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Acute Oral Toxicity of the Bark of Diospyros kaki in Mice  

Kim, Ju Hee (College of Pharmacy, Woosuk University)
Park, Yun Jeong (College of Pharmacy, Woosuk University)
Jo, Nam Sik (College of Pharmacy, Woosuk University)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Kim, Sang-Hyun (Department of Pharmacology, School of Medicine, Kyungpook National University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.45, no.2, 2014 , pp. 181-185 More about this Journal
Abstract
This study was carried out to investigate the acute toxicity of the bark of Diospyros kaki (Ebenaceae) in mice. The aqueous extract of the bark of Diospyros kaki (AEDK) was administered orally at a doses of 5 mg/kg, 50 mg/kg, 300 mg/kg and 2,000 mg/kg. In this study, number of deaths, clinical signs, body weights and pathological examinations were investigated after administration of AEDK. There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and AEDK treated groups in clinical signs, organ weights and gross pathological findings. AEDK did not show any toxic effect in mice.
Keywords
Bark of Diospyros kaki; acute toxicity; mice;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
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