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Diversity of vir Genes in Plasmodium vivax from Endemic Regions in the Republic of Korea: an Initial Evaluation

  • Son, Ui-han;Dinzouna-Boutamba, Sylvatrie-Danne;Lee, Sanghyun;Yun, Hae Soo;Kim, Jung-Yeon;Joo, So-Young;Jeong, Sookwan;Rhee, Man Hee;Hong, Yeonchul;Chung, Dong-Il;Kwak, Dongmi;Goo, Youn-Kyoung
    • Parasites, Hosts and Diseases
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    • v.55 no.2
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    • pp.149-158
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    • 2017
  • Variant surface antigens (VSAs) encoded by pir families are considered to be the key proteins used by many Plasmodium spp. to escape the host immune system by antigenic variation. This attribute of VSAs is a critical issue in the development of a novel vaccine. In this regard, a population genetic study of vir genes from Plasmodium vivax was performed in the Republic of Korea (ROK). Eighty-five venous blood samples and 4 of the vir genes, namely vir 27, vir 21, vir 12, and vir 4, were selected for study. The number of segregating sites (S), number of haplotypes (H), haplotype diversity (Hd), DNA diversity (${\pi}$ and ${\Theta}_w$), and Tajima's D test value were conducted. Phylogenetic trees of each gene were constructed. The vir 21 (S=143, H=22, Hd=0.827) was the most genetically diverse gene, and the vir 4 (S=6, H=4, Hd=0.556) was the opposite one. Tajima's D values for vir 27 (1.08530, P>0.1), vir 12 (2.89007, P<0.01), and vir 21 (0.40782, P>0.1) were positive, and that of vir 4 (-1.32162, P>0.1) was negative. All phylogenetic trees showed 2 clades with no particular branching according to the geographical differences and cluster. This study is the first survey on the vir genes in ROK, providing information on the genetic level. The sample sequences from vir 4 showed a clear difference to the Sal-1 reference gene sequence, whereas they were very similar to those from Indian isolates.

A Study on the Cultural Characteristics of the Design Material (디자인재료의 문화적 특성에 관한 연구)

  • 박종찬
    • Archives of design research
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    • v.11 no.3
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    • pp.149-162
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    • 1998
  • This study is what tried to examine the importance of material in industrial design. Then, if planning is to start of product design, the use of material is the last step to complete design. Design material has existed from the time before mankind were born, and the new material which is useful for human beings is developing rapidly. It is no exaggeration to say that our environment is the aggregation of material which was surrounded with us. Then, material has the timely, spatial and cultural feature as well as physical feature. Besides, all sorts of functions of communicating information are being contained in accordance with the character of material. The outside surface of material has the function to develop the sense organ of human beings. This study examines 4 kinds of cultural features in design materials and shown by findings is as follows : Rrst is the technical progressivity to lead new Design form. Second is the symbolic nature to perform the communication function. Third is the sensible attribute to develop surface effect of Design material. Fourth is the future-oriented nature to convince the future such as new material and technology etc. Thus, so as to perform the competitive product design, it is important to grasp the harmony between material and design, structure and processing, and the substantial meaning that the material has and apply them properly, above all. Because the discovery of material will be the measure to forecast future design.

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An Emotion Scanning System on Text Documents (텍스트 문서 기반의 감성 인식 시스템)

  • Kim, Myung-Kyu;Kim, Jung-Ho;Cha, Myung-Hoon;Chae, Soo-Hoan
    • Science of Emotion and Sensibility
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    • v.12 no.4
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    • pp.433-442
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    • 2009
  • People are tending to buy products through the Internet rather than purchasing them from the store. Some of the consumers give their feedback on line such as reviews, replies, comments, and blogs after they purchased the products. People are also likely to get some information through the Internet. Therefore, companies and public institutes have been facing this situation where they need to collect and analyze reviews or public opinions for them because many consumers are interested in other's opinions when they are about to make a purchase. However, most of the people's reviews on web site are too numerous, short and redundant. Under these circumstances, the emotion scanning system of text documents on the web is rising to the surface. Extracting writer's opinions or subjective ideas from text exists labeled words like GI(General Inquirer) and LKB(Lexical Knowledge base of near synonym difference) in English, however Korean language is not provided yet. In this paper, we labeled positive, negative, and neutral attribute at 4 POS(part of speech) which are noun, adjective, verb, and adverb in Korean dictionary. We extract construction patterns of emotional words and relationships among words in sentences from a large training set, and learned them. Based on this knowledge, comments and reviews regarding products are classified into two classes polarities with positive and negative using SO-PMI, which found the optimal condition from a combination of 4 POS. Lastly, in the design of the system, a flexible user interface is designed to add or edit the emotional words, the construction patterns related to emotions, and relationships among the words.

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Effect of PDA Guide Service on Users' Involvement, Satisfaction, and Reuse Intention -Focused on PDA Guide Service in Gyeongbokgung- (PDA를 활용한 안내서비스가 이용객의 몰입, 만족 및 재이용의도에 미치는 영향 -경복궁의 PDA안내서비스를 중심으로-)

  • Kim, Ju-Yeon;Lee, Min-Jae;Ahn, Kyung-Mo
    • The Journal of the Korea Contents Association
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    • v.12 no.3
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    • pp.373-381
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    • 2012
  • Due to IT(information technology) development, various ITs have been applied to tourism. Since June 2010, PDA guide service was launched in Kyungbok palace. This study tried to find how effectively the service is operated by comparing flow, satisfaction and reuse intention of PDA users with those of who have received guide service by professional interpreter. The result indicates that those who have received professional interpretation showed to be more involved, satisfied and have more intention to reuse. The paper explored the composing factors of PDA guide service, which are 'interpretation', 'design', 'ease of use', and 'stability of operation'. Among these factors, interpretation was analyzed to be only factor what affects users' involvement and also most influential attribute explaining users' satisfaction and reuse intention. 'Interpretation', 'stability' and 'ease of use' are shown to have impact on satisfaction, while 'interpretation' and 'stability' have significant effect on users' reuse intention of PDA guide service. The operational implications from these results are suggested.

The Effect of Career Preparation Program on Self-Leadership and Career Locus of control among University Students in Korea (대학생의 진로준비프로그램이 셀프리더십, 진로자기통제위에 미치는 효과)

  • Kim, Mijong;Kim, Sunhwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.11
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    • pp.399-408
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    • 2017
  • This study was conducted to investigate the effects of a career preparation program (CPP) on self-leadership (SL) and career locus of control (CLOC) among University Students in South Korea. Self-leadership is the ability to control and lead oneself to achieve goals. CLOC is that attribute own's success of failure to own's effort and ability internally or luck or environment externally. Both have been known to strongly affect variables associated with career planning. We also explored SL and CLOC based on the variable related subjects' characteristics. Method: After receiving informed consent, 58 subjects were collected from University in D metropolitan area in Korea from March to June 2016. CPP was provided to college students who agreed to join this study, which consisted of a 15 week career development program. During the program, recruitment information was provided as well as encouragement and motivation. The program also focused on self-exploring and self-initiating experiences by themselves. Data were collected before and post CPP and were analyzed using SPSS 21.0. Result: self-leadership increased from $3.02{\pm}0.36$ points to $3.23{\pm}0.35$ points after CPP (t=-4.45, p=0.00). There were significant differences in self-leadership and in internal attribution (t=-3.26, p=0.00). The CPP based on the understanding of oneself was effective to cultivate university students' self-leadership. Moreover, the CPP increased internal attribution of the college students significantly from $2.96{\pm}0.35$ points to $3.15{\pm}0.32$ points (t=-3.26, p=0.00). CPP was also found to effectively influence the internal locus of control. Although external attribution was reduced from $2.19{\pm}0.31$ to $2.13{\pm}0.35$, this different was not significant (t=1.68, p=0.09). Conclusion: The results of this study suggest that the CPP based on understanding of oneself should be actively applied in career education.

Mining Quantitative Association Rules using Commercial Data Mining Tools (상용 데이타 마이닝 도구를 사용한 정량적 연관규칙 마이닝)

  • Kang, Gong-Mi;Moon, Yang-Sae;Choi, Hun-Young;Kim, Jin-Ho
    • Journal of KIISE:Databases
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    • v.35 no.2
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    • pp.97-111
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    • 2008
  • Commercial data mining tools basically support binary attributes only in mining association rules, that is, they can mine binary association rules only. In general, however. transaction databases contain not only binary attributes but also quantitative attributes. Thus, in this paper we propose a systematic approach to mine quantitative association rules---association rules which contain quantitative attributes---using commercial mining tools. To achieve this goal, we first propose an overall working framework that mines quantitative association rules based on commercial mining tools. The proposed framework consists of two steps: 1) a pre-processing step which converts quantitative attributes into binary attributes and 2) a post-processing step which reconverts binary association rules into quantitative association rules. As the pre-processing step, we present the concept of domain partition, and based on the domain partition, we formally redefine the previous bipartition and multi-partition techniques, which are mean-based or median-based techniques for bipartition, and are equi-width or equi-depth techniques for multi-partition. These previous partition techniques, however, have the problem of not considering distribution characteristics of attribute values. To solve this problem, in this paper we propose an intuitive partition technique, named standard deviation minimization. In our standard deviation minimization, adjacent attributes are included in the same partition if the change of their standard deviations is small, but they are divided into different partitions if the change is large. We also propose the post-processing step that integrates binary association rules and reconverts them into the corresponding quantitative rules. Through extensive experiments, we argue that our framework works correctly, and we show that our standard deviation minimization is superior to other partition techniques. According to these results, we believe that our framework is practically applicable for naive users to mine quantitative association rules using commercial data mining tools.

The Effects of SLA on Service Quality Level and Service Productivity of Sub-contractor (서비스산업에서 아웃소싱 SLA계약이 서비스 수준과 서비스생산성에 미치는 영향 연구)

  • Lee, Kyung-Tae;Park, Sang-Bum
    • Journal of Distribution Science
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    • v.15 no.5
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    • pp.65-73
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    • 2017
  • Purpose - The Service Level Agreement which has been used in the IT information communication industry to maintain the level of service supplied by a vendor has been adopted in the service industry surrounding the airliners and airports. Considering that service quality is dependent on attitude of employees who are responsible to provide service, it is very important to understand what kinds of effects SLA(service level agreement) has on the attitude when SLA is applied to the service industry. SLA is an agreement between management authority and service providing contractor to make sure that certain level of service quality should be provided. For employees whose responsibilities are providing the service, SLA has both positive effects and negative effects. Negative side is that employees have to follow many irrigating complicated rules. On the other hand, the attribute of rules is that once one is become accustomed to them one may feel comfortable doing repeated same kinds of works, which is positive side for the workers. Research design, data, and methodology - We analyzed whether the SLA has moderating effects while service providers' job environment of outsourcing companies affects job satisfaction. Especially in the service industry, job satisfaction has great effects on productivity and efficiency. Results - The study results show the following. First, SLA has moderating effects while task performance environment affects treatment satisfaction. Second, SLA has moderating effects while task motivation environment affects treatment satisfaction. Third, SLA has moderating effects while physical work environment satisfaction affects treatment satisfaction. Fourth, on the other hand, the difficulties caused by SLA have moderating effects while the relationship among employees affects job dissatisfaction, which is negative side of SLA. From these results, we can tell that SLA has more positive moderating effects on treatment satisfaction on the whole. which results can be used to justify applying SLA to the service industry. Conclusions - In this study we analyzed the effects of SLA which have become more important in service industry nowadays on service providing employees. For managing side, the positive effects of SLA have to be emphasized while the negative effects should be avoided or minimized.

Automated Detecting and Tracing for Plagiarized Programs using Gumbel Distribution Model (굼벨 분포 모델을 이용한 표절 프로그램 자동 탐색 및 추적)

  • Ji, Jeong-Hoon;Woo, Gyun;Cho, Hwan-Gue
    • The KIPS Transactions:PartA
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    • v.16A no.6
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    • pp.453-462
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    • 2009
  • Studies on software plagiarism detection, prevention and judgement have become widespread due to the growing of interest and importance for the protection and authentication of software intellectual property. Many previous studies focused on comparing all pairs of submitted codes by using attribute counting, token pattern, program parse tree, and similarity measuring algorithm. It is important to provide a clear-cut model for distinguishing plagiarism and collaboration. This paper proposes a source code clustering algorithm using a probability model on extreme value distribution. First, we propose an asymmetric distance measure pdist($P_a$, $P_b$) to measure the similarity of $P_a$ and $P_b$ Then, we construct the Plagiarism Direction Graph (PDG) for a given program set using pdist($P_a$, $P_b$) as edge weights. And, we transform the PDG into a Gumbel Distance Graph (GDG) model, since we found that the pdist($P_a$, $P_b$) score distribution is similar to a well-known Gumbel distribution. Second, we newly define pseudo-plagiarism which is a sort of virtual plagiarism forced by a very strong functional requirement in the specification. We conducted experiments with 18 groups of programs (more than 700 source codes) collected from the ICPC (International Collegiate Programming Contest) and KOI (Korean Olympiad for Informatics) programming contests. The experiments showed that most plagiarized codes could be detected with high sensitivity and that our algorithm successfully separated real plagiarism from pseudo plagiarism.

Linguistic Characteristics of Middle School Students' Writing on Earth Science Themes Through Analysis of Its Genre and Register (장르와 레지스터 분석에서 나타난 중학생의 지구과학 주제 글쓰기의 언어적 특징)

  • Cha, Hyun-Jung;Kim, Chan-Jong;Maeng, Seung-Ho
    • Journal of the Korean earth science society
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    • v.32 no.1
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    • pp.84-98
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    • 2011
  • The study investigated the linguistic characteristics of middle school students' writing on the themes of earth science through analysis of its genre and register. Data for analysis included $7^{th}$ grade and $9^{th}$ grade students' writings about 'global warming' and 'classification of rocks'. The results of this study include: First, many students were not accustomed to writing in genre, especially exposition genre. Second, in terms of ideational meaning, the material verbs representing action or doing were more dominant than relational verbs that are related to the attribute or definition of things, and additional logical relations were predominant. Third, regarding interpersonal meaning, agents, emotions, subjective opinions appeared in the writings and students did not express their ideas conclusively and revealed feelings of doubt and uncertainty about their knowledge. Fourth, as for textual meaning, most students listed fragments of information using additional conjunctions in simple structures and were not accustomed to writing texts with organizing structures, logical patterns, cohesion, and coherence. From these results, we argued that the scientific writings should be emphasized in science learning that aims to foster scientific literacy. In addition, we discussed the necessity of improving science teachers' perceptions on scientific writing as well as setting up a specific plan in the national curriculum.

The Suggestion of Design Thinking Process and its Feasibility Study for Fostering Group Creativity of Elementary-Secondary School Students in Science Education (과학 교육에서 초·중등학생의 집단 창의성 함양을 위한 디자인적 사고 프로세스의 제안 및 타당성 검토 연구)

  • Lee, Dohyun;Yoon, Jihyun;Kang, Seong-Joo
    • Journal of The Korean Association For Science Education
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    • v.35 no.3
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    • pp.443-453
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    • 2015
  • In this study, we suggested the design thinking process that was possible to be introduced in science education and also examined the validity of the process in terms of group creativity. To do this, the design thinking process applicable to science education was selected from a variety of design thinking processes developed abroad, and then the process was modified and supplemented. We created the education program based on the developed design thinking process and applied it to high school students. The results revealed that we could offer the design thinking process through the five stages: 'understanding knowledge', 'empathy', 'sharing perspective', 'generating idea', and 'prototype'. With the results of the application of the program, we could confirm the relationship building and information seeking attributes in the understanding knowledge stage and the user-orientation, relationship building, and interpersonal understanding attributes in the empathy stage. We could also find the organization of the team attribute in the sharing perspective stage and the analytical strategic thinking attributes in the generating idea stage. Finally, the communication and analytical strategic thinking attributes in the prototype stage were confirmed. All of the key attributes of the group creativity found from skilled professionals were not confirmed from the students. However, we could ascertain the possibilities that the students should experience the process of group creativity and learn the relevant values through the developed design thinking process.