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Chiral Separation of Ibuprofen by Supercritical Fluid Chromatography  

한순구 (초정밀생물분리기술연구센터, 인하대학교 화학공학과)
노경호 (초정밀생물분리기술연구센터, 인하대학교 화학공학과)
Publication Information
KSBB Journal / v.19, no.4, 2004 , pp. 263-268 More about this Journal
Abstract
The separation method using chiral stationary phase in preparation of chiral compound was wildly used, but in this work, supercritical fluid chromatography was suggested in the stability to resolve the chiral mixtures. To determine the optimum operating condition of the racemic ibuprofen, the retention factor and resolution with change in pressures, temperatures and the contents of IPA % (vol.) in CO$_2$ were investigated. The retention factor was decreased with increase in pressure and decrease in temperature. The factor was also influenced by the content of IPA in mobile phase, while the resolution was worse with a increase in IPA %. From the experimental results, the desirable separation condition was 130 bar, 311.15 K and 4% IPA in CO$_2$. Compared to the asymmetric peak shape by liquid chromatography, that of supercritical fluid chromatography was symmetric which was a favorable condition for preparative separation.
Keywords
SFC; ibuprofen; chiral separation; resolution; retention factor;
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