• KSBB Journal
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• v.19 no.4
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• pp.263-268
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• 2004

The separation method using chiral stationary phase in preparation of chiral compound was wildly used, but in this work, supercritical fluid chromatography was suggested in the stability to resolve the chiral mixtures. To determine the optimum operating condition of the racemic ibuprofen, the retention factor and resolution with change in pressures, temperatures and the contents of IPA % (vol.) in CO$_2$ were investigated. The retention factor was decreased with increase in pressure and decrease in temperature. The factor was also influenced by the content of IPA in mobile phase, while the resolution was worse with a increase in IPA %. From the experimental results, the desirable separation condition was 130 bar, 311.15 K and 4% IPA in CO$_2$. Compared to the asymmetric peak shape by liquid chromatography, that of supercritical fluid chromatography was symmetric which was a favorable condition for preparative separation.

• Applied Chemistry for Engineering
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• v.18 no.6
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• pp.630-635
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• 2007

New chiral Co-salen complexes with one $C_3-^tBu$ group in the structure have been synthesized and applied as a chiral catalyst. A dimeric chiral salen having aluminum group metal salts such as $AlCl_3$ displayed very high catalytic reactivity and enantioselectivity for the asymmetric ring opening of epoxides to synthesize optically pure ${\alpha}$-aryloxy alcohols via phenolic kinetic resolution. The salen complexes immobilized on the inorganic support were also used as effective catalysts in that reaction. The identity of metal salts in the new chiral salen complex has proved to be important in the enantioselective reactions.

• KSBB Journal
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• v.17 no.4
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• pp.321-325
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• 2002

Chiral epoxides are valuable intermediates for the asymmetric synthesis of enantiopure bioactive compounds. Microbial epoxide hydrolases (EHs) are newly discovered enzymes and versatile biocatalysts for the preparation of chiral epoxides by enantioselective hydrolysis of cheap and easily available racemic epoxide substrates. EHs are commercially potential biocatalysts due to their characteristics such as high enantioselectivity, cofactor-independent catalysis, and easy-to-Prepare catalysts. In this Paper, recent progresses in biochemistry and molecular biology of EH and developments of novel reaction systems are reviewed to evaluate the commercial feasibility of EH-catalyzed hydrolytic kinetic resolution for the production of chiral epoxides.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.5
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• pp.70-75
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• 2014

Super-resolution near-field structure (super-RENS) read-out samples are affected by a nonlinear and noncausal channel, which results in inter-symbol interference (ISI). In this study, we investigate asymmetry or domain bloom in super-RENS in terms of equalization. Domain bloom is caused by writing process in optical recording. We assume in this work that the asymmetry symbol conversion scheme is to generate asymmetric symbols, and then a linear finite impulse response filter can model the read-out channel. For equalizing this overall nonlinear channel, the read-out signals are deconvolved with the finite impulse response filter and its output is decided based on the decision rule table that is developed from the asymmetry symbol conversion scheme. The proposed equalizer is investigated with the simulations and the real super-RENS samples in terms of raw bit error rate.

• The Korean Journal of Petroleum Geology
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• v.7 no.1_2 s.8
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• pp.7-12
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• 1999

A new high-resolution rnagnetotelluric (MT) survey was conducted for pull-apart basin analysis (Cretaceous Eumsung Basin), combined with surface sedimentological results. Two cross-basinal MT profiles represent an asymmetric form with a subbasin in the southeastern part. These basinal architectures are well compatible with paleoflow directions and facies transitions of surface sedimentology. The results also suggest that the basin fills reflect pull-apart opening with rapid subsidence of the central blocks. Combined with the surface sedimentological data on asymmetric lithofacies distribution, facies transitions, and paleoflow directions of the alluvio-lacustrine systems, the MT data help explain basin-fill processes during the basin formation. For petroleum exploration and basin analysis, the high-frequency MT technique can be a useful substitute for the costly burden of a seismic-reflection survey on land.

• Molecules and Cells
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• v.37 no.8
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• pp.592-597
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• 2014

The cell membrane provides critical cellular functions that rely on its elaborate structure and organization. The structure of turtle membranes is an important part of an ongoing study of erythrocyte membranes. Using a combination of atomic force microscopy and single-molecule force spectroscopy, we characterized the turtle erythrocyte membrane structure with molecular resolution in a quasi-native state. High-resolution images both leaflets of turtle erythrocyte membranes revealed a smooth outer membrane leaflet and a protein covered inner membrane leaflet. This asymmetry was verified by single-molecule force spectroscopy, which detects numerous exposed amino groups of membrane proteins in the inner membrane leaflet but much fewer in the outer leaflet. The asymmetric membrane structure of turtle erythrocytes is consistent with the semi-mosaic model of human, chicken and fish erythrocyte membrane structure, making the semi-mosaic model more widely applicable. From the perspective of biological evolution, this result may support the universality of the semi-mosaic model.

• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.3
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• pp.15-21
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• 2017

In the active SONAR system, various studies have been carried out to enhance the resolution of a received signal. In order to obtain higher resolution for detecting a bottoming cylindrical object, the design of a planar array for SONAR is investigated in this paper. It is necessary to employ planar structures for SONAR array to obtain narrower beam pattern which gives high resolution. In this study, the transmit frequency of each acoustic transducer, which consists of an array is 13 kHz. For efficient detection of a target of an asymmetric size, the concept of areal angle is applied, which considers resolution according to both azimuth and elevation angles in array design. In the design, the areal angle is first investigated to satisfy the resolution requirements, and then based on the value of areal angles, the azimuth angle and the elevation angle are calculated respectively to design an array.

• Nuclear Engineering and Technology
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• v.52 no.11
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• pp.2601-2606
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• 2020

In this study, we expanded the performance of the existing EXVol code and performed empirical experiments and calculations. A high-resolution gamma spectroscopy system was constructed, and a standard point source and a standard volume source were measured with an HPGe detector with 43.1% relative efficiency. EXVol was verified by quantitative comparison of the detection efficiencies determined by measurements and calculations. To introduce the concept of the detector scanning that occurs in the actual measurement into the EXVol code, a collimator was placed between the source and detector. The detection efficiency was determined in the asymmetric arrangement of the source and detector with a collimator. A collimator made of lead with a diameter of 15 mm and a thickness of 50 mm was installed between the source and the detector to determine the detection efficiency at a specific location. The calculation result was contour plotted so that the distribution of detection efficiency could be visually confirmed. The relative deviation between the measurements and calculations for the coaxial and asymmetric structures was 10%, and that for the collimation structure was 20%. The results of this study can be applied to research using γ-ray measurements.

• Journal of Life Science
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• v.15 no.5 s.72
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• pp.772-778
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• 2005

Chiral epoxides are important chiral synthons in organic synthesis for the production of chiral pharmaceuticals and functional food additives. Chiral epoxides can be synthesized by enantioselective introduction of oxygen to double bond of substrate by monooxygenase. Peroxidase also carry out asymmetric epoxidation of alkene in the presence of hydrogen peroxide. Kinetic resolution of racemic epoxides via enantioselective hydrolysis reaction by epoxide hydrolase (EH) is a very promising method since chiral epoxides with a high optical purity can be obtained from cheap and readily available racemic epoxides. In this review, various biocatalytic approaches for the production of chiral epoxides with several examples are presented and their commercial potential is discussed.

• Journal of Life Science
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• v.16 no.1
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• pp.168-174
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• 2006

Enantiopure epoxides are valuable intermediates for the asymmetric synthesis of enantiopure bioactive compounds. Microbial epoxide hydrolases (EHs) are versatile biocatalysts for the preparation of enantiopure epoxides by enantioselective hydrolysis of cheap and easily available racemic epoxide substrates. EHs are commercially potential biocatalysts due to their characteristics such as high enantioselectivity, cofactor-independent catalysis, and easy-to-prepare catalysts. In this paper, recent progresses In molecular engineering of EHs are reviewed to evaluate the commercial feasibility of EH-catalyzed hydrolytic kinetic resolution for the production of enantiopure epoxides.