• Proceedings of the PSK Conference
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• 2003.10b
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• pp.176.1-176.1
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• 2003

Bradykinin is an autocoid related to acute and chronic pain and inflammation. The non-peptide bradykinin antagonists are of interest as novel anti-inflammatory therapeutics. To understand the structural basis for the bradykinin antagonistic activity and to guide the design of more potent compounds we analysed the three dimensional pharmacophore model. Seven active compounds very recently reported such as FR 167344, FR 173657, LF 160687, and bradyzide were used as our pharmacophore model analysis. (omitted)

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.387-387
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• 2005

• Journal of Veterinary Clinics
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• v.17 no.1
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• pp.28-31
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• 2000

An animall health monitoring system in Gyeongnam area(near Chinju) was studied to analysis of biochemical risk factors in 617 herds. Clinical serum factors such as glutamate oxaloacetate transaminase(GOT), glutamate pyruvate transaminase(GPT), Ca, P, Mg, glucose, and cholesterol were measured with automatic biochemical analyzer(Ra-X7T Techmmicon, USA). In serum analysis, 613 cattle were within normal llimits(GOT: 9.5-85 IU-dl, GPT: 25-77IU/dl, total protein: 5.8-8.5g/dl, Ca: 4.2-12.4mg/dl, P: 4.6-9.7mg/dl, Mg: 1.5-3.0mg/dl, glucose: 48-120mg/dl, Cholesterol: 70-170mg/dl), the other cattle showed high glucose and high cholesterol level. It is proposed that clinical serum factors to be estimated may be valuable for developing of animal health monitoring system model.

• Journal of Microbiology and Biotechnology
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• v.11 no.5
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• pp.776-780
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• 2001

Based on the static and dynamic adsorption of Streamline DEAE, a modified tank-in-series model including particle size distribution was used to describe the adsorption performance of bovine serum albumin in an expanded bed. The calculated results indicated that the suggested model was able to simulate breakthrough curves under various conditions.

• Environmental Engineering Research
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• v.10 no.1
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• pp.22-30
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• 2005

Nitrite accumulation is not unusual in batch processes such as sequencing batch reactor (SBR) with high-strength of ammonium or nitrate wastewaters. A possible mechanism of nitrite inhibition on Acinetobacter was depicted in a biochemical model, which the protonated species, nitrous acid form of nitrite, affects proton relating transport at the proton-pumping site crossing the cell membrane under unlimited carbon and phosphorus conditions. This effect exerts inhibition of phosphorylation under aerobic condition and yields low APT/ADP ratio, consequently decrease poly-P synthesis and phosphorus uptake from outside the cell in the model.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.3
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• pp.262-269
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• 2005

Many researchers have employed cryopreserved amniotic membrane (CAM) in the treatment of a severely damaged cornea, using corneal epithelial cells cultured on an amniotic membrane (AM). In this study, two Teflon rings were made for culturing the cells on the LAM and CAM, and were then used to support the AM, which is referred to in this paper as an Ahn's AM supporter. The primary corneal epithelial cells were obtained from the limbus, using an ex-plantation method. The corneal epithelium could be reconstructed by culturing the third­passage corneal epithelial cells on the AM. A lyophilized amniotic membrane (LAM) has a higher rate of graft take, a longer shelf life, is easier to store, and safer, due to gamma irradiation, than a (AM. The corneal epithelium reconstructed on the LAM and (AM, supported by the two­Teflon rings, was similar to normal corneal epithelium. However, the advantages of the LAM over that of the (AM make the former more useful. The reconstruction model of the corneal epithelium, using AM, is considered as a good in vitro model for transplantation of cornel epithelium into patients with a severely damaged cornea.

• Korean Chemical Engineering Research
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• v.52 no.3
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• pp.307-313
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• 2014

In this study, an optimization process design has been performed to separate 99.9 mol% of Isobutyl Acetate from binary azeotropic mixture of Isobutyl Acetate and Isobutyl Alcohol system using a Pressure Swing Distillation (PSD). PSD is used to separate binary azeotropic mixtures using the difference between the relative volatilities and azeotropic compositions by changing the system pressure. Non-Random Two Liquid (NRTL) model for liquid phase and the Peng-Robinson equation for vapor phase are used. An optimization study for the reflux ratio and feed stage locations which minimize the total reboiler heat duties are studied. Since PSD process consists of two columns, i.e. high pressure and low pressure, the effect of column sequence on the optimum conditions is reported.

• Journal of Microbiology and Biotechnology
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• v.29 no.2
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• pp.268-273
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• 2019

The specificity of a Bacillus licheniformis uridine diphosphate (UDP) glycosyltransferase, YjiC, was increased towards thymidine diphosphate (TDP)-sugar by site-directed mutagenesis. The Arg-282 of YjiC was identified and investigated by substituting with Trp. Conversion rate and kinetic parameters were compared between YjiC and its variants with several acceptor substrates such as 7-hydroxyflavone (7-HF), 4',7-dihydroxyisoflavone, 7,8-dihydroxyflavone and curcumin. Molecular docking of TDP-glucose and 7-HF with YjiC model showed pi-alkyl interaction with Arg-282 and His-14, and pi-pi interaction with $His^{14}$ and thymine ring. YjiC (H14A) variant lost its glucosylation activity with TDP-glucose validating significance of His-14 in binding of TDP-sugars.

• Korean Journal of Environmental Biology
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• v.22 no.4
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• pp.494-500
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• 2004

In order to investigate the effect on morphology of Rhizopus oryzae and production of lactic acid, various interface materials were used. Morphology of fungal showed sheet and flock when resin was added. The production of lactic acid was increased dramatically when interface materials were added. Furthermore, the effect of resin was more significant than that of others. It was assumed that interface materials could absorb substrate and microorganism together, so microorganism was not inhibited by substrate. The effect of static electric field on the interface culture was studied. When the exerting potential was 6.78 voltage, the biomass y was obviously higher than that of zero voltage. A simulated gas-solid interface system was developed to study the growth and two phases model for the growth of Rhizopus oryzae was build up that depended on the symmetric branching theory. An important parameter F was researched. The results indicated that the value of F had obvious difference at exponential and deceleration period, respectively.

• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.889-896
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• 2008

A suitable simple model tested by experiments is required to address complex biological reactions like esterase synthesis by Saccharomyces cerevisiae. Such an approach might be the answer to a proper bioprocessing strategy. In this regard, a logistic model for esterase production from Saccharomyces cerevisiae has been developed, which predicts well the cell mass, the carbon source (glucose) consumption, and the esterase activity. The accuracy of the model has been statistically examined by using the Student's t-test. The parameter sensitivity analysis showed that all five parameters (${\mu}_m$, $K_a$, $X_m$, $Y_{x/s}$, and $Y_{p/x}$) have significant influence on the predicted values of esterase activity.