• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.253-260
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• 2023

The germanium-68/gallium-68 (⁶⁸Ge/⁶⁸Ga) generator has high spatial utilization and requires little maintenance, making it economical and easy to produce. Thus, the frequency of use of ⁶⁸Ga radiopharmaceuticals is rapidly increasing worldwide. Therefore, this study attempted to develop an automated synthesizer for the routine clinical application of ⁶⁸Ga radiopharmaceuticals. The automated synthesizer was based on a fixed tubing system and the structure was designed after adjusting the position of the parts to reflect the synthesis method. Using various components that can be supplied in Korea, the automated synthesizer was manufactured at a much lower price cost than that of a commercialized automated synthesizer sold by companies. ⁶⁸Ga-DOTA-[Tyr3]-octreotide (⁶⁸Ga-DOTATOC) was synthesized to evaluate the performance of the automated synthesizer. ⁶⁸Ga-DOTATOC could be synthesized with about 65% of non-decay corrected yield, and the synthesized ⁶⁸Ga-DOTATOC met all quality control standards. We have synthesized ⁶⁸Ga-DOTATOC more than 100 times, and only faced a few problems caused by mechanical errors. In this study, we successfully developed a simple automated synthesizer for ⁶⁸Ga radiopharmaceuticals with high reproducibility. As various ⁶⁸Ga radiopharmaceuticals have recently been developed, it is expected that the automated synthesizer developed in this study will be useful for routine clinical use.

• Bulletin of the Korean Chemical Society
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• v.19 no.9
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• pp.952-956
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• 1998

An automated system was developed for the routine preparation of carbon-11 ($^11C$) labeled radiopharmaceuticals, which consisted of three major parts including [$^11C$]methylation of the precursor with [$^11C$] iodomethane ($[^11C]CH_3I)$, purification of the desired product and formulation of the final $^11C$ labeled radiopharmaceutical. The whole system included seven three-way slider valves, eleven solenoid valves, four pneumatic cylinders, a HPLC (High Performance Liquid Chromatography) system and a rotary evaporator. Using this system, we investigated the radiochemical synthesis of L-[$methyl-^11C$]methionine, which is the most widely used amino acid in tumor PET (Positron Emission Tomography) studies. The overall operation took 3035 min including the production of $[^11C]CH_3I$ (10.5 min) and decay-corrected radiochemical yield was 25%. The automated system we described herein can be widely utilized for the preparation of many $^11C$ labeled radiopharinaceuticals and has been shown to be efficient, reliable and easy to operate.

• The Transactions of the Korea Information Processing Society
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• v.4 no.8
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• pp.2152-2162
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• 1997

We developed an approach to automatically synthesize time-stationary controllers for a given pipelined data path of Application Specific Integrated Circuits (ASICs). This work consists of automated production of control specifications and Finite State Machine (FSM) Optimization. A FSM controller is implemented by performing horizontal partitioning so as to minimize the total controller area. We compared our approach to published work on FSM generation and optimization, and the results indicate large savings in total controller area.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.2
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• pp.256-263
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• 1998

Among process synthesis problems, the heat exchanger network (HEN) has been subjected to the most concentrated effort because this kind of problems was well defined for solving it and 20-30% energy savings could be realized in the present chemical processes. In this paper, we use an evolutionary approach for HEN synthesis because this approach can overcome the local optimum and combine some heuristic rules. The basic evolutionary approach is composed of three parts, that is, initialization step, growth step and mutation step, as in the simulated annealing and genetic algorithm. This algorithm uses the ecological rule that a better cell will live and worse cell should decompose after repeated generations. With this basic concept, a new procedure is developed and a more efficient method is proposed to generate initial solutions. Its effectiveness is shown using test examples.

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.1
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• pp.8-12
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• 2010

Purpose: In $^{18}F$-FDG automated synthesizer, deliver is done in automated mode after synthesis until the dispenser. After the delivery, the yield is calculated from the radioactivity which was read by the dose calibrator located in the dispenser. However, when the distance between the automated synthesizer and the dispenser is far, there are $^{18}F$-FDG residues, which results in loss of the amount of $^{18}F$-FDG. This study investigated the usefulness of a method that minimizes $^{18}F$-FDG residues. Materials and Methods: The structure of the tubing between the (TRACERlab Mx FDG; GE.) and the dispenser is that the distance is 8 m and the internal diameter is 1/16 inch. The synthesis process of The module goes through the synthesis process of trap, synthesis, delivery in the automated module. The time taken for synthesis is about 25 to 26 minutes, after which rinsing is done. However, after rinsing, as the distance of the tubing increased, there were 10~13% of $^{18}F$-FDG residues. Therefore, a method of using push syringe and $N_2$ gas in manual mode to minimize $^{18}F$-FDG residues is analyzed. Results: In manual mode, there were $^{18}F$-FDG residues of 4~5% for the push syringe, and there were $^{18}F$-FDG residues of less than 1% for the $N_2$ gas, which showed that the method using $N_2$ gas had superior usefulness. Also, there were no $^{18}F$-FDG residues in the cleaning the next day. Conclusion: The distance between the synthesizer and the dispenser needs to be reduced as much as possible, to reduce the rate of loss of $^{18}F$-FDG resulting from the distance of the tubing. However, in case the distance between the synthesizer and the dispenser has to be increased due to the system structure, using push syringe and $N_2$ gas simultaneously is a useful method for minimizing $^{18}F$-FDG residues.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.165.3-165
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• 2001

Animation of 3-dimensional humans is a challenging task, however, its realistic synthesis is possible. Essentially, the nature of this project is to demonstrate and study the difficulties faced by an animator in making a movie with a state of art computer animation software (Maya Software by ,alias/wavefront) by creating a movie clip with the above-stated software ourselves. We will also analyze the aspect of automated animation to relieve the animator of some very tedious tasks.

• Proceedings of the KIEE Conference
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• 2000.11d
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• pp.679-681
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• 2000

This thesis presents a analysis method of hybrid synthesis petri net for automated manufacturing systems in discrete event dynamic system. There are many errors that can happen to petri net modeling of complex systems because petri net modeling process has so many steps. A new matrix analysis method presented in this thesis can confirm the property of petri net such as boundedness, liveness and reversibility, modify errors which can be occurred in modeling.

• The Journal of Engineering Research
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• v.4 no.1
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• pp.35-45
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• 2002

This paper deals with the scheduling problems which are the most important subtask in High-Level Synthesis. Especially, we have concentrated our attentions on the data-path scheduling which can get the structural informations from the behavioral algorithm as a first step in synthesis procedure. Suggest Forward scheduling methode is executed the ASAP and ALAP scheduling to use the fifth – order elliptic wave filter of a standard benchmark model, and then it is drawing up T.N matrix table by the number of resource and control-step, using the table extract of the simple than down-limit value of the control-step for the number of given resource to use this table. All of existing list scheduling techniques determine the priority functions first, and then do the operation scheduling, But, the suggested forward scheduling technique does the schedule first, and determines the priority functions if needed in scheduling process.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.5 no.2
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• pp.158-162
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• 2019

[¹¹C]GR205171, a Neurokinin 1 (NK1) radioligand, has been known as such a promising PET probe for quantitation of NK1 receptors in the brain by positron emission tomography (PET) imaging. First trial to synthesis of [¹¹C]GR205171 was to use methylene chloride and tetrabutylammonium hydroxide for preactivation of precursor, but the result was not successful in radiochemical yield (0~25%) and unreliable. 7 years later, inorganic base (Cs₂CO₃) was tried to achieve higher radiochemical yield, and they showed higher yield (~53%). We have tried to repeat the same synthesis method, but it did not work properly, because there were the lack of the detail procedure and still reproducibility in radiochemical yield. Here we report the improved synthesis protocol to produce [¹¹C]GR205171 in high yield via commercial automated synthesizer. The sonicator which combines water heating bath was used to activate desmethyl-GR205171, and this method showed high efficiency and reasonable yields (4.7 ± 0.6%, non-decay corrected from molecular sieve trap) with >95% radiochemical purity.

• The Transactions of the Korea Information Processing Society
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• v.2 no.2
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• pp.254-263
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• 1995

In this paper we discuss Moore and Mealy-model Time-stationary control schemes of pipelined data paths of Application Specific, Integrated Circuits (ASICs). We developed a method to synthesize both a Moore and a Mealy-style Finite State Machine(FSM) controller specifications given a pipelined data path with conditional branches. The control synthesis task consists of the generation of control specification and the FSM synthesis. The control specification procedure generates a FSM specification in the form of a state table. The different partitioning schemes are applied to each FSM controller so as to minimize the total area. Experimental results show the characteristics of the two different control styles and the effects of these two models on cost and performance.