• Toxicological Research
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• v.23 no.2
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• pp.97-105
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• 2007

Toll-like receptors (TLRs) playa crucial role in initiating and regulating innate and adaptive immune responses by detecting invading microbial pathogens. TLRs can also respond to non-microbial molecules derived from damaged tissue. Accumulating evidence suggests that deregulation of TLRs results in the dysfunction of immune system and ultimately increases the risk of many immune and inflammatory diseases including infectious diseases, allergy, and autoimmune diseases. Therefore, understanding how the immune system is controlled by TLRs will provide new insight to find the way to prevent or treat infectious diseases and immune disorders.

• Toxicological Research
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• v.35 no.3
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• pp.209-214
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• 2019

Cancer is the leading cause of mortality worldwide. In cancer progression, sex hormones and their receptors are thought to be major factors. Many studies have reported the effects of estrogen and estrogen receptors (ERs) in cancer development and progression. Among them, G protein-coupled estrogen receptor (GPER), a G protein-coupled receptor, has been identified as an estrogen membrane receptor unrelated to nuclear ER. The mechanism of GPER, including its biological action, function, and role, has been studied in various cancer types. In this review, we discuss the relation between GPER and estrogen or estrogen agonists/antagonists and cancer progression.

• Journal of Microbiology
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• v.43 no.4
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• pp.366-369
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• 2005

Avian influenza viruses playa crucial role i,n the creation of human pandemic viruses. In this study, we have demonstrated that both human and avian influenza receptors exist in cells in the respiratory and intestinal tracts of chickens. We have also determined that primarily cultured chicken lung cells can support the replication of both avian and human influenza viruses.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.186.2-186.2
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• 2003

PPARs (peroxisome proliferator activated receptors) are member of nuclear hormone receptors superfamily. Activations of PPARs upon binding with ligands modulate glucose metabolite, differentiation of adipocyte, inflammation response, and so on. Thiazolidinedione analog is one of the potential antidiabetic drug that binds and activates PPAR selectively and enhances insulin sensitivity. In an effort to develop novel and effective antidiabetic thiazolidindione analogs, we have synthesized tetrahydroquinoline and para-substituted benzene-linked thiazolidinedione analogs by coupling reaction of the hydrophobic segments with hydroxybenzylthiazolidinedione.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.183-185
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• 2002

The discovery of new ligands with affinity and selectivity for the dopamine $D_2$ receptor subtypes is an important area in medicinal chemistry. The distribution of the $D_2$ receptors in the limbic areas of brain suggests that these receptors may be particularly an attractive target for the design of potential selective antipsychotic drugs without causing extrapyramidal side effects. (omitted)

• Vacuum Magazine
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• v.5 no.1
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• pp.9-12
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• 2018

Electronic nose has been developed for detection of various hazardous molecules, especially vapor organic compounds (VOCs), by adsorption and desorption phenomenon. However, although conventional electronic noses have provided many advantages such as simple detection and high sensitivity, they still need advanced technologies for selective specificity in real samples. In this review, we provide bionanoelectronic noses with natural receptors for selective odorant detection. This review includes from fabrication of natural receptors and conducting nanomaterials to bioelectronic noses. We also discussed their perspective applications for the future at the conclusion.

• Applied Biological Chemistry
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• v.20 no.1
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• pp.10-25
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• 1977

The photobiological receptors of phototactic, phototropic, and photomorphogenic responses of various organisms have been described in terms of spectroscopic, photophysical and photochemical properties which may be relevant in elucidating the energy transduct ion mechanism(s) in photobiology. The photoreceptors discussed include carotenoids, flavins, stentorin and phytochrome. Although the molecular modes of their photobiological action still remain largely unexplained, it is possible to suggest several primary molecul ar processes of the photoreceptors in eliciting responses of various organisms to light.

• Bulletin of the Korean Chemical Society
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• v.28 no.9
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• pp.1531-1534
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• 2007

Anion receptor based on 2-imidazolidone molecular scaffold has been synthesized. Anion binding studies carried out using 1H NMR and UV?vis spectroscopy revealed that this receptor 6 displays selectivity for the for the oxyanions such as acetate and dihydrogenphosphate ions and the affinity for the anions simply reflects the basicity of anions.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.275.1-275.1
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• 2002

It has been proposed that G protein interacts with receptor via multiple interaction sites. With regard to this, C-terminus of the G${\alpha}$ subunit is clearly not the only structural determinant on the G proteins that is critical for receptor coupling selectivity, but the extreme N-terminus of Ga subunit and other structural elements were proposed to be responsible for dictating the interaction with receptors. (omitted)

• Bulletin of the Korean Chemical Society
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• v.32 no.spc8
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• pp.3101-3104
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• 2011