• The Journal of Korean Medical History
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• v.23 no.2
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• pp.37-41
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• 2010

There are two transcriptions of "ChiJongBang" in Korea at the moment. The first is the Jangseo-gak ibrary transcription(K3-380). The title is "ChiJongBang(治腫方)" and it starts with the contents of "ChiJongBang(治腫方)", followed by "HoeChunYoGyeol(回春要訣)", "NoInSeopYangBang(老人攝養方)", "SoABang(小兒方)". "ChiJongBang(治腫方)" does not even take up a large portion of the book. The other transcription is "ChiJongBang(治腫方)" in Geojil's "Uihui(宜彙)", which was presented into the worldin 1871(the 8th year of King Go-jong)by GeumRiSanIn(錦里山人). The contents of the two transcriptions are the same, and both are left by ImEonGuk. The latter part is identical to the contents of "ChimGuGyeongHeomBang". It was common fora medical book to have additional useful information attatched in the end, so it was thought that somebody added a part of "ChimGuGyeongHeomBang" at the end of "ChiJongBiBang". But the discovery of a woodcut "ChiJongBang" in Korean annotation confirmed that the making of this book was led by the government, and the fact that abscess was a big part of healthcare around the ImJinWaeRan(Japanese Invasion of Korea in 1592) period.

• The KIPS Transactions:PartB
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• v.11B no.4
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• pp.509-516
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• 2004

Semantic interpretation of image is incomplete without some mechanism for understanding semantic content that is not directly visible. For this reason, human assisted content-annotation through natural language is an attachment of textual description to image. However, keyword-based retrieval is in the level of syntactic pattern matching. In other words, dissimilarity computation among terms is usually done by using string matching not concept matching. In this paper, we propose a method for computerized semantic similarity calculation In WordNet space. We consider the edge, depth, link type and density as well as existence of common ancestors. Also, we have introduced method that applied similarity measurement on semantic image retrieval. To combine wi#h the low level features, we use the spatial color distribution model. When tested on a image set of Microsoft's 'Design Gallery Line', proposed method outperforms other approach.

• 한국어정보학회:학술대회논문집
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• 2017.10a
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• pp.309-313
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• 2017

개체명은 인명, 지명, 조직명 등 문서 내에서 중요한 의미를 가지므로 질의응답, 요약, 기계번역 분야에서 유용하게 사용되고 있다. 개체명 인식은 문서에서 개체명에 해당하는 단어를 찾아 개체명 범주를 부착하는 작업을 말한다. 개체명 인식 연구에는 개체명 범주가 부착된 개체명 말뭉치를 사용한다. 개체명의 범주는 연구 분야에 따라 다양하게 정의되므로 연구 분야에 적합한 개체명 말뭉치가 필요하다. 하지만 이런 말뭉치를 구축하는 일은 시간과 인력이 많이 필요하다. 따라서 본 논문에서는 개체명 사전 기반의 반자동 말뭉치 구축 도구를 제안한다. 제안하는 도구는 크게 전처리, 사용자 태깅, 후처리 단계로 나뉜다. 전처리 단계는 자동으로 개체명을 찾는 단계이다. 약 11만 개의 개체명을 기반으로 하여 트라이(trie) 구조의 개체명 사전을 구축한 후 사전을 이용하여 개체명을 자동으로 찾는다. 사용자 태깅 단계는 사용자가 수동으로 개체명을 태깅하는 단계이다. 전처리 단계에서 찾은 개체명 중 오류가 있는 개체명들은 수정하거나 삭제하고, 찾지 못한 개체명들은 사용자가 추가로 태깅하는 단계이다. 후처리 단계는 태깅한 결과로부터 사전 정보를 갱신하는 단계이다. 제안한 말뭉치 구축 도구를 이용하여 752개의 뉴스 기사에 대해 개체명을 태깅한 결과 7,620개의 개체명이 사전에 추가되었다. 제안한 도구를 사용한 결과 사용하지 않았을 때 비해 약 57.6% 정도 태깅 횟수가 감소했다.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7221-7227
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• 2013

Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.

• Journal of KIISE:Databases
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• v.35 no.2
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• pp.125-131
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• 2008

It is very useful to predict orthologs for new genome annotation and research on genome evolution. We showed that the previous work can be extended to construct OCs(Ortholog Clusters) automatically from multiple complete-genomes. The proposed method also has the quality of production of InParanoid, which produces orthologs from just two genomes. On the other hand, in order to predict more exactly the function of a newly sequenced gene it can be an important issue to prevent unwanted inclusion of paralogs into the OCs. We have, here, investigated how well it is possible to construct a functionally purer OCs with score cut-offs. Our OCs were generated from the datasets of 20 procaryotes. The similarity with both COG(Clusters of Orthologous Group) and KO(Kegg Orthology) against our OCs has about 90% and inclines to increase with the growth of score cut-offs.

• The KIPS Transactions:PartB
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• v.9B no.1
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• pp.105-112
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• 2002

In order to process video data effectively, we need to save its content on database and a content-based retrieval method which processes various queries of all users is required. In this paper, we present VRS(Video Retrieval System) which provides similarity query, SQBE(Scene Query By Example) query, and content-based retrieval by combining the feature-based retrieval and the annotation-based retrieval. The SQBE query makes it possible for a user to retrieve scones more exactly by inserting and deleting objects based on a retrieved scene. We proposed query language and query processing algorithm for SQBE query, and carried out performance evaluation on similarity retrieval. The proposed system is implemented with Visual C++ and Oracle.

• International Journal of Industrial Entomology and Biomaterials
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• v.17 no.2
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• pp.229-234
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• 2008

We used serial analysis of gene expression (SAGE) approach to derive a profile of expressed genes of the posterior silk glands (PSG) and to create a reference for understanding gene cluster related to the mechanism of silk protein synthesis in the silkworm, Bombyx mori. We constructed a 3' SAGE library from the PSG of the fifth instar larvae of the silkworm. In total we obtained 2,406 SAGE tags, of which 682 were unique tags. Sorted by tag count number, 27 (4%) unique tags were significantly more abundant genes (ten or more times), whereas 445 (65%) unique tags were detected as single copies. The annotation of 682 unique SAGE tags revealed that 462 (68%) of the SAGE tag sequences represented known genes, whereas 220 (32%) of the tag sequences had no matches in SAGE map and silkworm EST databases. Of the 682 SAGE tags, the most abundant tag sequences were that of the fibroin light chain gene and the silk protein P25. In addition, we compared two relative abundance results of the SAGE and the EST approaches to verify whether their transcript quantitative aspects are significant or not. The comparative results of relative abundances of the fibroin H-, L- chain and P25 glycoprotein genes indicated that the quantitative approach based on SAGE tags is effective for quantitative cataloging and comparison of expressed genes in same organs. The SAGE tag information reported in this study would be useful for researchers in the field to analyze genes associated with silk processing mechanisms of insects.

• Journal of Life Science
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• v.20 no.2
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• pp.176-182
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• 2010

Magnaporthe oryzae is destructive plant-pathogenic fungus and causes rice blast. The pathogen uses several mechanisms to circumvent the inhibitory actions of fungicides. ATP-binding cassette (ABC) transporters are known to provide protection against toxic compounds in the environment. PC facilitated bioinformatic analysis, particularly with respect to accessing and extracting database information and domain identification. We predicted ABC transporter genes from the M. oryzae genome sequence with computation and bioinformatics tools. A total of thirty three genes were predicted to encode ABC transporters. Three of thirty three putative genes corresponded to three known ABC transporter genes (ABC1, ABC2 and ABC3). Copy numbers of the ABC transporter genes were proven by Southern blot analysis, which revealed that twenty genes tested exist as a single copy. We amplified the DNA complementary to RNA corresponding to eleven of these by reverse transcriptase polymerase chain reaction.

• Journal of Digital Contents Society
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• v.9 no.4
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• pp.725-733
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• 2008

CDN(Content Delivery Network) has been used as contents transmission network for transmitting high capacity contents fastly and stably. Main goals of CDN are efficient distribution and management high capacity contents. Current CDN distributes contents by managing contents based on basic metadata created by contents provider. However, existing CDN management system doesn't provide a method for applying additional metadata in content itself that is necessary for efficient contents management and distribution. Since the existing system can not annotate additional information in metadata about contents itself, and can not search contents that user wants. This paper proposes a method for applying additional metadata in existing CDN and implemented it as contents metadata management system(CMMS). A user can search needed contents effectively via CMMS. Also, the searched result can help selecting and managing contents to distribute in CDN.

• Journal of Plant Biotechnology
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• v.47 no.3
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• pp.209-217
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• 2020

The presence of high amounts of seed storage proteins (SSPs) improves the overall quality of soybean seeds. However, these SSPs pose a major limitation due to their high abundance in soybean seeds. Although various technical advancements including mass-spectrometry and bioinformatics resources were reported, only limited information has been derived to date on soybean seeds at proteome level. Here, we applied a tandem mass tags (TMT)-based quantitative proteomic analysis to identify the significantly modulated proteins in the seeds of two soybean cultivars showing varying protein contents. This approach led to the identification of 5,678 proteins of which 13 and 1,133 proteins showed significant changes in Daewon (low-protein content cultivar) and Saedanbaek (high-protein content cultivar) respectively. Functional annotation revealed that proteins with increased abundance in Saedanbaek were mainly associated with the amino acid and protein metabolism involved in protein synthesis, folding, targeting, and degradation. Taken together, the results presented here provide a pipeline for soybean seed proteome analysis and contribute a better understanding of proteomic changes that may lead to alteration in the protein contents in soybean seeds.