• Archives of Plastic Surgery
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• v.37 no.4
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• pp.473-476
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• 2010

Purpose: Torus palatinus is a bony prominence at the middle of the hard palate. The size varies from barely discernible to very large, from flat to lobular. This oral exostosis is not a disease or a sign of disease, but if large, may be a problem. So, we present the clinical and histopathologic features and applied therapy and provide a comprehensive review of the rare case of the symptomatic exostoses. Methods: A 37-year-old woman had slowly growing exophytic nodular mass of the bone that arises the midline suture of the hard palate. The patient was concerned about discomfort associated with movement of her tongue and about frequent irritation of the palatal mucosa during mastification of the hard food. The patient had a large, unilobulated torus palatinus. It extended from the area adjacent to the canine to a point beyond the junction with the soft palate. The mass was oblong in shape, measuring about 3 cm long, 2 cm wide, and 0.8 cm in height. Results: Before surgical intervention a CT was obtained for the sake of estimating the thickness of the bone between the exostoses and the maxillary antrum and floor of the nose. The surgical procedure was performed with the patient under general anesthesia. Removal of the exostosis was performed after midline mucoperiosteal incision with osteotome and diamond burr. Histologic finding revealed decalcified dense bony tissue, the presence of lacunae, and normal osteocytes. Conclusion: Surgical removal is recommended when one or more of the following condition exist: interference with the construction of prosthesis, interference with oral function, irritation or pathology of the overlying tissue, inability of the patient to maintain proper oral hygiene, and fear of malignancy or other psychologic trauma. We report a rare case of the torus arising in hard palate with symptoms.

• Conservation Science in Museum
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• v.18
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• pp.65-76
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• 2017

Following advances in technology and with the growing need for renewable energy, fluorescent and halogen lamps are being replaced by LED lighting in museum systems. This paper researched the setting of standards for the diverse lighting systems in addition to the LED lighting that are expected to be introduced in museums in the future. Contrary to previous belief, LEDs were shown to only barely emit in the ultraviolet region, but the visible rays were confirmed to produce discoloration depending on illuminance-hours. When the color change by LED lamps at the color temperature of 2800K, or warm white, was compared with 5500K, or white, the emission spectrum analysis confirmed that the blue spike increased at a higher color temperature and caused more discoloration. This suggests that in addition to illumination, color temperature should be considered by including the emission spectrum when museums set lighting environment standards.

• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.98-103
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• 2020

Marfan syndrome (MFS), a connective tissue disorder caused by mutations in the fibrillin-1 (Fbn1) gene, has vascular manifestations including aortic aneurysm, dissection, and rupture. Its vascular pathogenesis is assumed to be attributed to increased transforming growth factor β (TGFβ) signaling and blockade of excessive TGFβ signaling has been thought to prevent dissection and aneurysm formation. Here, we investigated whether galunisertib, a potent small-molecule inhibitor of TGFβ receptor I (TβRI), attenuates aneurysmal disease in a murine model of MFS (Fbn1^C1039G/+) and compared the impact of galuninsertib on the MFS-related vascular pathogenesis with that of losartan, a prophylactic agent routinely used for patients with MFS. Fbn1^C1039G/+ mice were administered galunisertib or losartan for 8 weeks, and their ascending aortas were assessed for histopathological changes and phosphorylation of Smad2 and extracellular signal-regulated kinase 1/2 (Erk1/2). Mice treated with galunisertib or losartan barely exhibited phosphorylated Smad2, suggesting that both drugs effectively blocked overactivated canonical TGFβ signaling in Fbn1^C1039G/+ mice. However, galunisertib treatment did not attenuate disrupted medial wall architecture and only partially decreased Erk1/2 phosphorylation, whereas losartan significantly inhibited MFS-associated aortopathy and markedly decreased Erk1/2 phosphorylation in Fbn1^C1039G/+ mice. These data unexpectedly revealed that galunisertib, a TβRI inhibitor, showed no benefits in aneurysmal disease in MFS mice although it completely blocked Smad2 phosphorylation. The significant losartan-induced inhibition of both aortic vascular pathogenesis and Smad2 phosphorylation implied that canonical TGFβ signaling might not prominently drive aneurysmal diseases in MFS mice.

• Journal of Life Science
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• v.15 no.6 s.73
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• pp.928-934
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• 2005

ATF2 is a cellular transcription factor which belongs to the CREB/ATF class and it is leucine zipper protein which generally binds to DNA as dimers. This paper presents the procedure for subcloning the ATF2 gene and the results of experiment used the expressed ATF2. The pET expression vector was used since it produced 6xHis fusion protein for easy purification using affinity column. The Nickel chelating chromatography was used for Purifying the expressed ATE2 from E- codi BL2l. Subsequen시y In vitro binding pull-down assay showed the binding specificity of ATF2 with AP-1 family factors such as BATF, c-Fos, c-Jun and ATF2 itselgf. ATF2 forms homodimer as well as strong heterodimer with BATF. It also forms stable dimer with c-Jun but barely binds with c-Fos.

• Journal of Gifted/Talented Education
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• v.9 no.1
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• pp.63-84
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• 1999

This study is to examine the current problems of teaching gifted children and suggest elements(or factors) to be considered in setting up goals thereof by analyzing incumbent teachers awareness. 121 teachers were arbitrarily selected from 30 different kindergartens located in Seoul and Anyang, and they were interviewed with two parts questionnaires(or opinions) of improving current practice. The first part of the questionnaire is composed of the questions about teachers awareness of gifted children, actual state of teaching gifted children, effects of teaching in kindergarten for gifted children, and desired direction for teaching improvement. The second part of the questionnaire provided interpretation of precociousness by study habit, creativity and definitive properties and asked the number of children qualified in their classes. Since the results of the first interview as to awareness of gifted children were dismal, 40 teachers were thereafter randomly selected again, and the second interview was warranted. The results alarmingly revealed that program of teaching gifted children were barely existing even though the teachers awareness for the needs of special education for the precocious as well of study materials and programs thereof was high. In addition, the teachers familiarity of gifted children was surprisingly low. At the second interview whereby gifted children was explained, the teachers awareness of gifted children was dramatically improved to 40% in comparing with 7.4% at the first interview without explanation of gifted children. Teachers awareness of gifted children was low because of lacking direct or indirect experience of having gifted children and special programs therof in their classes as well as teachers nonchalance. Therefore not only adequate training and education of teachers, but also cultivation of qualified teachers for special programs for the precocious are obligatory. Training of incumbent teachers and determination of gifted children are prerequisite for timely discovery of gifted children and adequate education for them. Development of special education programs and diffusion are also crucial.

• Korean Journal of Metals and Materials
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• v.50 no.3
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• pp.206-211
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• 2012

Graphene has recently received high attention as a promising material for various applications, and many related studies have been undertaken to reveal its basic mechanical properties. However, the tribological properties of graphene film fabricated by the chemical vapor deposition (CVD) method are barely known. In this study, the contact angle and frictional wear characteristics of graphene coated copper film were investigated under room temperature, normal air pressure, and no lubrication condition. The contact angle was measured by sessile drop method and the wear test was carried out under normal loads of 660 mN and 2940 mN, respectively. The tribological behaviors of a graphene coating layer were also examined. Compared to heat treated bare copper foil, the graphene coated one shows a higher contact angle and lower friction coefficient.

• Korean Journal of Soil Science and Fertilizer
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• v.48 no.4
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• pp.285-294
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• 2015

Ordination has been recognized useful method to analyze the effects of multiple environmental factors on dozens of species in vegetation ecology because of summarizing community data by producing a low-dimensional graphics. Main objective of this study was the application of ordination method, especially principal components analysis (PCA), to analyze the soil characterization on paddy treated by different green manure crops and tillage methods. Treatments included the three tillage treatments and two green manure crops as the following; (i) moldrotary + rotary tillage without green manure crop (Con), with (ii) hairy vetch (ConHv), and (iii) hairy vetch + green barely (ConHvGb), (iv) rotary tillage without green manure crop (Rot), with (v) hairy vetch (RotHv), and (vi) hairy vetch + green barly (RotHvGb), and (vii) no-tillage (Notill). Vectorial distance result from PCA of soil properties including physical, chemical, and microbial properties showed the two main difference. Firstly, soil properties among plots without green manure were strongly affected by tillage strength [Vectorial distance: Con-Notil (5.88) > Rot-Notill (4.58)] at PC1 (35.0%) axis. But it was difficult to find the fixed trend among plots when green manure crop was added in plot. Nevertheless, two groups were separated by adding green manure crop at PC2 (29.2%) axis. These results show that PCA ordination methods could be used the research for change of soil characterization.

• The Journal of Korean Medical History
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• v.34 no.2
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• pp.1-10
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• 2021

During the Joseon Dynasty, Jeju had a unique aspect that differentiated it from other regions in terms of their medical system, such as the exclusive deployment of shimyak dispatched to Gamyeong and Barracks units due to the uniqueness of being an island. This study uses various historical sources to verify that these differences existed throughout the medical system and procedures of Jeju in the late Joseon Dynasty. The following significant conclusions were drawn: 1) Looking at the work and characters of Jejushimyak reveals the inherent limitations of Jeju medical care in the Joseon Dynasty. Compared to other regions' shimyak, Jejushimyak had two limitations: it was difficult to engage in only medicine and the quality of medical doctors declined due to the avoidance of major medical doctors' households. 2) The establishment of public health care in Jeju through Medical Cadets failed. Jeju medical science obviously played an essential role in public health care in the early 18th century. However, there was no continuity in the garden, etc. Hyangri, who was in charge of Medical Cadets, was in charge of various fragrances as needed. Thus expertise in medicine was lacking. 3) The cultivated herbs of Jeju's herb field show the failure to supply herbs for institutional medicine. It was impossible to supply enough herbs to implement institutional medicine in Jeju. In that case, it would have been necessary to discover alternative local herbs or to bring them in from outside, but there was barely any such effort. In conclusion, in the late Joseon Dynasty, Jeju failed to establish a foundation for centrally administered institutional medicine. There was a lack of all the entities that provided medical care and herbs that could be used for medical care. The reason that Jeju continued to follow traditional shaman medicine in the late Joseon Dynasty was because there was no other alternative.

• Journal of Korean Society for Quality Management
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• v.49 no.3
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• pp.269-279
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• 2021

Purpose: The purpose of this study was to suggest weapon system specifications for requirements of Condition-Based Maintenance(CBM/CBM⁺). Methods: The military documents and case studies with regard to condition-based maintenance were reviewed. Representative Korea defense specifications of weapon system such as an aircraft, a C4ISR etc. were analyzed and investigated the level of requirement for maintainability was. Results: Condition-based maintenance was defined in both U.S. instruction and Korean directive. While deparment of defense(U.S.) provide a guidebook for CBM⁺, detailed instruction was not sufficient for Korean. Ministry of national defense(ROK) define the CBM⁺ by means of IPS element which should be developed along with the system development. The maintainability was barely included in Korean defense specifications, except for BIT(Built-in test) function. As a first step for defining the condition-based maintenance requirement in defense specification, this study suggests a standard form for data needed to acquire according to types of system, fault, failure, and so on. Conclusion: The empirical researches on CMB/CBM⁺ with domestic weapon systems are not enough, and a logic which leads the maintenance strategy to CMB/CBM⁺ is not solved. Through technical researches and institutional improvements including this study, we hope that condition-based maintenance would be fully established in the Korean defense field.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.5
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• pp.39-47
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• 2021

With rising concerns about pesticide spray drifts, this study analyzed the drift patterns of two typically-used nozzles, XR nozzle and AI nozzle, concerning their working pressures and wind speeds by wind tunnel experiments. AI nozzle showed low drift potential with larger droplet sizes compared to XR nozzle. Airborne and deposition drifts of XR nozzle were two times higher than those of AI nozzle under high wind speeds (≥2 m s^-1). In all cases, higher working pressures decreased the droplet sizes, thereby increasing the airborne and deposition drifts. Higher wind speeds also resulted in more airborne drifts, while ground deposition was increased under lower wind speeds. These effects of working pressures and wind speeds on the airborne and deposition drifts were observed at leeward distances less than 4 m from the nozzles. However, the airborne and deposition drifts were barely affected by the working pressures and wind speeds at leeward distances more than 11 m. The measurements were fitted to regression models of the drift curve with acceptable R² values greater than 0.8, demonstrating that further studies will be useful to settle domestic issues of spray drifts.