• Journal of The Korean Society of Integrative Medicine
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• v.6 no.4
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• pp.1-13
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• 2018

Purpose : The purpose of this study has been performed to find the relationship between seafarers' cumulative fatigue and stress by evaluating autonomic nervous functions and the results of surveys conducted using questionnaires. Methods : The subjects were seafarers working on various ships (home trade ships) of South Korea, who were healthy adults without any diseases, as confirmed through preliminary surveys were recruited through simple random sampling. A device that measures autonomic nervous functions by analyzing heart rate variability, which is also used often in clinical diagnoses and studies at universities, university hospitals, and general hospitals was used to measure the seafarers' cumulative fatigue and stress. Pearson's correlation analyses were also conducted to test the relationship between cumulative fatigue and stress measured by evaluating autonomic nervous functions and the results of surveys conducted with questionnaires. Results : There was no correlation between mean cumulative fatigue measured for each ship type and seafarers position through autonomic nervous functions evaluation and fatigue severity scale (FSS). There also was no correlation between the mean levels of stress measured for each ship type and seafarers position through autonomic nervous functions evaluation and survey scores of Korean occupational stress scale (KOSS). Conclusion : Therefore, in order to prevent man-made accidents in the sea among seafarers working with irregular port entry/departure schedules and under environments involving continued vibration, noises, and shaking, it is necessary to analyzed cumulative fatigue and stress scientifically and objectively, such as through autonomic nervous functions evaluation rather than through surveys.

• Anxiety and mood
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• v.9 no.1
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• pp.38-44
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• 2013

Objective : The end-stage renal disease patients who shared fear of death, functional impairment due to hemodialysis are vulnerable to depression, anxiety and other mental problems. It is possible that their psychiatric characteristics and related autonomic nervous functions have some differences depending on their age. We purpose to find the differences of psychiatric characteristics and related autonomic nervous functions between adult and elderly hemodialysis patients. Methods : Our subjects are end-stage renal disease hemodialysis patients composed of 39 adults (<65 years) and 24 seniors (${\geq}65$ years). Outcome measures included the 17-item Hamilton Rating Scale for Depression, The Hamilton Rating Scale for Anxiety, The Apathy Evaluation Scale and Mini-International Neuropsychiatric Interview by clinician. And subjects fulfilled self-report scale, The Positive thinking scale and The Snaith-Hamilton Pleasure Scale. The autonomic nervous functions are measured by heart rate variability. Results : There are no significant differences in demographic factors between two groups. The 17-item Hamilton Rating Scale for Depression, The Hamilton Rating Scale for Anxiety, The Apathy Evaluation Scale, The Snaith-Hamilton Pleasure Scale and autonomic nervous functions are also not different. But only positive thinking scale is higher in adult hemodialysis group than the elderly (F=5.395, p=0.024). Conclusion : This study compared depression, anxiety and autonomic nervous functions between adult and senior hemodialysis patients. There are no significant differences in psychiatric characteristics and autonomic nervous functions between two groups except positive thinking traits. Senior patients endured their chronic disease similar to adult patients did in spite of their old age. This result suggests that elderly's higher positive thinking traits affect their endurances about the negative situations.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.49-59
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• 2023

Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status in pre-MetS subjects. In this study, we sought to examine cardiac autonomic functions in pre-MetS and to determine which MetS component is more responsible for impaired cardiac autonomic functions. A total of 182 subjects were recruited and divided into healthy controls (n=89) and pre-MetS subjects (n=93) based on inclusion and exclusion criteria. We performed biochemical profiles on fasting blood samples to detect pre-MetS. Using standardized protocols, we evaluated anthropometric data, body composition, baroreflex sensitivity (BRS), heart rate variability (HRV), and autonomic function tests (AFTs). We further examined these parameters in pre-MetS subjects for each MetS component. Compared to healthy controls, we observed a significant cardiac autonomic dysfunction (CAD) through reduced BRS, lower overall HRV, and altered AFT parameters in pre-MetS subjects, accompanied by markedly varied anthropometric, clinical and biochemical parameters. Furthermore, all examined BRS, HRV, and AFT parameters exhibited an abnormal trend and significant correlation toward hyperglycemia. This study demonstrates CAD in pre-MetS subjects with reduced BRS, lower overall HRV, and altered AFT parameters. Hyperglycemia was considered an independent determinant of alterations in all the examined BRS, HRV, and AFT parameters. Thus, hyperglycemia may contribute to CAD in pre-MetS subjects before progressing to MetS.

• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2693-2695
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• 2002

In this paper, the power spectral analysis of heart rate variability(HRV) was performed to evaluate effects of orthostatic stress with head-up tilt on autonomic nervous system(ANS) for 20 healthy male subjects(age : 245 yr.) and a new method was proposed to assess the autonomic balance. The ECG signals wore recorded for 3 minutes in both the supine and 70 head-up tilt positions, and then the HRV signals underwent power spectrum analysis at each position. The results of this study suggest that cardiac autonomic functions, such as sympathetic tone in autonomic balance with the increment of sympathetic tone and the decrement of parasympathetic tone which occur during head-up tilt position, arc not sufficient to overcome tile orthostatic stress arising in Cerebral Palsy.

• BMB Reports
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• v.48 no.12
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• pp.677-684
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• 2015

Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian clocks. Specific time scales of different cell types drive their functions: circadian gene regulation at hours scale, activation-inactivation cycles of ion channels at millisecond scales, the heart's beating rate at hundreds of millisecond scales, and low frequency autonomic signaling at cycles of tens of seconds. Heart rate and rhythm are modulated by a hierarchical clock system: autonomic signaling from the brain releases neurotransmitters from the vagus and sympathetic nerves to the heart's pacemaker cells and activate receptors on the cell. These receptors activating ultradian clock functions embedded within pacemaker cells include sarcoplasmic reticulum rhythmic spontaneous Ca²⁺ cycling, rhythmic ion channel current activation and inactivation, and rhythmic oscillatory mitochondria ATP production. Here we summarize the evidence that intrinsic pacemaker cell mechanisms are the end effector of the hierarchical brain-heart circadian clock system.

• Mood & Emotion
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• v.15 no.3
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• pp.117-122
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• 2017

Objectives : Early life stress (ELS) may have impact on functions of the autonomic nervous system. Heart rate variability (HRV) is a reliable psychophysiological marker for functions of the autonomic nervous system. The purpose of this study was to investigate characteristics of HRV associated with ELS in patients with major depressive disorder (MDD). Methods : We compared HRV measures of MDD patients with ELS and without ELS in a 5-minute resting-state electrocardiogram recoding. Forty subjects participated in the study (25 with ELS, 15 without ELS). The Mann-Whitney test was conducted to identify group differences. Results : We found significant group differences in standard deviation of the NN interval (SDNN) and total power (TP). SDNN was lower in the ELS group (M=38.80 ms, SD=13.05 ms) than in the Non-ELS group (M=53.53 ms, SD=19.47 ms). TP was lower in the ELS group ($M=7.07ms^2$, $SD=0.69ms^2$) than in the Non-ELS group ($M=7.72ms^2$, $SD=0.77ms^2$). Conclusion : ELS may have a negative impact on the autonomic nervous system function in patients with MDD. ELS and dysfunction of autonomic nervous system should be considered in treatment for patients with MDD.

• Journal of Korean Academy of Nursing
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• v.51 no.3
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• pp.294-304
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• 2021

Purpose: This study aimed to investigate objectively measured physical activity (PA) in institutionalized older adults with mild cognitive impairment (MCI) and to elucidate the influence of autonomic nervous function, salivary cortisol, and PA on cognitive functions based on neurovisceral integration model. Methods: Overall cognitive function was evaluated using the mini-mental state examination (MMSE) and executive function was evaluated using semantic verbal fluency test and clock drawing test. Actigraph for PA, HRV and sAA for autonomous function, and the geriatric depression scale for depression were used. Saliva specimens were collected in the morning for sAA and cortisol. Results: Ninety-eight older adults from four regional geriatric hospitals participated in the study. They took 4,499 steps per day on average. They spent 753.93 minutes and 23.12 minutes on average in sedentary and moderate-to-vigorous activity, respectively. In the multiple regression analysis, lower salivary cortisol level (β = - .33, p = .041) and greater step counts (β = .37, p = .029) significantly improved MMSE score. Greater step count (β = .27, p = .016) also exerted a significant influence on verbal fluency, and greater sAA (β= .35, p = .026) was significantly associated with a better clock drawing test result. Conclusion: Salivary cortisol, sAA and physical activity were significantly associated with cognitive functions. To prevent older adults from developing dementia, strategies are needed to increase their overall PA amount by decreasing sedentary time and to decrease salivary cortisol for cognitive function, and to maintain their sympathetic nervous activity for executive function.

• CELLMED
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• v.5 no.1
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• pp.4.1-4.4
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• 2015

Yoga is an ancient Indian system of life, encompassing various practices including practices for self-discipline and also for regulating the health states of the individual, being practiced for thousands of years. The present study aims at understanding the effect of two high frequency breathing practices over autonomic nervous system. Forty healthy male volunteers of age $21{\pm}2$ years with $9{\pm}3$ months of Yoga practice experience were recruited. The two high frequency Yoga breathing practices, kapalabhati (KB) and bhastrika (BH) were given as interventions randomly on either of the two days to minimise laboratory bias. They were assessed before and immediately after the interventions for heart rate, respiratory rate, heart rate variability (HRV), blood pressure and peripheral oxygen saturation. There was a significant increase in heart rate (p<0.01; p<0.001), systolic blood pressure (p<0.01; p<0.001), NN50 (p<0.01; p<0.001) component of HRV for both KB and BH groups respectively. There was a significant reduction in respiratory rate in both the groups (p<0.001, and p<0.05, BH and KB respectively) immediately following intervention. A significant increase in LF component of HRV and reduction in Diastolic blood pressure and high frequency (HF)component following KB was also observed (p<0.05, for all comparisons). The Mean peripheral oxygen saturation remained unaltered in both the groups (p>0.05).The results suggest that high frequency yoga breathing practices induce physiological arousal immediately as evidenced by increased blood pressure and heart rate. The sympathetic arousal was more following KB session as evidenced by an increased diastolic blood pressure, LF power and a decrease in HF power of HRV as compared to the BH session.

• The Journal of Korean Medicine
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• v.18 no.2
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• pp.148-154
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• 1997

In the pharmacology of traditional Korean medicine, each drug has its own specific characters. The different characters of drugs are employed to treat diseases, rectify the hyperactivity or hypoactivity of yin or yang, and help the body restore its normal physiological functions, consequently curing the diseases and restoring health. The various characters and functions of these drugs concerning medical treatment include drugs' properties, flavours, actions of lifting, lowering, floating and sinking, channel tropism, toxicity, etc. Among these theories, theory of properties and flavours of drugs provides the basis for drug analysis and application. 'Property' refers to the cold, hot, warm or cool nature of a drug. These properties of drugs are so sorted out according to the different actions of the drugs on the human body and thier therapeutic effects. Drugs which cure heat syndrome(yang syndrome) have a cold or cool property, whereas drugs which cure cold syndrome (yin syndrome) have hot or warm property Drugs of cold and cool-natured and drugs of warm and hot natures are of opposite properties. A cold-natured drug is different from a cool-natured on only in degree, and so is a warm-natured drug from a hot-natured drug. Most of the cool- or cold- natured drugs have the effects of clearing heat, purging fire, removing toxic substances, and nourishing yin, and are uese to cure heat syndromes. On the contrary, drugs of warm or hot nature usually have the effects of dispersing cold, warming up the interior, supporting yang, and treating collapse, and are therefore used to treat cold syndromes. We thought that the property of drug may be related to the autonomic nervous system in western medicine. In other words, drugs of warm or hot nature increase heart rate or acts like sympathomimetics, and drugs of cool or cold nature decrease heart rate or acts like para sympathomimetics . According to this hypothesis, we administrated some drugs to isolated rat right atrium in magnus tube. But there is no correlation between 'property' in traditional Korean medicine and autonomic nervous system in western medicine.

• Journal of Information Processing Systems
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• v.5 no.2
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• pp.69-76
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• 2009

Self healing systems are considered as cognation-enabled sub form of fault tolerance system. But our experiments that we report in this paper show that self healing systems can be used for performance optimization, configuration management, access control management and bunch of other functions. The exponential complexity that results from interaction between autonomic systems and users (software and human users) has hindered the deployment and user of intelligent systems for a while now. We show that if that exceptional complexity is converted into self-growing knowledge (policies in our case), can make up for initial development cost of building an intelligent system. In this paper, we report the application of AHSEN (Autonomic Healing-based Self management Engine) to in OKKAM Project infrastructure backbone cluster that mimics the web service based architecture of u-Zone gateway infrastructure. The 'blind' load division on per-request bases is not optimal for distributed and performance hungry infrastructure such as OKKAM. The approach adopted assesses the active threads on the virtual machine and does resource estimates for active processes. The availability of a certain server is represented through worker modules at load server. Our simulation results on the OKKAM infrastructure show that the self healing significantly improves the performance and clearly demarcates the logical ambiguities in contemporary designs of self healing infrastructures proposed for large scale computing infrastructures.