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Clinical Study of Tumor Angiogenesis and Perfusion Imaging Using Multi-slice Spiral Computed Tomography for Breast Cancer

  • Xu, Na;Lei, Zhen;Li, Xiao-Long;Zhang, Jun;Li, Chen;Feng, Guo-Quan;Li, Di-Nuo;Liu, Jing-Yi;Wei, Qiang;Bian, Ting-Ting;Zou, Tian-Yu
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.429-433
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    • 2013
  • Objectives: To explore the correlation between multi-slice spiral CT (MSCT) perfusion parameters and the expression of vascular endothelial growth factor (VEGF) as well as matrix metalloproteinase-2 (MMP-2) in breast cancer. Methods: Forty five breast cancer patients and 16 patients with benign breast tumor, both confirmed by pathology examination, were enrolled. All underwent MSCT perfusion imaging to obtain perfusion maps and data for parameters including blood flow (BF), blood volume (BV) and permeability surface (PS). Cancer patients did not receive treatment prior to surgery. The expression of VEGF and MMP-2 were examined with both immunohistochemistry and Western blotting. Results: The levels of VEGF and MMP-2 by immunohistochemistry were significantly higher in the breast cancer group (P < 0.01) than the benign tumor group. Relative OD values from Western blotting were also higher in cancer cases (P < 0.05). Similarly, the mean MSCT perfusion parameters (BF, BV, PS) were significantly higher in the breast cancer group (P < 0.01), BF and BV positively correlating with VEGF expression (r = 0.878 and 0.809 respectively, P < 0.01); PS and VEGF and MMP-2 expression were also positively correlated (r= 0.860, 0.786 respectively, P < 0.01). Conclusion: There is a correlation between breast cancer MSCT perfusion parameters and VEGF andMMP-2 expression, which might be useful for detection of breast lesions, qualitative diagnosis of breast cancer, and evaluation of breast cancer treatment.

ADOLESCENT VIOLENCE TOWARD PARENTS (청소년의 부모폭행에 대한 연구)

  • Chun, Ryo-Sook;Min, Sung-Kil;Oh, Kang-Sup;Lee, Si-Hyung;Lee, Ho-Bun
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.8 no.2
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    • pp.199-206
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    • 1997
  • Object:The purpose of this study was to investigate frequency and risk factor of violence toward parents seen in adolescents. We also want to apply this data toward developing a prevention program for adolescent violence. Method:A total of 1,345 students from 5 middle schools in Seoul, participated in this study:675 males, 670 females. We administered self-reporting questionnaire including violence toward parents, exposure to violence, family history of alcoholism, substance abuse of adolescetnt and dermographic data etc. Result:The frequency of boys’ violence toward parent was 2.8%, which was significantly higher than girls’(p<0.001). The frequency of violence toward the father was higher than the mother. The risk factors for violence toward parents were sex, parental alcohol problem, adolescent alcohol-smoking-drug problem, exposure to violence at home in the last year and exposure to violence in the life(p<0.0001). The grade, punishment, socioeconomic status, educational level of parent were not significantly related to violence toward parents. Conclusion:These suggest that adolescent violence toward parents is not rare problem any more and preventive intervention is needed for high-risk groups, that is related with experience domestic violence, substance abuse, alcoholic parent.

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Constructing a Green Network and Wind Corridor to Alleviate the Urban Heat-Island (도시열섬현상 완화를 위한 녹지네트워크 및 바람길 구축)

  • Cha, Jae-Gyu;Jung, Eung-Ho;Ryu, Ji-Won;Kim, Dae-Wuk
    • Journal of the Korean Association of Geographic Information Studies
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    • v.10 no.1
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    • pp.102-112
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    • 2007
  • Like other organic beings, modern cities change every day. Unlike in the past, changes of space which have been taking place in concentrated spaces during short periods of time have worsened the environment of cities creating environmental problems. In particular, the urban heat-island phenomenon, which is caused by changes in using the earth's surface, has emerged as a key social issue along with health problems and economic difficulties. The Green Network has been introduced as an urban planning approach to solve the urban heat-island phenomenon. This study suggests constructing a Green Network through analyzing the urban heat island phenomenon, land cover classification, and linkage possibility with the Green Network and wind corridors by researching Jung-Gu, and Nam-Gu in Daegu Metropolitan City. In conclusion, this study presented the construction of a broad and detailed Green Network of object areas by assigning Apsan to the southern area and mountain area as the core, two areas of Nam-Gu and six areas of Jung-Gu such as Duryu Park and, Dalsung Park as footholds and other school land and park facility areas as footholds-to-be areas. In particular, Camp Walker, which is connected with Apsan, is not only a foothold but connected to the core, is necessary to preserve after being transferred from the U.S. Army. In addition, assigning the Susung Bridge area of Jung-Gu and the Camp Walker area of Nam-Gu as the wind corridor areas is recommended.

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Numerical Simulation of Crash Impact Test for Fuel Tank of Rotorcraft (회전익항공기용 연료탱크 충돌충격시험 수치모사 연구)

  • Kim, Hyun-Gi;Kim, Sung-Chan;Lee, Jong-Won;Hwang, In-Hee;Kim, Kyung-Soo
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.24 no.5
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    • pp.521-530
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    • 2011
  • Since aircraft fuel tanks have many interfaces connected to the airframe as well as the fuel system, they have been considered as one of the system-dependent critical components. Crashworthy fuel tanks have been widely implemented to rotorcraft and rendered a great contribution for improving the survivability of crews and passengers. Since the embryonic stage of military rotorcraft history began, the US army has developed and practised a detailed military specification documenting the unique crashworthiness requirements for rotorcraft fuel tanks to prevent most, hopefully all, fatality due to post-crash fire. The mandatory crash impact test required by the relevant specification, MIL-DTL-27422D, has been recognized as a non-trivial mission and caused inevitable delay of a number of noticeable rotorcraft development programs such as that of V-22. The crash impact test itself takes a long-term preparation efforts together with costly fuel tank specimens. Thus a series of numerical simulations of the crash impact test with digital mock-ups is necessary even at the early design stage to minimize the possibility of trial-and-error with full-scale fuel tanks. In the present study the crash impact simulation of a few fuel tank configurations is conducted with the commercial package, Autodyn, and the resulting equivalent stresses and internal pressures are evaluated in detail to suggest a design improvement for the fuel tank configuration.

Military Security Policy Research Using Big Data and Text Mining (빅데이터와 텍스트마이닝 기법을 활용한 군사보안정책 탐구)

  • Kim, Doo Hwan;Park, Ho Jeong
    • Convergence Security Journal
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    • v.19 no.4
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    • pp.23-34
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    • 2019
  • This study utilized big data, one of the new technologies of the Fourth Industrial Revolution as a policy direction study related to the military security of the Army. By utilizing Text mining and analyzing military security trends in domestic and foreign papers, it will be able to set policy directions and reduce trial and error. In this study, we found differences in domestic and international studies on military sucurity. At first, Domestic research has shown that in the course of the fourth industrial revolution, there is a strong interest in technological security, such as IT technology in security and cyber security in North Korea. On the other hand, Foreign research confirmed that policies are being studied in such a way that military sucurity is needed at the level of cooperation between countries and that it can contribute to world peace. Various academic policy studies have been underway in terms of determining world peace and security levels, not just security levels. It contrasted in our immediate confrontation with North Korea for decades but suggest complementary measures that cannot be overlooked from a grand perspective. Conclusionally, the direction of academic research in domestic and foreign should be done in macro perspective under national network cooperation, not just technology sucurity research, recognizing that military security is a policy product that should be studied in a security system between countries.

A Study on User Perception for the Efficient Utilization of Camp Page - Focus on Chuncheon Citizen and Tourist - (캠프페이지의 효율적인 활용을 위한 이용자인식 연구 - 춘천시민과 관광객을 중심으로 -)

  • Jun, Mi-Ri;Kang, Eun-Ji;Kim, Yong-Geun
    • Journal of the Korean Institute of Landscape Architecture
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    • v.45 no.3
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    • pp.9-20
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    • 2017
  • Camp Page, which has been located in front of Chuncheon Station for about 50 years since 1958, recently opened to the public. Chuncheon City is currently struggling to construct a park on this site due to an uncertainty of general plans and financial difficulties. Accordingly, this research conducted a cognitive survey about site usage with Camp Page users in order to clarify directions for efficient establishment of parks within the former military base. The course of research includes analytical methods such as a survey targeting Chuncheon citizens and tourists both in the field and online, a frequency analysis of 1,360 index samples, a cross analysis and t-test. As a result, firstly, Chuncheon citizens recognized the image of Chuncheon as a city with a fresh, clean lakeshore whereas tourists think of it as a city for sightseeing and leisure. Hence, it was justifiable to conclude that the city should organize various programs for people to enjoy leisure activities while at the same time protecting the environment. Second, the awareness of tourists about Camp Page was relatively low and both citizens and tourists recognize that it was not sufficient enough for enjoyment of free time. The majority answered "space for culture and art and for experiencing the natural environment" when asked about the direction of space creation at Camp Page, which indicates that the site will need to be available both for cultural art and nature experiences. Lastly, it was thought that the direction of developing leisure facilities in Chuncheon city should include the improvement of worn out installations and developing chain products among programs. This research will be able to use fundamental data for the efficient utilization of the returned U.S. military camps that are constantly merging.

I3A Framework of Defense Network Centric Based C2 Facilities (국방 NC 기반 C2 시설 I3A Framework)

  • Kim, Young-Dong;Lee, Tae-Gong;Park, Bum-Shik
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.39C no.8
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    • pp.615-625
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    • 2014
  • Ministry of National Defense, MND, established a "Master Plan of Military Facility" in 2010 based on the defense reform to prepare for future war. It was a plan for consolidating small military facilities into battalion units, reflecting on and preparing for the needs of various changes in defense environment as well as balanced growth of ROK Army, Navy, and Air Force. However, to move forward with "Military Facility Master Plan," current design criteria for military facilities need to be revised to be enacted due to numerous calculation errors in facility footprints because of the absence of a sound facility criteria. Because the future war environment will be changed from Platform basis to Network Centric Warfare basis, Command & Control capability of C4I systems is getting more important. Therefore, Successful mission accomplishment can be secured by convergence of facility and military Information Technology(IT). So, MND should quickly prepare for the operational guidance, design criteria and policy that are suitable for Network Centric Warfare accomplishment, and implement infrastructure of IT and installation of C2 facility in conjunction with consolidation movement of military facilities. In this paper, we propose the defense I3A framework in order to solve this problem.

A Study on Improvement of Test & Evaluation of Vehicle Part in Mixed Equipment and Defense Industrial Technology (혼성장비 차량부 시험평가 및 방위산업기술 보호 제도 개선에 관한 연구)

  • Yoon, Heung-Soo;Ryu, Yeon-Seung
    • Journal of the Korea Convergence Society
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    • v.9 no.7
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    • pp.241-249
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    • 2018
  • The military purpose vehicles are developed by using the platform of civil vehicles according to the commercial vehicle expansion plan and military supplied product commercialization policy. But the information related to the military purpose vehicle which adopts the same platform with the civil vehicle is forced to be exposed because its information is revealed by containing into the maintenance manual and electric circuit diagram. Especially, the information disclosure should be blocked by reviewing the application of technology protection because the military vehicle becomes combating purposed mixed equipment when the missile and radar are mounted. The mixed equipment means the one configured with more than 2 types of equipment, and it is categorized into the main and sub equipment. This study was performed to derive the problems in Korean system for vehicle part test evaluation on the mixed equipment and the defense industry technology protection system, and to derive the methods for improving through interviews with the specialists. The conflicts between the civil laws and army regulation were reduced by adding a clause that the engine reflected with the newest emission gas standard should be mounted based on the time of force integration, and the commercialized military supplies were designated as element technology of defense industry technology in consideration of its roles and functions.

Evaluation on South and North Korean Military Power by Military Officers (남북 군사력 우열에 대한 군간부들의 인식 평가)

  • Lee Sang-Jin
    • Survey Research
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    • v.7 no.1
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    • pp.29-53
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    • 2006
  • This paper analyzes which of the military sub-fields has an effect on a soldier's evaluation of South and North Korean military power. There are three objectives of this paper. First, it is to analyze whether the South is superior to the North in the overall military power and military sub -fields, without the presence of the US armed forces in South Korea. Second, it is to assess which of the military sub-fields influences the overall evaluation of military power through a regression analysis. Finally, it is to look at whether the professional soldiers have a motivational bias, due to an argument that the military personnel tend to exaggerate the inferiority of their own military power to get more budget for defense construction. Research in 2002 and 2003 tell us that South Korean military power is slightly inferior to North Korea's. However, research in 2005 shows that military power of South and North Korea is almost equal. The sub-fields in which South Korea is superior are in the order of War Sustainability, Information Warfare, Air Force, and Navy. North Korea is regarded to be superior in the fields of Atomic Biological Chemical Warfare Capability, Special Force, Reserve Mobilization, and Army. The higher ranked soldiers tend to evaluate that the North is superior to the South.

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Determination of Economic Injury Levels and Control Thresholds for Spodoptera exigua on Chinese Cabbage (배추 파밤나방의 경제적 피해수준 및 요방제 수준 설정)

  • Kim, Seon-Gon;Kim, Do-Ik;Ko, Suk-Ju;Kang, Beom-Ryong;Kim, Hong-Jae;Choi, Kyeong-Ju
    • Korean journal of applied entomology
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    • v.48 no.1
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    • pp.81-86
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    • 2009
  • Economic injury level and control thresholds for the management of beet army worm, Spodoptera exigua (Lepidoptera: Noctuidae) were evaluated on chinese cabbage of two different planting time. Two inoculation times were tested for each planting and the number of inoculated larva was 10, 20, 40, 80, respectively. Damages of leaves by first inoculation were 63.2% after eight days planting on 80 larva inoculation plot. By the second inoculation, those were below 50% after 20 days planting on the end of September. The linear relationships between population density and yield reduction were as following; Y = -10.62x + 867.9 ($R^2\;=\;0.643$) for 5 days and Y=-6.432x + 1074 ($R^2\;=\;0.720$) for 20 days. Based on these results the economic injury level was 5.4 larva for five days and 9.0 larva for 20 days per 20 chinese cabbage. The control thresholds calculated by 80% level of economic injury level were 4.3 and 7.2 larva, respectively.