• Nuclear Engineering and Technology
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• v.44 no.8
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• pp.897-910
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• 2012

Inappropriate communications can cause a lack of necessary information exchange between operators and lead to serious consequences in large process systems such as nuclear power plants (NPPs). In this regard, various kinds of taxonomies of inappropriate communications have been developed to prevent inappropriate communications. However, there seems to be difficult to identify inappropriate communications from verbal protocol data between operators. Because the existing taxonomies were developed for use in report analysis, there is a problem of 'uncertainty'. In consequence, this paper proposes a new taxonomy of inappropriate communications and provides some insights to prevent inappropriate communications. In order to develop the taxonomy, existing taxonomies for four industries from 1980 to 2010 were collected and a new taxonomy is developed based on the simplified one-way communication model. In addition, the ratio of inappropriate communications from 8 samples of audio-visual format verbal protocol data recorded during emergency training sessions by operating teams is compared with performance scores calculated based on the task analysis. As a result, inappropriate communications can be easily identified from the verbal protocol data using the suggested taxonomy, and teams with a higher ratio of inappropriate communications tend to have a lower performance score.

• The Journal of Internal Korean Medicine
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• v.40 no.6
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• pp.1081-1100
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• 2019

Objectives: This study is an overview of the meta-analysis and systematic review of randomized controlled trials investigating the clinical effectiveness and safety of pharmacopuncture for patients with stroke. Methods: Core electronic databases were searched from their inception to 21 May 2019. A measurement tool to assess systematic reviews (AMSTAR 2) was applied to screen high-quality studies. The results of these studies were summarized, and additional meta-analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the certainty of evidence. Results: Sixteen studies met eligibility criteria. Four were excluded owing to insufficiency of AMSTAR 2 or low data reliability. The finally selected 12 studies were about pharmacopuncture using either a single herb extract, such as Dengzhan xixin, Sanch, Ginkgo biloba, or Acanthopanax, or a mixture of herbs, such as Compound danshen, Shenxiong, Xingnaojing, or Mailuoning. Most of the patients were from China, with acute ischemic stroke. All the studies using a pharmacopuncture versus a non-pharmacopuncture design reported the significant superiority of pharmacopuncture on every outcome measure. On the other hand, in a few studies, pharmacopuncture was inferior to active control in improving neurological deficit. Few studies reported adverse events. Conclusions: It is difficult to apply the results of this study directly to Korea, because the level of evidence is generally low and the clinical settings and social acceptance of pharmacopuncture therapy differ in Korea and China. Further studies are warranted to confirm the domestic applicability of evidence generated in China and to create evidence that supports the domestic situation.

• Toxicological Research
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• v.31 no.1
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• pp.69-75
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• 2015

The objective of this study was to investigate the toxicological information of freeze-dried powder from Allomyrina dichotoma (A. dichotoma) larvae as a food ingredient. The powder, suspended in distilled water, was administered once daily by oral gavage to four groups of Sprague-Dawley (SD) rats at dose levels of 0 (vehicle control), 250, 850, and 2500 mg/kg/day. After 13 wks of repeated administration, the standard toxicological parameters such as mortality, clinical signs, body weight, food consumption, ophthalmologic examination, clinical pathology, organ weights and macro/microscopic examination were applied for assessment of general toxicity. In addition, serum IgE and histamine levels were determined to evaluate allergenicity. The freeze-dried powder from A. dichotoma larvae did not produce treatment-related changes or findings in any toxicological parameters in either sex of any dosed groups except for slight increases in serum histamine levels at 2500 mg/kg/day. The changes were considered not to be adverse since the magnitude was minimal. In conclusion, the NOAEL (No Observed Adverse Effect Level) of the freeze-dried powder from A. dichotoma larvae was determined to be 2500 mg/kg/day or more in both sexes of SD rats and it is considered a candidate to be edible material.

• Toxicological Research
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• v.31 no.2
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• pp.181-189
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• 2015

In recent years, the use of both nano- and micro-sized lanthanum has been increasing in the production of optical glasses, batteries, alloys, etc. However, a hazard assessment has not been performed to determine the degree of toxicity of lanthanum. Therefore, the purpose of this study was to identify the toxicity of both nano- and micro-sized lanthanum oxide in cultured cells and rats. After identifying the size and the morphology of lanthanum oxides, the toxicity of two different sized lanthanum oxides was compared in cultured RAW264.7 cells and A549 cells. The toxicity of the lanthanum oxides was also analyzed using rats. The half maximal inhibitory concentrations of micro-$La_2O_3$ in the RAW264.7 cells, with and without sonication, were 17.3 and 12.7 times higher than those of nano-$La_2O_3$, respectively. Similar to the RAW264.7 cells, the toxicity of nano-$La_2O_3$ was stronger than that of micro-$La_2O_3$ in the A549 cells. We found that nano-$La_2O_3$ was absorbed in the lungs more and was eliminated more slowly than micro-$La_2O_3$. At a dosage that did not affect the body weight, numbers of leukocytes, and concentrations of lactate dehydrogenase and albumin in the bronchoalveolar lavage (BAL) fluids, the weight of the lungs increased. Inflammatory effects on BAL decreased over time, but lung weight increased and the proteinosis of the lung became severe over time. The effects of particle size on the toxicity of lanthanum oxides in rats were less than in the cultured cells. In conclusion, smaller lanthanum oxides were more toxic in the cultured cells, and sonication decreased their size and increased their toxicity. The smaller-sized lanthanum was absorbed more into the lungs and caused more toxicity in the lungs. The histopathological symptoms caused by lanthanum oxide in the lungs did not go away and continued to worsen until 13 weeks after the initial exposure.

• Structural Engineering and Mechanics
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• v.37 no.2
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• pp.233-251
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• 2011

The seismic provisions of the current edition (2005) of the National Building Code of Canada (NBCC) differ significantly from the earlier edition. The current seismic provisions are based on the uniform hazard spectra corresponding to 2% probability of exceedance in 50 years, as opposed to the seismic hazard level with 10% probablity of exeedance in 50 years used in the earlier edition. Moreover, the current code is presented in an objective-based format where the design is performed based on an acceptable solution. In the light of these changes, an assessment of the expected performance of the buildings designed according to the requirements of the current edition of NBCC would be very useful. In this paper, the seismic performance of a set of six, twelve, and eighteen story buildings of regular geometry and with concrete moment resisting frames, designed for Vancouver western Canada, has been evaluated. Although the effects of non-structural elements are not considered in the design, the non-structural elements connected to the lateral load resisting systems affect the seismic performance of a building. To simulate the non-structural elements, infill panels are included in some frame models. Spectrum compatible artificial ground motion records and scaled actual accelerograms have been used for evaluating the dynamic response. The performance has been evaluated for each building under various levels of seismic hazard with different probabilities of exceedance. From the study it has been observed that, although all the buildings achieved the life-safety performance as assumed in the design provisions of the building code, their performance characteristics are found to be non-uniform.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.25 no.1
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• pp.7-13
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• 2013

Bio Clean Room(BCR) and pharmaceutical product manufacturing facilities require careful assessment of many factors, including HVAC, controls, room finishes, process equipment, room operations, and utilities. Flow of equipment, personnel, and product must also be considered along with system flexibility, redundancy, and maintenance shutdown strategies. It is important to involve designers, operators, commissioning staff, quality control, maintenance, constructors, validation personnel, and the production representative during the conceptual stage of design. Critical variables for room environment and types of controls vary greatly with the clean space's intended purpose. It is particularly important to determine critical parameters with quality assurance to set limits and safety factors for temperature, humidity, room pressure, and other control requirements. In this paper, oxygen cluster ion equipment was utilized in order to enhance the indoor air quality and to prevent the airborne infection of ward in hospital. Moreover, the performance test of the equipment was also performed in order to develop the optimal sterilization system of BCR using the equipment.

• Journal of the Society of Naval Architects of Korea
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• v.32 no.4
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• pp.19-26
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• 1995

The assessment of maneuverability of a ship is very important from the view point of safety of human beings and of pollution of ocean. And, it is quite natural that every ship yard wants to have some tools with which they can build a ship with good maneuverability. But, maneuvarability of a ship is very subtle problem, and to calculate the exact maneuvering motion, lots of captive model tests must be carried out. Futhermore, in the initial design stage we can not make the scale model, because the lines of a ship is not fixed. In this paper, some approximate method to calculate the maneuvering motion of a ship, with the principal dimensions of hull, and propeller, rudder characteristics only, is studied. And, proposed approximate method is used to calculate the turning and zig-zag maneuver of several ships. The results of those calculations and the usability of the method are discussed.

• Korean Journal of Agricultural Science
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• v.46 no.1
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• pp.113-124
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• 2019

Insect-resistant transgenic (Bt-9) rice was generated by inserting mCry1Ac1, a modified gene from the soil bacterium Bacillus thuringiensis, into the genome of a conventional variety of rice (Ilmi). With regard to potential problems such as safety, an evaluation of non-target organisms is necessary as an essential element of an environmental risk assessment of genetically modified (GM) crops. We studied the effects of the Bt-9 rice on the survival of cantor Daphnia magna, a commonly used model organism in ecotoxicological studies. D. magna fed on the Bt-transgenic rice (Bt-9) and its near non-GM counterparts (Ilmi) grown in the same environment (a 100% ground rice suspension). The Bt-9 rice was confirmed to have the inserted T-DNA and protein expression evident by the PCR and ELISA analyses. The feeding study showed a similar cumulative immobility and abnormal response of the Daphnia magna between the Bt-9 rice and Ilmi. Additionally, the 48 h-EC50 values of the Bt-9 and Ilmi rice were 4,400 mg/L (95% confidence limits: 3861.01 - 5015.01 mg/L) and 5,564 mg/L (95% confidence limits: 4780.03 - 6476.93 mg/L), respectively. The rice NOEC (No observed effect concentration) value for D. magna was suggested to be 1,620 mg/L. We conclude that the tested Bt-9 and Ilmi have a similar cumulative immobility for D. magna, a widely used model organism, and the growth of Bt-9 did not affect non-target insects.

• Journal of The Korea Institute of Healthcare Architecture
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• v.25 no.3
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• pp.75-83
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• 2019

Purpose: There are no clear criteria for slip performance in the BF certification process, so the evaluator relies on subjective judgments depending on the field situation. Physical criteria for determining the slip performance of various floor finishes are not clear. C.S.R., the only criterion currently being used to check slip performance, may raise questions about its coverage, feasibility and reliability. Method: For an analysis of domestic standards and status, KS L 1001, KS M 3510, and KS F 2375. External standards are analyzed for ADA Standard, ANSI Standard, and BS EN Standard. Analyze the test methods and evaluation criteria of O-Y-PSM, BPT, and the dynamic slip resistance test used in these criteria. It also presents an improvement plan for the rational presentation of standards. Results: To date, various kinds of test methods and measuring devices of the slip resistance coefficient have been developed, but there are not many ways to trust useful results related to user safety. Reliability and thoroughly verified test methods and criteria should be used to assess the slip performance of the floor. In order to improve the standard for the evaluation of slip performance in Korea, the existing standard should first be raised to the same level as the overseas standard, and the application of the discriminatory standard should be applied considering the characteristics and usage patterns of each space. Implication: Currently, Korean standards propose various test methods, but the proper use of test methods, scope and assessment criteria are not established, so improvement of the comprehensive standard is necessary.

• Structural Engineering and Mechanics
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• v.80 no.6
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• pp.645-655
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• 2021

Performance-based reliability analysis is a practical approach to investigate the seismic performance and stochastic nonlinear response of structures considering a random process. This is significant due to the uncertainties involved in every aspect of the analysis. Therefore, the present study aims to evaluate the performance-based reliability within a stochastic finite element (FE) framework for reinforced concrete (RC) shear walls that are considered as one of the most essential elements of structures. To accomplish this purpose, deterministic FE analyses are conducted for both squat and slender shear walls to validate numerical models through experimental results. The presented numerical analysis is performed by using the ABAQUS FE program. Afterwards, a random-effects investigation is carried out to consider the influence of different random variables on the lateral load-top displacement behavior of RC members. Using these results and through utilizing the Monte-Carlo simulation method, stochastic nonlinear analyses are also performed to generate random FE models based on input parameters and their probabilistic distributions. In order to evaluate the reliability of RC walls, failure probabilities and corresponding reliability indices are calculated at life safety and collapse prevention levels of performance as suggested by FEMA 356. Moreover, based on reliability indices, capacity reduction factors are determined subjected to shear for all specimens that are designed according to the ACI 318 Building Code. Obtained results show that the lateral load and the compressive strength of concrete have the highest effects on load-displacement responses compared to those of other random variables. It is also found that the probability of shear failure for the squat wall is slightly lower than that for slender walls. This implies that 𝛽 values are higher in a non-ductile mode of failure. Besides, the reliability of both squat and slender shear walls does not change significantly in the case of varying capacity reduction factors.