• Korean Journal of Occupational Health Nursing
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• v.28 no.4
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• pp.262-270
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• 2019

Purpose: This study aims to provide preliminary data for weight management, and prevention and management of cardiovascular and cerebrovascular diseases. We examined the effect of changes in the weight of workers at a manufacturing company over three years on their metabolic syndrome and metabolic syndrome diagnosis components. Methods: Necessary data were collected from the questionnaire and the results of the Korean National Health Screening of 2015 and 2017, which included 228 workers at a manufacturing company in G region. The collected data were analyzed using the SPSS/WIN 23.0 program. ANCOVA was used to examine the differences in the metabolic syndrome diagnosis components according to weight change. In addition, multiple logistic regression analysis was used to obtain the odds ratios of metabolic syndrome and metabolic syndrome analysis component, based on the weight changes in the normal weight group and the obesity group. Results: Waist measure, systolic blood pressure, and blood pressure were found to have significant effects based on participants' weight change over three years. These factors increased with a larger increase in weight at a statistically significant level. This study analyzed the weight changes of the normal weight group and the obesity group considering the data from the National Health Screening of 2015, and found that the risk of metabolic syndrome increased at a statistically significant level as body weight increased; thus, the obesity group showed a higher risk in this regard. It was also found that waist measure, fasting blood sugar, and high-density low cholesterol increased at a statistically significant level as body weight increased. Conclusion: Health administrators need to recognize the importance of workers' weight management, select an intensive management group based on a time series analysis of weight changes, and develop and implement programs to manage the metabolic syndrome diagnosis components.

• Korean Journal of Oriental Medicine
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• v.16 no.1
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• pp.119-134
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• 2010

Objectives & Method：Based on the statistic from January 2008 to December 2008 include 66-year-old 375 people (159 men, 216 women) who got examined in National Health Insurance Corporation, this study set a goal to establish a new health index by analyzing the relation between the cardio-cerebra vascular disease and risk factor such as obesity, smoking, exercise, alcohol consumption, blood pressure, blood sugar and cholesterol. Results：1) Examine results, health status according to gender；People who are diagnosed as abnormal health status have higher risk for both men and women. As for the detailed diseases, high blood pressure was highest followed by hyperlipidemia and obesity. In case of the women, 96.3% in bone mineral density was highest. 2) Correlation of disease and health risk factors based on gender；Correlation of disease according to gender in the obesity(p<0.001), lipid abnormalities(p<0.001), kidney diseases(p<0.001), chest diseases(p<0.05), osteoporosis(p<0.001) showed a statistically significant difference. The analysis showed that the men have more obesity and lipid abnormalities as well as thoracic disease than the women, but the women have more kidney disease than the men. As for the osteoporosis examine which is conducted only for the women, most of the women were abnormal even though it cannot compare the result according to gender. Obesity(p<0.001), alcohol(p<0.001), smoking(p<0.001) and LDLcholesterol(p<0.001) showed statistical correlation between gender and health risk factor. And only high blood pressure(p<0.001) showed a statistical correlation between gender and risk of cardio-cerebra vascular disease. 3) Risk of cardio-cerebra vascular disease related to health risk factor characteristic；Obesity assessment(p<0.001), alcohol(p<0.05), smoking(p<0.05), blood pressure(p<0.001), glucose(p<0.001) showed correlation between health risk factor and stroke. Drinking(p<0.001), smoking(p<0.05), exercise(p<0.001), blood pressure(p<0.001), LDL cholesterol(p<0.001) showed health risk factor and myocardial infarction. Obesity assessment(p<0.001), smoking(p<0.05), blood pressure(p<0.001), glucose(p<0.001) and showed correlation between health risk factor and diabetes. Obesity assessment(p<0.001), blood pressure(p<0.001) showed correlation between health risk factor and high blood pressure. Conclusion：Therefore, we have to take one step farther after the health examination. In order to prevent and reduce the risk of disease, people have to understand their health status exactly first, and correct their habit with recognizing the amount of risk related to cardio-cerebra vascular disease.

• 한국벤처창업학회:학술대회논문집
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• 2008.04a
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• pp.143-178
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• 2008

This study is to look into the spin-off ventures which was incorporated based on the technology developed by public research institute, but underwent difficulties confronted during the development stages focused on the growth process and the factors contributed to their success. The case study was conducted with i-Sense Co., Ltd. which is a ventures organized by professors as a form of research based spin-off venture. i-Sense Co., Ltd. is a new-technology based ventures to produce self-tester for blood sugar level which was incorporated by Prof. Cha, Keun-sik and Prof. Nam, Hak-hyun of Department of Chemistry in Kwangwoon University along with the graduate course students of the Research Laboratory of the University. The two professors operated the Chemical Sensor Research Center at the Kwangwoon University where they produced many preliminary research outputs related with bio-sensors. They also executed the service works at the specialized company they established for research development to make research fund. They established i-Sense Co., Ltd. with the aim to carry out the research they want to. But contrary to the initial intention of the founders of the company, i-Sense Co., Ltd. has grown up as manufacturing company which produces and sells the self-tester for blood sugar level and is expected to be listed by Initial Public Offering (IPO) on the KOSDAQ in 2008. This study is to analyze the foundation and the growth process of i-Sense Co., Ltd. as successful research based spin-off ventures, to find out the factors contributed to their success by enabling them to overcome the difficulties experienced during the growth process, and eventually to provide with suggestive meanings in policy and practical point of view that leaded the research based spin-off ventures to success.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.16-26
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• 2023

Diabetes is an untreatable metabolic disorder characterized by alteration in blood sugar homeostasis, with submucosal insulin therapy being the primary treatment option. This route of drug administration is attributed to low patient comfort due to the risk of pain, distress, and local inflammation/infections. Nanoparticles have indeed been suggested as insulin carriers to allow the drug to be administered via less invasive routes other than injection, such as orally or nasally. The organic-based nanoparticles can be derived from various organic materials (for instance, polysaccharides, lipids, and so on) and thus are prevalently used to enhance the physical and chemical consistency of loaded bioactive compounds (drug) and thus their bioavailability. This review presents various forms of organic nanoparticles (for example, chitosan, dextron, gums, nanoemulsion, alginate, and so on) for enhanced hypoglycemic drug delivery relative to traditional therapies.

• Journal of Technologic Dentistry
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• v.41 no.2
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• pp.103-112
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• 2019

Purpose: This article tried to find the relations between periodontal diseases, body mass index and clinical level for Korean adults over the age of 19, utilizing data of the 6th national nutrition survey. Methods: In the collected data, 14,940 adults aged 19 years or older were included in the study to determine the relationship between the general health status of Korean adults and periodontal disease. Results: As the result, 28.6% of Korean adults had periodontal diseases, there were significant differences depending on gender, age, smoking, residential aria, education level, body mass index, HDL-cholesterol, leukocyte value and fasting blood sugar. When general factors were controlled for multiple logistic regression analysis, there was significance as BMI cross rate was 1.029(95% C1, 1.007-1.051). HDL-cholesterol cross rate was 0.989(95% C1, 0.980-0.999), leukocyte cross rate was 1.086(95% C1, 1.040-1.134) and fasting bloody sugar cross rate was 1.006(95% C1, 1.003-1.009), so there were significance. In conclusion, there was a significance relation between periodontal diseases, body mass index, HDL-cholesterol and fasting bloody sugar. Conclusion: Based on the results of this study, oral health education should be used to manage and maintain healthy oral cavity by improving periodontal disease management and awareness. In addition, it will be necessary to develop periodic oral examinations and age - specific oral health education programs, and it can be used as a basic data for public oral health plan.

• Journal of Korean Public Health Nursing
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• v.32 no.2
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• pp.235-248
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• 2018

Purpose: This qualitative study examined the participation in ICT-based management from the perspectives of patients with chronic diseases. This study was conducted as one of several studies evaluating the effectiveness of chronic disease management in the Ministry of Health and Welfare. Methods: Focus group interviews were used as its guiding methodology. Group interviews with 16 patients were carried out using semi-structured interview questions developed from a literature review and discussion with researchers. Content analysis was used to analyze the data. Results: A total of 11 sub-themes were extracted through a comparison of the concepts and semantic analysis, and finally, four themes were derived: "Satisfied with systematic management of health care", "Leading in health care", "Understanding the pattern of blood pressure and blood sugar change" and "Adherence to existing health care habits". Conclusion: This study is meaningful in that it used qualitative analysis through FGI to evaluate the effects of an ICT-based chronic disease management project. Based on this study, a mixed-method design study and an intervention study among patients with metabolic syndrome is proposed.

• Journal of Korean Academy of Rural Health Nursing
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• v.6 no.1
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• pp.5-14
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• 2011

Purpose: The primary goal of this study was to develop a case management with exercise program for community dwelling elders who live alone, and examine the effects of the program. Method: The design of this research was a one group pre-post test study. The participations were 85 elders diagnosed with hypertension and diabetes mellitus and who lived alone as residents of D city. The case management with exercise program included exercise and counseling as the intervention and was provided for 12 weeks. Data were collected before and after the intervention which lasted from September 3 to November 26, 2009. Collected data were analyzed using descriptive statistics, and paired t-test. Results: There were significant differences in blood pressure (t=-5.24, p<.001, t=-1.94, p= .040), fasting blood sugar (t=-4.41, p<.001), ADL (t=-5.43, p=.022) and cognitive function (t=7.41, p=.008) between pre- and post intervention. Conclusion: These results indicate that the case management program is an important intervention for health promotion for community-dwelling elders, and exercise improves functional status of older persons with diseases. Therefore, now is the time to develop new supportive community-based programs for elders who live alone. However, it is also necessary to do further longitudinal studies to confirm the results of this study.

• Journal of Home Health Care Nursing
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• v.16 no.1
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• pp.12-21
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• 2009

Purpose: The survey-based study aimed to determine the distribution and clustering tendency of metabolic syndrome risk factors in urban residents, and cluster odds ratios. Methods: Cluster sampling involved 827 urban participants and analysis of the collected data. Results: Regarding the prevalence of metabolic syndrome risk factors used for diagnosis, abdominal obesity was higher in women(69.5%) than in men(34.3%), high blood pressure was higher in men(57%) than in women(46.5%), and blood sugar was higher in men(6.9%) than in women(5.7%). Clustering increased with increasing body mass index(BMI), weight:height ratio(W/Ht) and abdominal obesity Risk factors for females were 1.7 times higher than for males. Participants with a family history of metabolic syndrome displayed related risk factors 1.5 times more than participants without a family history. Participants having a BMI ranking them as obese were 9.5 times more likely to display metabolic syndrome risk factors than non-obese participants. Obese participants were 20 times more likely to display risk factors than non-obese participants. Conclusion: BMI, W/Ht and abdominal obesity correlate with clustering of metabolic syndrome risk factors. The risk is increased by smoking and family history. Exercise weight control and non-smoking are recommended for comprehensive management of clustering of metabolic syndrome risk factors.

• The Korean Journal of Food And Nutrition
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• v.32 no.3
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• pp.251-258
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• 2019

The purpose of this study was to examine the association nutrition education experience in regards to metabolic risk and nutrition intake in Korean adult male using the 2016~2017 Korea National Health and Nutrition Examination Survey as the reference. The study involved a total of 1,978 male subjects aged 40~64 who were classified into the 2 groups based on their nutrition education experience: Educated group (n=88) and non-educated group (n=1,890). The household income and education level of educated group were higher than those of the non-educated group. The two groups showed no significant difference in the level of fasting blood sugar, blood lipid profile including total cholesterol and triglyceride, LDL-cholesterol, and hypertension. Vitamin C intake of the educated group (127.5 mg) was higher compared to the non-educated group (88.2 mg) (p<0.05). The percentage of the subjects utilizing nutritional labels was higher in the educated group. The nutrition education experience was inversely proportional to lower Odds Ratio in hyperLDL-cholesterolemia (OR: 0.47, 95% CI: 0.36, 0.84) and HypoHDL-cholesterolemia (OR: 0.57, 95% CI: 0.37, 0.87). This result indicates that nutritional education can be used as an effective tool to avert chronic diseases and develop healthy eating habits.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.2
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• pp.234-240
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• 2012

The purpose of this case-control study is to investigate the relationship between storke and stroke risk factors, such as family history and past history. The case-control study over clinical data registered from Daejeon Oriental Medical Hospital in the period of November 2006 to July 2010. Study subjects consisted of 108 patients with acute stroke within 1 month as the case group (Cases) and 108 people who visited hospital for health care as the genreral control group (Controls). The participants had been interviewed by residents to find out their family history and past history. Their blood was taken to check the blood lipid level and liver function. 1. The people whose family history included cerebrovascular accident had more probability of stroke than the people who did not have cerebral vascular accident as their family history. 2. The people who suffered from hypertension had more probability of stroke than the people who did not suffer from hypertension. 3. The people who suffered from diabetes mellitus had more probability of stroke than the people who did not suffer from diabetes mellitus. Based on this study, the people who had cerebral vascular accident as their family history should thoroughly treat their blood pressure and blood sugar level to prevent the cerebral vascular accident.