• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 V
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• pp.2911-2914
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• 2003

Conventionally, biological manipulations have been performed manually with long training and pretty low success rates. To overcome this problem, a novel biological manipulation system has been developed to manipulate biological cells without any interference of a human operator, In this paper, we demonstrate a development of tole-autonomous Cell Manipulation System (CMS) using an image processing at a remote site. The CMS consists of two manipulators, a plane stage, and an optical microscope. We developed deformable template-model-matching algorithm for micro objects and pattern matching algorithm of end effect for these manipulators in order to control manipulators and the stage. Through manipulation of biological cells using these algorithms, the performance of the CMS is verified experimentally.

• Korea-Australia Rheology Journal
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• 제17권1호
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• pp.15-20
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• 2005

In this study, the relationship between morphology and viscosity of the main culture broth of Cephalosporium acremonium M25 was investigated in a 2.5 L bioreactor. The differentiation of C. acremonium M25 showed a complex pattern during the main culture. The morphological changes of C. acremonium M25 were related to the rheological properties of the culture broth and it was well agreed with the power law model. As a result of rheology study, it was found that rheological properties of the main culture broths of C. acremonium M25 in bioreactor were closely related to morphological changes. Also, fractal dimension fairly predicted morphological and rheological changes in the main culture broth.

• 시큐리티연구
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• 제7호
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• pp.287-307
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• 2004

Mass killing and injuring by purpose, the countries that is hurrying countermeasure preparation of investigators who enforce that necessity to compare to intimidation of doing creature weapon is common concerns of the several countries including advanced nation such as the United States of America. Development and use of biological weapon have increased too recently to private citizens unlike development of military purpose in country dimension. The latest WHO is preparing proposal of standard stroke model who each department solidifies preparedness for chemical biological and electronic weapon revising report about biological weapon. But in case of korea, confrontation plan that bamboo broom about possibility of attack to the common people and attack comparing actual state in case of attained nothing but is readying remedy about biological warfare partially in military dimension was not readied. The purpose of this article is a study on threat of bio-weapons and the countermeasure.

• Korea-Australia Rheology Journal
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• 제18권4호
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• pp.209-215
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• 2006

Recent research results on viscocapillary models of various pre-metered coating flows such as curtain, slide, and slot coatings have been reviewed in this paper. Such one-dimensional models have been simplified from two-dimensional Navier-Stokes equations for viscous coating flows with free surfaces, using integral momentum balances and lubrication approximation. It has been found that these viscocapillary models is capable of predicting flow dynamics in various coating systems, providing the good agreement with results by 2-D models.

• Genomics & Informatics
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• 제9권1호
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• pp.5-11
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• 2011

Treating genomes just as languages raises the possibility of producing concise generalizations about information in biological sequences. Grammars used in this way would constitute a model of underlying biological processes or structures, and that grammars may, in fact, serve as an appropriate tool for theory formation. The increasing number of biological sequences that have been yielded further highlights a growing need for developing grammatical systems in bioinformatics. The intent of this review is therefore to list some bibliographic references regarding the recent progresses in the field of grammatical modeling of biological sequences. This review will also contain some sections to briefly introduce basic knowledge about formal language theory, such as the Chomsky hierarchy, for non-experts in computational linguistics, and to provide some helpful pointers to start a deeper investigation into this field.

• 생태와환경
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• 제45권4호
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• pp.420-443
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• 2012

An Individual-Based Model (IBM) was developed by employing natural and toxic survival rates of individuals to elucidate the community responses of benthic macroin-vertebrates to anthropogenic disturbance in the streams. Experimental models (dose-response and relative sensitivity) and mathematical models (power law and negative exponential distribution) were applied to determinate the individual survival rates due to acute toxicity in stressful conditions. A power law was additionally used to present the natural survival rate. Life events, covering movement, exposure to contaminants, death and reproduction, were simulated in the IBM at the individual level in small (1 m) and short (1 week) scales to produce species abundance distributions (SADs) at the community level in large (5 km) and long (1~2 years) scales. Consequently, the SADs, such as geometric series, log-series, and log-normal distribution, were accordingly observed at severely (Biological Monitoring Working Party (BMWP<10), intermediately (BMWP<40) and weakly (BMWP${\geq}50$) polluted sites. The results from a power law and negative exponential distribution were suitably fitted to the field data across the different levels of pollution, according to the Kolmogorov-Smirnov test. The IBMs incorporating natural and toxic survival rates in individuals were useful for presenting community responses to disturbances and could be utilized as an integrative tool to elucidate community establishment processes in benthic macroin-vertebrates in the streams.

• Genomics & Informatics
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• 제3권1호
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• pp.30-34
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• 2005

Microarray technology makes it possible to measure the expressions of tens of thousands of genes simultaneously under various experimental conditions. Identifying differentially expressed genes in each single experimental condition is one of the most common first steps in microarray gene expression data analysis. Reasonable choices of thresholds for determining differentially expressed genes are used for the next-stap-analysis with suitable statistical significances. We present a supervised model for identifying DEGs using pathway information based on the global connectivity structure. Pathway information can be regarded as a collection of biological knowledge, thus we are trying to determine the optimal threshold so that the consequential connectivity structure can be the most compatible with the existing pathway information. The significant feature of our model is that it uses established knowledge as a reference to determine the direction of analyzing microarray dataset. In the most of previous work, only intrinsic information in the miroarray is used for the identifying DEGs. We hope that our proposed method could contribute to construct biologically meaningful structure from microarray datasets.

• Journal of Ecology and Environment
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• 제35권3호
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• pp.157-166
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• 2012

Many models intending to explain the latitudinal gradient of increasing species diversity from the poles to the equator are presented, which are a formalisation of the species-energy hypothesis. The model predictions are consistent with patterns of increasing species number with increasing mean air or water temperatures for plants and animals. An increase in species richness is also correlated with net primary production or the Normalised Difference Vegetation Index. This implies that increased availability of resources favours increased diversity capacity. The explanatory variables included in the biodiversity prediction models represent measures of water, energy, water-energy, habitat, history/evolution and biological responses. Water variables tend to be the best predictors when the geographic scope of the data is restricted to tropical and subtropical areas, whereas water-energy variables dominate when colder areas are included. In major models, about 20-35% of species in the various global regions (European, Africa, etc.) will disappear from each grid cell by 2050 and >50% could be vulnerable or threatened by 2080. This study provides good explanations for predictive models and future changes in biodiversity depending on various scenarios.

• 한국환경농학회지
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• 제41권4호
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• pp.276-281
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• 2022

BACKGROUND: Plastics that are used in our daily lives largely end up in the environment. In agricultural environments, plastic wastes and microplastics can be found due to the uses and improper management of plastic products (e.g., vinyl greenhouses and mulching vinyl). Microplastics can also interact with contaminants in the agricultural environment. Therefore, this study was set to investigate the sorption characteristics of tetracycline, one of widely used antibiotics, on microplastics. METHODS AND RESULTS: The sorption tests were carried out with the tetracycline solutions (0-30 mg L^-1) and microplastic films prepared from low density polyethylene (LDPE) and polyvinyl chloride (PVC). The residual tetracycline concentrations were analyzed and fitted to the Freundlich and Langmuir isotherm models. The tetracycline sorption patterns on LDPE and PVC films were described better with the Freundlich isotherm model than the Langmuir isotherm model. The isotherm model parameters suggested that the maximum sorption amount of tetracyline was greater for PVC, while the sorption affinity was greater for LDPE. CONCLUSION(S): Different types of microplastics can have different sorption characteristics of tetracycline. Therefore, there is a need for continuous research on the interaction of various types and shapes of microplastics and contaminants in the environment.

• 한국간호교육학회지
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• 제8권1호
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• pp.61-71
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• 2002

purpose : The purpose of this study was to find out the influencing factors of smoking-cessation behavior of patients with coronary heart disease and to suggest the model of smoking-cessation behavior which was based on the relationship between influencing factors and then to test its fitness empirically. method : This study was based on the Theory of Reasoned Action and a hypothetical model was constructed with fifteen paths in consideration of main predictive factors of smoking-cessation behavior such as biological factor, disease-related characteristics, self-efficacy, supportive factor, environmental factor, disease-related perception factor, intention-to-quit, and psychological factor. The validity of a smoking- cessation model was tested to 264 patients with coronary heart disease by using SPSS 8.0 and Window LISREL 8.12a. results : 1. Seven of the 15 paths of smoking-cessation behavior proved to be significant. 2. The final model excluded three paths in the hypothetical model was demonstrated to be improved by $x^2$=44.31 (df=38, p=.22), Goodness of Fit Index (GFI)=.98, Adjusted Goodness of Fit Index (AGFI)=.96, Non-Normed Fit Index(NNFI)=1.00, Normed Fit Index(NFI)=1.00, and Root Mean Square Residual(RMR)=.24. 3.The smoking-cessation behavior was influenced directly by biological factor, self-efficacy, supportive factor, environmental factor, intention-to-quit, and psychological factor. The smoking-cessation behavior was accounted for 82% of variance by these factors. conclusion : although the adolescents' smoking behavior can be predicted by only smoking intention, it is hard to predict the adults' smoking-cessation behavior by only this factor. Therefore, intention-to-quit, self-efficacy, supportive factor should be improved because these are promotive factors for smoking-cessation behavior. Biological factor, environmental factor, and psychological factor are inhibitive factors, so nicotine replacement therapy is helpful to the high nicotine-dependents, and ex-smokers avoid other smokers in their environment and also patients should learn and practice the stress coping-skills.