• 대한암한의학회지
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• 제20권1호
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• pp.11-21
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• 2015

Objectives : The cancer incidence and cancer burden is increasing. In addition, the use of botanical agents in cancer care is increasing. This article aims to review a research strategy for botanical agents. Methods : The clinical studies of anticancer botanical agents and the papers about clinical research methodology of botanical agents were reviewed. Results : In phase I study, safety confirmation, optimal dose determination and drug interaction study are important. Most botanical agents have low toxicity and some have non-monotone dose response. Therefore, dose-response curve must be evaluated separately from the dose-toxicity curve to determine optimal dose. Although anticancer botanical agents can't shrink tumor size rapidly, they do extend survival. So, in phase II study, response should be evaluated by the survival. Conclusions : Clinical research of botanical agents in cancer is different from traditional methods and strategies. Considering the characteristics of botanical agents and experimental mechanism is necessary in conducting botanical based clinical trials.

• 한국조경학회지
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• 제47권3호
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• pp.49-59
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• 2019

본 연구는 토머스 제퍼슨의 버지니아대학교 식물원 구상의 배경과 내용을 고찰한다. 제퍼슨이 식물원 설립을 추진했던 시기가 유럽에서 식물원이 약용 식물원에서 진화한 때이자 미국에서 여러 식물원이 설립된 초창기라는 사실에 주목하여 동시대 식물원과 비교하여 버지니아대학교 식물원 구상의 특징을 짚어내고자 하였다. 이를 위해 19세기 전후 구미 주요 식물원의 역할과 공간 구조를 분석하여 경향을 파악하였다. 이와 함께 식물학과 식물원에 대한 제퍼슨의 관점과 식물원 구상안을 검토하며 버지니아대학교 식물원을 당대 사례와 비교 검토하였다. 연구 결과 그 배경은 18세기 후반 유럽에서 두드러지게 나타난 국가 경제를 견인하는 실용 과학으로서 식물 교육과 연구의 중요성에 대한 사회 인식, 그리고 식물학과 식물원에 대한 정보와 식물을 교환하는 네트워크에서 찾을 수 있다. 버지니아대학교 식물원 구상은 공공 식물원의 역할에 대한 식물학자 코레아의 의견이 바탕이 되어 제퍼슨에 의해 부지 조성과 개략적인 공간 구성, 식물 수급 방안을 포함한 실행 전략으로 발전되었다. 동시대 식물원 사이에서 버지니아대학교 식물원 구상이 지니는 특징은 다음과 같다. 첫째, 초본 이외에 교목 정원을 별도로 구성하고 의학이 아닌 식물학 연구와 교육을 강조했던 측면에서 18세기 후반 유럽 식물원의 약용 식물원에서 식물원으로의 진화와 같은 경향을 보인다. 둘째, 장식적 요소를 배제하고 온실 설치를 거부하며 지역 기후에 적합한 해외 실용 식물을 확산시키려 했다는 점에서 유럽과 미국의 많은 식물원과 다르다. 본 연구는 버지니아대학교 식물원 구상을 사례로 19세기 전후 식물원의 역사와 문화에 대한 이해의 폭을 넓히는데 기여한다는 점에서 의의를 지닌다.

• Natural Product Sciences
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• 제10권4호
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• pp.168-172
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• 2004

In India, Gymnema sylvestre due to the unique property of the plant to antagonize the sweet taste is known as 'Gur-mar'. It has several ethnomedicinal values as various tribals/traditional communities and rural peoples of India find diverse medicinal uses viz. antidiabetic, stomachic, diuretic, and is useful in cough and throat troubles. Besides, it has strong effect on reducing blood sugar. The present communication deals with the detailed pharmacognostical evaluation of the aerial parts of G. sylvestre collected from three places of the country-Varanasi (U.P), Panchmarhi (M.P), Salem (Tami Nadu) and commercial sample procured from local market. The botanical and physico-chemical parameters of all the samples were quite similar though little variations were observed in foaming index, alcohol and water soluble extractives of local sample. The microscopic characteristics of the drug are horse shoe shaped petiole with 3 amphicribal vascular bundles, sieve tubes well developed; anomocytic stomata only on the abaxial surface of the leaf, the fan shaped amphicribal vascular bundle, presence of intraxylary phloem. The TLC fingerprint profile of all the samples was more or less similar only the quantity of some of the compounds varied.

• 한국자원식물학회지
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• 제9권2호
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• pp.183-188
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• 1996

Chinese crude drug 'Se Sin'(細辛)has been used to cure headache, cough and expectorant. To the botanical origin of 'Se Sin', Zhong-yao-zhi(中葯志) reported Asarum heterotropoides var. mandshuricum. A. sieboldii and A. sieboldii var. seoulensis, and Zhong-yao-da-ci-dian(中葯大辭典) reported Asarum heterotropoides var. mandshuricum and A. sieboldii of Aristolochiaceae. In Korea, this crude drug has been used as a Korean folk remedy for tothache and aromatic. The botanical origin of 'Se Sin' is considered to be Asarum species of Aristolochoaceae. But there has no pharmacognostical confirmation on it. To clarify the botanical origin of 'Se Sin', we studied on the anatomical characteristics of Asarum species growing wildly in Korea i.e. A. maculatum, A. sieboldii, A. sieboldii var. seoulensis, and of 'Se Sin' from Korea on Korean market. Through our studies, the botanical origin of 'Se Sin' from Korea was proved to be whole plant of Asarum sieboldii and A. sieboldii var. seoulensis.

• 생약학회지
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• 제37권4호
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• pp.302-306
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• 2006

'Pae Jang (敗醬)' is one of Chinese crude drugs used mainly as a edema, abdominal pain and hemoptysis, etc. With regard to the botanical origin of 'Pae Jang', it has been considered to be Patrinia scabiosaefolia of Valerianaceae, but there has never been studied pharmacognostically. To clarify the botanical origin of the 'Pae Jang', we studied on the anatomical characteristics of the roots of three species growing in Korea. Through our studies, the botanical origin of 'Pae Jang' from Korea was proved to be the under ground portions of Patrinia scabiosaefolia and Patrinia villosa.

• 생약학회지
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• 제32권1호통권124호
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• pp.1-5
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• 2001

The Chinese crude drug, 'Yong Dam (龍膽)' which is derived from the root of Gentiana plants of the family Gentianaceae, has been used as remedy for stomachic, intestinal catarrh, convulsion, etc. With regard to the botanical origin of 'Yong Dam', it has been considered to be Gentiana species of Gentianaceae, especially Gentiana scabra, but there has no pharmacognostical confirmation on it. To clarify the botanical origin of 'Yong Dam' from Korea, we studied on the anatomical characteristics of Gentiana species growing wild in Korea i.e. Gentiana scabra var. buergeri, G. uchiyamai, G. triflora, G. axillariflora var. coreana and of 'Yong Dam' from Korea on Korean market. Through our studies, the botanical origin of 'Yong Dam' from Korea was proved to be Gentiana scabra var. buergeri and Gentiana axillariflora var. coreana.

• 생약학회지
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• 제38권2호통권149호
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• pp.148-151
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• 2007

Ig Mo Cho (益母草) has been used as remedy for invigorating blood circulation to remove blood stasis and relieving edema by inducing diuresis. With regard to the botanical origin of Ig Mo Cho, it has been considered to be Leonurus spiecies of Labiatae, but there has never been pharmacognostical confirmation on it. To clarify the botanical origin of Ig Mo Cho from Korea, the anatomical characteristics of Leonurus japonicus and L. sibiricus were studied. As a result, the botanical origin of Ig Mo Cho from Korea was proved the herba of Leonurus japonicus.

• 생약학회지
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• 제34권1호통권132호
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• pp.6-9
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• 2003

‘Maig Moon Dong(麥問冬)’ is one of the chinese crude drugs used mainly to cure a cough and sputum, etc. With regard to the botanical origin of ‘Maig Moon Dong’, it has been considered to be Liriope species of Liliaceae, but there has not been studied pharmacognostically. To clarify the botanical origin of Maig Moon Dong, we studied on the anatomical characteristics of Liriope and Ophiopogon species growing wild in Korea i.e. L. platyphylla, L. spicata, O. jaburan, O. japonicus and Maig Moon Dong from Korea. As a result, the botanical origin of Maig Moon Dong from Korea was proved as Liriope platyphylla and L. spicata.

• 생약학회지
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• 제32권3호통권126호
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• pp.233-237
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• 2001

Korean folk medicine 'Koaeng I Bab' has been used to cure hemorrhoid, boil and dermatopathy and as an antidote. The botanical origin of the crude drug has not been studied pharmacognostically. To clarify the botanical origin of 'Koaeng I Bab', the morphological and anatomical characteristics of the leaves of Oxalis species growing in Korea, i.e. O. acetosella, O. acetosella var. purpurascens, O. corniculata, O. obtriangulata were studied. As the result, the botanical origin of 'Koaeng I Bab' has been proved to be O. corniculata and O. acetosella var. purpurascens.

• 생약학회지
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• 제44권4호
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• pp.313-319
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• 2013

A Korean folk medicine, "DangYak (當藥)" has been used as a bitter stomachic in Korea. With regard to the botanical origin of this crude drug, it has been considered to be from Swertia species (Gentianaceae), but there was no pharmacognostical confirmation on it. In this study, the morphological and anatomical characteristics of three Swertia species growing in Korea, Swertia japonica Makino, S. pseudochinensis Hara and S. tetrapetala Pall. were compared to clarify the botanical origin of "DangYak". As a result, it was determined that the commercial "DangYak" from Korean traditional market was proved to be the whole plant body mixture of Swertia japonica and Swertia pseudochinensis.