• Molecules and Cells
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• v.44 no.1
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• pp.26-37
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• 2021

Human papillomaviruses (HPVs) cause cellular hyperproliferation-associated abnormalities including cervical cancer. The HPV genome encodes two major viral oncoproteins, E6 and E7, which recruit various host proteins by direct interaction for proteasomal degradation. Recently, we reported the structure of HPV18 E7 conserved region 3 (CR3) bound to the protein tyrosine phosphatase (PTP) domain of PTPN14, a well-defined tumor suppressor, and found that this intermolecular interaction plays a key role in E7-driven transformation and tumorigenesis. In this study, we carried out a molecular analysis of the interaction between CR3 of HPV18 E7 and the PTP domain of PTPN21, a PTP protein that shares high sequence homology with PTPN14 but is putatively oncogenic rather than tumor-suppressive. Through the combined use of biochemical tools, we verified that HPV18 E7 and PTPN21 form a 2:2 complex, with a dissociation constant of 5 nM and a nearly identical binding manner with the HPV18 E7 and PTPN14 complex. Nevertheless, despite the structural similarities, the biological consequences of the E7 interaction were found to differ between the two PTP proteins. Unlike PTPN14, PTPN21 did not appear to be subjected to proteasomal degradation in HPV18-positive HeLa cervical cancer cells. Moreover, knockdown of PTPN21 led to retardation of the migration/invasion of HeLa cells and HPV18 E7-expressing HaCaT keratinocytes, which reflects its protumor activity. In conclusion, the associations of the viral oncoprotein E7 with PTPN14 and PTPN21 are similar at the molecular level but play different physiological roles.

• Korean Medical Education Review
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• v.23 no.2
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• pp.128-138
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• 2021

This study examined the relationships among personality traits, coping efficacy, and academic stress in medical and non-medical students in South Korea, and investigated the mediating effect of coping efficacy in the relationship between personality traits and academic stress. The study group comprised 210 medical students and 175 non-medical students. They were asked to rate their personality traits, coping efficacy, and academic stress. The data were analyzed using IBM SPSS ver. 26.0 (IBM Corp., Armonk, NY, USA) and AMOS ver. 26.0 (IBM Corp.). Medical students scored higher for examination stress and lower for extroversion than non-medical students. In both groups, extroversion and conscientiousness positively affected coping efficacy, while neuroticism influenced it negatively. Neuroticism directly influenced all types of academic stress in both groups, while extroversion and conscientiousness only had direct effects on examination stress among medical students. Coping efficacy mediated the associations between personality traits and academic stress, except for the relationship between neuroticism and grade stress among medical students. The study indicates that coping efficacy had a significant effect on relieving academic stress among students with higher scores for extroversion and conscientiousness. Efforts should be made to decrease neuroticism to lower academic stress, as the relationship between neuroticism and academic stress is not directly influenced by coping efficacy. The implications of these results are discussed regarding a consultation system for students, especially those in medical school.

• The Korean Journal of Food & Health Convergence
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• v.5 no.1
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• pp.1-11
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• 2019

Smoking has become one of the public health harzard affecting the world. In the UK, smoking is responsible for around one in five deaths. The illnesses caused by smoking extend beyond the well-reported links with cancer, heart disease and respiratory illnesses. Hence the research to determine the awareness of the predisposing factor to smoking among adults in sokoto metropolis. A cross-sectional form of descriptive survey research design was used for this study. This is because descriptive studies are used when the characteristics of a population are either unknown or partially known (Hennekens & Buring, 2007), and it was used by Ganley and Rosario (2013) in a related research this justified the use of similar design in a study of similar nature.Two hundred and seventy returned questionnaire was collected, analyzed using descriptive statistic of frequency count, normative percentage and grand mean; as well as inferential statistics of chi-square (${\chi}^2$). The level of significant was fixed at 0.05. Appropriate degrees of freedom were worked out. There was statistical significant influence or relationship with marital status on the predisposing factors of smoking chi-square of 19716.516 greater than the critical value 43.77297at df 30 p<0.05. There were statistical significance chi-square =27468.348 which is greater than the critical value 43.77297 at df= 30. These show that there is a relationship on gender awareness of predisposing factors to smoking rejecting the null hypotheses. The respondents across different lever/year higher institution shows that the awareness of predisposing factors of smoking there were a statistical significance difference chi-square =7168.429 (df=88) greater than critical value 102.342 rejecting the null hypotheses. There is consistent evidence that links exposure to depictions of smoking in movies and initiation of smoking in young people. Over the years television shows and films have effectively built up associations between smoking and glamour, sex and risk-taking. Social learning theory describes how we learn by example from others. We are strongly influenced by our parents, and other people we look up to, such as peers, actors and pop stars. This can lead us to emulate their behaviour and try smoking.

• (The)Korea Educational Review
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• v.24 no.1
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• pp.199-225
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• 2018

Using the 3rd to the 6th wave data from the Korean Children and Youth Panel Survey(KCYPS), we examined the effects of academic characteristics and social relations on the trajectories of the life satisfaction among adolescents. OLS results showed that male students were more satisfied with their lives than female students in the 3rd grade of middle school. As academic characteristics, academic achievement and the level of class adjustment improved life satisfaction but the amount of learning time spent had a negative effect on life satisfaction. However, the effect of academic achievement lost its statistical significance after including variables of social relations. Relationships with parents, teachers, and friends had positive effects on life satisfaction. The longitudinal analysis using the fixed effect estimation also showed a similar result of the associations among the variables to that in the OLS analysis. The life satisfaction gap between male and female students narrowed over time from the 3rd grade of middle school to the 2nd grade of high school. The effects of relationships with parents and friends showed significant effects on both female and male students, but the relationship with their teachers was significant only for female students. Based on the results, we discussed the issues of Korean education related to the life satisfaction among adolescents.

• (The)Korea Educational Review
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• v.22 no.3
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• pp.169-192
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• 2016

The purpose of this study is to investigate the relations between religious socialism and education of Martin Buber(1878~1965), a theistic existentialist. Buber suggested religious socialism as an alternative to modern capitalist society which has many problems. Buber's religious socialism is based on the communitarianism of Hasidism. Buber considered 'true' socialism must be based on decentralized associations, not based on centralized state apparatuses. For establishing this kind of socialism, human will and mind are the most important. Thus, education takes a very important role in the process of social transformation. According to Buber, education and pedagogy should contribute to overcoming modern society's problems by pursuing the construction of community(true socialist society). For Buber, education for individuals' character and education for building community are not separated but combined. That is, although education takes a main role in the social transformation, it should not be considered just as an instrument for the social transformation. This is the main distinction between Buber's thought and other key socialists' thoughts on social transformation and education, because many of socialists who stress the role of education in the process of social transformation, tend to regard education as an instrument for the social transformation. According to Buber, education can contribute to social transformation without being an instrument for the social transformation. These ideas of Buber on religious socialism and education have important implications for educators and educationalists who hope education contributes to solving problems of modern society.

• Korean journal of psychology:General
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• v.36 no.3
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• pp.325-358
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• 2017

We employed meta-analysis to identify associations between self-compassion and various psychological variables using Korean literature. Various psychological variables were categorized by mutual consent of researchers who referred to the relative previous researches and hand books of psychology. We gathered 114 dissertations and journal articles published in Korea until now, including a total of 423 effect sizes, and calculated mean effect sizes using CMA2. We found large effect sizes for the relationships between self-compassion and positive psychological variables group of r = .45, and between self-compassion and negative psychological variables group of r = -.44. In addition, sub forms of positive psychological variables group and negative psychological variables group had statistically significant relationships with self-compassion. According to the results, we determined that self-compassion is an important explanatory and meaningful variable in understanding psychology of Korean. This study could help explore and develop the evidence for self-compassion in psychology.

• Survey Research
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• v.18 no.4
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• pp.25-59
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• 2017

The current study investigated how elderly husbands and wives' marital satisfaction and depression change over time and examined how changes in marital satisfaction account for changes in depression between and within the dyads. The longitudinal dyadic data from the first wave(2006) to the fifth wave(2014) of the Korean Longitudinal Study of Aging(KLoSA), collected by the Korea Employment Information Service, were used for the analyses. Because husbands and wives are interdependent within couples, we applied statistical models for dyadic data. The dyadic growth model(DGM) was used to model the trajectories of marital satisfaction and depressive symptoms. In order to analyze the association of these growth factors, we proposed the dyadic growth actor-partner interdependence model(DG-APIM) and applied the model to the data. The results showed that on average the husbands' marital satisfaction was higher but decreased faster over the course of the study than the wives'. It also showed that the average depression of the husbands was lower than that of the wives but the husbands' depression increased faster than the wives' over the course of the study. The variance of the averages of husbands' (wives's) depression was accounted for by that of wives'(husbands') marital satisfaction, showing a partner effect. The variance of the slopes of husbands'(wives') depression was accounted for by that of marital satisfaction of themselves, showing an actor effect. The results showed that there is a longitudinal interdependence between husbands and wives' marital satisfaction and depression and supported the marital discord model of depression.

• 한국사회정책
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• v.24 no.2
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• pp.61-86
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• 2017

Along with the well-established evidence on the negative effect of social isolation on physical and mental health, increasing attention has been paid to multi-dimensional nature of social isolation. One line of study on social isolation has discussed different pathways between objective and subjective social isolation and health. Another stream of the research focused on the possibly non-linear association between social isolation and health by age cohort groups. Drawing from the two lines of research, this study aimed at empirically examine to what extent objective and subjective social isolation are associated with physical and mental health independently and how the associations vary by three age cohorts(i.e. the middle-aged, the young old, the old-old). Data came from the first wave of Korean Social Life, Health and Aging Project (KSHAP) (N= 814). Findings showed 1) objective subjective isolation were significantly related with worse physical and mental health, interestingly, subjective social isolation was associated with mental health only, 2) pattern of association between social isolation and physical health varied by age cohorts. Specifically, compared to the middle-aged, the young old with higher objective social isolation exhibited lower level of physical health, while the old-old with higher subjective social isolation were likely to experience lower physical health. Based on the findings, we discussed implications and suggestions for future research and relevant policy/program development for ameliorating objective and subjective social isolation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.17 no.4
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• pp.115-129
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• 2007

The ubiquitous and autonomic computing environments is open and dynamic providing the universal wireless access through seamless integration of software and system architectures. The ubiquitous computing have to offer the user-centric pervasive services according to the wireless access. Therefore the roaming services with the predefined security associations among all of the mobile devices in various networks is especially complex and difficult. Furthermore, there has been little study of security coordination for realistic autonomic system capable of authenticating users with different kinds of user interfaces, efficient context modeling with user profiles on Smart Cards, and providing pervasive access service by setting roaming agreements with a variety of wireless network operators. This paper proposes a Roaming Coordinator-based security management framework that supports the capability of interoperator roaming with the pervasive security services among the push service based network domains. Compared to traditional mobile systems in which a Universal Subscriber Identity Module(USIM) is dedicated to one service domain only, our proposed system with Roaming Coordinator is more open, secure, and easy to update for security services throughout the different network domains such as public wireless local area networks(PWLANs), 3G cellular networks and wireless metropolitan area networks(WMANs).

• Imaging Science in Dentistry
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• v.51 no.2
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• pp.117-127
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• 2021

Purpose: The aim of this study was to evaluate the volumetric characteristics of mucous retention cysts(MRCs) in the maxillary sinus and to analyze potential associations of MRCs with dentoalveolar pathologies. Materials and Methods: Cone-beam computed tomography (CBCT) scans exhibiting bilateral maxillary sinuses that were acquired from January 2016 to February 2019 were initially screened. A total of 227 scans(454 sinuses) that fulfilled the inclusion criteria were included. The presence, location, and volumetric characteristics of the diagnosed MRCs were evaluated on CBCT images using the 3D-Slicer software platform. The presence of MRCs was correlated with potential influencing factors including age, sex, and dentoalveolar pathology. For MRCs located on the sinus floor, factors with a potential impact on the volume, surface, and diameter were analyzed. Results: An MRC was present in 130 (28.6%) of the 454 sinuses. Most MRCs were located on the sinus walls and floor. The mean MRC volume, surface, and diameter were 551.21±1368.04 mm³, 228.09±437.56 mm², and 9.63±5.40 mm, respectively. Significantly more sinuses with associated endodontically treated teeth/periapical lesions were diagnosed with an MRC located on the sinus floor. For MRCs located on the sinus floor, endodontic status exhibited a significant association with increased volume, surface, and diameter. Conclusion: Periapical lesions might be a contributing factor associated with the presence and volume of MRCs located on the sinus floor. The 3D-Slicer software platform was found to be a useful tool for clinicians to analyze the size of MRCs before surgical interventions such as sinus floor elevation procedures.