• Journal of Animal Science and Technology
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• 제44권2호
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• pp.171-180
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• 2002

본 연구는 1996년부터 2000년까지 축산기술연구소 남원지소에서 사육되고 있는 한국 재래산양의 발육형질 자료를 이용하였다. 조사형질로는 생시, 3개월령, 6개월령 체중으로 개체모형(Animal model)을 이용하여 분석하였고, 고정효과로 성별, 출생년도－계절, 사양형태를 고려하였으며, 각 형질에 대한 분산성분 및 유전모수를 추정하기 위하여 MTDFREML Program을 이용하였다. 본 연구에서 얻어진 결과를 요약하면 다음과 같다. 생시, 3개월령, 6개월령의 평균체중은 각각 1.78${\pm}$0.32, 7.99${\pm}$2.66, 12.08${\pm}$3.20kg이었고, 부수적으로 조사된 3개월령과 6개월령 평균체위는 각각 체고가 36.46, 40.27 cm, 체장은 38.06, 42.01cm, 흉위는 45.56, 51.07cm이었다. 생시, 3개월령, 6개월령 체중에 대한 개체의 유전력은 각각 0.66, 0.34, 0.27이었으며, 생시와 3개월령 체중에 대한 모체의 유전력은 각각 0.28, 0.03으로 추정되었고, 분산성분과 유전모수 추정 결과 생시와 3개월령 체중에 대해서는 모체유전효과가 중요하게 작용되었으며, 3개월령 체중에서는 모체환경효과가 고려되어야 하나, 6개월령 체중에서는 모체유전효과가 중요하지 않는 것으로 분석되었다.

• Journal of Nutrition and Health
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• 제38권8호
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• pp.637-648
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• 2005

This study was performed to investigate the effect of feeding garcinia cambogia extract (HCA) and/or L-carnitine and exercise (swimming) on body weight in rats. Forty-eight male rats (Charles River CD (SD) IGS) of eight weeks old and weighing $323.5\pm2.4g$ were raised for two months with high fat diet ($40\%$ fat as calorie) to induce obesity. After induction of obesity, rats weighing $552.8\pm5.8g$ were blocked into eight groups according to body weight and raised for six weeks with diet containing HCA and/or L-carnitine. Plasma aspartate aminotransferase, alanine aminotransferase, total protein and albumin levels were in normal ranges. Food and calorie intakes of H + C and H + C/H groups were highest among non-exercise (m) groups and exercise (I) groups. Food and calorie intakes of m groups were higher than those of I groups. E groups showed significantly lower body weight gain and calorie efficiency ratio than m groups and H/E group was the lowest among all groups. Perirenal fat pad weights of E groups were lower than m groups, and epididymal fat pad weights of H and H + C groups were lower than CO and C groups among m groups regardless of exercise treatment. Brown adipose tissue weights of I groups were higher than fn groups and highest in H/E group among all groups. Liver citrate lyase activities of H and C groups were lower than CO and H + C groups regardless of exercise treatment. The differences between NE groups and E groups were not found to be significantly. Liver carnitine acyltranferase activity was not significantly different among all groups. Fecal total lipid, triglyceride and total cholesterol excretions were found to be higher in H and H + C uoups compared to CO and C groups both in NE and E animals, those of lipid excretions of NE groups were higher than E groups. In conclusion, HCA was more effective in reduction of body weight and body fat than L-carnitine or HCA + L-carnitine. HCA ingestion with exercise was far more effective than without exercise treatment in reducing body weight and body fat.

• 대한수의학회지
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• 제13권2호
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• pp.141-146
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• 1973

In order to investigate the effect of sulfamonomethoxine on the thyroid gland, healthy mongrel dogs were selected at random. The body weights of these animals ranged between 1850 and 2050g at the beginning of the experiment. The 12 dogs used in this work were allotted to groups of two. Dogs in one group served as controls and the others were administered sulfamonomethoxine of 50 mg/kg/day for 15 weeks. The results obtained in this work were summerized as follows: 1. Mean body weights of experimental dogs revelled a slow increasing tendency but weights of thyroid glands were increased highly. 2. Thyroid follicles were atrophied significantly in accordance with experimental term and their colloidal substance was not found on stained sections. 3. It indicated the appearance of typical hyperplastic goiter. New follicular epithelial cells which were changed into hypertrophic cuboidal and columnar in type showed degeneration and necrosis and those cells multiplied difusely and made new small follicles.

• Journal of Nutrition and Health
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• 제35권7호
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• pp.713-728
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• 2002

This study was performed to see effects of whole grape, grape pomace or grape juice intakes on lipid metabolism during aging in old Sprague-Dawely male rats. One hundred twenty rats of 13 months old Sprague-Dawely were blocked into eight groups according to body weight and raised for 3, 5 or 7 months with diets containing 2% (w/w) dried powders of three different pars of grape and 0.02% (w/w) CdCl₂. Body weights of Cd groups were lower than Cd free groups. Kidney and spleen weights were incre ased with age, and EEP weights of Cd groups were lower than those of Cd free groups. Total lipid, triglyceride and total cholesterol concentration in plasma increased with age. Whole grape, grape pomace or grape juice intake lowered plasma total lipid triglyceride and total cholesterol concentrations, and especially grape pomace lowered them markedly. Whole grape, grape pomace or grape juice intake decreased liver total lipid, triglyceride and total cholesterol concentrations and increased fecal lipid excretion. Grape diets decreased and Cd administration increased TBARS concentration in LDL fraction. In conclusion, grape diets were effective in decreasing lipid levels of liver and plasma, TBARS in LDL, and in increasing HDL cholesterol. The grape pomace was most effective among three grape parts. It is plausible that grape might be recommended for the treatment or prevention of cardiovascular disease and delaying aging. (Korean J Nutrition 35 (7): 713∼728, 2002)

• 한국잠사곤충학회지
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• 제38권2호
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• pp.124-129
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• 1996

4령과 5령 누에에 1%, 3%, 5%의 dimethyl sulfoxide를 침식시키면 누에의 실용형질인 잠체중, 견사선 무게, 암·수 견중 및 견충중과 산란량이 현저히 증가했다. 그러나 경과일수, 족중생존율과 부화율은 대조와 큰 차이를 보이지 않았다. 한편 dimethyl sulfoxide 1.3%구에서는 누에의 혈액내 단백질과 트리할로스량을 제외하고는 차이가 없었다.

• 생약학회지
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• 제45권2호
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• pp.181-185
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• 2014

This study was carried out to investigate the acute toxicity of the bark of Diospyros kaki (Ebenaceae) in mice. The aqueous extract of the bark of Diospyros kaki (AEDK) was administered orally at a doses of 5 mg/kg, 50 mg/kg, 300 mg/kg and 2,000 mg/kg. In this study, number of deaths, clinical signs, body weights and pathological examinations were investigated after administration of AEDK. There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and AEDK treated groups in clinical signs, organ weights and gross pathological findings. AEDK did not show any toxic effect in mice.

• 대한한방내과학회지
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• 제34권2호
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• pp.155-164
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• 2013

Objectives : This study aimed to evaluate the single oral dose toxicity of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus in male and female ICR mice. Methods : In this single oral toxicity study, non-fermented and fermented Jaeumganghwa-tang (Ziyinjianghuo-tang) were administered to male and female ICR mice as an oral dose of 500, 1000 and 2000 mg/kg. After single administration, body weight changes, general behavior, adverse effects and mortality were determined for 14 days. Serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There were no mortality or signs of toxicity for 14 days. There were also no significant differences in body weights, organ weights, or serum chemistry values between treatment and control groups. Conclusions : These results indicate that the 50% lethal dose of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acipophullus may be over 2000 mg/kg. This finding can be expected to provide scientific evidence for the safety of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus.

• 한국식생활문화학회지
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• 제9권1호
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• pp.1-10
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• 1994

This study was undertaken to investigate the relationship between body mass index and the food habits of college students. For this purpose, 1030 students of Seoul National University were asked to fill out the questionnaires for the food habit and weight control. Actual weights were also measured, on the spot. The results obtained were as follows. 1. Average height and weight were 173.15 cm, 63.83 kg for male, and 160.52 cm, 52.73 kg for females. The prevalence of underweight, normal and overweight was 32.3, 61.7, 5.5%, respectively. 2. Food habit scores of obese females were lower than normal or underweight females. Male subjects did not show significantly different scores among three groups. 3. Female obese subjects have lower scores than the other groups on the balanced intake of five basic food groups and on the regular meal intakes. Male obese subjects have cholesterol-rich food and animal fat more frequently than normal and underweight males. Male underweight subjects have lower food habit scores on the balanced intake of five basic food groups. 4. Males want to gain weight slightly and females want to lose 4.65 kg weight. All females want to lose weights. Obese males and females want to lose 10 kg weights.

• Journal of Ginseng Research
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• 제42권3호
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• pp.356-360
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• 2018

The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speeding up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, and echocardiographic studies. The results exhibited that body weights were significantly reduced and the gain of different organ weights were partly eased by GBCK25 treatment. Echocardiography results proposed the amelioration of heart function through normalized levels of left ventricle systolic pressure, ejection fraction, and fractional shortening. These outcomes deliver straight confirmation that GBCK25 could be a potential nutraceutical source for the relief of HFD-induced obesity mediated cardiac dysfunctions.

• 한국발생생물학회지:발생과생식
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• 제25권2호
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• pp.83-91
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• 2021

The present study was performed to investigate the effect of maternal hypothyroidism and puberty onset in female rat pups. To do this, we employed propylthiouracil (PTU) to prepare a hypothyroid rat model. Pregnant rats were treated with PTU (0.025%) in drinking water from gestational day 14 to postnatal day 21 of offspring. Comparison of general indices such as body and tissue weights and puberty indices such as vaginal opening (VO) and tissue histology between control and PTU-treated rats were conducted. There was no significant difference in the date of VO between control and PTU group. The body weights of the PTU group were significantly lower, only 36.8% of the control group (p<0.001). Although the absolute thyroid weight was not changed by PTU treatment, the relative weight increased significantly about 2.8 times (p<0.001), indicating that hypothyroidism was successfully induced. On the other hand, the absolute weights of the ovary and uterus were markedly decreased by PTU administration (p<0.001), and the relative weight was not significantly changed. The ovarian histology of PTU group revealed the advanced state of differentiation (i.e., presence of corpora lutea). Inversely, the uterine histology of PTU group showed underdeveloped structures compared those in control group. Taken together, the present study demonstrates that our maternal hypothyroidism model resulted in minimal effect on pubertal development symbolized by VO despite of huge retardation in somatic growth. More sophisticatedly designed hypothyroidism model will be helpful to achieve a better understanding of pubertal development and related disorders.