Browse > Article

Effect of Vitamin E on Cadmium Accumulation and Excretion in Chronic Cadmium Poisoned Rats  

Kim, Mi-Ji (Department of Food Science and Nutrition, Catholic University of Daegu)
Hong, Jung-Hee (Department of Food Science and Nutrition, Catholic University of Daegu)
Rhee, Soon-Jae (Department of Food Science and Nutrition, Catholic University of Daegu)
Publication Information
Journal of Nutrition and Health / v.36, no.7, 2003 , pp. 691-698 More about this Journal
Abstract
The purpose of this study was to investigate the effect of vitamin E on the cadmium accumulation in body, cadmium excretion and detoxification functions in chronic cadmium poisoned rats. Sprague-Dawley male rats weighing 100$\pm$10 g were randomly assigned to one normal group and three cadmium poisoned groups. Cadmium poisoned groups were classified to vitamin E free diet (Cd-0E group), vitamin E 40 mg/kg diet (Cd-400E group) and 400 mg/kg diet (Cd-400E group) according to the levels of vitamin E supplement. Animals were maintained on 0, 40 mg and 400 mg vitamin E/kg diets for 20 weeks and simultaneously administered 50 ppm Cd$^{2+}$ dissolved in the drinking water. Body weight, food intakes and food efficiency ratio were significantly decreased in all cadmium groups, compared with those of normal group. The accumulation of cadmium in rat liver, kidney and blood was reduced by sufficient vitamin E supplementation. The metallothionein (MT) content in liver and kidney were increased in all cadmium groups compared with that of normal group. The ratio of cadmium absorption and retention were significantly decreased in vitamin E supplementation groups. Accordingly, vitamin E supplementation resulted in an excretion of cadmium in urine and feces and a lowered accumulation of cadmium in liver and kidney. It can be suggested that increased MT synthesis lead to the significant decrease in cadmium absorption and retention ratios.s.
Keywords
chronic cadmium poisoning; vitamin E; cadmium accumulation and excretion; metallothionein;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Anderson WAD. Selective of organ response to cadmium injury and various protective measures /
[ Samuel,A.G.;Thelma,C.G. ] / J PATH BACT   DOI
2 Effect of hspridine extracted from tangerine peel on Cd and lipid metabolism and antioxidative capacity in rats /
[ Kim,HJ,;Bae,K.H.;Lee,HJ,;Eun,JB,;Kim,MK ] / Korean J Nutrition   과학기술학회마을
3 Acute pressor of Intra-Arterial Cadmium and Mercuric lons in Anestherized Rats /
[ Perry,H.M.Jr.;Yunice,A. ] / Proc Soc Exp Bio Med   DOI
4 Metallothioneins and their role in the metabolism and toxicity of metals /
[ Cherian,M.G.;Goyer,R.A. ] / Life Science   DOI
5 Cadmium copper and zinc distribution in blood of rats after long-term cadmium administration /
[ Suzuki,Y. ] / J Toxical Environ Health
6 /
[ Page,A.L.;Chang,A.C. ] / Cadmium
7 The importance of vitamins in relation to the presence of heavy metals in food /
[ Place,V.;Lannucci,E. ] / Panmimerva Med
8 Protective effects of GSH, vitamin E and selenium on lipid peroxidation in cadmium-fed rats /
[ Rana,S.V.;Verma,S. ] / Biol Trace Elem Res   DOI   ScienceOn
9 Influence of long term Cd exposure in urinary excretion of protein and Cd in mice /
[ Nordberg,G.F.;Piscator,M. ] / Environ Physiol Biochem
10 Renal Tubular dysfunction and abnormalities of calcium metabolism in cadmium workers /
[ Kazantzis,G. ] / Environ Health Perspect   DOI
11 Internations of cadmium with copper, zinc and iron in different organs and tissue of the rat /
[ Juhslshamn,K.;Utone,F.;Bracckan,O.R. ] / Acta Pharmacol Toxicol   DOI   ScienceOn
12 Defense mechanisms against cadmium toxicity III.Effect of pretreatment with small oral does of cadmium on metallothionein synthesis after a large oral does of cadmium in mice /
[ Morita,S. ] / Japan J Pharmacol   DOI
13 Determination of lead in biological and related material by atomic absorption spectrophotometry /
[ Yeager,D.W.;Cholak,J.;Henderson,E.W. ] / Environ Sci Technol   DOI
14 Effects of dietary cadmium asn protein levels on the body protein metabolism and cadmium toxicity in growing rats /
[ Lee,H.Y.;Kim,M.K. ] / Korean J Nutr   과학기술학회마을
15 /
[ Kim,K.R. ] / Effects of vitamin E on Arachidonic acid cascade of platelet and aorta in cadmium poisoned rats
16 Exercise and detrains. Effect on food iantake, adiposity and lipogenesis in osborne-mendol rats mode obese by a high fat diet /
[ Applegate,E.A.;Sterm,J.S. ] / J Nutr
17 On the distribution of cadmium in blood /
[ Nordberg,F;Fiscator,M.;Nordberg,M. ] / Acta Pharmacol Toxicol   DOI
18 Effects of dietary vitamin E and protein on cadmium oxicity in rats /
[ Kim,H.J.;Cho,S.Y.;Park,J.M. ] / J Korean Soc Food Nutr
19 Inhibition of renal adenosine triphosphatase by cadmium /
[ Nechay,B.R.;Saunders,J.P. ] / J Pharmacol Exp Ther
20 Dietary exposure to cadmium and health effect:impact of environmental exchanges /
[ Piscator,M. ] / Environ Health perspect   DOI
21 Effects of calcium and vitamin D on the cadmium intoxification of rats /
[ Cho,S.Y.;Huh,S.Y.;Lee,S.H. ] / J of Korean Soc Food Nutr
22 Effects of green tea catechin on cadmium accumulation in chronic cadmium poisoned rats /
[ Choi JH;Hahn SH ] / Korean Journal of Nutrition   과학기술학회마을
23 Restraintstress-induced changes in rat liver and serum metallothionein and in zinc metabolism /
[ Hidalgo,J.;Amario,A.;Flos,R.;Garvey,J.S. ] / Experimentia Basel   DOI
24 Effects of dietary calcium level on cadmium and lead toxicity in rats /
[ Kim,M.K.;Baek,S.M. ] / Korean J Nutr   과학기술학회마을
25 Atomic absorption determination of lead in blood and urine in the presence of EDTA /
[ Zinterhofer,L.J.;Jatlow,P.I.;Fappiano,A. ] / J Lab Clin Med
26 Influence of cadmium in renal ischemic hypertension in rats /
[ Schroeder,H.A.;Nason,A.P.;Prior,R.E.;Reed,J.B.;Haessler,W.T. ] / Am J Physiol
27 Increase of cadmium-thiolate clusters as a measure of morphological non-toxic cadmium accumulation in the liver /
[ Morselt,A.F.;Suzuki,K.T.;Roelofsen,A.M.;Hazelhoff,Reelfzen,W.;Copius,Peereboom-Stegeman,J.H. ] / Toxicology   DOI   ScienceOn
28 A suppresive effect of alginate on intestinal absorption of cadmium in vitro /
[ Yang,J.S.;Hahn,S.H.;Lee,S.R. ] / Korean J Nutr
29 Preventive effect of vitamin E in cadmium intoxification /
[ Tadon,S.K.;Singh,S.;Dhawan,M. ] / Biomed Environ Sci