Browse > Article
http://dx.doi.org/10.4014/jmb.2111.11031

Protective Effects of Bacillus coagulans JA845 against D-Galactose/AlCl3-Induced Cognitive Decline, Oxidative Stress and Neuroinflammation  

Song, Xinping (College of Agriculture, Yanbian University)
Zhao, Zijian (Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences)
Zhao, Yujuan (Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences)
Jin, Qing (College of Agriculture, Yanbian University)
Li, Shengyu (Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences)
Publication Information
Journal of Microbiology and Biotechnology / v.32, no.2, 2022 , pp. 212-219 More about this Journal
Abstract
Recently, the efficacy of probiotics in treatment of neurodegenerative disorders has been reported in animal and clinical studies. Here, we assessed the effects of Bacillus coagulans JA845 in counteracting the symptoms of D-galactose (D-gal)/AlCl3-induced Alzheimer's disease (AD) in a mice model through behavioral test, histological assessment and biochemical analysis. Ten weeks of pre-treatment with B. coagulans JA845 prevented cognitive decline, attenuated hippocampal lesion and protected neuronal integrity, which demonstrated the neuroprotective features of B. coagulans JA845 in vivo. We also found that supplementation of B. coagulans JA845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of D-gal/AlCl3-induced AD model mice. Furthermore, B. coagulans JA845 administration attenuated oxidative stress and decreased serum concentration of inflammatory cytokines by regulating the Nrf2/HO-1 and MyD88/TRAF6/NF-κB pathway. Our results demonstrated for the first time that B. coagulans has the potential to help prevent cognitive decline and might be a novel therapeutic approach for the treatment of neurodegenerative diseases.
Keywords
Bacillus coagulans; cognitive decline; oxidative stress; neuroinflammation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lim J, Kou J, Song M, Pattanayak A, Jin J, Lalonde R, et al. 2011. MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease. Am. J. Pathol. 179: 1095-1103.   DOI
2 Jiang C, Li G, Huang P, Liu Z, Zhao B. 2017. The gut microbiota and Alzheimer's disease. J. Alzheimers Dis. 58: 2018.
3 Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. 2000. Oxidative stress in Alzheimer's disease. Biochim. Biophys. Acta 1502: 139-144.   DOI
4 George Kerry R, Patra JK, Gouda S, Park Y, Shin H-S, Das G. 2018. Benefaction of probiotics for human health: A review. J. Food Drug Anal. 26: 927-939.   DOI
5 Cao J, Yu Z, Liu W, Zhao J, Zhang H, Zhai Q, et al. 2020. Probiotic characteristics of Bacillus coagulans and associated implications for human health and diseases. J. Funct. Foods 64: 103643.   DOI
6 Fitzpatrick L, Small J, Greene W, Karpa K, Farmer S, Keller D. 2012. Bacillus coagulans GBI-30, 6086 limits the recurrence of clostridium difficile-induced colitis following vancomycin withdrawal in mice. Gut Pathog. 4: 13.   DOI
7 Ramsey C, Glass C, Montgomery M, Lindl K, Ritson G, Chia L, et al. 2007. Expression of Nrf2 in neurodegenerative diseases. J. Neuropathol. Exp. Neuroldlq. 66: 75-85.   DOI
8 Grady C, Furey M, Pietrini P, Horwitz B, Rapoport S. 2001. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain 124: 739-756.   DOI
9 Varadarajan S, Yatin S, Aksenova M, Butterfield D. 2000. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130: 184-208.   DOI
10 Nyangale E, Farmer S, Cash H, Keller D, Chernoff D, Gibson G. 2015. Bacillus coagulans GBI-30, 6086 modulates faecalibacterium prausnitzii in older men and women. J. Nutr. 145: 1446-1452.   DOI
11 Venkataraman R, Madempudi R, Neelamraju J, Ahire J, Vinay H, Lal A, et al. 2021. Effect of multi-strain probiotic formulation on students facing examination stress: a double-blind, placebo-controlled study. Probiotics Antimicrob. Proteins 13: 12-18.   DOI
12 Rojo A, Pajares M, Rada P, Nunez A, Nevado-Holgado A, Killik R, et al. 2017. Nrf2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and tau pathology. Redox biol. 13: 444-451.   DOI
13 Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji O, et al. 2016. Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer's disease: a randomized, double-blind and controlled trial. Front. Aging Neurosci. 8: 256.
14 Walter S, Letiembre M, Liu Y, Heine H, Penke B, Hao W, et al. 2007. Role of the Toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol. Biochem. 20: 947-956.   DOI
15 Abulfadl Y, El-Maraghy N, Ahmed A, Nofal S, Badary O. 2018. Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes. Neurol. Res. 40: 324-333.   DOI
16 Serrano-Pozo A, Frosch M, Masliah E, Hyman B. 2011. Neuropathological alterations in Alzheimer disease. Cold Spring Harb. Perspect. Med. 1: a006189.   DOI
17 Haider S, Liaquat L, Ahmad S, Batool Z, Siddiqui R, Tabassum S, et al. 2020. Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress. PLoS One 15: e0227631.   DOI
18 Jensen GS, Cash HA, Farmer S, Keller D. 2017. Inactivated probiotic Bacillus coagulans GBI-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro. J. Inflamm. Res. 10: 107-117.   DOI
19 Drouin-Ouellet J, LeBel M, Filali M, Cicchetti F. 2012. MyD88 deficiency results in both cognitive and motor impairments in mice. Brain Behav. Immun. 26: 880-885.   DOI
20 Kanninen K, Malm TM, Jyrkkanen H-K, Goldsteins G, Keksa-Goldsteine V, Tanila H, et al. 2008. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. Mol. Cell. Neurosci. 39: 302-313.   DOI
21 Jazwa A, Cuadrado A. 2010. Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases. Curr. Drug Targets 11: 1517-1531.   DOI
22 Wang Q, Shen Y, Wang X, Fu S, Zhang X, Zhang Y, et al. 2020. Lactobacillus plantarum concomitant memantine and treatment attenuates cognitive impairments in APP/PS1 mice. Aging 12: 628-649.   DOI
23 Heneka MT, Carson MJ, Khoury JE, Landreth GE, Brosseron F, Feinstein DL, et al. 2015. Neuroinflammation in Alzheimer's disease. Lancet Neurol.14: 388-405.   DOI
24 Kobayashi Y, Sugahara H, Shimada K, Mitsuyama E, Kuhara T, Yasuoka A, et al. 2017. Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease. Sci. Rep. 7: 13510.   DOI
25 Majeed M, Nagabhushanam K, Arumugam S, Majeed S, Ali F. 2018. Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study. Food Nutr. Res. 62:2018.
26 Lim J-E, Song M, Jin J, Kou J, Pattanayak A, Lalonde R, et al. 2012. The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 mice. Behav. Brain Res. 227: 36-42.   DOI
27 Bonfili L, Cecarini V, Cuccioloni M, Angeletti M, Berardi S, Scarpona S, et al. 2018. SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model. Mol. Neurobiol. 55: 7987-8000.   DOI
28 Madempudi R, Ahire J, Neelamraju J, Tripathi A, Nanal S. 2019. Randomized clinical trial: the effect of probiotic Bacillus coagulans unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults. Sci. Rep. 9: 12210.   DOI
29 La Rosa M, Bottaro G, Gulino N, Gambuzza F, Di Forti F, Ini G, et al. 2003. Prevention of antibiotic-associated diarrhea with Lactobacillus sporogens and fructo-oligosaccharides in children. a multicentric double-blind vs placebo study. Minerva Pediatr. 55: 447-452.
30 Minamida K, Nishimura M, Miwa K, Nishihira J. 2015. Effects of dietary fiber with Bacillus coagulans lilac-01 on bowel movement and fecal properties of healthy volunteers with a tendency for constipation. Biosci. Biotechnol. Biochem. 79: 300-306.   DOI
31 Takashima A. 2009. Amyloid-beta, tau, and dementia. J. Alzheimers Dis. 17: 729-736.   DOI