• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.10
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• pp.895-903
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• 2016

Spaceborne imaging sensors require periodic calibrations using an on-board calibration device for an image quality of observation satellites. The on-board calibration device consists of a blackbody to provide uniform radiance temperatures and calibration mechanism with a function of stow and deploy to target the blackbody during the calibration. Among these devices, the calibration mechanism is required to implement a fail-safe function to prevent blocking of the main optical path when the mechanism stops at a certain position during on-orbit calibration. In addition, structural safety of the mechanical driving part of the mechanism within the launch environment must be guaranteed. In this study, we proposed a deploy/stow-type calibration mechanism that provides launch-lock and fail-safe function. The effectiveness of the functionality of the proposed mechanism was validated through functional test using engineering model.

• Journal of The Korean Association For Science Education
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• v.17 no.3
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• pp.251-260
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• 1997

The instructional influences of cooperative learning strategies, which emphasize mutual interdependency of learners, group goal, and individual accountability, upon students' achievement, the attitude toward science instruction and the perception of learning environment were investigated. Before instruction, the prior knowledge test about atoms and molecules, the test of attitudes toward science instruction, and the perception questionnaire of learning environment were administered, and the grade in the previous mathematics course was obtained. These scores were used as covariates. Mid-term examination score was used as blocking variable. For instruction, three different strategies-traditional individual learning, small group learning, and cooperative learning-were used and teaching materials for the units of mole and stoichiometry were also prepared. After instruction, the researcher-made achievement test, the test of attitudes toward science instruction, and the perception questionnaire of learning environment were administered. The perception questionnaire of group activities was also administered to the two treatment groups. In the quantitative subtest, the scores of cooperative learning group and small group learning group were significantly higher than those of traditional individual learning group. However, the cooperative learning group's scores in the achievement test and the qualitative subtest were significantly higher than those of small group learning group and traditional individual learning group. The students in the cooperative learning group were found to have the most positive perception of learning environment but to have similar attitudes toward science instruction. No interaction between the treatment and the level of the previous achievement was found in any of the analyses. In the perception questionnaire of group activities, students in both small group learning group and cooperative learning group exhibited positive perception of group activities. However, students in the cooperative learning group tended to think that their activities were related with their group's success. Educational implications are discussed.

• Biomolecules & Therapeutics
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• v.28 no.2
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• pp.152-162
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• 2020

Cerebral ischemia exhibits a multiplicity of pathophysiological mechanisms. During ischemic stroke, the reactive oxygen species (ROS) concentration rises to a peak during reperfusion, possibly underlying neuronal death. Recombinant human erythropoietin (EPO) supplementation is one method of treating neurodegenerative disease by reducing the generation of ROS. We investigated the therapeutic effect of PEGylated EPO (P-EPO) on ischemic stroke. Mice were administered P-EPO (5,000 U/kg) via intravenous injection, and middle cerebral artery occlusion (MCAO) followed by reperfusion was performed to induce in vivo ischemic stroke. P-EPO ameliorated MCAO-induced neurological deficit and reduced behavioral disorder and the infarct area. Moreover, lipid peroxidation, expression of inflammatory proteins (cyclooxygenase-2 and inducible nitric oxide synthase), and cytokine levels in blood were reduced by the P-EPO treatment. In addition, higher activation of nuclear factor kappa B (NF-κB) was found in the brain after MCAO, but NF-κB activation was reduced in the P-EPO-injected group. Treatment with the NF-κB inhibitor PS-1145 (5 mg/kg) abolished the P-EPO-induced reduction of infarct volume, neuronal death, neuroinflammation, and oxidative stress. Moreover, P-EPO was more effective than EPO (5,000 U/kg) and similar to a tissue plasminogen activator (10 mg/kg). An in vitro study revealed that P-EPO (25, 50, and 100 U/mL) treatment protected against rotenone (100 nM)-induced neuronal loss, neuroinflammation, oxidative stress, and NF-κB activity. These results indicate that the administration of P-EPO exerted neuroprotective effects on cerebral ischemia damage through anti-oxidant and anti-inflammatory properties by inhibiting NF-κB activation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.16 no.8
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• pp.710-718
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• 1991

In this pape, an analysis approach for the performance of serial search burst-format direct sequence spread-spectrum code acquisiion system using matched filter is presented. And an acquistion system using analog matched filter is analyzed by this approach. And special consideration is focused on the effect of the code autocorelation sideobes. The basic idea of thi approach is the constuction of state tansition digram at the time of random packet arrival and the calculation of the packet loss probability, which is deveoped in terms of the following parameters: the false alarm probability. the etection probability, and the probability of receiver blocking obtained from the blocked customers cleae queeing system model. The analysis results reveal that the performance of the acquisition system is degraded by the effet of the code autocorrelation sidelobes above a certain value of SN/chip.

• Journal of KIISE:Information Networking
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• v.28 no.3
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• pp.447-453
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• 2001

In this paper, we consider the scheduling of SE(switching element)-disjoint multicasting in photonic Banyan-type switching networks constructed with directional couplers. This ensures that at most, one connection holds each SE in a given time thus, neither crosstalk nor blocking will arise in the network. Such multicasting usually takes several routing rounds hence, it is desirable to keep the number of rounds(i.e., scheduling length) to a minimum. We first present the necessary and sufficient condition for connections to pass through a common SE(i.e., make crosstalk) in the photonic Banyan-type networks capable of supporting one-to-many connections. With definition of uniquely splitting a multicast connection into distinct subconnections, the crosstalk relationship of a set of connections is represented by a graph model. In order to analyze the worst case crosstalk we characterize the upper bound on the degree of the graph. The successor paper(Part II)[14] is devoted to the scheduling algorithm and the upper bound on the scheduling length. Comparison with related results is made in detail.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.4
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• pp.327-335
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• 2009

The aim of this study was to determine whether losartan, an angiotensin II (Ang II) type 1 ($AT_1$) receptor could influence the CA release from the isolated perfused model of the rat adrenal medulla. Losartan (5${\sim}$50 ${\mu}$M) perfused into an adrenal vein for 90 min produced dose- and time-dependent inhibition of the CA secretory responses evoked by ACh (5.32 mM), high $K^+$ (56 mM, a direct membrane depolarizer), DMPP (100 ${\mu}$M) and McN-A-343 (100 ${\mu}$M). Losartan failed to affect basal CA output. Furthermore, in adrenal glands loaded with losartan (15 ${\mu}$M) for 90 min, the CA secretory responses evoked by Bay-K-8644 (10 ${\mu}$M, an activator of L-type $Ca^{2+}$ channels), cyclopiazonic acid (10 ${\mu}$M, an inhibitor of cytoplasmic $Ca^{2+}$ -ATPase), veratridine (100 ${\mu}$M, an activator of $Na^+$ channels), and Ang II (100 nM) were markedly inhibited. However, at high concentrations (150${\sim}$300 ${\mu}$M), losartan rather enhanced the CA secretion evoked by ACh. Collectively, these experimental results suggest that losartan at low concentrations inhibits the CA secretion evoked by cholinergic stimulation (both nicotininc and muscarinic receptors) as well as by membrane depolarization from the rat adrenal medulla, but at high concentration it rather inhibits ACh-evoked CA secretion. It seems that losartan has a dual action, acting as both agonist and antagonist to nicotinic receptors of the rat adrenal medulla, which might be dependent on the concentration. It is also thought that this inhibitory effect of losartan may be mediated by blocking the influx of both $Na^+$ and $Ca^{2+}$ into the rat adrenomedullary chromaffin cells as well as by inhibiting the $Ca^{2+}$ release from the cytoplasmic calcium store, which is thought to be relevant to the $AT_1$ receptor blockade, in addition to its enhancement of the CA release.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.6
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• pp.617-625
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• 2018

Neddylation is a post-translational protein modification process. MLN4924 is a newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several cancer types. In our study, we first investigated the effect of MLN4924 on colon cancer cells (HCT116 and HT29). MLN4924 significantly inhibited the neddylation of cullin-1 and colon cancer cell growth in a time and dose-dependent manner. MLN4924 induced G2/M cell cycle arrest and apoptosis in HCT116 and HT29 cells. Moreover, MLN4924 also triggered autophagy in HCT116 and HT29 cells via suppressing the PI3K/AKT/mTOR pathway. Inhibiting autophagy by autophagy inhibitor 3-MA or ATG5 knockdown reversed the function of MLN4924 in suppressing colon cancer cell growth and cell death. Interestingly, MLN4924 suppresses colon cell growth in a xenograft model. Together, our finding revealed that blocking neddylation is an attractive colon cancer therapy strategy, and autophagy might act as a novel anti-cancer mechanism for the treatment of colon cancer by MLN4924.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.4
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• pp.207-214
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• 2002

The present study was designed to clarify whether tacrine affects the release of catecholamines (CA) from the isolated perfused model of rat adrenal gland or not and to elucidate the mechanism of its action. Tacrine $(3{\times}10^{-5}{\sim}3{\times}10^{-4}\;M)$ perfused into an adrenal vein for 60 min inhibited CA secretory responses evoked by ACh $(5.32{\times}10^{-3}\;M),$ DMPP (a selective neuronal nicotinic agonist, $10^{-4}$ M for 2 min) and McN-A-343 (a selective muscarinic M1-agonist, $10^{-4}$ M for 2 min) in relatively dose- and time- dependent manners. However, tacrine failed to affect CA secretion by high $K^+\;(5.6{\times}10^{-2}\;M).$ Tacrine itself at concentrations used in the present experiments did not also affect spontaneous CA output. Furthermore, in the presence of tacrine $(10^{-4}\;M),$ CA secretory responses evoked by Bay-K-8644 (an activator of L-type $Ca^{2+}$ channels, $10^{-4}\;M),$ but not by cyclopiazonic acid (an inhibitor of cytoplasmic $Ca^{2+}-ATPase,\;10^{-4}\;M),$ was relatively time-dependently attenuated. Also, physostigmine $10^{-4}\;M),$ given into the adrenal gland for 60 min, depressed CA secretory responses evoked by ACh, McN-A-343 and DMPP while did not affect that evoked by high $K^+.$ Collectively, these results obtained from the present study demonstrate that tacrine greatly inhibits CA secretion from the perfused rat adrenal gland evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors, but does fail to affect that by direct membrane-depolarization. It is suggested that this inhibitory effect of tacrine may be exerted by blocking both the calcium influx into the rat adrenal medullary chromaffin cells without $Ca^{2+}$ release from the cytoplasmic calcium store, that is relevant to the cholinergic blockade. Also, the mode of action between tacrine and physostigmine in rat adrenomedullary CA secretion seems to be similar.

• Journal of Satellite, Information and Communications
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• v.7 no.3
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• pp.1-7
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• 2012

In this paper, we was performed the interference analysis to determine an optimal coexisting criteria for the european digital video broadcasting service (DVB-T2) and the IMT-advanced LTE based TV Band Device (TVBD). The TVBD was equipped with the spectrum cognition method. To this end, we set the various transmission parameters, that includes the emission and blocking mask, antenna height and gain, transmission power and bandwidth, channel model etc. Based on this parameters, we were calculated the allowable transmit power, the number of TVBD and the change in probability of interference for the TVBD user operating in the adjacent channels of the DVB-T2 user. Also this paper presents how many TVBD users can sharing with DVB-T2 for spectral cognition performance.

• Journal of Satellite, Information and Communications
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• v.2 no.2
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• pp.1-9
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• 2007

In this paper, we describe the performance degradation of satellite Wibro system and compensation method in the high-speed railroad channel environment. High-speed railroad channel environment is divided into LOS channel and tunnel. In the LOS channel, signal blocking caused by railroad power feeder structures can be a critical problem which is can be solved with antenna diversity. On the other hand, multi path interference phenomenon, representable by propagation model of Optic Fiber, occurred in the tunnel may be another obstacle. These satellite Wibro system performance degradations in railroad channel environment are addressed and adequate compensation methods are proposed and verified through computer simulation. In addition, the ICI caused by Doppler shift in OFDM system is analyzed with its compensation method.