• Journal of Korean Medicine Rehabilitation
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• v.23 no.2
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• pp.17-31
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• 2013

Objectives : Peripheral nerve injuries are commonly encountered clinical problems and often result in serve functional deficit. Bee venom and scolopendra subspinipes have been traditionally used in oriental medicine to treat several inflammatory diseases and chronic pain conditions. Methods : In the present study, the effects of bee venom pharmacopuncture and scolopendra subspinipes pharmacopuncture on functional recovery, severity of pain, and expressions of neurofilament, cycloxygenease-2(COX-2), and tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) following sciatic crushed nerve injury in rats were investigated. For this study, walking tract analysis, plantar test, western blot for COX-2 and TNF-${\alpha}$, and immunohistochemistry for neurofilament were performed. Results : In the present results, sciatic functional index(SFI) in walking tract analysis was significantly decreased following sciatic crushed nerve injury, and pain severity in plantar test was significantly increased. COX-2 and TNF-${\alpha}$ expressions were increased whereas neurofilament expression was decreased by sciatic crushed nerve injury. On the other hand, bee venom pharmacopuncture and scolopendra subspinipes pharmacopuncture improved SFI in walking tract analysis and suppressed the pain severity in sciatic crushed nerve injury. Bee venom pharmacopuncture and scolopendra subspinipes pharmacopuncture suppressed COX-2 and TNF-${\alpha}$ expression and enhanced the neurofilament expression in sciatic crushed nerve injury. Conclusions : In the present study, we have shown that treatment with bee venom or scolopendra subspinipes is the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury. The efficacies of bee venom and scolopendra subspinipes were similar.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.3
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• pp.67-77
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• 2016

Objectives To evaluate the evidence supporting the effectiveness of Bee Venom therapy for traumatic injury. Methods We conducted search across 3 electronic databases (Pubmed, CAJ and Oasis) to find clinical trials that used Bee Venom therapy as treatment for traumatic injury. The methodological quality of RCTs (Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias (RoB) tool, while NRCTs (Non-Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool. Results Among 87 articles that were searched, 10 RCTs and 19 NRCTs were finally selected. Among 19 selected studies, all studies showed that Bee Venom therapy has significant effect on traumatic injury. Conclusions Our systematic review found encouraging but limited evidence of Bee Venom therapy for traumatic injury. We recommend clinical trials which compare the effectiveness of Bee Venom therapy with other pharmacopuncture therapies to clarify the effectiveness of Bee Venom therapy from other pharmacopuncture therapies.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.3
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• pp.57-69
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• 2011

Objectives : The purpose of this study is to know the effects of the bee venom pharmacopuncture on muscle activity and pain reception of trapezius and deltoid the upper limbs muscles. Methods : We allocated healthy volunteers into two groups. After having exercise with barbell for load to trapezius and deltoid, we measured sEMG(surface electromyography) and VAS(visual analogue scale). In a moment, inject bee venom pharmacopuncture and saline each group. After 30 minutes, we measured sEMG and VAS again. We compared before and after sEMG and VAS data. Results : On sEMG data, bee venom pharmacopuncture had effects on muscle fatigue on left trapezius, muscle fatigue and fatigue and recovery on right trapezius and both deltoid. On VAS data, values of bee venom pharmacopuncture decreased more than that of saline. Conclusions : These results show that bee venom pharmacopuncture have effects on muscle activity aid pain reception of trapezius and deltoid the upper limbs muscle. But further studies should be carried out to verify the exact effects of bee venom.

• Journal of Acupuncture Research
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• v.22 no.2
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• pp.19-32
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• 2005

Objectives : to evaluate the analgesic effect of bee venom acupuncture on Choksamni (ST36) in the collagen-induced arthritis rats and investigate the role played by serotonergic receptor subtypes (5-HT1a, 5-HT2a) in the antinociceptive effect of bee venom acupuncture in a thermal hyperalgesia test Methods : Experiments were performed on 5 week-aged 60 male Sprague-Dawley rats according to National Institute of Health guidelines and the ethical guidelines of the International Association for the Study of Pain (IASP). Arthritis was induced with arthrogenic collagen emulsion (Bovine type II collagen ${\mu}g$ with incomplete Freund's adjuvant $100\;{\mu}g$). The onset of arthritis was considered to be present when erythema and swelling were detected in at least one joint. The thermal hyperalgesia was evaluated weekly with tail flick test in the rats of severity grade 3 without any injury at tail and foot (including inflammation, ulceration, snap). In the fourth week after first immunization, the analgesic effect of bee venom acupuncture (Choksamni, ST36) was measured with consecutive tail flick latency after intraperitoneal injection of spiroxatrine (1mg/kg) and spiperone (1mg/kg). Results : Chronic inflammatory pain was induced as time elapsed after the immunization of arthrogenic collagen and the maximum value was reached from third to fifth week. Chronic inflammatory pain induced by CIA was inhibited by bee venom acupuncture on the left ST36. The analgesic effect of bee venom acupuncture was inhibited by intraperitoneal injection of 5-HT1a antagonist spiroxatrine and 5-HT2a antagonist spiperone. Conclusions : Therefore, a conclusion. that the analgesic effect of bee venom acupuncture in the chronic inflammatory pain is partially mediated by 5-HT1a and 5-HT2a receptors can be made.

• Journal of Acupuncture Research
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• v.30 no.3
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• pp.117-124
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• 2013

Objectives : This study was designed to compare the effect of bee venom pharmacopuncture treatment and Hwangryun pharmacopuncture treatment in patients with cervical disc herniation Methods : This study was done on 48 cases of patients with cervical disc herniation diagnosed by MRI, symptoms and physical test who admitted in Bu-cheon Jaseng Hospital of Oriental Medicine from January 1st, 2012 to August 31th, 2012. We divided patients into two groups. Bee venom group was treated by bee venom pharmacopuncture treatment and Hwangryun group was treated by Hwangryun pharmacopuncture treatment. We measured the efficacy of treatment with numerical rating scale(NRS) and neck disability index(NDI). The evaluations performed at admission day and 14th day after admission. Results : In both bee venom group and Hwangryun group, NRS and NDI decreased significantly in statistics as treatment was performed. Though bee venom group showed a decreasing NRS and NDI score compared to Hwangryun group, there is no statistical significant difference between the result of both groups. Conclusions : The result of this study suggest that both bee venom pharmacopuncture treatment and Hwangryun pharmacopuncture treatment is effective in reducing pain for patients with cervical disc herniation. Further clinical research is needed to verify these results and findings.

• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.47-55
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• 2007

Objectives : To verify pain relief effects and allergy inhibitory action for the osteoarthritis of the knee joint in Sweet Bee Venom in which allergy causing enzyme is removed. Methods : We randomly allocated 36 participants to treatment group Sweet Bee Venom and Bee Venom. Outcomes on pain reduction were measured by 100mm VAS(Visual Analog Scale). And we recorded into details allergic responses during Pharmacopuncture treatment. Results : Whole body condition and pain rate through VAS measurement were improved significantly in 2 weeks. We could get difference in pain score of two Pharmacopuncture groups significantly in 2 weeks. BV group showed superior reduction in pain compared to the Sweet BV group. But we could not get difference in whole score of two pharmacopuncture groups significantly. On the other hand other allergic responses such as edema, itchiness, pain were significantly lower in the Sweet BV group.

• Analytical Science and Technology
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• v.29 no.4
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• pp.194-201
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• 2016

The stability comparison tests on purified bee venom (PBV) and bee venom melittin (BVM) in different conditions of temperature, solvent, and concentration were studied. High purity BVM (98.2 %) was separated from PBV by prep-HPLC (column, C₄) and used to stability tests in aqueous phase. The stability of the PBV has been increased in the saline solution, while BVM was reduced. In distilled water, the stability of PBV has been reduced, while BVM showed an increasing result. As a result, the appropriate conditions for maintaining the long term stability of BVM were found to be the low temperature (4 ℃), distilled water, and concentration (1.0 mg/mL).

• Journal of Pharmacopuncture
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• v.7 no.2
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• pp.75-81
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• 2004

Objective : The purpose of this study is to report the efficiency of Bee Venom Therapy by managering of radial nerve palsy patients. Method : Three patients were treatmented by Bee Venom therapy and acupucture therapy. And we took pictures of someone's wrist and checked the power of muscles by the improving phase. Results : Almost cases shows the improvement in the movement of wrist and the numbness of hand. By using acuputure and Bee Venom therapy, the symptoms of radial nerv palsy was more fastly recovered.

• Journal of Acupuncture Research
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• v.29 no.4
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• pp.99-103
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• 2012

Objectives : This study was performed to report a case of adhesive capsulitis treated by intra-articular bee venom pharmacopuncture. Methods : Patient was treated by intra-articular bee venom pharmacopuncture four times during two weeks, and after that the patient had intermission period for 2 weeks. The same treatment was administered four times during two weeks after the intermission. The effect of treatment was evaluated by visual analog scale(VAS), range of motion(ROM). Results : After treatment, VAS score declined from 7 to 4, ROM increased. Conclusions : Intra-articular bee venom pharmacopuncture was effective for adhesive capsulitis.

• Korean Journal of Acupuncture
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• v.21 no.4
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• pp.133-143
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• 2004

Objective : The purpose of this study is to compare the effect of Bee-Venom Therapy and common acupuncture therapy for the acute ankle sprain Methods : This study has been carried out for 32 cases of ankle sprain patients who have visited Cheon-an Oriental Medical Hospital from may 1, 2004 to June 30, 2004. We have treated 16 cases of them by Bee-Venom therapy(group I) and the other 16 cases by common acupuncture therapy(group II). And we have compared those two group. Results and Conclusions : 1. There were good effect on the ankle sprain in both two groups. 2. There were no significant difference at the ROM of ankle joint in both two groups. 3. Common acupuncture therapy had more quick effect on the joint of swelling. 4. In the VAS score, Bee-Venom therapy had more quick effect on total improvement of ankle sprain.