• Science of Emotion and Sensibility
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• v.17 no.4
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• pp.41-50
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• 2014

This study examined the characteristics of brain's reaction pattern concerning the preference for product images and compared them with the result of subjects' intuitive evaluation of their preference for the same materials. Two tests were conducted; the first one that calculated comfort properties based on brainwave measurements in order to examine the impression given by the images of products presented separately, one-by-one, and the second one that had subjects evaluate the preference directly by comparing the images of all products simultaneously. The first test was titled 'Independent Cognitive Response' and the second test, 'Relative Cognitive Response', and their characteristics were as follows. In the 'Independent Cognitive Response', the state of emotion was expressed in absolute values based on the comparison with the information accumulated through the subject's own experience and the feeling expressed as 'pleasant' or 'unpleasant' persisted as absolute values. In the 'Relative Cognitive Response', the state of emotion relative to the information of other images compared in the stage of perceiving the images was expressed, and in this case, the state of emotion described as 'calm' or 'excited' acted as relative values.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.411-416
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• 2023

Methamphetamine (METH) is a powerful neurotoxic psychostimulant affecting dopamine transporter (DAT) activity and leading to continuous excess extracellular dopamine levels. Despite recent advances in the knowledge on neurobiological mechanisms underlying METH abuse, there are few effective pharmacotherapies to prevent METH abuse leading to brain damage and neuropsychiatric deficits. α-Pinene (APN) is one of the major monoterpenes derived from pine essential oils and has diverse biological properties including anti-nociceptive, anti-anxiolytic, antioxidant, and anti-inflammatory actions. In the present study, we investigated the therapeutic potential of APN in a METH abuse mice model. METH (1 mg/kg/day, i.p.) was injected into C57BL/6 mice for four alternative days, and a conditioned place preference (CPP) test was performed. The METH-administered group exhibited increased sensitivity to place preference and significantly decreased levels of dopamine-related markers such as dopamine 2 receptor (D2R) and tyrosine hydroxylase in the striatum of the mice. Moreover, METH caused apoptotic cell death by induction of inflammation and oxidative stress. Conversely, APN treatment (3 and 10 mg/kg, i.p.) significantly reduced METH-mediated place preference and restored the levels of D2R and tyrosine hydroxylase in the striatum. APN increased the anti-apoptotic Bcl-2 to pro-apoptotic Bax ratio and decreased the expression of inflammatory protein Iba-1. METH-induced lipid peroxidation was effectively mitigated by APN by up-regulation of antioxidant enzymes such as manganese-superoxide dismutase and glutamylcysteine synthase via activation of nuclear factor-erythroid 2-related factor 2. These results suggest that APN may have protective potential and be considered as a promising therapeutic agent for METH-induced drug addiction and neuronal damage.

• Journal of Korean Elementary Science Education
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• v.34 no.1
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• pp.109-122
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• 2015

In National Curriculum of Science revised in 2007, free inquiry was newly introduced to increase student's interest in science and to foster creativity by having students make their own curiosity questions and find answers by themselves. The purpose of this study is to analyze elementary school students' perceptions on free science inquiry activities applying a brain-based evolutionary approach. For this study, 106 the fifth grade students participated, and then completed a questionnaire on free inquiry activities according to a brain-based evolutionary science teaching and learning principles. The students performed a series of steps of the Diversifying, Estimating-Evaluating-Executing, and Furthering activities in each of Affective, Behavioral, and Cognitive domains (ABC-DEF approach) and constructed their own free inquiry diary, then the observations by the researcher and interviews with the students were analyzed both quantitatively and qualitatively. The major results of the study were as follows: First, the majority of the students perceived the each domain and step positively although a few of them perceived negatively. The reasons perceived as negatively were categorized into two; preference dimension of like or dislike and ability dimension of metacognitive or self-reflective capacity. Also, they perceived the free inquiry experience in the form of ABC-DEF as helpful to understand the nature of scientists' scientific activities. Based on these findings, implications for supporting authentic inquiry in school science are discussed.

• Science of Emotion and Sensibility
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• v.8 no.1
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• pp.55-61
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• 2005

The purpose of the study was to examine any difference in academic achievement, self-concept and achievement motivation by the types of hemispheric dominance. 189 high school students participated in the study. They were taken three kinds of different psychological tests i.e., the brain hemispheric preference (dominance), the self-concept and the achievement motivation tests. Three types of hemispheric dominance were classified as the left hemispheric, the right hemispheric and whole brain dominances. The results showed that students with the right hemispheric dominance showed lower academic achievement and self concept than the other groups students. Those who had left hemisphere dominance showed higher achievement motivation than the right hemispheric students. These results could be interpreted that education in the high school in Korea mainly focuses left hemisphere related topics or subjects.

• Journal of Ginseng Research
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• v.47 no.4
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• pp.552-560
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• 2023

Background: Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressant effects of Korean red ginseng water extract (KGE) and its active component in an unpredictable chronic mild stress (UCMS)-induced animal model and elucidate the underlying mechanisms. Methods: The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats. Results: KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats. Conclusion: Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.

• Korean Institute of Interior Design Journal
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• v.20 no.2
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• pp.120-130
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• 2011

The purpose of this study is to propose cognitive ecological effects of fractal patterns in space design. This study investigated the perception and cognition problems regarding landscape patterns showing fractal properties from the cognitive perspective instead of the traditional speculative approach. In particular, the researcher has verified that fractal geometry theory and fractal pattern concept provide insight in space aesthetic values and cognitive effects. Research results are as follows. First, most environmentally-friendly fractal urban forms provide cognitive connectivity. In particular, this space provides a positive emotional response and preference to humans and displays self-organized complexity. This study found that such complexity of space form has characteristics corresponding to parallel cognitive structures of the human brain. Simultaneously, the researcher suggests that the fractal landscape pattern is an alternative for stiff and homogenized modern space. Second, fractal patterns provide hierarchical connectivity within the brain through continuous difference and repetition. In particular, self-similarities of fractal patterns administer significant visual grouping and coherence in human perception. It can be determined whether scaling coherence facilitates easier organization in cognitive organization. Third, fractal patterns in space design provide the basic method for achieving the connection between concept, construction, and urban factors. As a result, the researcher has suggested that scale distribution of geometrical factors, such as fractal patterns, an be a design method to connect various space typologies.

• KIEAE Journal
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• v.9 no.1
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• pp.47-53
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• 2009

To know the effect of smells from eco-friend and existing interior construction materials to human response, EEG of subjects' were measured. EEG signals were measured from 8 electrodes according to the international 10-20 system (Fp1, Fp2, F3, F4, Fc3, Fc4, P3, P4) from 10 healthy subjects in seven odor construction material. Followings are results. When stimuli of smell were suggested, non-stimuli pattern of ${\alpha}$-wave is largely in right occipitallobe part and rare in frontallobe part respectively. In case of eco-friend materials' smell, there is a activation of EEG in right occipitallobe part for every stimuli. But in case of eco-friend paint and Hwang-to, ${\alpha}$-wave is appeared in most part of brain even in frontallobe part. Especially for wet cedar case, activation of brain is very positive in right occipitallobe part and in frontallobe part. When comparing the normalized sensitivity of ${\beta}$-wave which appears in negative response, the preference ratio order is like this. Normal paint ${\rightarrow}$ MDF ${\rightarrow}$ Eco-friend paint ${\rightarrow}$ Gypsum board ${\rightarrow}$ Cedar ${\rightarrow}$ Wet cedar ${\rightarrow}$ Hwang-to.

• Journal of Korean Neurosurgical Society
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• v.30 no.11
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• pp.1263-1270
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• 2001

Objective : To analyze the radiosurgical results of intracranial meningiomas after Gamma Knife radiosurgery (GKS) and to assess the possible factors related to the outcome and complications in treating meningiomas. Patients and Methods : We retrospectively reviewed the clinical and radiological data in 179 patients(194 lesions) treated with GKS for intracranial meningiomas between May 1992 and October 2000. Radiosurgical responses were categorized as shrinkage, stasis and enlargement, and we defined the shrunken and static group as a radio-logical control. A Cox proportional hazards model was used to evaluate the correlation between the radiosurgical outcomes and various factors such as location and size of tumor, age and gender of patients, relation to venous sinus, pre-GKS degree of edema, treatment modality, radiosurgical parameters, and pathologic findings. Results : Patients were grouped into skull base meningiomas(57.7%), non-skull base tumor including convexity, parasagittal, and falx meningiomas(37.1%), and others(5.2%) according to the location of tumors. The mean maximum dose and the margin dose of tumor was 30.0Gy(19-45Gy) and 15.1Gy(9.5-24.5Gy), respectively. The mean volume of the tumors was 9.4cc(0.003-45.0cc). The radiologic control rate was 97.1%. The radiation induced imaging change with or without neurologic deficit was the most common complication(23.6%). There were seen mostly in convexity, parasagittal, and falx meningiomas which were deeply embedded in cortex. Conclusion : GKS for intracranial meningioma seems to be safe and effective treatments. However, GKS should be considered very cautiously in non-skull base tumor such as convexity, parasagittal, or falx meningiomas with regards to patient's age and general condition, size and location of tumor, pattern of embedding into cortex, presenting symptoms and patient's preference.

• Journal of the Korean Institute of Landscape Architecture
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• v.31 no.4
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• pp.49-56
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• 2003

This study is to find physiological effects of acoustic information on landscape preference. Both the volume and the rate of $\alpha$-waves and $\beta$-waves were used to measure the effects in the study. The result of this study are summarized as follows: The outputting amount of $\alpha$-waves are sorted by different types of visual and acoustic factors. The results show that acoustic factors interacted with visual factors. That is, although visual factors are positive, the volume of $\alpha$-waves depends upon the character of acoustic factors; positive acoustic factors produce more $\alpha$-waves than negative or neutral(soundless) acoustic factors. Also the volume of $\alpha$-waves increase in the case of positive acoustic factors even if there is the same negative visual information. The results show that the volume of $\alpha$-waves increase without connecting with the types of visual factors. The volume of $\beta$-waves are largely reduced when visual stimulus is positive and soundless stimulus is provided. On the other hand, they generally increase when both visual and acoustic stimuli are negative, which fosters extremely unstable, tense and upset stress. The rate of $\alpha$-waves increase according to supplying positive acoustic factors in the opposed visual factors. The rate of wave(shouldn't be $\alpha$-waves\ulcorner) is high if both visual and acoustic factors are positive, so it is the most comfortable and causes no stress. Preference is the lowest if visual and acoustic factors are negative, but a -waves are conspicuously low in positive visual and negative acoustic factors.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2013.11a
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• pp.155-156
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• 2013

최근 뇌파에 관련된 연구가 IT 분야와 결합하여 많이 진행되고 있다. 우리의 연구에서는 음악의 선호/비선호를 구분 문제를 뇌파를 이용해서 접근하려 한다. 이를 위해서 데이터를 모으고 분석하는 과저에서 나온 실험결과를 이 논문에서 발표한다. 최대한 편안한 상태에서 음악을 들으면서 뇌파를 취득하였을 때, 선호하는 음악과 비선호하는 음악을 구분해서 들었을 때의 뇌파취득 결과와, 그렇지 않았을 때의 뇌파 취득 결과를 간단한 분류방법을 통해서 비교한다.