• Environmental Analysis Health and Toxicology
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• 제2권1_2호
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• pp.17-24
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• 1987

Changes in cholinesterase (ChE) activity, electrophoretic pattern of ChE and histopathologic state on the mice serum, brain and liver by administration of organophos-phorous insecticides were studied. The mice ChE activities on serum, brain and liver decreased by increasing of concentration and time both administration of malathion and DDVP, whereas on serum and brain the activities of the 7 days after administration decreased, and then presented the gradually slight recovery in course of time. The ChE on serum and liver showed many isozyme bands by polyacrylamide gel electrophoresis but several on brain. And isozyme bands disappeared and diffused by administration of organophosphorous insecticides and development of time. The mice liver with administration group of malathion on histopathologic test showed midzonal necrosis between central vein and portal area, and with administration group of DDVP mainly presented portal necrosis on location of potal area.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제36회 동계학술대회 초록집
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• pp.169.1-169.1
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• 2009

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.298-298
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• 2000

This paper presents the optimization technique to analyze the effect of the design parameters of rapid prototyping system for human brain model fabrication. The optimization method considers the functional relationships among the design parameters such as thickness gap, shrink rate, and laser speed that govern the operation of fabrication system. This paper applies a discrete optimization technique as the optimization method to determine the dominant parameter values. Additional study includes manner of complement surface image of ellipse which approximates the brain model using the adaptive slicing and the offset contour. According to the parameters tuning and interaction of effect, more suitable parameter values can be obtained by enhanced 3D brain model fabrication.

• 한국수의병리학회지
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• 제3권2호
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• pp.73-76
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• 1999

The tissue distribution and cellular localization of viral antigen in the brain of aborted fetus with bovine viral diarrhea virus(BVDV) infection was studied; BVDV antigens was detected in spleen, kidney, lung, eyelid as well as brain. In the brain, the virus was recognized in neurons and non-neuronal cells in the cerebellum and cerebrum. Many cells in the superficial layer and occasional Purkinje cells had BVDV antigens. As well, BVDV was also found in the perivascular cells, vascular endothelial cells and smooth muscle cells in the vessels and neuroglial cells in the white matter. This finding suggests that BVD virus favors infect progenitor cells in the brain, notably in the superficial layer of cerebellum, and damage normal development of cerebellum, which leads to cerebellar hypoplasia.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2011년도 추계학술대회
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• pp.583-591
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• 2011

A number of Brain-Computer Interface (BCI) studies have been performed to assess the cognitive status through EEG signal. However, there are a few studies trying to prevent user from unexpected safety-accident in BCI study. The EEGs were collected from 19 subjects who participated in two experiments (rest & event-related potential measurement). There was significant difference in EEG changes of both spontaneous and event-related potential. Beta power and P300 latency may be useful as a biomarker for prevention of response to safety-accident.

• 대한안전경영과학회지
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• 제14권1호
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• pp.1-6
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• 2012

A number of Brain-Computer Interface (BCI) studies have been performed to assess the cognitive status through EEG signal. However, there are a few studies trying to prevent user from unexpected safety-accident in BCI study. The EEGs were collected from 19 subjects who participated in two experiments (rest & event-related potential measurement). There was significant difference in EEG changes of both spontaneous and event-related potential. Beta power and P300 latency may be useful as a biomarker for prevention of response to safety-accident.

• Nuclear Medicine and Molecular Imaging
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• 제41권2호
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• pp.85-90
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• 2007

Acute event in cerebrovascular disease is the second most common cause of death in Korea following cancer, and it can also cause serious neurologic deficits. Understanding of perfusion status is important for clinical applications in management of patients with cerebrovascular diseases, and then the attacks of ischemic neurologic symptoms and the risk of acute events can be reduced. Therefore, the normal vascular anatomy of brain, various clinical applications of acetazolamide-enhanced brain perfusion SPECT, including meaning and role of assessment of vascular reserve in carotid stenosis before procedure, in pediatric Moyamoya disease before and after operation, in prediction of development of hyperperfusion syndrome before procedure, and in prediction of vasospasm and of prognosis in subarachnoid hemorrahge were reviewed in this paper.

• 환경생물
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• 제27권1호
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• pp.95-99
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• 2009

Transcriptomic changes in the brain of Limanda yokohamae were investigated to understand the environmental condition of Masan Bay, Korea. Differentially expressed genes (DEGs) in the brain of the flat fish from Masan Bay were identified by comparing those from the reference site Gangneung using annealing control primers-based polymerase chain reaction. The results demonstrated that two different kinds of the cytoplasmic ribosomal proteins, 40 s ribosomal protein S27a and ribosomal protein L6, were identified by the BLAST searching followed by sequence analysis. These findings suggest that environmental status of Masan Bay could hinder protein synthesis that is required for maintaining brain functions and thus cause the dysfunction of fish physiology.

• 한국과학교육학회지
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• 제30권5호
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• pp.647-667
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• 2010

이 연구의 목적은 과학 교수-학습프로그램을 평가하기 위한 두뇌기반 분석틀을 개발하는 것이다. 분석틀의 개발을 위해, 이 연구는 과학 교수-학습과 관련된 선행연구들로부터 교수-학습 프로그램의 분석항목을 3가지로 범주화 하였다: 인지, 동기, 감성. 첫 번째로, 각 항목에 관련된 두뇌활성 영역을 파악하기위하여 과학수업과 관련된 두뇌 기능에 대한 93편의 뇌과학 문헌들을 분석하였다. 두 번째로, 두뇌의 해부학적 영역별로 범주화된 연구결과를 바탕으로 과학 교수-학습프로그램 분석을 위한 분석틀을 제작하였다. 분석틀의 제작은 R & D 방법을 따랐다. 그 결과, 두뇌활성 결과들은 대뇌 피질, 보상계, 변연계의 세 영역으로 범주화되어 나타났다. 이를 바탕으로 개발된 두뇌기반 과학 교수-학습 프로그램 분석틀인 'CORE Brain Map'은 양측 배외측전전두피질, 양측 복외측 전전두피질, 양측 안와전두피질, 전대상이랑, 양측 두정피질, 양측 측두피질, 양측 후두피질, 양측 해마, 양측 편도체, 양측 측좌핵, 양측 선조체 그리고 중뇌영역으로 구성된다. 두뇌기반 과학 교수-학습프로그램 분석틀은 다양한 과학 교수-학습프로그램의 분석 및 진단에 활용 가능할 것으로 전망된다.

• 한국과학교육학회지
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• 제30권8호
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• pp.1031-1043
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• 2010

이 연구의 목적은 과학 교수-학습프로그램의 두뇌 기반 분석을 위한 정성적 정량적 분석방법을 제시하는 것이다. 연구목적 달성을 위해, 첫 번째로 두뇌기반 분석을 위한 분석방법의 고안에는 중학교 과학 교수-학습프로그램 중 한 단원을 연구대상으로 선정하여 분석하였다. 제시된 분석방법의 유용성 검증에는 7차 및 2007 개정 교육과정의 초등학교 과학 교수-학습프로그램 중 네 단원을 연구대상으로 선정하여 검증하였다. 그 결과, 교수-학습 프로그램을 CORE Brain Map을 통해 정성적으로 컨설팅 할 수 있었다. 또한 네트워크 이론으로부터 정량적 분석을 위한 두뇌맞춤지수 산출식(BCI=$\frac{L_o}{11(N_o-1)}{\cdot}{\sum}\limits_{i=1}^4l_iw_i$)을 유도하였다. 이를 통해 단원 및 교육과정에 따른 연구대상 교수-학습프로그램들 간의 정량적 차이를 확인할 수 있었다. 이 연구를 통해 개발된 두뇌기반 과학 교수-학습 프로그램의 정성적 정량적 분석방법은 두뇌기반 다양한 과학 교수-학습 프로그램의 분석 및 진단에 활용 가능할 것으로 전망된다.