• Journal of the Computational Structural Engineering Institute of Korea
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• v.36 no.6
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• pp.391-398
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• 2023

In this paper, a penalized maximum likelihood estimation (PMLE) method that applies a penalty to increase the accuracy of a basis-screening-based Kriging model (BSKM) is introduced. The maximum order and set of basis functions used in the BSKM are determined according to their importance. In this regard, the cross-validation error (CVE) for the basis functions is employed as an indicator of importance. When constructing the Kriging model (KM), the maximum order of basis functions is determined, the importance of each basis function is evaluated according to the corresponding maximum order, and finally the optimal set of basis functions is determined. This optimal set is created by adding basis functions one by one in order of importance until the CVE of the KM is minimized. In this process, the KM must be generated repeatedly. Simultaneously, hyper-parameters representing correlations between datasets must be calculated through the maximum likelihood evaluation method. Given that the optimal set of basis functions depends on such hyper-parameters, it has a significant impact on the accuracy of the KM. The PMLE method is applied to accurately calculate hyper-parameters. It was confirmed that the accuracy of a BSKM can be improved by applying it to Branin-Hoo problem.

• International Journal of Industrial Entomology and Biomaterials
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• v.7 no.1
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• pp.5-10
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• 2003

The nuclear polyhedrosis virus (NPV) resistance of silkworm is controlled by a pair of dominant genes on autosome and micro-effect modificator genes on sex chromosome Z and has the phenomenon of patroclinal inheritance. Based on its hereditary characteristics, methods of preparing near isogenic lines and their $F_2$ populations for screening molecular markers were designed.

• Culinary science and hospitality research
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• v.9 no.3
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• pp.114-129
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• 2003

This study aimed at drawing a scheme for more developmental and rational improvement of the screening examination system to cope with the rapidly changing industrial environment positively, enhance the food service industry qualitatively, and reinforce engaged specialty of those engaged in the industry. To set a rational improvement scheme for a cook screening system, the study conducted a prior study on job analysis of those engaged in cooking, a review on relevant laws, and a theoretical research on those problems in the current cook screening examination system. On this basis, it understood the actual condition of the current cook screening system and implemented a demonstrative analysis through a survey to draw a section on a future improvement scheme. The results were analyzed largely from two viewpoints: the general condition of the cook screening system and the future improvement scheme for the system.

• Clinical and Experimental Pediatrics
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• v.57 no.7
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• pp.329-332
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• 2014

3-methylcrotonyl-coenzyme A carboxylase (3MCC) deficiency is an autosomal recessive disorder in which leucine catabolism is hampered, leading to increased urinary excretion of 3-methylcrotonylglycine. In addition, 3-hydroxyisovalerylcarnitine levels increase in the blood, and the elevated levels form the basis of neonatal screening. 3MCC deficiency symptoms are variable, ranging from neonatal onset with severe neurological abnormality to a normal, asymptomatic phenotype. Although 3MCC deficiency was previously considered to be rare, it has been found to be one of the most common metabolic disorders in newborns after the neonatal screening test using tandem mass spectrometry was introduced. Additionally, asymptomatic 3MCC deficient mothers have been identified due to abnormal results of unaffected baby's neonatal screening test. Some of the 3MCC-deficient mothers show symptoms such as fatigue, myopathy, or metabolic crisis with febrile illnesses. In the current study, we identified an asymptomatic 3MCC deficient mother when she showed abnormal results during a neonatal screening test of a healthy infant.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.365-368
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• 2006

The implementation of a screening procedure for removing non-conforming products has become a common practice especially in high-tech manufacturing industries. Screening procedures involve a measurement on the quality characteristic of interest since decisions regarding the conformance to specifications are usually made on the basis of the realization of measurement. A significant variability in measurement procedures may result in the misclassification of an outgoing product (that is, falsely accepting defectives or falsely rejecting conforming items), which may lead to wrong interpretation on product quality, It may thus be necessary to consider the impacts of misclassification errors due to measurement variability when designing screening procedures. Along this line, this article investigates the design of screening procedures based on the assessment of misclassification errors. The main objective is to determine the screening limits on measured values so that two types of misclassification errors may properly be compromised.

• Journal of Korean Institute of Industrial Engineers
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• v.27 no.2
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• pp.135-139
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• 2001

A process control procedure is suggested when screening inspection is performed with a surrogate variable correlated with the performance variable. Assuming bivariate normal distribution for the performance and screening variable, the procedure is designed on the basis of the time required for detecting process shift.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2721-2728
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• 2012

Background: There are limited data evaluating the cost-effectiveness of gastric cancer screening using endoscopy or upper gastrointestinal x-ray in the general population. Objective: To evaluate the cost-effectiveness of population-based screening for gastric cancer in South Korea by decision analysis. Methods: A time-dependent Markov model for gastric cancer was constructed for healthy adults 30 years of age and older, and a deterministic sensitivity analysis was performed. Cost-utility analysis with multiple strategies was conducted to compare the costs and effects of 13 different screening alternatives with respect to the following eligibility criteria: age at the beginning of screening, screening interval, and screening method. The main outcome measurement was the incremental cost-effectiveness ratio. Results: The results revealed that annual endoscopic screening from ages 50-80 was the most cost-effective for the male population. In the females, biennial endoscopy screening from ages 50-80 was calculated as the most cost-effective strategy among the 12 screening alternatives. The most cost-effective screening strategy may be adjustable according to the screening costs and the distribution of cancer stage at screening. The limitation was that effectiveness data were obtained from published sources. Conclusions: Using the threshold of $19,162 per quality-adjusted life year on the basis of the Korean gross domestic product (2008), as suggested by the World Health Organization, endoscopic gastric cancer screening starting at the age of 50 years was highly cost-effective in the Korean population. The national recommendation for gastric cancer screening should consider the starting age of screening, the screening interval, and the screening modality.

• Health Policy and Management
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• v.29 no.4
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• pp.399-411
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• 2019

Background: This study aimed to explore the associations of social-demographic, health-behavioral, and woman-specific factors with the non-screening status of the cervical cancer screening test in Korean adult women. Methods: This study was a cross-sectional analysis of 9,698 Korean adult women aged 20 years or more who participated in the Korea National Health and Nutrition Examination Surveys V (2010-2012). Rao-Scott chi-square tests and survey logistic regression analyses were employed respectively to analyze the difference in the non-screening status of the cervical cancer screening test by each characteristic and to explore the factors related to the non-screening status. Results: The rate of the non-screening status of the cervical cancer screening test was 53.5% over the previous 2 years. In the survey logistics regression analysis, age, marital status, educational levels, income levels, residential area, occupation, private health insurance, smoking, alcohol, obesity, menstrual status, pregnancy experience, and hormone replacement therapy were significantly associated with the non-screening status of the cervical cancer screening test. Conclusion: On the basis of the results of this study, some social-demographic, health-behavioral, and woman-specific characteristics of Korean adult women seem to affect the non-screening status of the cervical cancer screening test. Therefore, appropriate health policies need to be designed, implemented, monitored, and evaluated to reduce the non-screening status of the cervical cancer screening test of them.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.975-981
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• 2014

Cervical cancer is an issue of foremost importance globally, specifically affecting the developing nations. Significant advances have taken place with regard to diagnosis of cervical cancer, especially with screening. Appropriate screening measures can thus reduce the incidence of cervical cancer. The most desirable screening technique should be less invasive, easy to perform, cost-effective and cover a wide range of diagnostic icons. Manual liquid based cytology (MLBC) can be considered as one of the suitable technique for screening with the above-mentioned benefits. The aim of the current study was to compare two cervical screening techniques on the basis of different morphological parameters and staining parameters by using modified acetic acid Pap staining to see the possibility of reducing time economy involved in conventional Pap staining (CPS). The study was conducted on a total 88 cases and all were analyzed with both MLBC and CPS. Forty eight cases that were regarded as satisfactory on the basis of Bethesda system by both methods were further recruited for investigation. Their morphological parameters and staining quality were compared and scored according to a scoring system defined in the study. Quality indices was calculated for both staining procedures and smear techniques.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.1
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• pp.17-36
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• 1996

An economic two-stage screening procedure is presented when both lower and upper specification limits are given on the performance variable. A screening variable which is highly correlated with the performance variable is used first to decide whether an item should be accepted, rejected, or undecided. The performance variable is then used to classify the undecided items. The two variables are assumed to be jointly normally distributed. A cost model is constructed on the basis of six cost components; inspection costs of screening and performance variables and costs caused by type I and type II misclassification errors related with lower and upper specification limits. Optimal cutoff values on the screening variable are determined so that the average outgoing quality exceeds a prespecified level. Solution methods are provided for both known-parameter and unknown-parameter cases.