• 대한관절경학회:학술대회논문집
• /
• 2009.10a
• /
• pp.41-41
• /
• 2009

• 대한관절경학회:학술대회논문집
• /
• 2009.10a
• /
• pp.42-43
• /
• 2009

• The Korean Journal of Physiology and Pharmacology
• /
• v.17 no.1
• /
• pp.9-13
• /
• 2013

The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.

• Proceedings of the IEEK Conference
• /
• 2005.11a
• /
• pp.703-706
• /
• 2005

본 논문에서는 스테레오 비전 알고리즘을 ARM9 프로세서를 사용하는 SoC의 IP 개념으로 구현하였다. 구현하고자 하는 스테레오 비전 시스템을 기능에 따라서 하드웨어와 소프트웨어 모듈로 나누어서 성능을 최대화할 수 있도록 설계하였다. SAD correlator는 한 쌍의 이미지에 많은 계산을 필요로 하기 때문에 성능을 우선시하여 하드웨어로 구성하였고, 소프트웨어는 프로세서를 초기화 시키고, 인터럽트 처리와 SAD correlator, TFT-LCD controller, 메모리 등의 하드웨어를 제어하는 역할을 하는 firmware로 구성을 하였다. 메모리에 기저장된 영상정보를 스테레오 비전 알고리즘을 이용한 결과를 외부 TFT-LCD 모듈에서 필요로 하는 포맷에 맞게 변환시켜서 depth map을 출력하는 시스템을 ARM922T 프로세서가 내장된 Altera Excalibur를 target으로 설계하여 테스트 보드에서 정상적으로 동작하는 것을 확인하였다.

• Proceedings of the KIEE Conference
• /
• 1995.07b
• /
• pp.751-753
• /
• 1995

Practical controllers of industrial systems are usually designed and realized in continuous time domain. However, due to the programmable and flexible nature of digital computers and the speed and stability superioity of digital components over analog ones, it seems more effective to adapt digital controllers. When an existing analog controller performs satisfactory, it is often advantageous to use the digital redesign techinque to obtain an equlivalent digital controller which substitutes the analog one. One method of the digital redesign is to use a periodic gain. This method gives a riffle effect on the steady state response, although it's transient response is satisfactory. This paper suggests a method which eliminates or deminishes periodic ripples generated by the periodic function.

• Medical Lasers
• /
• v.9 no.1
• /
• pp.76-78
• /
• 2020

Verruca plana is a cutaneous infection caused by the human papilloma virus. Although various treatment methods are currently available, most have limitations due to the risk of complications such as hyperpigmentation, edema, and scarring. Moreover, as the infection tends to spread easily, new verrucae can potentially develop, and treatment procedure times tend to be lengthy. Thus, novel treatment methods are required. The 2790-nm wavelength erbium:yttrium-scandium-gallium-garnet (Er:YSGG) laser is a superficial resurfacing laser. Here, we present a case of a 25-year-old woman with multiple verrucae treated using a 2790-nm Er:YSGG laser. Compared to traditional methods, this novel laser is convenient, produces better cosmetic outcomes, and is less time-consuming; it is therefore suitable for the treatment of facial verruca plana.

• Biomolecules & Therapeutics
• /
• v.17 no.1
• /
• pp.57-61
• /
• 2009

This study examined whether or not a pretreatment with dehydroepiandrosterone (DHEA) has an effect on indomethacin-induced gastric mucosal damage. The DHEA group, male Sprague-Dawley rats, was administrated with DHEA orally at a dose of 4 mg/day for one week before inducing gastritis with indomethacin (50 mg/kg, p.o.). Histological assay, lipid peroxidation assay, superoxide dismutase (SOD), glutathione peroxidase (GPx) and Catalase activities were determined. Interestingly, it was found that the DHEA pretreatment attenuated the gastric lesion area induced by indomethacin. Rather, the pretreatment with high dose of DHEA led to submucosal edema, leukocyte infiltration in submucosa and mucosal necrosis. The levels of MDA in the DHEA pretreatment were also higher than those in the rats given with vehicle pretreatment. This suggests that the DHEA pretreatment deteriorates severe inflammation in indomethacin-induced gastritis. DHEA supplementation significantly increased SOD activity in the gastric mucosa. However, the catalase and GPx activities were not altered by DHEA. The co-administration of DHEA with an indomethacin might not offer a protective effect against the acute gastritis induced by indomethacin.

• Molecules and Cells
• /
• v.41 no.10
• /
• pp.923-932
• /
• 2018

Ethylene regulates numerous aspects of plant growth and development. Multiple external and internal factors coordinate ethylene production in plant tissues. Transcriptional and post-translational regulations of ACC synthases (ACSs), which are key enzymes mediating a rate-limiting step in ethylene biosynthesis have been well characterized. However, the regulation and physiological roles of ACC oxidases (ACOs) that catalyze the final step of ethylene biosynthesis are largely unknown in Arabidopsis. Here, we show that Arabidopsis ACO1 exhibits a tissue-specific expression pattern that is regulated by multiple signals, and plays roles in the lateral root development in Arabidopsis. Histochemical analysis of the ACO1 promoter indicated that ACO1 expression was largely modulated by light and plant hormones in a tissue-specific manner. We demonstrated that point mutations in two E-box motifs on the ACO1 promoter reduce the light-regulated expression patterns of ACO1. The aco1-1 mutant showed reduced ethylene production in root tips compared to wild-type. In addition, aco1-1 displayed altered lateral root formation. Our results suggest that Arabidopsis ACO1 integrates various signals into the ethylene biosynthesis that is required for ACO1's intrinsic roles in root physiology.

• Journal of Microbiology and Biotechnology
• /
• v.26 no.4
• /
• pp.666-674
• /
• 2016

The bacterial strains were screened as potential starters for fermenting low-salt doenjang (a Korean traditional fermented soybean paste) using Korean doenjang based on proteolytic and antipathogenic activities under 6.5-7.5% NaCl conditions. Phylogenetic analysis based on 16S rRNA gene sequences showed that they all belonged to the genus Bacillus. Proteolytic and antipathogenic activities against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, and Aspergillus flavus, as well as fibrinolytic, amylase, and cellulase activities of the 10 strains were quantitatively evaluated. Of these, strains D2-2, JJ-D34, and D12-5 were selected, based on their activities. The functional, phenotypic, and safety-related characteristics of these three strains were additionally investigated and strains D2-2 and D12-5, which lacked antibiotic resistance, were finally selected. Strains D2-2 and D12-5 produced poly-γ-glutamic acid and showed various enzyme activities, including α-glucosidase and β-glucosidase. Growth properties of strains D2-2 and D12-5 included wide temperature and pH ranges, growth in up to 16% NaCl, and weak anaerobic growth, suggesting that they facilitate low-salt doenjang fermentation. Strains D2-2 and D12-5 were not hemolytic, carried no toxin genes, and did not produce biogenic amines. These results suggest that strains D2-2 and D12-5 can serve as appropriate starter cultures for fermenting low-salt doenjang with high quality and safety.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.3
• /
• pp.205-209
• /
• 2012

The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin oxidation and anti-oxidative effect of genistein formulations were evaluated by determining levels of hydrogen peroxide. The mechanism involved in the determination of hydrogen peroxide is based on a color reaction between ferric ion ($Fe^{3+}$) and xylenol orange, often called FOX assay and subsequent monitoring of absorbance values of the reactant at 540 nm. The reaction was to some extent pH-dependent and detection sensitivity was greatest at pH 1.75. Genistein liposomal gel demonstrated better anti-oxidative effect with regard to lowering hydrogen peroxide levels elevated by UVB irradiation compared to genistein-suspended gel. A linear relationship has been observed between anti-oxidative effect of genistein and drug deposition in the skin tissue. Genistein liposomal gel resulting in the localization of the drug in the deeper skin led to improved anti-oxidative effect compared to genistein gel. The suggested method for evaluation of oxidation of the skin can be used as a tool to screen effective anti-oxidative agents and their delivery systems acting on the skin.