• Transactions of the Korean Society of Machine Tool Engineers
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• v.14 no.4
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• pp.104-109
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• 2005

The catalyst layer design is one of the most important factors to enhance the performance of PEMFC(Proton Exchange Membrane Fuel Cell) system. The hydrophobic and ion conductive type is studied for the MEA(Membrane Electrolyte Assembly). It is found that those have some limitations for performance enhancement when they are used separately. Thus, the dual catalyst type, a mixed model, is developed for the better MEA performance. In the meantime, the design of flow field plate is subsequently carried out in order to give more enhanced output during its operation. The conductivity of flow field plate showed better performance in the case of manufactured by the more compressed process(20MPa) than by the less compressed process(10MPa). The micro-structure of the flow field plate is examined in details using SEM(Scanning Electron Microscope) to analyse the effects on the different compression processes.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.9
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• pp.916-921
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• 2009

The technology to inspect and measure an inner structure of micro parts has become an important tool in the semi-conductor industrial field with the development of automation and precision manufacturing. Especially, the inspection skill on the inside of highly integrated electronic device becomes a key role in detecting defects of a completely assembled product. X-ray inspection technology has been focused as a main method to inspect the inside structure. However, there has been insufficient research done on the customized inspection technology for the flip-chip assembly due to the interior connecting part of flip chip which connects the die and PCB electrically through balls positioned on the die. In this study, therefore, it is implemented to detect shape error of flip chip bonding without damaging chips using an x-ray inspection system. At this time, it is able to monitor the solder bump shape by introducing an edge-extracting algorithm (exponential approximation function) according to the attenuating characteristic and detect shape error compared with CAD data. Additionally, the bonding error of solder bumps is automatically detectable by acquiring numerical size information at the extracted solder bump edges.

• Molecules and Cells
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• v.27 no.2
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• pp.225-235
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• 2009

Antibody phage display provides a powerful and efficient tool for the discovery and development of monoclonal antibodies for therapeutic and other applications. Antibody clones from synthetic libraries with optimized design features have several distinct advantages that include high stability, high levels of expression, and ease of downstream optimization and engineering. In this study, a fully synthetic human scFv library with six diversified CDRs was constructed by polymerase chain reaction assembly of overlapping oligonucleotides. In order to maximize the functional diversity of the library, a ${\beta}$-lactamase selection strategy was employed in which the assembled scFv gene repertoire was fused to the 5'-end of the ${\beta}$-lactamase gene, and in-frame scFv clones were enriched by carbenicillin selection. A final library with an estimated total diversity of $7.6{\times}10^9$, greater than 70% functional diversity, and diversification of all six CDRs was obtained after insertion of fully randomized CDR-H3 sequences into this proofread repertoire. The performance of the library was validated using a number of target antigens, against which multiple unique scFv sequences with dissociation constants in the nanomolar range were isolated.

• Journal of the Korea Institute of Military Science and Technology
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• v.8 no.2 s.21
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• pp.58-66
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• 2005

This paper presents miniaturized setback generators based on the conversion of mechanical energy into electrical energy for military applications, especially power supply for electronic fuzes. In order to minimize the volume of setback generators, a ring-shaped magnet enclosing a coil assembly is adopted. A mechanical safety system, shear plate, is used as a release mechanism of the setback generators to prevent the generators from operating accidentally. The setback generators are intended not to ignite an electrical detonator but to charge a capacitor which is capable of driving electronic circuit of fuze. We design the setback generators using the simulation results of an electromagnetic analysis tool, $Maxwell^{(R)}$ 2D. In experimental study, we perform safety tests of the shear plate and firing tests of the fabricated setback generators. The present setback generators show that the voltage of 14.2V is charged at the capacitor of $30{\mu}F$ within the charging time of 0.68msec and the critical acceleration for safety is 5,000G, thus verifying that the setback generators with a ring-shaped permanent magnet can be applicable to the power supply of small-caliber electronic fuze.

• Journal of Microbiology and Biotechnology
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• v.13 no.2
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• pp.317-320
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• 2003

Genome-wide systematic deletion mutants were generated using a PCR-based targeted mutagenesis of Schizosacchaaromyces pombe. In a drug-sensitivity assay using thiabendazole(TBZ), an inhibitor of microtubule assembly, a heterozygous nda2 mutant ($nda2^+/nda2^-$), deleting one copy of nda2 encoding the microtubule subunit alpha1 demonstrated a distinct sensitivity to TBZ, indicating TBZ-induced haploinsufficiency. This result suggests that profiling drug-induced haploinsufficiency can be exploited to identify target genes for drugs and discover new drugs.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.260-265
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• 1996

The purpose of this study was to implemented a general purpose programmable nerve stimulator system as a research tool for studying psychophysiological performance associated with various stimulation waveform. This system is composed of hardware and software, the former are the personal computer(180586) and control unit(one-chip microprocessor, D/A converter, digital output), the latter are programmed in VISUAL BASIC and ASSEMBLY Which are programmed for the programmable nerve stimuli pattern editor and communication interface, waveform preprocessing, and stimuli generator. The control unit which is entrolled by the personal computer is capable of delivering the programmable nerve stimuli waveform. This system has research potential for determining the effect of various neuromuscular blockade in alternated physiological stat is.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.28-30
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• 2003

Hot Spring Law of Taiwan was passed in legislative assembly on 3 June 2003. Hot springs would become one of the most important natural resources for recreation purposes. Both public and private sectors will invest large amount of capital in this area in the near future. The value of remote sensing technology is to give a critical tool for observing the landscape to find out mega-scaled geological structures, which may not be able to be found by conventional approaches. The occurrences of the hot springs in Taiwan are mostly in metamorphic and sedimentary rocks , other than in volcanic environments. Local geothermal anomaly or heat of springs transfer by liquid convection other than conduction or radiation. The deeply -seated fractures of hard rocks are the conduit of the convection of hot water, which could be as deep as 3000 meters in a hypothetical model of Taiwan. Clues to find outcrops of hot spring can be obtained by a structure-controlled model deduced by geological lineaments observed by satellite images and stereoscopic interpretation of aerial photographs. A case study conducted in Eastern Taiwan will be demonstrated.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.11
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• pp.199-205
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• 2000

The vibration and noise of gears is due to the vibration exciting force caused by the tooth stiffness which changes periodically as the mesh of teeth proceeds and by the transmission error, that is, the rotation delay between driving gear and driven gear caused by manufacturing error and alignment error in assembly and so on. The purpose of this study is to develop how to calculate simultaneously the optimum amounts of tooth profile modification, end relief and crowning by minimizing the vibration exciting force of helical gears. We estimate the vibration exciting force by the mesh analysis of gears. The constraints of this problem consist of contact ratio and strengths of gear teeth such as tooth fillet stress, surface durability and scoring. ADS(Automated Design Synthesis) is used as an optimization tool. And, since the aspect ratio is an important parameter of tooth modification, we investigate the relation between it and the optimum values of tooth modification. The proposed method can calculate the optimum amount of tooth modification automatically and is to be utilized to resolve the problem of vibration of helical gears.

• Nuclear Engineering and Technology
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• v.51 no.4
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• pp.968-976
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• 2019

This paper presents a number of verification case studies for a recently developed sensitivity/uncertainty code package. The code package, ROMUSE (Reduced Order Modeling based Uncertainty/Sensitivity Estimator) is an effort to provide an analysis tool to be used in conjunction with reactor core simulators, in particular the Virtual Environment for Reactor Applications (VERA) core simulator. ROMUSE has been written in C++ and is currently capable of performing various types of parameter perturbations and associated sensitivity analysis, uncertainty quantification, surrogate model construction and subspace analysis. The current version 2.0 has the capability to interface with the Design Analysis Kit for Optimization and Terascale Applications (DAKOTA) code, which gives ROMUSE access to the various algorithms implemented within DAKOTA, most importantly model calibration. The verification study is performed via two basic problems and two reactor physics models. The first problem is used to verify the ROMUSE single physics gradient-based range finding algorithm capability using an abstract quadratic model. The second problem is the Brusselator problem, which is a coupled problem representative of multi-physics problems. This problem is used to test the capability of constructing surrogates via ROMUSE-DAKOTA. Finally, light water reactor pin cell and sodium-cooled fast reactor fuel assembly problems are simulated via SCALE 6.1 to test ROMUSE capability for uncertainty quantification and sensitivity analysis purposes.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.1
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• pp.57-65
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• 2021

With the increased utilization of CAM programs, end-mill processing is most commonly used for machining and metal processing. In particular, hole or shaft machining has high assembly precision, which inevitably leads to high utilization of end mills. However, the analysis of quality characteristics according to the process conditions of end mills is not performed systematically at the site, causing poor quality and productivity. The most influential factor of quality is the runout of the end mill. In this paper, the number of turns of the end mill, number of tool blades, cutting direction, and artificial runout volume were determined to identify the correlation between the epicenter, cylindricality, and surface roughness. Two types of end mills, three levels of runout, three levels of rotational speed, and two cutting directions were considered and 36 rounds of hole processing were conducted. For the analysis of shape characteristics according to the set process variables, the experimental planning method was applied to the measured specimen and the processing characteristics were analyzed according to the runout of the end mill through correlation analysis.