• Title/Summary/Keyword: autism-spectrum

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Differences in Social Maturity and Behavioral Problems According to the Level of Sleep Problems in Infants With Autism Spectrum Disorder (자폐스펙트럼장애 영유아의 수면문제 경계선 및 임상 수준 집단과 정상 수준 집단 간 사회성숙도와 문제행동의 차이)

  • Lee, Jin Kyeong;Ha, Eun Hye
    • Therapeutic Science for Rehabilitation
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    • v.10 no.2
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    • pp.129-140
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    • 2021
  • Objective : The purpose of this study was to examine differences in social maturity and behavioral problems according to the level of sleep problems in children with ASD. Methods : The participants were 102 mothers of infants with ASD aged 1-5 years. The Social Maturity Scales (SMS) and Child Behavior Checklist 1.5-5 were used as the measuring tools. Results : The level of sleep problems in infants with ASD was 56.58T on the sleep problems scale. The participants were grouped based on scores on the sleep problems scale: those with scores <65 (good sleepers) or scores ≥65 (poor sleepers). Sleep problems significantly correlated with all the scales on the CBCL. However, no association was found between sleep problems and social quotients. Poor sleepers achieved significantly lower scores on the social quotient scale of the SMS than good sleepers. Poor sleepers achieved significantly higher scores in internalizing problems, externalizing problems, and DSM-oriented scales on the CBCL compared to those in the good sleepers. Conclusion : The significance of this study is that it has verified the severity of sleep problems in infants with ASD and has examined the differences in social maturity and behavioral problems between poor sleepers and good sleepers.

Dysphagia Rehabilitation Treatment for Children With Feeding Disorder : A Systemic Review (섭식장애가 있는 아동의 연하재활치료 : 체계적 고찰)

  • Jeon, Joo Young;Park, Hae Yean
    • The Journal of Korean Academy of Sensory Integration
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    • v.19 no.1
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    • pp.39-53
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    • 2021
  • Objective : The purpose of this study was to systematically review dysphagia rehabilitation treatment for children with feeding disorders. Methods : The articles evaluated in this study were collected from the PubMed, Medline Complete, and CINAHL databases and subsequently reviewed using the PRISMA flow chart and PICOS approach. A total of 13 papers were analyzed for study quality, disease groups, evaluation tools, interventions, and post-intervention effects. Results : Of the reviewed papers, six (46.15%) related to autism spectrum disorder (ASD) and seven (53.85%) to cerebral palsy (CP) with age ranges of between 2 and 8 years for the ASD studies and between 12 months and 18 years for CP. In evaluating the types of feeding disorder involved, the ASD group exhibited predominantly behavioral conditions while the CP subjects had a larger number of functional oral and swallowing issues. In terms of interventions, behavior modifications were used most frequently with ASD while oral-sensory motor, texture modifications, and electrical stimulation were applied at the same frequency with children with CP. All interventions were found to be effective. Conclusion : In this study, research into children with feeding disorders was reviewed according to condition, evaluation tool, and method of intervention. It is expected that this review can be used as basic data for developing a protocol that will allow clinicians to efficiently apply condition-specific interventions for eating disorders without resorting to trial and error.

Investigating the Role of Microglia in Maternal Immune Activation in Rodent Models (모체 면역 활성화 유도 설치류 모델에서 미세아교세포의 역할 조사)

  • Hyunju Kim
    • Journal of Life Science
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    • v.33 no.5
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    • pp.429-435
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    • 2023
  • Epidemiological studies suggest that maternal infection, maternal stress, and environmental risk factors during pregnancy increase the risk of brain development abnormalities associated with cognitive impairment in the offspring and increase susceptibility to schizophrenia and autism spectrum disorder. Several animal models have demonstrated that maternal immune activation (MIA) is sufficient to induce abnormal brain development and behavioral defects in the fetus. When polyinosine:polycytodylic acid (poly I:C) or lipopolysaccharide (LPS), which is commonly used in maternal immune activation animal models, was introduced into a pregnant dam, an increase in pro-inflammatory cytokines and microglial activity was observed in the offspring's brain. Microglia are brain-resident immune cells that play a mediating role in the central nervous system, and they are responsible for various functions, such as phagocytosis, synapse formation and branching, and angiogenesis. Several studies have reported that microglia are activated in MIA offspring and influence offspring behavior through interactions with various cytokines. In addition, it has been reported that they play an important role in brain circuits through interactions with neurons and astrocytes. However, there is controversy concerning whether microglia are essential to brain development or lead to behavioral defects, and the exact mechanism remains unknown. Therefore, for the potential diagnosis and treatment of brain developmental disorders, a functional study of microglia should be conducted using MIA animal models.

Feasibility of a Parent-Led Home-Based Music Program to Enhance Parental Competence and the Parent-Child Relationship for Parents of Children With ASD (자폐스펙트럼장애 아동 부모의 양육효능감 및 부모-아동 관계 증진을 위한 부모 주도 가정 기반 음악프로그램의 실행 가능성)

  • Yang, Hye young
    • Journal of Music and Human Behavior
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    • v.20 no.2
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    • pp.89-113
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    • 2023
  • This study aimed to assess the feasibility and impact of a 5-week parent-led home-based music program for parents of children with autism spectrum disorder (ASD). The program aimed to enhance the parents' sense of competence and their relationships with their child. Each week for 5 weeks, 10 parents of 10 children with ASD (aged 3 to 9 years) received weekly 30-minute personalized lessons on how to implement the home-based music program and implemented the educated music program at home with activities involving receptive and active engagement. On average, the parents conducted the music program 2.5 times a week for about 9.2 minutes per session. At the end of the 5 weeks, parents reported increased comfort and effectiveness in interacting with their child through music. In addition, positive changes were noted on the Parenting Sense of Competence Scale and the closeness aspect of the parent-child relationship. Participants affirmed the program's feasibility, emphasizing its potential for supporting families with children with ASD. These results provide foundational data for future home-based music activities and programs, emphasizing the importance of tailoring interventions to the unique needs of families with children with ASD.

Study of Validity and Reliability of the Korean Translation Version of the Sensory Processing and Self-Regulation Checklist (SPSRC) (한글판 감각처리 및 자기조절 체크리스트(SPSRC)의 타당도와 신뢰도 연구)

  • Kim, Ye-Eun;Lee, Hye-Rim;Lee, Sun-Min
    • The Journal of Korean Academy of Sensory Integration
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    • v.21 no.3
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    • pp.27-38
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    • 2023
  • Objective : This study aims to verify the validity and reliability of the Korean version of the Sensory Processing and Self-Regulation Checklist (SPSRC) for children with and without autism spectrum disorder. Methods : The Pearson product-moment correlation coefficient was calculated using Short Sensory Profile (SSP) to verify concurrent validity. Construct validity was verified by comparing the sensory processing ability and self-regulation ability of the two groups. Cronbach's α was calculated in the case of internal consistency for reliability verification, and the test-retest reliability was verified through the Pearson correlation coefficient. Results : Based on the verification of the concurrent validity, the Korean version of SPSRC and SSP showed a statistically significant correlation (p < 0.01). The construct validity was found to have a statistically significant difference between the two groups in the area and sub-items of the Korean version of SPSRC (p < 0.001). For the internal consistency, Cronbach's α ranged from 0.700 to 0.975. The test-retest reliability showed that the correlation coefficient ranged from 0.937 to 0.997. Conclusion : The Korean version of SPSRC was confirmed to be an evaluation tool with high validity and reliability. It is expected to be used as an evaluation tool for planning treatment goals in clinical trials and as a meaningful basis for future research.

The Relationships Between the Auditory Behavioral Characteristic and the Sociality of Children With Autism Spectrum Disorder (자폐스펙트럼장애아동의 청각행동특성과 사회성과의 관계)

  • Chang, Ki-Yeon;Lee, Heon-Ju;Kim, Kil-Soon;Ra, Dae-Yeop;Jang, Ae-Jeong;Shin, Sook-Yeon
    • The Journal of Korean Academy of Sensory Integration
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    • v.12 no.2
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    • pp.1-12
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    • 2014
  • Objective : The purpose of this study is to investigate about what autistic-spectrum disorder child's relationship between the sensory process types, the auditory behavioral characteristic and sociality Methods : The study performed from May to June, 2014. Targeting 15 children diagnosed as the autistic spectrum disorder and other 11 children suspected as having the autistic spectrum disorder in their ages of full 2-14 years old. This study used the Auditory Behavioral Checklist, Ewha-Check List for Autistic Children, Social Maturity Scale, School Function Assessment and sensory profile. For the data analysis, the statistical analysis was conducted with the SPSS 18.0. Results : First, in the relationship between the sensory process type and the auditory behavior, the preschool children and the school children showed some positive correlations with the hearing in the background noise and the communication, respectively. Second, the hearing in the background noise and the communication showed some meaningful relationship with sociality. Conclusion : The occupational therapists need to investigate effects of the sensory integrative intervention with sensory diet to improve sociality.

Effects of the Attachment Promotion Therapy Program for the Children with Autistic Spectrum Disorder (자폐장애 아동을 위한 애착증진치료 프로그램의 효과)

  • Im Sook-Bin;Ju Se-Jin;Hong Kang-E M.
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.17 no.2
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    • pp.91-97
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    • 2006
  • The effects of the Attachment Promotion Therapy (APT) program for the autistic children were reviewed by 8 papers. The program was consisted with play activity centered mother-child interaction, educational activity for parents, lecture, video-feedback, and support. APT program was effective to improve the attachment behaviors and attachment security. And the mother's behaviors to her child became more child-centered, positively responsive, expressive supportively. Ninety six point seven percent of the mothers were satisfied with the APT program. They described that it was helpful to understand their children's developmental limitation and strength, to learn how to play with their children, to make supportive social network among the mothers, to minimize familial conflicts, and to make them much more comfortable with their children. They thought the APT Program was to be a steppingstone of the further educational program. APT program is an effective early intervention to promote social development and decrease autistic problems.

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Neurobiological basis for learning disorders with a special emphasis on reading disorders (학습장애의 신경생물학적 기전 : 읽기장애를 중심으로)

  • Chung, Hee Jung
    • Clinical and Experimental Pediatrics
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    • v.49 no.4
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    • pp.341-353
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    • 2006
  • Learning disorders are diagnosed when the individual's achievement on standardized tests in reading, mathematics, or written expression is substantially below that expected for age, schooling, and level of intelligence. Subtypes of learning disorders may be classified into two groups, language-based type learning disorders including reading and writing disorder, and nonverbal type learning disorder (NLD) such as those relating to mathematics & visuospatial skills, and those in the autism spectrum. Converging evidence indicates that reading disorder represents a disorder within the language system and more specifically within a particular subcomponent of that system, phonological processing. Recent advances in neuroimaging technology, particularly the development of fMRI, provide evidences of a neurobiological basis for reading disorder, specifically a disruption of two left hemisphere posterior brain systems, one parieto-temporal, the other occipito-temporal. The former is the reading system for beginner reading, the latter for skilled reading. Compensatory engagement of anterior systems around the inferior frontal gyrus(Broca's area) and a posterior(right occipito-temporal) system is noted in persistent poor readers in long-term follow up study. The theoretical model proposed to explain NLD's source is not right hemisphere damage, but rather the white matter model. The working hypothesis of the white matter model is that the underdevelopment of, damage to, or dysfunction of cerebral white matter(long myelinated fibers) is the source of this disorder. The role of an evidence-based effective intervention in the remediation of children with learning disorder is discussed.

nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders

  • Lee, Sang-Eun;Chang, Sunghoe
    • BMB Reports
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    • v.49 no.9
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    • pp.457-458
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    • 2016
  • Recent studies have strongly implicated postsynaptic scaffolding proteins such as SAPAP3 or Shank3 in the pathogenesis of various mood disorders, including autism spectrum disorder, bipolar disorder (BD), and obsessive-compulsive disorders. Neural Abelson-related gene-binding protein 2 (nArgBP2) was originally identified as a protein that interacts with SAPAP3 and Shank3. Recent study shows that the genetic deletion of nArgBP2 in mice leads to manic/bipolar-like behavior resembling symptoms of BD. However, the function of nArgBP2 at synapse, or its connection with the synaptic dysfunctions, is completely unknown. This study provides compelling evidence that nArgBP2 regulates the spine morphogenesis through the activation of Rac1/WAVE/PAK/cofilin pathway, and that its ablation causes a robust and selective inhibition of excitatory synapse formation, by controlling actin dynamics. Our results revealed the underlying mechanism for the synaptic dysfunction caused by nArgBP2 downregulation that associates with analogous human BD. Moreover, since nArgBP2 interacts with key proteins involved in various neuropsychiatric disorders, our finding implies that nArgBP2 could function as a hub linking various etiological factors of different mood disorders.

Two Case Studies of Scalp Acupuncture on Post-stroke Global Aphasia Patients (뇌졸중으로 유발된 전체성 실어증 환자에 대한 두침치료 치험 2례)

  • Kang, Ah-reum;Woo, Ji-myung;Lee, Mi-rim;Kim, Su-bin;Cho, Ki-ho;Moon, Sang-kwan;Jung, Woo-sang
    • The Journal of Internal Korean Medicine
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    • v.37 no.2
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    • pp.265-272
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    • 2016
  • Objectives: This study presents two cases of patients with post-stroke global aphasia who were treated with scalp acupuncture with electrical stimulation.Method: The two patients were treated by scalp acupuncture with electrical stimulation six times a week. The degree of aphasia was measured via the Korean version of the western aphasia battery (K-WAB).Results: After treatment, aphasia was improved in both cases (autism-spectrum quotient [AQ] scores increased from 13.7 to 37.1 and from 4.1 to 18.4 in the two patients).Conclusion: Based on the results of these two cases, scalp acupuncture could be effective in treating post-stroke global aphasia.