• Archives of Plastic Surgery
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• v.35 no.1
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• pp.7-12
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• 2008

Purpose: Since the report of artificial dermis manufacturing method using collagen by Yannas in 1980, collagen has been effectively used as dermal substitute with its merits such as, lower antigeneicity, controllable biodegradation rate, and minimal inflammatory cytotoxic properties in the dermal tissue engineering field. However, weak mechanical durability was the main drawback of collagen dermal substitute. To improve its stability, mechanical or chemical cross-linking was used. Despite of such process, its clinical use was restricted due to weak durability. To improve the durability of collagen matrix, we designed elastin-incorporated collagen matrix and compared its durability with conventional collagen matrix. Methods: 15mm diameter with 4mm thick collagen dermal matrix was made according to Yannas protocol by mixing 0.5% bovine collagen and chondroitin-6-sulfate followed by degassing, freeze drying, dehydrodermal cross-linking and chemical cross-linking procedure. In elastin incorporated collagen matrix, same procedure was performed by mixing elastin to previous collagen matrix in 4:1 ratio(collagen 80% elastin 20%). In comparison of the two dermal matrix in vitro tests, matrix contracture rate, strain, tensile strength, was measured and stiffness was calculated from comparative analysis. Results: In terms of matrix contracture, the elastin-incorperated added collagen dermis matrix showed 1.2 times more contraction compared to conventional collagen matrix. However, tensile strength showed 1.6 times and stiffness showed 1.6 times increase in elastin-incorporated matrix. Conclusion: Elastin incorperated collagen matrix manufactured by our team showed increased durability due to improvement in tensile strength and stiffness compared to previous collagen matrix($Integra^{(R)}$).

• Journal of the Korean Wood Science and Technology
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• v.41 no.5
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• pp.385-391
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• 2013

X-ray computed tomography is a very powerful nondestructive technique in safety inspection of historic timber building. But, in field, various testing condition makes it difficult to carry out X-ray CT testing. Limited size in X-ray digital detector is one of the problems. In this study, a pitch pine disk with two holes was used to know how imperfection in X-ray projection affects CT image resolution. Using various number of projections, CT image was reconstructed by filtered back projection method, and then it was investigated how many projection is required to identify the holes in different location. Two artificial holes could be differently detected according to their location in cross section of specimen. One hole in center part of specimen was identified using more than 9 radiographs, but the other one which located in outer part of cross section could not be detected until more than 36 projections were used. Even though there is data missing in outer part of cross section due to limited size of detector, the center part of CT image could be reconstructed well and the resolution of outer part became higher with increase of the number of projections. For field application, the number of projections for CT image reconstruction needs to be decided with consideration of another nondestructive testing and the location of interest.

• Restorative Dentistry and Endodontics
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• v.34 no.5
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• pp.424-429
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• 2009

This study aimed to assess the influence of different cross-sectional area on the cyclic fatigue fracture of Ni-Ti rotary files using a fatigue tester incorporating cyclical axial movement. Six brands of Ni-Ti rotary files (ISO 30 size with. 04 taper) of 10 each were tested: Alpha system (KOMET), HeroShaper (MicroMega), K3 (SybronEndo), Mtwo (VDW), NRT (Mani), and ProFile (Dentsply). A fatigue-tester (Denbotix) was designed to allow cyclic tension and compressive stress on the tip of the instrument. Each file was mounted on a torque controlled motor (Aseptico) using a 1:20 reduction contra-angle and was rotated at 300 rpm with a continuous, 6 mm axial oscillating motion inside an artificial steel canal. The canal had a $60^{\circ}$ angle and a 5 mm radius of curvature. Instrument fracture was visually detected and the time until fracture was recorded by a digital stop watch. The data were analyzed statistically. Fractographic analysis of all fractured surfaces was performed to determine the fracture modes using a scanning electron microscope. Cross-sectional area at 3 mm from the tip of 3 unused Ni-Ti instruments for each group was calculated using Image-Pro Plus (Imagej 1.34n, NIH). Results showed that NRT and ProFile had significantly longer time to fracture compared to the other groups (p < .05). The cross-sectional area was not significantly associated with fatigue resistance. Fractographycally, all fractured surfaces demonstrated a combination of ductile and brittle fracture. In conclusion, there was no significant relationship between fatigue resistance and the cross-sectional area of Ni-Ti instruments under experimental conditions.

• The Journal of the Acoustical Society of Korea
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• v.29 no.7
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• pp.458-467
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• 2010

In this paper, a new audio reproduction system was developed in which the cross-talk signals would be reasonably cancelled at an arbitrary listener position. To adaptively remove the cross-talk signals according to the listener's position, a method of tracking the listener position was employed. This was achieved using the two microphones, where the listener direction was estimated using the time-delay between the two signals from the two microphones, respectively. Moreover, room reverberation effects were taken into consideration where linear prediction analysis was involved. To remove the cross-talk signals at the left-and right-ears, the paths between the sources and the ears were represented using the KEMAR head-related transfer functions (HRTFs) which were measured from the artificial dummy head. To evaluate the usefulness of the proposed listener tracking system, the performance of cross-talk cancellation was evaluated at the estimated listener positions. The performance was evaluated in terms of the channel separation ration (CSR), a -10 dB of CSR was experimentally achieved although the listener positions were more or less deviated. A real-time system was implemented using a floating-point digital signal processor (DSP). It was confirmed that the average errors of the listener direction was 5 degree and the subjects indicated that 80 % of the stimuli was perceived as the correct directions.

• Journal of Communications and Networks
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• v.17 no.1
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• pp.40-46
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• 2015

In a mobile ad hoc network (MANET), communication between mobile nodes occurs without centralized control. In this environment the mobility of a node is unpredictable; this is considered as a characteristic of wireless networks. Because of faulty or malicious nodes, the network is vulnerable to routing misbehavior. The resource constrained characteristics of MANETs leads to increased query delay at the time of data access. In this paper, AntHocNet+ Security (ANTSEC) framework is proposed that includes an enhanced cooperative caching scheme embedded with artificial immune system. This framework improves security by injecting immunity into the data packets, improves the packet delivery ratio and reduces end-to-end delay using cross layer design. The issues of node failure and node malfunction are addressed in the cache management.

• Korean Journal of Clinical Pharmacy
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• v.1 no.1
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• pp.15-21
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• 1991

This study was attempted to investigate the dissolution rate and bioavailability of commercially available furosemide preparations. A. B. and C. The dissolution test was conducted in an artificial gastric juice using the basket method. and furosemide (40 mg) was administered orally to 8 normal volunteers by cross-over design. The results were as follows: the AUC and dissolution rate in 100 min ($D_{100\;min}$) were higher in order of preparations. A > C > B. But the peak concentration. time to reach peak concentration $(T_{max})$, and mean dissolution time (MDT) were in order of preparations. C > A > B. There were significantly linear correlations between the AUC and the $D_{100\;min}$, and between the $T_{max}$ and the MDT. From the results of this experiment. it can be concluded that commercially available preparations bioavailability of furosemide, which may be predicted from the dissolution rate.

• Proceedings of the Korea Concrete Institute Conference
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• 1995.04a
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• pp.372-377
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• 1995

Expert systems which represent the appllication of artificial intelligence research are now nearly 20 years old. It is said that the present technology together with ever- increasing computing applicability of Combined Hypertext-Expert System Techniques to the design of reinforced concrete structures. Hypertext systems allow the user to control the system while expert systems alone don't give the user any control over the system. Therefore the combination of these two techniques, offered by KnowledgePro, may bring us closer to real user-expert communication. The system developed in this work offers information on design in general by reorganizing ACI Manual 318-89, detailed stress analysis and cross sectional design of simple PC/RC beams and optimum design of reinforced concrete building frames. The system also includes the author's earlier work on guidance to identify types of cracks in concrete. It is also includes the author's earlier work on guidance to identify types of cracks in concrete. It is also demonstrated how well and conveniently existing programs can be used by reorganizing the user manuals in the context of hypertext.

• Wind and Structures
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• v.8 no.3
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• pp.147-161
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• 2005

Two identical tall building models with square cross-sections are experimentally studied in a wind tunnel with high-frequency-force-balance (HFFB) technique to investigate the interference effects on wind loads and dynamic responses of the interfered building. Another wind tunnel test, in which the interfered model is an aeroelastic one, is also carried out to further study the interference effects. The results from the two kinds of tests are compared with each other. Then the influences of turbulence in oncoming wind on dynamic interference factors are analyzed. At last the artificial neural networks method is used to deal with the experimental data and the along-wind and across-wind dynamic interference factor $IF_{dx}$ & $IF_{dy}$ contour maps are obtained, which could be used as references for wind load codes of buildings.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.97.5-97
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• 2002

A sensor modeling via artificial neural network is presented in this paper. The optical sensor has been designed to treasure absolute 3-dimensional positions and orientations of objects in 6-DOF. The method utilizes a triangular pyramidal mirror having an equilateral cross-sectional shape referred as 3-facet mirror. The mirror has three lateral reflective surfaces inclined 45 degrees to its bottom surface. The 3-facet mirror is mounted on the object whose 6-DOF motion is to be measured. As optical components, a He-Ne laser source and three position-sensitive detectors(PSD) are used. The laser beam is emitted from the He-Ne laser source located at the upright position and vertically incident o...

• Journal of the Korean Chemical Society
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• v.58 no.6
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• pp.543-552
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• 2014

A quantitative structure activity relationship (QSAR) study is performed for modeling and prediction of oral bioavailabilities of 216 diverse set of drugs. After calculation and screening of molecular descriptors, linear and nonlinear models were developed by using multiple linear regression (MLR), artificial neural network (ANN), support vector machine (SVM) and random forest (RF) techniques. Comparison between statistical parameters of these models indicates the suitability of SVM over other models. The root mean square errors of SVM model were 5.933 and 4.934 for training and test sets, respectively. Robustness and reliability of the developed SVM model was evaluated by performing of leave many out cross validation test, which produces the statistic of $Q^2_{SVM}=0.603$ and SPRESS = 7.902. Moreover, the chemical applicability domains of model were determined via leverage approach. The results of this study revealed the applicability of QSAR approach by using SVM in prediction of oral bioavailability of drugs.