• 대한본초학회지
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• 제28권2호
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• pp.9-15
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• 2013

Objectives : The root of Codonopsis pilosula (Fr.) Nannf. (Codonopsis Pilosulae Radix) has been traditionally used as a oriental medicine with an anti-thrombotic, antidiabetic, anticancer, and anti-gastric ulcer effects and immunological adjuvant. In this study, we investigated the effect of 70% ethanol extract of Codonopsis Pilosulae Radix (CPR-E) on ovalbumin (OVA)-induced allergic responses in mice. Methods : Mice were sensitized (1, 8, and 15 days) with OVA and airway challenged(22, 24, 26, 28, and 30 days) to induced allergic responses. CPR-E extract at doses of 50 and 100 mg/kg/body weight was orally administered from days 21 to 30 consecutively. The levels of allergic mediators such as histamine, OVA-specific immunoglobulin (Ig) E, and Th1/Th2 cytokines such as IFN-${\gamma}$ and IL-4 were measured in the sera of mice by ELISA. The histological change of lung tissue was observed by hematoxylin and eosin (H&E) staining. Results : CPR-E extract significantly decreased the serum levels of histamine, OVA-specific IgE, and IL-4 compared with those of OVA control group, but significantly increased the serum level of IFN-${\gamma}$. Based on H&E staining, CPR-E extract inhibited the infiltration of inflammatory cells into lung tissues with histological changes. Conclusions : These results indicate that CPR-E extract has anti-inflammatory and anti-allergic responses through regulating the cytokine balance, suggesting that the extract may be useful for the treatment of allergic inflammatory diseases such as bronchial asthma and allergic rhinitis.

• 대한통합의학회지
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• 제10권4호
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• pp.165-173
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• 2022

Purpose : This study was conducted to apply a 12-week resistance exercise program to obese elderly people with sarcopenia and verify the risk factors of sarcopenia and metabolic syndrome as well as the effects of this program on improving muscle function, and thus to serve as basic data for preventing and improving sarcopenia. Methods : Forty elderly people aged 65 or older were recruited and underwent dual energy x-ray absorptiometry. Based on the criteria of appendicular skeletal muscle mass (ASM/Height²: less than 5.4 kg/m²) and body fat percentage (at least 30 % for women and 25 % for men), 18 obese elderly people with sarcopenia were finally selected after excluding 22 elderly people who did not meet the criteria. Variables related to sarcopenia, metabolic syndrome, and muscle function were measured before the 12-week resistance exercise program. Results : The 12-week resistance exercise program significantly increased the bone density and muscle mass and decreased the fat mass and fat percentage in obese elderly with sarcopenia. The 12-week resistance exercise program significantly increased the HDL-C and decreased the LDL-C and waist circumference in obese elderly people with sarcopenia (p<.05). The 12-week resistance exercise program significantly increase grip strength, static balance, and 6-minute walking in obese elderly people with sarcopenia (p<.05). Conclusion : Accordingly, resistance exercise is considered a way to reduce the exorbitant medical expenses of patients who are bedridden for long and improve the lowered quality of individuals in a super-aged society.

• Journal of Animal Science and Technology
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• 제64권2호
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• pp.247-261
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• 2022

Ketosis is associated with high milk yield during lactating or insufficient feed intake in lactating dairy cows. However, few studies have been conducted on the metabolomics of ketosis in Korean lactating dairy cows. The present study aimed to investigate the serum and urine metabolites profiling of lactating dairy cows through proton nuclear magnetic resonance (¹H-NMR) spectroscopy and comparing those between healthy (CON) and subclinical ketosis (SCK) groups. Six lactating dairy cows were categorized into CON and SCK groups. All experimental Holstein cows were fed total mixed ration. Serum and urine samples were collected from the jugular vein of the neck and by hand sweeping the perineum, respectively. The metabolites in the serum and urine were determined using ¹H-NMR spectroscopy. Identification and quantification of metabolites was performed by Chenomx NMR Suite 8.4 software. Metabolites statistical analysis was performed by Metaboanalyst version 5.0 program. In the serum, the acetoacetate level was significantly (p < 0.05) higher in the SCK group than in the CON group, and whereas acetate, galactose and pyruvate levels tended to be higher. CON group had significantly (p < 0.05) higher levels of 5-aminolevulinate and betaine. Indole-3-acetate, theophylline, p-cresol, 3-hydroxymandelate, gentisate, N-acetylglucosamine, N-nitrosodimethylamine, xanthine and pyridoxine levels were significantly (p < 0.05) higher in the urine of the SCK group than that in the CON group, which had higher levels of homogentisate, ribose, gluconate, ethylene glycol, maltose, 3-methyl-2-oxovalerate and glycocholate. Some significantly (p < 0.05) different metabolites in the serum and urine were associated with ketosis diseases, inflammation, energy balance and body weight. This study will be contributed useful a future ketosis metabolomics studies in Korea.

• Journal of Nutrition and Health
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• 제55권4호
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• pp.441-449
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• 2022

This review is focused on analyzing the limits and shortage of zinc (Zn) for the 2020 Dietary Reference Intakes for Koreans (KDRIs), and provides suggestions for the future establishment of the 2025 KDRIs for Zn. The 2020 KDRIs for Zn have been established to estimate the adequate requirement (EAR), recommended nutrient intakes (RNI), adequate intake (for only 0-5 mon) and tolerable upper intake level (UL). EAR was estimated in 2-stages: the first stage was to construct of the frame of analysis for Zn requirement and the second stage involved a factorial approach by considering the various factors which affect Zn requirement, such as intestinal and urine Zn loss, Zn requirement for growth and development, and Zn absorption rate. For a more precise and accurate establishment of the Zn requirement, we suggest for the following to be considered: 1) considering that Zn is present in minuscule amounts as a trace element in our body, the present values for Zn EAR (as 6-9 mg/d) should be expressed as a decimal point for more accurate DRIs; 2) the frame of analysis for Zn requirement has to be more specifically and should includes the factors which affect Zn requirement; 3) both, the factorial approach and extrapolation method need to be well reviewed and thoroughly understood for establishing precise Zn requirement; 4) currently, human clinical study and balance study (Zn intake, excretion and absorption rate) are limited and more human Zn subject studies are required. All these suggestions are provided to better establish the Zn requirement in the 2025 KDRIs.

• 대한물리의학회지
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• 제18권1호
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• pp.99-110
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• 2023

PURPOSE: This study was conducted to suggest a way to easily understand and utilize the International Classification of Functioning, Disability and Health (ICF) or Korean Standard Classification of Functioning, Disability and Health (KCF), a common and standard language related to health information. METHODS: The tools used by physical therapists to evaluate the functioning of neurological patients were collected from 10 domestic hospitals. By applying the ICF linking rule, two experts compared, analyzed, and linked the concepts in the items of the collected tools and the ICF/KCF codes. The frequency of use of the selected tool, the matching rate of the liking results of two experts, and the number of the codes linked were treated as descriptive statistics and the code set was presented as a list. RESULTS: The berg balance scale, trunk impairment scale, timed up and go test, functional ambulation category, 6 Minute walk test, manual muscle test, and range of motion measurements were the most commonly used tools for evaluating the functioning. The total number of items of the seven tools was 33, and the codes linked to the ICF/KCF were 69. Twenty-two codes were mapped, excluding duplicate codes. Ten codes in the body function, 11 codes in the activity, and one code in the environmental factor were included. CONCLUSION: The information on the development process of the code set will increase the understanding of ICF/KCF and the developed code set can conveniently be used for collecting patients' functioning information.

• 대한한방내과학회지
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• 제44권1호
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• pp.1-11
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• 2023

Objective: There are currently no disease-modifying medications or definite long-term sustainable interventions for patients with Parkinson's disease (PD), indicating an unmet treatment need. Our goal was to create a long-term sustainable intervention for PD patients that can be used in Korean medicine clinics. Methods: The Meridian Activation Remedy System (MARS) was created to stimulate a patient's 12 meridians and sinew channels using a combination of acupoint stimulation and exercise. The acupoints and motions used in MARS were selected through literature studies and expert advice. The methodologies were refined using observational and case studies. With slow and fast movements, the MARS intervention was intended to activate both slow- and fast-twitch muscle fibers. Intradermal acupuncture and motion that shift the center of gravity were employed to enhance the patient's balance and proprioception. In addition, the intervention included alternating movement exercises to address the complex cognitive decline commonly occurring in PD patients. Results: The following acupoints were chosen for the MARS intervention: bilateral Hegu (LI4), Houxi (SI3), Waiguan (TE5), Neiguan (PC6), Zhongchong (PC9), Yuji (LU10), Zusanli (ST36), Yanglingquan (GB34), Taichong (LR3), Kunlun (BL60), and Taixi (KI3). We also developed actions that can stimulate the body's 12 meridians. Conclusion: We developed the MARS intervention, which combines acupuncture and exercise, to address the unmet therapeutic needs of PD patients. We hope that with additional research, the MARS intervention can be set as an effective therapeutic program for PD patients.

• 대한물리치료과학회지
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• 제29권4호
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• pp.27-42
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• 2022

Background: Although children with cerebral palsy (CP) are able to walk independently, gait imbalance occurs due to abnormal muscle tone, musculoskeletal deformity, loss of balance, and selective motor control impairment. Gait restriction in the community and school is a major problem of rehabilitation in CP. Home-based therapy (HBT) provides a variety of interventions in which the therapist and the parent work together to resolve the activities and problems caused by the child's body structure. Therefore, we investigate the effectiveness of home-centered therapy on gross motor function in CP and try to present the possibility of clinical application. Design: A Systematic Review Methods: Research papers were published from Jan, 2012 to Jan, 2022 and were searched using Medline and PubMed. The search terms are 'family-centered' OR 'home-based' AND 'cerebral palsy'. A total of nine papers were analyzed in this study. The paper presented the quality level based on Physiotherapy Evidence Database (PEDro) scores to assess the quality of randomized clinical trials studies. Results: The results showed that HBT for strengthening exercise in lower extremity has a positive effect on the isokinetic torque and gross motor function. home-based treadmill therapy in CP is effective to perform at least 12 sessions of treadmill HBP in which the therapist determines the treadmill speed every week and the child's own gait pattern is modified. Conclusion: These results suggest that it will be important data for founding evidence on the effectiveness of home-centered therapy on gross motor function in children with cerebral palsy to advance clinical protocols.

• International journal of advanced smart convergence
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• 제12권2호
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• pp.76-83
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• 2023

Squatting of agricultural work can cause musculoskeletal disorders due to excessive pressure and rotational force on the knee joint In order to improve the assistive chair used in squatting agricultural work so that it can be used in a narrow groove, it is intended to improve the musculoskeletal harm of squatting work by attaching a spring on the assistive chair. Therefore, in the presenty study, 3D drawing was done using ProEngineer (3D), and a mock-up was produced and tested. Using pro-Engineer, it was judged that it was rare for plastic to be broken by a spring, so the analysis was conducted with a focus on springs. It was found that the structure that can absorb the shock according to the rigidity of the tape spring and balance the body is that the power to withstand the load of the weight is distributed as a whole when five springs are used. Electromyography was measured using ME600 (Mega Electronics, Finland) Measuring equipment attached to the waist, thighs, calves, and shins. EMG values were measured and compared with the prototype in two ways, when the worker did not wear the product and when he wore an existing product on the market. As a result of the experiment when using the prototype, the maximum EMG value for each part is considered to be helpful in preventing musculoskeletal diseases as the amount of muscle used is reduced in the waist, thighs, calves, and shins.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.369-372
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• 2021

요즘 시대에는 사람들이 학업이나 일 때문에 앉아있는 시간이 많아지고 있다. 또한 휴식 시간에도 사람들이 컴퓨터, 스마트폰, 태블릿 PC를 많이 사용하므로 자세가 더 나빠지고 있다. 장시간 동안 이러한 자세를 유지하면 목, 어깨, 척추와 관련된 근골격계에 문제가 발생한다. 또한 육체 피로와 자세 변형 등의 문제는 다양한 연령대로 확대될 것으로 추정된다. 따라서 본 연구에서 개발 중인 시스템의 핵심 기능은 본인의 자세가 올바른지 확인하고 제작된 모바일 애플리케이션을 사용하여 경고 알림을 수신하게 하는 것이다. 이를 위해 휨 센서, 압력 센서, 기울기 센서를 부착하여 활용한다. 휨 센서는 자세의 휘어짐을 감지하여 비교하여 아두이노 우노 보드로 송신한다. 또한 몸의 밸런스, 기울기 등의 정보를 취합하여 지금의 자세가 올바른지 판단한다. 자세가 올바르지 않을 때 경고하는 방법은 모바일 애플리케이션을 통하여 알림을 받으며, 사용자와 보호자의 애플리케이션에 본인의 자세가 올바르지 않는다는 것을 표시한다. 본 연구에서 제안한 시스템을 통하여서 앞으로의 자세관련 연구에 큰 도움이 될것이 기대된다.

• 한국노년학
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• 제30권4호
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• pp.1377-1392
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• 2010

본 연구는 농촌여성노인들이 체험하는 여가생활의 의미와 본질이 무엇인지 이해하고, 그들의 삶의 과정에 있어서 여가생활이 어떤 영향과 의미를 주는지 밝혀내어 건강과 관련된 간호중재 개발을 위한 기초자료를 제공하는데 목적을 두고 있다. 연구방법은 질적연구방법으로 van Manen의 해석학적 현상학적 분석방법을 사용하였다. 그 결과 농촌여성노인이 체험하는 여가생활은 '어울림을 통해 외로움 극복하기', '몸을 활용해 심신(心身)의 조화 이루기', '내 힘으로 자식(子息)의 짐 덜어주기', '무료한 세월보내기', '소소한 즐거움 찾기', '새로운 것을 익히며 뿌듯함 얻기', '세상과 소통하며 살아가기' 등의 7개의 본질적 주제를 도출하였다. 농촌여성노인이 체험하는 여가생활은 자연과 동화되면서, 건강과 사회관계를 유지하는 것으로 나타났다. 또한 농촌의 사회·경제적 특성으로 인한 외로움과 소외감 등을 연배노인들과 어울리며, 이를 극복하기 위한 시간임을 확인할 수 있었다.