• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.70-73
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• 1996

Many researchers had considered biological systems as linear systems. In many cases of biological systems, the phenomena that show the regular and periodic dynamics are considered the normal state. However, some clinical experiments reported, in some cases, the periodic signals represented the abnormal state. We assume that signals from human body system are generated from deterministic, intrinsic mechanisms and can be represented a simple equation that show nonlinear dynamics dependent on control parameters. The objective of our study is to model a nonlinear dynamics correctly from the nonlinear time series using the genetic programming method; to find a simple equation of nonlinear dynamics using collected time series and its nonlinear characteristics. We applied genetic programming to model RR interval of ECG that shows chaotic phenomena. We used 4 statistic measures and 2 fractal measures to estimate fitness of each chromosome, and could obtain good solutions of which chaotic features are similar.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.197-198
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• 1998

We tested the capability of Pointwise Correlation Dimension(PD2), Approximate Entropy (ApEn) and LZ complexity, as alternative measures of a biological signal. For this purpose, we analyzed standard data and a healthy child's 24-hour heart rate variability. Our conclusion is as follows. First, PD2, ApEn and LZ complexity can be used for discerning chaotic attractor, white noise, and periodic signal. Second, these measures show different characteristics on day and night. Third, these measures can be used for detecting time-varying characteristics of biological signals.

• Journal of Applied Biological Chemistry
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• v.57 no.3
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• pp.279-286
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• 2014

The purpose of this study was to evaluate the biological activities of extracts of ramie (Boehmeria nivea (L.) Gaud.), hereafter referred to as Bn. Bn extracts from various collecting area were extracted with methanol. Two extracts from our study, Bn-13 and -82, showed significant antioxidant properties, likely due to their ability to scavenge free radicals. In addition, Bn extracts showed stronger anti-bacterial activity against Escherichia coli (Bn-40), Stapylococcus aureus (Bn-33), and Helicobacter pylori (Bn-05). In addition, this study was conducted to evaluate the anti-inflammatory effects of Bn extracts in lipopolyssacharide (LPS)- and interferon-${\gamma}$ (IFN-${\gamma}$)-stimulated RAW 264.7 macrophages cells. Bn-37 significantly inhibited the production LPS/IFN-${\gamma}$-induced nitric oxide. The most noteworthy anti-cancer effect was found in Bn-23. Bn-08 showed inhibition of aldose reductase. This study provides basic information for the development of functional foods.

• Journal of the Korea Society of Computer and Information
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• v.24 no.8
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• pp.113-121
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• 2019

The personalized meal service is being developed to prevent and alleviate illnesses according to the individual's health condition. However, the current meal does not provide a fully customized service to individuals and a diet that meets the consumer's information needs. The cause is the lack of information on the ingredients and the difficulty of comparative analysis between the materials. Therefore, in this study, we propose basic analysis process for basic information acquisition and database construction for food composition before providing personalized food. In this study, we investigated the content of carbohydrate, reducing sugar and protein as basic components of Grifola frondosa and investigate the content of polyphenol as a biological active ingredients. Respectively. Studies on the hypoglycemic effect of the diabetic rat model have been carried out in relation to the prevention of diseases. Based on the results of this study, it is also possible to obtain information on the basic ingredients of the food and to analyze the information on the content and activity of the biological active ingredients. Using animal models, information on disease prevention and mitigation was also available. The process introduced in this study is applied to various food materials, accumulating data, and utilizing Database, this results will be an excellent tool for providing more efficient service by providing a proper dietary composition for consumers.

• Mycobiology
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• v.50 no.5
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• pp.326-344
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• 2022

The fungal-like family Saprolegniaceae (Oomycota), also called "water mold," includes mostly aquatic saprophytes as well as notorious aquatic animal pathogens. Most studies on Saprolegniaceae have been biased toward pathogenic species that are important to aquaculture rather than saprotrophic species, despite the latter's crucial roles in carbon cycling of freshwater ecosystems. Few attempts have been made to study the diversity and ecology of Saprolegniaceae; thus, their ecological role is not well-known. During a survey of oomycetes between 2016 and 2021, we investigated the diversity and distribution of culturable Saprolegniaceae species in freshwater ecosystems of Korea. In the present study, members of Saprolegniaceae were isolated and identified at species level based on their cultural, morphological, and molecular phylogenetic analyses. Furthermore, substrate preference and seasonal dynamics for each were examined. Most of the species were previously reported as animal pathogens; however, in the present study, they were often isolated from other freshwater substrates, such as plant debris, algae, water, and soil sediment. The relative abundance of Saprolegniaceae was higher in the cold to cool season than that in the warm to hot season of Korea. This study enhances our understanding of the diversity and ecological attributes of Saprolegniaceae in freshwater ecosystems.

• Mycobiology
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• v.44 no.3
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• pp.137-145
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• 2016

Most known species in the Strophariaceae are decomposers and grow on various kind of organic matter. Approximately 18 genera and 1,316 species in the Strophariaceae have been reported worldwide. Through an ongoing survey of indigenous fungi in Korea, 29 specimens belonging to the Strophariaceae were collected from 2012 to 2016. These specimens were identified based on morphological characteristics and molecular analysis of internal transcribed spacer sequences. Fifteen taxa were confirmed, with eight species matching those previously recorded. Seven species in five genera were shown to be new records in Korea: Galerina marginata, Gymnopilus crociphyllus, Gymnopilus picreus, Hebeloma birrus, Hebeloma cavipes, Pholiota multicingulata, and Psilocybe thaizapoteca. In this study, we provide detailed morphological descriptions of these species and investigate their evolutionary relationships by constructing phylogenetic trees.

• The Korean Journal of Mycology
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• v.46 no.3
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• pp.249-254
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• 2018

Nannizziopsis mirabilis (KNU17-67) was isolated from a field soil sample collected from Jejudo in 2017. This fungal isolate was identified and described by its morphological characters and the internal transcribed spacer rDNA gene sequencing. Potato dextrose agar medium was used to study its macro and micromorphology. In addition, a molecular phylogenetic tree was constructed for its precise confirmation as N. mirabilis. This fungal isolate has not officially been reported previously in Korea.

• ALGAE
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• v.27 no.3
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• pp.215-224
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• 2012

Growth dynamics of the seagrass, Zostera marina were examined at the two stations (Myungju and Dagu) in Jindong Bay on the southern coast of Korea. Eelgrass leaf productivities, underwater irradiance, water temperature, dissolved inorganic nitrogen (DIN) in water column and sediments, and tissue carbon (C) and nitrogen (N) content were monitored monthly from March 2002 to January 2004. Underwater irradiance fluctuated highly without a clear seasonal trend, whereas water temperature showed a distinct seasonal trend at both study stations. Water column DIN concentrations were usually less than $5{\mu}M$ at both study sites. Sediment pore water $NH_4{^+}$ and $NO_3{^-}+NO_2{^-}$ concentrations were higher at the Myungju site than at the Dagu site. Eelgrass leaf productivity at both study sites exhibited a distinct seasonality, increasing during spring and decreasing during summer. Seasonal variation of eelgrass productivity was not consistent with seasonal patterns of underwater irradiance, or water temperature. Eelgrass tissue C and N content at both study sites also showed significant seasonal variations. Relationships between tissue C and N content and leaf productivities exhibited usually negative correlations at both study sites. These negative correlations implied that the growth of Z. marina at the study sites was probably limited by C and N supplies during the high growth periods.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.7
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• pp.972-979
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• 2008

It has been recently shown that expression of the LH receptor (LHR) in cumulus cells is related with FSH-induced meiotic resumption of mouse cumulus enclosed oocytes (CEOs). However, to date, it is still unclear whether LHR expression in cumulus cells plays a key role during FSH-induced oocyte maturation. The purpose of this study was to characterize the functional role of LHRs in cumulus cells. CEOs were isolated from eCG-primed preovulatory follicles and cultured in hypoxanthine (HX) arrested medium. LHR protein expression in cumulus cells was time-dependent increasing during the process of FSH-induced oocyte maturation. While the sense oligodeoxynucleotide (ODN) had no effect, antisense ODN inhibited FSH-induced LHR expression and meiotic resumption. Moreover, this antisense ODN against LHR could inhibit FSH-induced mitogen-activated protein kinase (MAPK) phosphorylation. This study suggested that LHR expression in cumulus cells is involved in FSH-induced oocyte meiotic resumption, which process is possibly regulated by MAPK cascade.

• Korean Journal of Materials Research
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• v.25 no.11
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• pp.616-621
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• 2015

Atmospheric pressure plasma is used in the biological and medical fields. Miniaturization and safety are important in the application of apply atmospheric plasma to bio devices. In this study, we made a small, pocket-sized inverter for the discharge of atmospheric plasma. We used pulse power to control the neutral gas temperature at which the, when plasma was discharged. We used direct current of 5 V of bias(voltage). The output voltage is about 1 to 2 kilo volts the frequency is about 80 kilo hertz. We analyzsed the characteristics of the atmospheric plasma using OES(Optical emission spectroscopy) and the Current-Voltage characteristic of pulse power. By calculating of the current voltage characteristics, we were able to determine that, when the duty ratio increased, the power that actually effects the plasma discharge also increased. To apply atmospheric plasma to human organisms, the temperature is the most important factor, we were able to control the temperature by modulating the pulse power duty ratio. This means we can use atmospheric plasma on the human body or in other areas of the medical field.