• Journal of Microbiology and Biotechnology
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• v.32 no.2
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• pp.212-219
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• 2022

Recently, the efficacy of probiotics in treatment of neurodegenerative disorders has been reported in animal and clinical studies. Here, we assessed the effects of Bacillus coagulans JA845 in counteracting the symptoms of D-galactose (D-gal)/AlCl₃-induced Alzheimer's disease (AD) in a mice model through behavioral test, histological assessment and biochemical analysis. Ten weeks of pre-treatment with B. coagulans JA845 prevented cognitive decline, attenuated hippocampal lesion and protected neuronal integrity, which demonstrated the neuroprotective features of B. coagulans JA845 in vivo. We also found that supplementation of B. coagulans JA845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of D-gal/AlCl₃-induced AD model mice. Furthermore, B. coagulans JA845 administration attenuated oxidative stress and decreased serum concentration of inflammatory cytokines by regulating the Nrf2/HO-1 and MyD88/TRAF6/NF-κB pathway. Our results demonstrated for the first time that B. coagulans has the potential to help prevent cognitive decline and might be a novel therapeutic approach for the treatment of neurodegenerative diseases.

• Journal of Ginseng Research
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• v.45 no.3
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• pp.433-441
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• 2021

Background: Multiple sclerosis (MS) and its animal model, the experimental autoimmune encephalomyelitis (EAE), are primarily characterized as dysfunction of the blood-brain barrier (BBB). Ginsenoside-Rg3-enriched Korean Red Ginseng extract (Rg3-KRGE) is known to exert neuroprotective, anti-inflammatory, and anti-oxidative effects on neurological disorders. However, effects of Rg3-KRGE in EAE remain unclear. Methods: Here, we investigated whether Rg3-KRGE may improve the symptoms and pathological features of myelin oligodendroglial glycoprotein (MOG)_35-55 peptide - induced chronic EAE mice through improving the integrity of the BBB. Results: Rg3-KRGE decreased EAE score and spinal demyelination. Rg3-KRGE inhibited Evan's blue dye leakage in spinal cord, suppressed increases of adhesion molecule platelet endothelial cell adhesion molecule-1, extracellular matrix proteins fibronection, and matrix metallopeptidase-9, and prevented decreases of tight junction proteins zonula occludens-1, claudin-3, and claudin-5 in spinal cord following EAE induction. Rg3-KRGE repressed increases of proinflammatory transcripts cyclooxygenase-2, inducible nitric oxide synthase, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha, but enhanced expression levels of anti-inflammatory transcripts arginase-1 and IL-10 in the spinal cord following EAE induction. Rg3-KRGE inhibited the expression of oxidative stress markers (MitoSOX and 4-hydroxynonenal), the enhancement of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) and NOX4, and NADPH activity in the spinal cord of chronic EAE mice. Furthermore, apocynin, a NOX inhibitor, mimicked beneficial effects of Rg3-KRGE in chronic EAE mice. Conclusion: Our findings suggest that Rg3-KRGE might alleviate behavioral symptoms and pathological features of MS by improving BBB integrity through modulation of NOX2/4 expression.

• Journal of Korean Academy of Nursing
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• v.9 no.2
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• pp.49-61
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• 1979

A review of this literature and discussions reveal a development of ideas concerning the elements of nursing models. The elements of a nursing model are the nurses view of the human being, nursing's goal, and nursing activities. It has long been recognized that human beings, at one time or another, require nursing care. Varieties of literature were reviewed in regard to the human being as recipient of nursing care through the theory development in nursing. Florence Nightingale initiated the modern era of nursing and described more clearly man as the recipient of nursing care. She looked at man as responding to the laws of nature whether the person was healthy or sick. Henderson added to Nightingale's concept of man , the recipient of nursing care by emphasizing that man is a whole, complete, and independent being. Her view is further specified by her enumeration of the activities the human being must perform. Johnson has developed a very comprehensive view of man as the recipient of nursing care. Man is a behavioral system which has a tendency to achieve and maintain stability in patterns of functioning. Like Nightingale, Johnson sees that similar patterns occur in both health and illness. Johnson postulates that the whole behavioral system of the human is composed of eight sub-systems: affiliative, achievement, aggressive, dependency, eliminative, ingestive, restorative, sexual. Roger's main contribution to the development of nursing models was her emphasis upon unitary man. She pointed out that man is a unified whole, possessing his own integrity and manifesting characteristics that“are more than and different from the sum of his parts.”Rogers focuses on the life processes of the human and points out that these processes have the following characteristics. Wholeness, openness, unidirectionality, pattern and organization, sentence, and thought. According to Roy, man is a biopsychosocial being in constant interaction with a changing environment. To cope with this changing environment, man has certain innate and acquired mechanisms. Man's ability to respond positively or to adapt, depends upon the degree of the change taking place and the state of the person coping with the change. When she analyzes man as an adaptive organism she further describes man as being composed of four adaptive modes: physiological needs, self-concept, role function, and interdependence. Based on the literary review through the theory development in nursing, general approach by a unified nursing model to a view of the recipient of nursing care may be stated as follows: Man is a unified whole composed of subsystems with a flexible and normal line of defense; his internal regulating mechanisms help him to cope with a changing environment; he functions by the principles of homeodynamics.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.240-248
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• 2020

Over the past 20 years, brain science has developed rapidly thanks to new technologies such as functional magnetic resonance imaging (fMRI), leading to more accurate knowledge of human nature and behavioral changes. This knowledge is also actively applied in the field of management. This research aimed to gain insights into how neuroscience can be incorporated into management through the case of Midas IT Co. This construction software company has a separate organization with the purpose of studying brain science, and it makes and implements human resource management policies based on brain science. The founder Lee Hyung-woo has a humanist management philosophy, and the company's brain science research supports that philosophy. The case study method was adopted as the research method, and procedures such as interviews and direct observation, participation observation, and document information were carried out. The company's human resource management system can be explained by a brain science model called "SCARF", which combines various neuroscience discoveries. As this model suggests, the company has improved the trust and satisfaction of its members by reducing threat of status and by increasing certainty, autonomy, relationship, and fairness in the workplace, resulting in the creation of a platform for creativity, integrity, and high performance.

• Journal of Convergence for Information Technology
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• v.8 no.1
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• pp.115-121
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• 2018

The purpose of this study is to examine the effects of kindergarten teachers' rights and obligations on teacher - A questionnaire survey was conducted on 174 teachers in kindergartens in Seoul, Gyeonggi, and Incheon. The results of this study are as follows: First, teachers' rights have a statistically significant effect on the rights of education and status in linguistic interaction, which is a sub-domain of teaching-infant interaction. And in behavioral interactions, the rights of labor have had a negative impact. In the linguistic interaction and emotional interaction, which are subdivisions of teacher-infant interaction, teacher's duty had a statistically significant effect on the duties of status, while teacher's duty was the sub-domain of inter- Duties of integrity and duty and duty of status did not affect.

• Korean Journal of Biological Psychiatry
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• v.15 no.2
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• pp.110-117
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• 2008

Objectives : Posttraumatic stress disorder(PTSD) has been primarily associated with emotional problems. Recently, however, the impact of PTSD on cognitive processes has interested a growing number of researchers. The current study is aimed at investigating the cognitive aspects of PTSD at both behavioral and neurological levels. Methods : We recruited individuals with PTSD who survived the Daegu subway explosion in 2003 as well as non-PTSD individuals as a control group. To evaluate the inhibitory processes and the neural mechanisms, we had these individuals perform the negative priming task simultaneously with functional MRI scanning. Results : Behaviorally, the negative priming effect was intact in the control group but was not evident in the PTSD group. In the imaging results, only the PTSD group showed the negative priming effect (i.e., increased activation of the negative priming condition as opposed to the neutral condition) in the dorsolateral prefrontal cortex, anterior cingulate cortex, and inferior temporal gyrus. The PTSD group also showed increased activity for the positive priming condition as opposed to the neutral condition in the claustrum. These results confirm and extend the previous findings that the integrity of the ACC is compromised in the trauma survivors due to disrupted white matter tract. Conclusions : The current results suggest that deteriorated performance of the PTSD group may be due to the functional problem as well as the structural abnormalities.

• Journal of Korean Neurosurgical Society
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• v.52 no.1
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• pp.32-36
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• 2012

Objective : Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of the present study is to investigate the effect of rolipram, a phosphodiesterase 4 inhibitor, against alcohol-induced neuropathy in rats. Methods : Allodynia was induced by administering 35% v/v ethanol (10 g/kg; oral gavage) to Spraue-Dawley rats for 8 weeks. Rolipram and saline (vehicle) were administered intraperitoneally. Mechanical allodynia was measured by using von Frey filaments. Somatosensory evoked potential (SEP) was proposed as complementary measure to assess the integrity of nerve pathway. Results : The ethanol-induced mechanical allodynia began to manifest from 3 week, and then peaked within 1 week. Beginning from 3 week, latency significantly started to increased in control group. In rolipram treated rats, the shorter latency was sustained until 8 weeks (p<0.05). The mechanical allodynia, which began to manifest on the 3 weeks, intraperitoneal injections of rolipram sustained statistical difference until 8 weeks, the final week of the study (p<0.05). Conclusion : This study suggests that rolipram might alleviate mechanical allodynia induced by alcohol in rats, which clearly has clinical implication.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.2
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• pp.160-167
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• 2009

This paper describes how to protect the personal information of a biometric reference provider wherein biometric reference and personally identifiable information are bounded in a biometric system. To overcome the shortcomings of the simple personal authentication method using a password, such as identify theft, a biometric system that utilizes physical and behavioral characteristics of each person is usually adopted. In the biometric system, the biometric information itself is personal information, and it can be used as an unique identifier that can identify a particular individual when combining with the other information. As a result, secure protection methods are required for generating, storing, and transmitting biometric information. Considering these issues, this paper proposes a method for ensuring confidentiality and integrity in storing and transferring personally identifiable information that is used in conjunction with biometric information, by extending the related X9.84 standard. This paper also outlines the usefulness of the proposition by defining a standard format represented by ASN.1, and implementing it.

• International Journal of Computer Science & Network Security
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• v.21 no.9
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• pp.118-124
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• 2021

The article examines the formation of a competitive paradigm of economic security of industrial enterprises in the formation of a circular economy. The basic laws of industrial enterprises are formed, which determined the characteristics of competitive positions and threats. The basic competitive concepts and their application at maintenance of economic safety of the industrial enterprises in the conditions of formation of circular economy are described. Thus, the technological approach to the formation of a competitive paradigm is based on production technologies, opportunities for technological modernization and development of infrastructure and intellectual competencies. The institutional concept reveals the regulatory mechanisms for ensuring competitiveness through the protectionism of national industrial enterprises, standardization and regulation of market imbalances. The innovation-investment approach within the competitive paradigm is also manifested in the creation of competitive advantages due to the presence of active innovative developments and their commercialization, knowledge and competencies of staff, capitalization of intelligence and communications, constant updating of infrastructure and technologies. Collectively, innovation and investment effects on the level of economic security allow industrial enterprises to ensure resilience to increasing competition, the emergence of new market challenges in the formation of a circular economy. A strategic approach to the application of a competitive paradigm to ensure the economic security of industrial enterprises allows you to justify the prospects for development and design behavioral models to predict and assess potential threats. The concept of system management is based on the complexity of threat analysis, the integrity of the economic security system, system-forming functions and patterns of implementation of industrial development tasks in the formation of a circular economy. The application of the described concepts is formalized by the authors through the definition of the basic patterns, directions and characteristics of their impact on the elements of the security system of industrial enterprises in the formation of a circular economy.

• Computers and Concrete
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• v.31 no.5
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• pp.405-417
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• 2023

The submerged floating tunnel (SFT) is tethered by mooring lines anchored to the seabed, therefore, the structural integrity of the anchor should be sensitively managed. Despite their importance, reaction forces cannot be simply measured by attaching sensors or load cells because of the structural and environmental characteristics of the submerged structure. Therefore, we propose an effective method for estimating the reaction forces at the seabed anchor of a submerged floating tunnel using a structural pattern model. First, a structural pattern model is established to use the correlation between tunnel motion and anchor reactions via a deep learning algorithm. Once the pattern model is established, it is directly used to estimate the reaction forces by inputting the tunnel motion data, which can be directly measured inside the tunnel. Because the sequential characteristics of responses in the time domain should be considered, the long short-term memory (LSTM) algorithm is mainly used to recognize structural behavioral patterns. Using hydrodynamics-based simulations, big data on the structural behavior of the SFT under various waves were generated, and the prepared datasets were used to validate the proposed method. The simulation-based validation results clearly show that the proposed method can precisely estimate time-series reactions using only acceleration data. In addition to real-time structural health monitoring, the proposed method can be useful for forensics when an unexpected accident or failure is related to the seabed anchors of the SFT.