• Title/Summary/Keyword: anti-allergic effect

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The study on the anti-allergic effect of a number of herb-extract. (數種의 韓藥 抽出物이 抗알레르기 反應에 미치는 影響)

  • Roh, Tae-Seok;Roh, Seok-Sun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.15 no.1
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    • pp.1-30
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    • 2002
  • This experimental study was done to research effects of a number of extract on the anti-allergic effect. The results were obtained as follows: 1. In effect of herb-extract on compound $\frac{48}{80}$-mediated histamine release from Evans blue skin assay, Isatis Japonica Miquel, Dictamnus dasycarpus Turcz, Spirodela polyrhiza, Cimicifuga heracleifolia, Bupleurum chinense, Magnolia liliflora, Forsythia koreana, Aster tataricus L., Xanthium strumarium L.(MtOH), Trichosanthes kirilowii, Phellodendron amurense Rupr, Schizonepeta tenuifolia Var, Betula platyphylla show considerable visible anti-allergic effect. In the result of quantification of histamine induced compound $\frac{48}{80}$, Spirodela polyrhiza, Isatis Japonica Miquel, Trichosanthes kirilowii, Bupleurum chinense, Forsythia koreana inhibit histamine release effectively. 2. In effect of Herb-Extract on compound $\frac{48}{80}$-mediated histamine release from RPMC, Spirodcla polyrhiza, Cimicifuga heracleifolia inhibit histamine release effectively. 3. In effect of Herb-Extract on anti-DNP IgE-mediated histamine release from Evansblue skin assay. Spirodela polyrhiza, Cimicifuga heracleifolia(0.1mg/ml). Forsythia koreana, Aster tataricus L., Xanthium strumarium L.(0.1mg/ml), Trichosanthes kirilowii(0.1mg/ml) show considerable visible anti-allergic effect. In the result of quantification of histamine induced anti-DNP IgE, Spiradela polyrhiza, Isatis Japonica Miquel, Trichosanthes kirilowii, Bupleurum chinense, Forsythia koreana inhibit histamine release effectively 4. In the result of genetic manifestative inhibition about the human mast cell-1(HMC-1), Cimicifuga heracleifolia has considerable effect in IL-4 in IL-5, and Tussilage farfara L. has in IL-4. According to the above results, it is suggested that several Herb-Extract have anti-allergic effect.

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The study on the anti-allergic effect of SoPungSan-Gami (消風散加味의 抗알레르기 效果에 關한 實驗的 硏究)

  • Lee, Jun-Seong;Seo, Hyung-Sik;Roh, Seok-Seon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.14 no.2
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    • pp.9-20
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    • 2001
  • This study was carried out to prove the anti-allergic effect of SPS-GM, which is gained by controlled Cytokines making all the difference to Th2 cell development. The results were obtained as follows : 1. From the SPS-GM treatment about BMC cell, in case of the IL-4, an important factor of the Th2 cell development, SPS-GM didn't show considerable effect. 2. The INF-${\gammer}$, mutual Cytokines of IL-4, was increased more than twice. 3. Histamine from the Master cell and Nitric oxide from indisposition response were a little decreased. According to the above results, it is suggested that SPS-GM has anti-allergic effect.

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The Effect of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. (回春凉膈散이 抗알레르기 및 消炎, 鎭痛, 解熱效果에 미치는 影響)

  • Kim Gyung Jun;Kim Joong Ho;Chae Byung Yoon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.7 no.1
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    • pp.1-13
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    • 1994
  • The Effects of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. Experimental studies were done to research the clinical effects of Hoichunyanggyuksan on the Anti-allergic effect, Analgesic action, Anti-inflammatory action and Antipyretic action. The results obtained as follows; 1. On vascular permeability responses to intradermal histamine, Hoichnyanggyuksan showed significant effect. 2. In the homologous PCA provoked by the IgE-like antibody against white egg albumin, Hoichunyanggyuksan showed the decreasing tendency, but was none significant effect. 3. In the delayed type hypersensitivity responses to Picryl chloride, Hoichunyanggyuksan was proved significant effect. 4. In the delayed type hypersensitivity resposes to SRBC, Hoichunyanggyuksan revealed significant effect. 5. In Anti-pyretic action by yeast method, Hoichunyanggyuksan showed significant effect. 6. In Anti-inflammatory action by carrageenin method, Hoichunyanggyuksan showed significant effect. 7. In analgesic action by acetic acid method, Hoichunyanggyuksan was recognized significantly.

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Study on the Anti-allergic Effect of Armeniacae Semen Herbal Acupuncture Solution (행인약침(杏仁藥鍼)이 항알레르기에 미치는 영향)

  • Kim, Yu-Seung;Song, Choon-Ho
    • Korean Journal of Acupuncture
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    • v.24 no.4
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    • pp.151-162
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    • 2007
  • Objectives : The purpose of this study was to examine the anti-allergic effect in vivo, and to observe single toxicity in mice of Armeniacae Semen herbal acupuncture solution (ASHA). Methods : We investigated anti DNP IgE-mediated passive cutaneous anaphylaxis in rodents and compound 48/80-induced active systemic anaphylatic shock in mice after treatment at both BL13 with ASHA of 25 ${\mu}{\ell}$(mice) or 50 ${\mu}{\ell}$(rats) 3 times for 5 days. To ascertain safety and toxicity of ASHA, we examined single toxicity test. In single test, three groups were treated with different dosages of ASHA (ASHA250, ASHA500 and ASHA1000) according to on Korean Food and Drug Administration, respectively. We observed attentively motality, abnormal clinical sign, body weight change, and organ weight of mice after ASHA treatment. Results : ASHA inhibited passive cutaneous anaphylaxis and active systemic anaphylatic shock by oral administration. During toxicity experiment period, there was no difference in body weight change, and organ weight among different dose groups. Death were not found in single test i.p. group. (ASHA250, ASHA500 and ASHA1000). Several individuals of single test i.p. group were observed yellow brown discharge around anus in early period after administration. Conclusions : These results indicate that ASHA have inhibition effects on passive cutaneous anaphylaxis and active systemic anaphylatic shock, and suggest that has some toxicity in high dosage.

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Effects of Yongdamsagantang and Yongdamsagantang-gamibang on the Anti-allergic effect in rats and mice (용담사간탕(龍膽瀉肝湯) 및 용담사간탕가미방(龍膽瀉肝湯加味方)의 항(抗)알레르기에 관(關)한 실험적(實驗的) 효과(?果))

  • Seo Man-Seon;Jin Yeong-Sang;Jeong Gyu-Man
    • The Journal of Pediatrics of Korean Medicine
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    • v.5 no.1
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    • pp.15-27
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    • 1991
  • Experimental studies were done to research the clinical effects of Yongdamsagantang and Yongdamsagantang-gamibang (Yongdamsagantang with Lonicerae Flos and Forsythiae Fructusadded) on the Anti-allergic effect in rats and mice. The results obtained as follows; 1. In the effects of Yongdamsagantang and Yongdamsagantang-gamibang on vascular permeability responses to intradermal histamine in rats, Yongdamsagantang group revealed none significant affect, but Yongdamsagantang-gamibang group revealed significant effect. 2. In the effects of Yongdamsagantang and Yongdamsagantang-gamibang on vascular permeability responses to intradermal serotonin in rats, Yongdamsagantang and Yongdamsagantang-gamibang group revealed significant effect. 3. In the 48hrs homologous passive cutaneous anaphylaxis in rats provoked by the IgE-like antibody against egg albumin, Yongdamsagantang group revealed none significant effect, but Yongdamsagantang-gamibang group revealed significant effect. 4. In the delayed type hypersensitivity responses to Picryl Chloride in mice, Yongdamsagantang and Yongdamsagantang-gamibang group revealed none significant effect, in the delayed type hypersensitivity responses to SRBC in mice, Yongdamsagantang group revealed none significant effect, but Yongdamsagantang-gamibang group revealed significant effect. According to above-stated results, Yongdamsagantang is none significant Anti-allergic effect. But Yongdamsagantang-gamibang is concluded to be effective as immediated type hypersensitivity and recommended to be used for the treatment of allergic diseases. (Asthma, Allergic urticaria, Allergic rhinitis, etc.)

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Inhibitory Effect of Penthorun chinense Extract on Allergic Responses in vitro and in vivo (낙지다리 식물 추출물의 알레르기 억제효과)

  • Jo, So young;Kim, Young Mi
    • Journal of Food Hygiene and Safety
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    • v.30 no.4
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    • pp.376-382
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    • 2015
  • Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF-${\alpha}$ and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.

An analysis of the Study Tendency after 2001 on Anti-allergic effect of Herbal Acupuncture (2001년 이후 약침(藥鍼)의 항(抗)알러지에 대한 연구 경향)

  • Lee, Woo-Youl;An, Sang-Woo;Oh, Min-Seok
    • Journal of Haehwa Medicine
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    • v.15 no.2
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    • pp.239-246
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    • 2006
  • Objective : To research the trend of studies about anti-allergic response on Herbal Acupuncture therapy by analysing domestic theses, published after 2001, about Herbal Acupuncture therapy. Methods : I reviewed and analyzed domestic theses, published after 2001, mentioning anti-allergic response of Herbal Acupuncture therapy. And these theses were classified by university, year, field of study, subject. Results : In theses focusing on anti-allergic effect, there were some cases trying to prove remedial value of operating herbal acupuncture on acupuncture points, and cases trying to prove its effect on immunity.

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Study on the Effects of Sopoongyangjetang on the Anti-allergic Effect, Analgesic Action and Anti-inflammatory Action. (消風痒除湯이 抗알레르기 및 鎭痛·消炎效果에 미치는 影響)

  • Kim, Su-Jeong;Kim, Jung-Ho;Chae, Byeong-Yun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.6 no.1
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    • pp.1-13
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    • 1993
  • Experimental studies were done to research the clinical effects of Sopoongyangjetang on the Anti-allergic effect, Analgesic action and Anti-inflammatory action. The results obtained as follows ; 1. In effect of Sopoongyangjetang on vascular permeability responses to intradermal serotonin, it had tendency to decrease, but was none significant effect. 2. In effect of Sopoongyangjetang on vascular permeability responses to intradermal histamine, it revealed significant effect. 3. In the homologous PCA provoked by the IgE-like antibody against white egg albumin, Sopoonyangjetang showed significant effect. 4. In the delayed type hypersensitivity responses to picryl chloride, Sopoongyangjetang was proved significant effect. 5. In the delayed type hypersensitivity responses to SRBC, Sopoongyangjetang revealed significant effect. 6. In analgesic action by acetic acid method, Sopoongyangjetang was recognized significantly. 7. In Anti-inflammatory action by carrageenine method, Sopoongyangjetang showed significant effect.

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The Inhibitory Effect of Agrimonia pilosa Ledeb Extract on Allergic Reaction (짚신나물 추출물의 알레르기 반응 억제 효과)

  • Kim, Young-Mi
    • Korean Journal of Medicinal Crop Science
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    • v.18 no.6
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    • pp.398-404
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    • 2010
  • Complementary and alternative medicines are considered as a promising research field to develop new therapies for various allergic diseases. In this study, we investigated the anti-allergic effect of Agrimonia pilosa Ledeb (AP) by using passive cutaneous anaphylaxis in mice and its mechanism of action in mast cells. The extract of AP reversibly inhibited degranulation in RBL-2H3 cells and bone marrow-derived mast cells (BMMCs). AP also suppressed the passive cutaneous anaphylaxis inducing by IgE and antigen (Ag) in a dose-dependent manner. In the study to find its mechanism of action, AP inhibited the phosphorylation of Syk kinase, a pivotal protein which is regulated by Src-family kinase for activation of mast cells. In addition, AP also suppressed activation of Akt and Erk1/2 that are critical for the production of cytokines in mast cells. The results strongly suggest that AP exerts anti-allergic activity in vitro and in vivo through the inhibition of activation of Syk in mast cells.

Study of the effects of Hyunggaeyeungyotang on the Anti-allergic effect in rats and mice (형개연교탕(刑芥連翹湯)의 항(抗)알레르기작용(作用)에 대(對)한 실험적(實驗的) 효과)

  • Yu, Tae-Seop;Jin, Yeong-Sang;Jeong, Gyu-Man
    • The Journal of Pediatrics of Korean Medicine
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    • v.4 no.1
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    • pp.19-30
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    • 1990
  • Experimental Studies were done to research the clinical effects of Hyunggaeyeugyotang on the Anti-allergic effect in mice and rats. The results obtained as follows; 1. In the effect of Hyunggaeyeungyotang on vascular permeability responses to intradermal histamine in rats, Hyunggaeyeugyotang revealed Significant effect. 2. In the effect of Hyunggaeyeungyotang on vascular permeability responses to intradermal serotonin in rats, Hyunggaeyeungyotang revealed significant effect. 3. In the 48hr homologous passive cutaneous anaphylaxis in rats provoked by the IgE-like antibody against egg albumin, Hyunggaeyeungyotang revealed significant effect. 4. In the effect of Hyunggaeyeungyotang on Delayed-type hypersensitivity responses to picryl chloride in mice, Hyunggaeyeungyotang revealed none of significant. 5. In the effect of Hyunggaeyeungyotang on Delayed-type hypersensitivity responses to SRBC in mice, Hyunggaeyeungyotang revealed none of significant. According to above-stated results, Hyunggaeyeungyotang is concluded to be effective as anti-allergic regimen and recommended to be used for treatment of allergic disease.

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