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ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis

  • Przemyslaw, Leszczynski;Boguslaw, Hendrich Andrzej;Elzbieta, Szmida;Malgorzata, Sasiadek Maria
    • BMB Reports
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    • v.46 no.3
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    • pp.139-150
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    • 2013
  • The ADAM and ADAMTS families, also called adamalysins belong to an important group of extracellular matrix proteins. The ADAMs family belong to both the transmembrane and secreted proteins, while ADAMTS family only contains secreted forms. Adamalysins play an important role in the cell phenotype regulation via their activities in signaling pathways, cell adhesion and migration. The human proteome contains 21 ADAM, and 19 ADAMTS proteins, which are involved in extracellular matrix remodeling, shedding of various substrates such as: adhesion ligands, growth factors, their receptors and diverse cytokines. Recent studies provide evidence that adamalysins play a crucial role in colorectal cancer (CRC) etiopathogenesis. It seems possible that adamalysins might be used as CRC prediction markers or potential pharmaceutical targets.

Molecular Vibrational Study of the Allosteric Effect in 2,2'-Bipyridyl Crown Ether (분자진동방법을 사용한 2, 2'-Bipyridyl Crown Ether 의 다른자리 입체성 효과에 관한 연구)

  • Wan Kyu Kim;Soon Ryang Chung
    • Journal of the Korean Chemical Society
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    • v.29 no.3
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    • pp.205-212
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    • 1985
  • By using the Mass-Weighted-Cartesian coordinate method, the allosteric effect of 2,2'-bipyridyl crown(4) ether is studied. The vibrational modes of 235, 234, 188, and 178cm$^{-1}$ belong to the pore opening motion of crown ether and those of 168, 104, and 67cm$^{-1}$ belong to the rotational vibration motion of bipyridyl. Especially the mode appearing at 178cm$^{-1}$ shows a large allosteric effect by activation of the allosteric site.

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Rule Selection Method in Decision Tree Models (의사결정나무 모델에서의 중요 룰 선택기법)

  • Son, Jieun;Kim, Seoung Bum
    • Journal of Korean Institute of Industrial Engineers
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    • v.40 no.4
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    • pp.375-381
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    • 2014
  • Data mining is a process of discovering useful patterns or information from large amount of data. Decision tree is one of the data mining algorithms that can be used for both classification and prediction and has been widely used for various applications because of its flexibility and interpretability. Decision trees for classification generally generate a number of rules that belong to one of the predefined category and some rules may belong to the same category. In this case, it is necessary to determine the significance of each rule so as to provide the priority of the rule with users. The purpose of this paper is to propose a rule selection method in classification tree models that accommodate the umber of observation, accuracy, and effectiveness in each rule. Our experiments demonstrate that the proposed method produce better performance compared to other existing rule selection methods.

Five Unrecorded Ostreacean Species (Mollusca, Bivalvia) from Korean Waters (한국산 굴상과(연체동물문, 이매패강)의 5미기록종)

  • Hongying Qi;Byung Lae Choe
    • Animal Systematics, Evolution and Diversity
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    • v.16 no.2
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    • pp.133-140
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    • 2000
  • As a result of study on the oysters collected from 8 localities of Korean coastal area, The following five species were found to be new to the Korean fauna: Parahyotissa chemnitzi ( Hanley, 1786) and P. inaequivalvis (Sowerby, 1971) belong to the Pycnodonteidae; Dendostrea folium (Linnaeus, 1758), Ostrea futamiensis Seki, 1929, and Saccostrea mordax (Gould, 1850) belong to the Ostreidae.

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The Need for a Table of Descent in Studying Medical Persons (의학인물 연구에 있어서 족보의 필요성)

  • Lee, Suna
    • The Journal of Korean Medical History
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    • v.20 no.2
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    • pp.65-69
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    • 2007
  • Although a table of descent is a mandatory primary source for studying medical persons, but most of those who practiced medicine were not but of step families. Because members of step families are not usually recorded accurately, preceeding studies did not put much emphasis on them. But as more researchers study biography and the number of studies done on historical figures are increasing tremendously, its value as a source has increased as well. In order to research a person, obtaining background information is a priority, which includes to what family they belong to, to what specific branch of the family they belong to, etc. Whether or not the person has ever worked with a public institution is important as well.

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The Leisure behaviors of single households in Korea : A generational analysis (1인 가구의 세대별 여가행태 분석)

  • Jeong, Yeongkeum;Yoon, Soyoung
    • Journal of Family Resource Management and Policy Review
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    • v.22 no.4
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    • pp.1-15
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    • 2018
  • The purposes of this study is to analyze the leisure behaviors of single households in Korea on the basis of generation, and identify leisure characteristics or factors that influence levels of happiness in these households. The sample comprised 1,144 single householders, among whom 74 belong to the teenage generation, 288 are of the eco generation, 154 belong to generation X, 104 are baby boomers, and 524 are of the older generation. Various leisure characteristics were compared across the generations, namely, conditions for leisure, degree of leisure participation, level of work-leisure balance, persistence of participation, and type of activity. Results showed differences in leisure characteristics and leisure factors that influence levels of happiness among the generations.

A checklist of the family Drosophilidae (Diptera, Ephydroidea) of Vietnam

  • Hyun Suk Lee;Thi Hang Ho
    • Journal of Species Research
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    • v.13 no.2
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    • pp.255-267
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    • 2024
  • We reviewed the available drosophilid literature and listed any drosophilid species with Vietnamese records. Vietnamese drosophilid flies belong to two subfamilies. In this paper, we provided a taxonomic checklist of 68 nominal species. However, this checklist is based on information of diverse literature, and we have not confirmed identification of each species. In total, the number of drosophilid species in Vietnam amounted to 68 species belong to 16 genera. Drosophilinae consists of 12 genera and 51 species, while Steganinae includes four genera and 17 species. This checklist will be the fundamental base for comprehensive taxonomic research of drosophilid fauna in Vietnam.

A Study of the Young Aged Women′s Bust (청년기 여성의 상반신 체형 연구)

  • 엄정옥;문명옥
    • Journal of the Korean Society of Costume
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    • v.50 no.5
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    • pp.117-130
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    • 2000
  • The purpose of this thesis is to offer basic data for clothing design which is intended to apply appropriate shape and capacity to clothes. The following are the analyzed results of an investigation which was conducted to characterize the upper half of the female body of 193 women whose ages are 18 to 25, taking part in this investigation. According to the results of analyzing young women's bust, I came to find a large individual difference of the wide varying factor numbers at the items of the side feature, the body stance, and the dart quantity. For the analysis of the female's upper body, 11 factors are used. The are as follows: Factor 1. width of the bust Factor 2. height of the bust and length of the arm Factor 3. side thickness of the bust and the upside type Factor 4. length of the bust on the front Factor 5. length of the bust on the back Factor 6. salient ratio of the breast Factor 7. width of the neck. the armhole, and measurement of the droop Factor 8. length of the shoulder Factor 9. flat ratio of the bust Factor 10. inclination of the shoulder factor 11. form of the back The shape of young women's upper bodies can be divided into four groups. The character ization of each group are as follows : Group 1 . 28.5% of the women who take part in this investigation belong to Group 1 These women have the shortest body, with a longer length of the front than the back and more thickness on the front than the back. Group 2. 21.1% of the women who take part in this investigation belong to this group. They show a longer length of the back and more thickness of the back than the front. In addition, this group is bent forward. Group 3. This group is the mast common type, showing the shortest and thickest character. 37.8% of the women who take part in this investigation have this bust character Group 4. 12.4% of the women belong to Group 4. They possess the highest and fattest character, skewing smaller necks, armholes, and waists than the other groups. This group also shows the drooping shoulders.

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Studies on Herbal Resources Plants in Chollabuk-do Area (전라북도 지방의 한약자원 식물에 관한 연구)

  • 길봉섭;김영식;김창환;유현경
    • Korean Journal of Plant Resources
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    • v.13 no.1
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    • pp.61-65
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    • 2000
  • It was investigated 91 families, 305 genera, 470 species, 1 subspecies, 30 varieties, 2 forma and total 503 taxa of herbal resources plants in Chollabuk-do area in this study. Among them 45 taxa belong to Compositae, 30 taxa belong to Rosaceae and 23 taxa belong to Leguminosae in order were occurred frequently. In general the herbal resources plants were distributed abundantly in Togyusan, Naejangsan, Changansan and Taedunsan area. Comparatively high frequent species was surveyed as follows: Schizandra chinensis, Cimicifuga heracleifolia, C. simplex, Asarum sieboldii, Arisaema amurense var. serratum, Polygonatum odoratum var. pluriflorum, Prunella vulgaris var. lilacina and Veratrum patulum etc. There was growing 30-50 individuals of Codonopsis lanceolata in 5m$\times$5m quadrat, 90 Chrysanthemum zawadskii var. latilobum plant in 1m$\times$1m and 100 Polygonatum odoratum var. pluriflorum plant in 1m$\times$1m quadrat from Togyusan quantitatively. Rare and herbal worth species were observed to distribute such as Gastrodia elata in Naejangsan and Togyusan and Acanthopanax senticosus in Mandoksan, Chinan-gun, respectively. Cultivating species in the farm now and/or favorable species in the future will be recommended here, for example, Codonopsis pilosus, A. senticosus, G. elata, Rubus coreanus, C. lanceolata and Pleuropterus multiflorus.

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A Study of Selecting Target Species for Rooftop Greening Construction from Urban Ecological Network Point of View (도시생태네트워크 측면에서의 옥상녹화입지를 위한 목표종 선정에 관한 연구)

  • 최희선;김귀곤;홍수영
    • Journal of the Korean Institute of Landscape Architecture
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    • v.32 no.3
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    • pp.18-31
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    • 2004
  • Ecological network can solve the ecological problems such as habitat cutting and fragmentation that are resulted from urbanization. Recently, rooftop biotope construction has been appeared as a usefull method for ecological networking in urban area. The objective of this study is to seek the possibility of rooftop greening introduction as well as to select target species for rooftop greening construction from the urban ecological network point of view. In order to select target species, we monitored two adjacent rooftop greening sites, where we found 22 species of birds and insects and 33 species of plants. We set criteria to select target species through documents research, and gave marks species according to the criteria with the help of specialists. We divided the target species into 5 groups on the basis of the 12 selecting criteria. In those two monitored rooftop greening sites, we did not find any species belong to group A, which is the best target species, but we found species belong to the other groups. Orthetrum albistylum, Sympetrum dawinianum belong to group B, which is the priority target species, 7 species besides Passer montanus, Coccinella axyridis, Agrionidae to group C, which is the possible target species, 6 species besides Atractomorpha lata to group D, which is the potential target species, and the others were found to be inadequate to the target species. We found Orthetrum albistylum, Sympetrum dawi-nianum to be the best appropriate target species in the two sites. According to the result of this study, the method of ecological network construction from the dra-gonfly habitat network point of view through the construction of rooftop habitat is ideal for Orthetrum albistylum, and Sympetrum dawinianum. For successful urban ecological network construction, selection criteria and construction techniqes & methods for rooftop habitat should be developed through future research.