorization ability. Last, researchers have provided a new method for predicting an individual's categorization ability by measuring brain activation.