• BMB Reports
• /
• 제36권1호
• /
• pp.95-109
• /
• 2003

Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant imbalance. The sources of the increased oxidative stress in patients with chronic inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) derive from the increased burden of inhaled oxidants, and from the increased amounts of reactive oxygen species (ROS) generated by several inflammatory, immune and various structural cells of the airways. Increased levels of ROS produced in the airways is reflected by increased markers of oxidative stress in the airspaces, sputum, breath, lungs and blood in patients with lung diseases. ROS, either directly or via the formation of lipid peroxidation products such as 4-hydroxy-2-nonenal may play a role in enhancing the inflammation through the activation of stress kinases (JNK, MAPK, p38) and redox sensitive transcription factors such as NF-${\kappa}B$ and AP-1. Recent evidences have indicated that oxidative stress and pro-inflammatory mediators can alter nuclear histone acetylation/deacetylation allowing access for transcription factor DNA binding leading to enhanced pro-inflammatory gene expression in various lung cells. Understanding of the mechanisms of redox signaling, NF-${\kappa}B$/AP-1 regulation, the balance between histone acetylation and deacetylation and the release and expression of pro- and anti-inflammatory mediators may lead to the development of novel therapies based on the pharmacological manipulation of antioxidants in lung inflammation and injury. Antioxidants that have effective wide spectrum activity and good bioavailability, thiols or molecules which have dual antioxidant and anti-inflammatory activity, may be potential therapeutic agents which not only protect against the direct injurious effects of oxidants, but may fundamentally alter the underlying inflammatory processes which play an important role in the pathogenesis of chronic inflammatory lung diseases.

• 응용통계연구
• /
• 제31권1호
• /
• pp.67-75
• /
• 2018

다차원척도법은 개체간의 비유사성을 저차원 공간에 기하적으로 표현하기 위한 다변량 자료의 탐색적 분석기법이다. 그러나 일반적인 다차원척도그림에서는 개체들의 유사성 정보만이 표현될 뿐 변수와 관련된 정보가 나타나지 않기 때문에 그림의 해석 상에 한계점이 존재한다. 본 연구에서는 범주형 자료를 다중표시행렬로 변환하고 Torgerson (1958)의 알고리즘에 의한 다차원척도법을 적용하여 개체들의 군집화 성향과 군집들의 상대적 크기를 다차원척도그림으로 시각화하였다. 그리고 Shin 등 (2015)의 분할법을 적용하여 범주형변수의 범주수준별 정보를 다차원척도그림 상에 투영하여 추가적인 정보를 표현하였다. 따라서 본 연구에서 제안하고자 하는 다차원척도그림을 이용하면 개체들의 유사성 정보와 함께 범주형변수들 사이의 연관성도 탐색할 수 있는 장점이 있다.

• 대한영양사협회학술지
• /
• 제16권4호
• /
• pp.369-377
• /
• 2010

This study was conducted to investigate the effects of food consumption monitoring based on a digital photography method using a mobile phone on food consumption and weight reduction. Eighteen female college students (>30% body fat) participated in the weight control program using a mobile-phone for 4 wks. The energy intake was reduced significantly after 3 wks compared to baseline (P<0.05, baseline: 1,453.0 kcal, 3rd wk: 1,171.1 kcal, 4th wk: 1,130.8 kcal). The subjects lost 2.8 kg of body weight, 1.4% of % body fat, and 1.1 $kg/m^2$ of body mass index (BMI) after 4 wks. There were also significant differences in blood pressure (P<0.001) and serum cholesterol (total cholesterol: P<0.05, LDL-cholesterol: P<0.01) before and after the self-regulated diet program. In this study, the digital photography method using a mobile-phone influenced weight control through trained consumption monitoring, which helps individuals reduce discrepancies between perceived and actual consumption levels. Therefore, effective monitoring by taking food pictures using a mobile-phone can lead individuals to rely more heavily on easy-to-monitor visual cues.

• 한국융합학회논문지
• /
• 제2권4호
• /
• pp.47-52
• /
• 2011

치주질환(periodontal disease, 잇몸병)은 인구의 50%이상이 이환되는 만성질환이다. 치주질환을 치료하지 않으면, 치아 지지조직의 염증을 악화시켜 치아손실(tooth loss)을 가져온다. 고혈압은 성인의 30%에서 발병하며, 심혈관계통 질환의 이환(morbidity)과 사망(mortality)의 중요한 원인이다. 약 20년 전까지만 해도 두 가지 질환은 깊은 관련이 없어 보였지만, 최근 서로 연관성이 있다는 사실이 밝혀졌다. 심혈관계통의 위험요소에 대한 연구결과, 죽상경화증(atherosclerosis) 합병증 발생은 치주(periodontium) 질환과 관계가 있다. 즉, 뇌졸중(stroke), 관상동맥질환, 말초동맥질환에 대한 위험요소가 치주염이라는 증거가 있다. 이런 인과관계는 두 가지 질환이 서로 공통의 위험요소를 갖는다는 의미이다. C-reactive protein(CRP)은 치주염에서 증가하고, 치주질환 환자는 혈관운동 기능(vasomotor function)이 손상된다는 보고가 있었으며, 치주질환으로 인해 고혈압이 발생한다. 본 연구의 목적은 문헌 고찰을 통해, 치주염과 고혈압을 비롯한 심혈관계통 질환의 인과관계를 밝히고자 한다. 고혈압은 당뇨와 함께 대표적인 생활습관질병이기 때문에, 본 연구를 통해서 적절한 치아관리를 통해 고혈압으로 인한 여러 가지 합병증을 예방하고자 한다.

• Journal of Nutrition and Health
• /
• 제36권7호
• /
• pp.691-698
• /
• 2003

The purpose of this study was to investigate the effect of vitamin E on the cadmium accumulation in body, cadmium excretion and detoxification functions in chronic cadmium poisoned rats. Sprague-Dawley male rats weighing 100$\pm$10 g were randomly assigned to one normal group and three cadmium poisoned groups. Cadmium poisoned groups were classified to vitamin E free diet (Cd-0E group), vitamin E 40 mg/kg diet (Cd-400E group) and 400 mg/kg diet (Cd-400E group) according to the levels of vitamin E supplement. Animals were maintained on 0, 40 mg and 400 mg vitamin E/kg diets for 20 weeks and simultaneously administered 50 ppm Cd$^{2+}$ dissolved in the drinking water. Body weight, food intakes and food efficiency ratio were significantly decreased in all cadmium groups, compared with those of normal group. The accumulation of cadmium in rat liver, kidney and blood was reduced by sufficient vitamin E supplementation. The metallothionein (MT) content in liver and kidney were increased in all cadmium groups compared with that of normal group. The ratio of cadmium absorption and retention were significantly decreased in vitamin E supplementation groups. Accordingly, vitamin E supplementation resulted in an excretion of cadmium in urine and feces and a lowered accumulation of cadmium in liver and kidney. It can be suggested that increased MT synthesis lead to the significant decrease in cadmium absorption and retention ratios.s.

• Journal of Nutrition and Health
• /
• 제38권1호
• /
• pp.56-66
• /
• 2005

The purpose of this study was to assess the zinc and copper status of type 2 diabetic women and to analyse the relation-ship among zinc and copper status, and diabetic control indices of diabetes. The mean age of diabetes was 57.9 years old. The mean duration of diabetes was 8.0 $\pm$ 6.5 years. The mean daily energy intake of diabetes was 1562 kcal. There were no significant differences of age, BMI, %body fat, nutritional intakes, total energy intake, and energy composition from carbohydrate, protein, and fat between diabetes (n = 50) and control group (n = 68). However, both zinc intake density (4.15 mg/1000 kcal) and zinc %RDA (62.0%) of diabetes were significantly lower than control group (p <0.05, P < 0.01, respectively). The plasma zinc level was not significantly different between diabetes and control group (90$\mu$g/dl, 91$\mu$g/dl respectively). The proportion of diabetic women whose plasma zinc levels were lower than 76 $\mu$g/dl(borderline zinc deficiency) was 18.8%. This was about 38% higher than control group. It has been suggested that insulin secretion might decrease in borderline plasma zinc and copper deficiency and increase in normal plasma zinc and copper status. The urinary zinc excretion was twice higher in diabetes than in control group (p < 0.001). The urinary zinc loss was positively correlated with the duration of diabetes (p < 0.05), hyperglycemia (p < 0.001) and insulin resistance (p < 0.05). These results lead us to conclude that normal blood glucose level controlled by diet therapy could improve the hyperzincuria in diabetic women.

• 한국식품영양과학회지
• /
• 제30권3호
• /
• pp.540-546
• /
• 2001

The purpose of this study was to investigate the relationship among nutritional status of copper and zinc, serum leptin, and lipids of 99 middle school girls residing in kyunggi-do, Korea. Subjects were divided assigned to one of two groups such as normal (BMI<85 percentile, n=58) and obese (85$\leq$BMI, n=41) groups. Subjects were evaluated based on anthropometric measurements, 24-hr dietary recalls and blood analysis. The mean age was 13.93 years. The mean weight (p<0.001), BMI (p<0.001), body fat (p<0.001) of obese were significantly higher then those of normal group. The mean daily energy intake was 94.2% of RDA for Korean. The ratio of energy coming from carbohydrate, fat and protein was 63:24:13. The mean daily intakes of Cu and Zn were 1.4 mg and 7.4 mg (73.7% of RDA), and there were no significant difference between two groups. The mean serum levels of leptin (p<0.001), LDL-cholesterol (p<0.05), triglyceride (p<0.01), TPH (total cholesterol/HDL; p<0.001), LPH (LDL/HDL; p<0.001) and AI (atherogenic index; p<0.001) of obese were significantly higher than those of normal group. The mean serum Cu level of obese was significantly higher than normal group but, the mean serum Zn level of obese was significantly lower than normal group. Serum Cu showed a significantly positive correlations with body weight (p<0.001), BMI (p<0.001), body fat (p<0.001), serum leptin, and LPH. However, serum Zn showed a significantly negative correlations with body weight (p<0.001), BMI (p<0.001), serum leptin (p<0.001), TPH (p<0.05), and AI (Atherogenic index; p<0.05). To summarize the results, the Zn intakes of middle school girls did not reach to RDA for Koreans. Also, increase of BMI may lead to decrease of serum zinc level and increase of serum copper level, and this change of serum zinc related to the change of serum leptin and serum lipids level in middle school girls during rapid growth.

• 대한간호학회지
• /
• 제46권1호
• /
• pp.140-148
• /
• 2016

Purpose: This study was performed to determine the physical and psychological effects of an urban forest-walking program for office workers. For many workers, sedentary lifestyles can lead to low levels of physical activity causing various health problems despite an increased interest in health promotion. Methods: Fifty four office workers participated in this study. They were assigned to two groups (experimental group and control group) in random order and the experimental group performed 5 weeks of walking exercise based on Information-Motivation-Behavioral skills Model. The data were collected from October to November 2014. SPSS 21.0 was used for the statistical analysis. Results: The results showed that the urban forest walking program had positive effects on the physical activity level (U=65.00, p <.001), health promotion behavior (t= - 2.20, p =.033), and quality of life (t= - 2.42, p =.020). However, there were no statistical differences in depression, waist size, body mass index, blood pressure, or bone density between the groups. Conclusion: The current findings of the study suggest the forest-walking program may have positive effects on improving physical activity, health promotion behavior, and quality of life. The program can be used as an effective and efficient strategy for physical and psychological health promotion for office workers.

• 여성건강간호학회지
• /
• 제27권2호
• /
• pp.75-92
• /
• 2021

Purpose: This study aimed to analyze the content and effectiveness of psychosocial support interventions for women with gestational diabetes mellitus (GDM). Methods: The following databases were searched with no limitation of the time period: Ovid-MEDLINE, Cochrane Library, Ovid-Embase, CINAHL, PsycINFO, NDSL, KoreaMed, RISS, and KISS. Two investigators independently reviewed and selected articles according to the predefined inclusion/exclusion criteria. ROB 2.0 and the RoBANS 2.0 checklist were used to evaluate study quality. Results: Based on the 14 selected studies, psychosocial support interventions were provided for the purpose of (1) informational support (including GDM and diabetes mellitus information; how to manage diet, exercise, stress, blood glucose, and weight; postpartum management; and prevention of type 2 diabetes mellitus); (2) self-management motivation (setting goals for diet and exercise management, glucose monitoring, and enhancing positive health behaviors); (3) relaxation (practicing breathing and/or meditation); and (4) emotional support (sharing opinions and support). Psychosocial supportive interventions to women with GDM lead to behavioral change, mostly in the form of self-care behavior; they also reduce depression, anxiety and stress, and have an impact on improving self-efficacy. These interventions contribute to lowering physiological parameters such as fasting plasma glucose, glycated hemoglobin, and 2-hour postprandial glucose levels. Conclusion: Psychosocial supportive interventions can indeed positively affect self-care behaviors, lifestyle changes, and physiological parameters in women with GDM. Nurses can play a pivotal role in integrative management and can streamline the care for women with GDM during pregnancy and following birth, especially through psychosocial support interventions.

• Nutrition Research and Practice
• /
• 제5권6호
• /
• pp.511-519
• /
• 2011

Dietary intake of whole grains reduces the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. In an earlier study, we showed that Panicum miliaceum L. extract (PME) exhibited the highest anti-lipogenic activity in 3T3-L1 cells among extracts of nine different cereal grains tested. In this study, we hypothesized that PME in the diet would lead to weight loss and augmentation of hyperlipidemia by regulating fatty acid metabolism. PME was fed to ob/ob mice at 0%, 0.5%, or 1% (w/w) for 4 weeks. After the experimental period, body weight changes, blood serum and lipid profiles, hepatic fatty acid metabolism-related gene expression, and white adipose tissue (WAT) fatty acid composition were determined. We found that the 1% PME diet, but not the 0.5%, effectively decreased body weight, liver weight, and blood triglyceride and total cholesterol levels (P < 0.05) compared to obese ob/ob mice on a normal diet. Hepatic lipogenic-related gene ($PPAR{\alpha}$, L-FABP, FAS, and SCD1) expression decreased, whereas lipolysis-related gene (CPT1) expression increased in animals fed the 1% PME diet (P < 0.05). Long chain fatty acid content and the ratio of C18:1/C18:0 fatty acids decreased significantly in adipose tissue of animals fed the 1% PME diet (P < 0.05). Serum inflammatory mediators also decreased significantly in animals fed the 1% PME diet compared to those of the ob/ob control group (P < 0.05). These results suggest that PME is useful in the chemoprevention or treatment of obesity and obesity-related disorders.