| 1 |
Petrie, W.K., Dennis, M.K., Hu, C., Dai, D., Arterburn, J.B., Smith, H.O., Hathaway, H.J. and Prossnitz, E.R. (2013) G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet. Gynecol. Int., 2013, 472720.
|
| 2 |
Zhang, L., Li, Y., Lan, L., Liu, R., Wu, Y., Qu, Q. and Wen, K. (2016) Tamoxifen has a proliferative effect in endometrial carcinoma mediated via the GPER/EGFR/ERK/cyclin D1 pathway: a retrospective study and an in vitro study. Mol. Cell. Endocrinol., 437, 51-61.
DOI
|
| 3 |
Williams, G. (2012) Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-alpha and GPER signalling. Mol. Cell. Endocrinol., 351, 269-278.
DOI
|
| 4 |
Thomas, P., Pang, Y., Filardo, E.J. and Dong, J. (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology, 146, 624-632.
DOI
|
| 5 |
Klaassen, C.D., Watkins, J.B. and Casarett, L.J. (2010) Casarett & Doull's Essentials of Toxicology (2nd edition), McGraw-Hill Medical, New York.
|
| 6 |
Jala, V.R., Radde, B.N., Haribabu, B. and Klinge, C.M. (2012) Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer. BMC Cancer, 12, 624.
DOI
|
| 7 |
Zhang, H., Wang, X., Chen, Z. and Wang, W. (2015) MicroRNA-424 suppresses estradiol-induced cell proliferation via targeting GPER in endometrial cancer cells. Cell. Mol. Biol., 61, 96-101.
|
| 8 |
Lu, Z., Nian, Z., Jingjing, Z., Tao, L. and Quan, L. (2017) MicroRNA-424/E2F6 feedback loop modulates cell invasion, migration and EMT in endometrial carcinoma. Oncotarget, 8, 114281-114291.
DOI
|
| 9 |
Krakstad, C., Trovik, J., Wik, E., Engelsen, I.B., Werner, H.M., Birkeland, E., Raeder, M.B., Oyan, A.M., Stefansson, I.M., Kalland, K.H., Akslen, L.A. and Salvesen, H.B. (2012) Loss of GPER identifies new targets for therapy among a subgroup of ERalpha-positive endometrial cancer patients with poor outcome. Br. J. Cancer, 106, 1682-1688.
DOI
|
| 10 |
Zhang, K.S., Chen, H.Q., Chen, Y.S., Qiu, K.F., Zheng, X.B., Li, G.C., Yang, H.D. and Wen, C.J. (2014) Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER/EGFR/ERK1/2 signal pathway. Biomed. Pharmacother., 68, 1037-1043.
DOI
|
| 11 |
Hadjimarkou, M.M. and Vasudevan, N. (2018) GPER1/GPR30 in the brain: crosstalk with classical estrogen receptors and implications for behavior. J. Steroid Biochem. Mol. Biol., 176, 57-64.
DOI
|
| 12 |
O'Dowd, B.F., Nguyen, T., Marchese, A., Cheng, R., Lynch, K.R., Heng, H.H., Kolakowski, L.F., Jr. and George, S.R. (1998) Discovery of three novel G-protein-coupled receptor genes. Genomics, 47, 310-313.
DOI
|
| 13 |
Prossnitz, E.R. and Hathaway, H.J. (2015) What have we learned about GPER function in physiology and disease from knockout mice? J. Steroid Biochem. Mol. Biol., 153, 114-126.
DOI
|
| 14 |
Lu, C.L. and Herndon, C. (2017) New roles for neuronal estrogen receptors. Neurogastroenterol. Motil., 29, doi:10.1111/nmo.13121 [Epub ahead of print].
DOI
|
| 15 |
Olde, B. and Leeb-Lundberg, L.M. (2009) GPR30/GPER1: searching for a role in estrogen physiology. Trends Endocrinol. Metab., 20, 409-416.
DOI
|
| 16 |
Meyer, M.R., Prossnitz, E.R. and Barton, M. (2011) GPER/GPR30 and regulation of vascular tone and blood pressure. Immunol. Endocr. Metab. Agents Med. Chem., 11, 255-261.
DOI
|
| 17 |
Meyer, M.R., Prossnitz, E.R. and Barton, M. (2011) The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function. Vascul. Pharmacol., 55, 17-25.
DOI
|
| 18 |
Zhu, G., Huang, Y., Wu, C., Wei, D. and Shi, Y. (2016) Activation of G-protein-coupled estrogen receptor inhibits the migration of human nonsmall cell lung cancer cells via IKK-beta/NF-kappaB signals. DNA Cell Biol., 35, 434-442.
DOI
|
| 19 |
Hsu, L.H., Chu, N.M. and Kao, S.H. (2017) Estrogen, estrogen receptor and lung cancer. Int. J. Mol. Sci., 18, E1713.
DOI
|
| 20 |
Jacenik, D., Cygankiewicz, A.I. and Krajewska, W.M. (2016) The G protein-coupled estrogen receptor as a modulator of neoplastic transformation. Mol. Cell. Endocrinol., 429, 10-18.
DOI
|
| 21 |
Santolla, M.F., Lappano, R., De Marco, P., Pupo, M., Vivacqua, A., Sisci, D., Abonante, S., Iacopetta, D., Cappello, A.R., Dolce, V. and Maggiolini, M. (2012) G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17beta-estradiol in cancer cells and cancer-associated fibroblasts. J. Biol. Chem., 287, 43234-43245.
DOI
|
| 22 |
Ohlsson, C. and Vandenput, L. (2009) The role of estrogens for male bone health. Eur. J. Endocrinol., 160, 883-889.
DOI
|
| 23 |
Sharma, G. and Prossnitz, E.R. (2011) Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells. Endocrinology, 152, 3030-3039.
DOI
|
| 24 |
Avino, S., De Marco, P., Cirillo, F., Santolla, M.F., De Francesco, E.M., Perri, M.G., Rigiracciolo, D., Dolce, V., Belfiore, A., Maggiolini, M., Lappano, R. and Vivacqua, A. (2016) Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells. Oncotarget, 7, 52710-52728.
DOI
|
| 25 |
Liu, Q., Chen, Z., Jiang, G., Zhou, Y., Yang, X., Huang, H., Liu, H., Du, J. and Wang, H. (2017) Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer. Mol. Cancer, 16, 87.
DOI
|
| 26 |
Gilligan, L.C., Gondal, A., Tang, V., Hussain, M.T., Arvaniti, A., Hewitt, A.M. and Foster, P.A. (2017) Estrone sulfate transport and steroid sulfatase activity in colorectal cancer: implications for hormone replacement therapy. Front. Pharmacol., 8, 103.
|
| 27 |
Sharma, G. and Prossnitz, E.R. (2017) G-protein-coupled estrogen receptor (GPER) and sex-specific metabolic homeostasis. Adv. Exp. Med. Biol., 1043, 427-453.
DOI
|
| 28 |
Filardo, E.J. and Thomas, P. (2012) Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology. Endocrinology, 153, 2953-2962.
DOI
|
| 29 |
Prossnitz, E.R. and Barton, M. (2014) Estrogen biology: new insights into GPER function and clinical opportunities. Mol. Cell. Endocrinol., 389, 71-83.
DOI
|
| 30 |
Prossnitz, E.R. and Barton, M. (2011) The G-protein-coupled estrogen receptor GPER in health and disease. Nat. Rev. Endocrinol., 7, 715-726.
DOI
|
| 31 |
Sharma, G., Mauvais-Jarvis, F. and Prossnitz, E.R. (2018) Roles of G protein-coupled estrogen receptor GPER in metabolic regulation. J. Steroid Biochem. Mol. Biol., 176, 31-37.
DOI
|
| 32 |
Liu, C., Liao, Y., Fan, S., Fu, X., Xiong, J., Zhou, S., Zou, M. and Wang, J. (2017) G-protein-coupled estrogen receptor antagonist G15 decreases estrogen-induced development of non-small cell lung cancer. Oncol. Res. doi: 10.3727/096504017X15035795904677 [Epub ahead of print].
DOI
|
| 33 |
Meng, R., Qin, Q., Xiong, Y., Wang, Y., Zheng, J., Zhao, Y., Tao, T., Wang, Q., Liu, H., Wang, S., Jiang, W.G. and He, J. (2016) NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer. Oncotarget, 7, 54983-54997.
DOI
|
| 34 |
Prossnitz, E.R. and Barton, M. (2009) Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER. Prostaglandins Other Lipid Mediat., 89, 89-97.
DOI
|
| 35 |
Bustos, V., Nolan, A.M., Nijhuis, A., Harvey, H., Parker, A., Poulsom, R., McBryan, J., Thomas, W., Silver, A. and Harvey, B.J. (2017) GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget, 8, 84258-84275.
DOI
|
| 36 |
Chimento, A., Sirianni, R., Casaburi, I., Zolea, F., Rizza, P., Avena, P., Malivindi, R., De Luca, A., Campana, C., Martire, E., Domanico, F., Fallo, F., Carpinelli, G., Cerquetti, L., Amendola, D., Stigliano, A. and Pezzi, V. (2015) GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo. Oncotarget, 6, 19190-19203.
DOI
|
| 37 |
Girgert, R., Emons, G. and Grundker, C. (2012) Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy. Breast Cancer Res. Treat., 134, 199-205.
DOI
|
| 38 |
Chan, Q.K., Lam, H.M., Ng, C.F., Lee, A.Y., Chan, E.S., Ng, H.K., Ho, S.M. and Lau, K.M. (2010) Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. Cell Death Differ., 17, 1511-1523.
DOI
|
| 39 |
Pisolato, R., Lombardi, A.P., Vicente, C.M., Lucas, T.F., Lazari, M.F. and Porto, C.S. (2016) Expression and regulation of the estrogen receptors in PC-3 human prostate cancer cells. Steroids, 107, 74-86.
DOI
|
| 40 |
Lau, K.M. and To, K.F. (2016) Importance of estrogenic signaling and its mediated receptors in prostate cancer. Int. J. Mol. Sci., 17, E1434.
DOI
|
| 41 |
Prossnitz, E.R., Arterburn, J.B., Smith, H.O., Oprea, T.I., Sklar, L.A. and Hathaway, H.J. (2008) Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu. Rev. Physiol., 70, 165-190.
DOI
|
| 42 |
Ariazi, E.A., Brailoiu, E., Yerrum, S., Shupp, H.A., Slifker, M.J., Cunliffe, H.E., Black, M.A., Donato, A.L., Arterburn, J.B., Oprea, T.I., Prossnitz, E.R., Dun, N.J. and Jordan, V.C. (2010) The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res., 70, 1184-1194.
DOI
|
| 43 |
Gu, Y., Chen, T., Lopez, E., Wu, W., Wang, X., Cao, J. and Teng, L. (2014) The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors. J. Transl. Med., 12, 16.
DOI
|
| 44 |
Carmeci, C., Thompson, D.A., Ring, H.Z., Francke, U. and Weigel, R.J. (1997) Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics, 45, 607-617.
DOI
|
| 45 |
Vivacqua, A., De Marco, P., Santolla, M.F., Cirillo, F., Pellegrino, M., Panno, M.L., Abonante, S. and Maggiolini, M. (2015) Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs). Oncotarget, 6, 16573-16587.
DOI
|
| 46 |
Yu, T., Liu, M., Luo, H., Wu, C., Tang, X., Tang, S., Hu, P., Yan, Y., Wang, Z. and Tu, G. (2014) GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17beta-estradiol in triple-negative breast cancer cells. J. Steroid Biochem. Mol. Biol., 143, 392-403.
DOI
|
| 47 |
Marjon, N.A., Hu, C., Hathaway, H.J. and Prossnitz, E.R. (2014) G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol. Cancer Res., 12, 1644-1654.
DOI
|
| 48 |
Grundker, C. and Emons, G. (2017) The role of gonadotropin-releasing hormone in cancer cell proliferation and metastasis. Front. Endocrinol. (Lausanne), 8, 187.
DOI
|
| 49 |
Georgescu, M.M., Morales, F.C., Molina, J.R. and Hayashi, Y. (2008) Roles of NHERF1/EBP50 in cancer. Curr. Mol. Med., 8, 459-468.
DOI
|
| 50 |
Wang, Y., Peng, Z., Meng, R., Tao, T., Wang, Q., Zhao, C., Liu, H., Song, R., Zheng, J., Qin, Q. and He, J. (2017) NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling. Oncol. Rep., 38, 221-228.
DOI
|
| 51 |
Girgert, R., Emons, G. and Grundker, C. (2014) Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17beta-estradiol. BMC Cancer, 14, 935.
DOI
|
| 52 |
Girgert, R., Emons, G. and Grundker, C. (2017) 17beta-estradiol-induced growth of triple-negative breast cancer cells is prevented by the reduction of GPER expression after treatment with gefitinib. Oncol. Rep., 37, 1212-1218.
DOI
|
| 53 |
Girgert, R., Emons, G. and Grundker, C. (2018) Inhibition of growth hormone receptor by Somavert reduces expression of GPER and prevents growth stimulation of triple-negative breast cancer by 17beta-estradiol. Oncol. Lett., 15, 9559-9566.
|
| 54 |
Smith, H.O., Arias-Pulido, H., Kuo, D.Y., Howard, T., Qualls, C.R., Lee, S.J., Verschraegen, C.F., Hathaway, H.J., Joste, N.E. and Prossnitz, E.R. (2009) GPR30 predicts poor survival for ovarian cancer. Gynecologic Oncology, 114, 465-471.
DOI
|
| 55 |
Lau, K.M., Ma, F.M., Xia, J.T., Chan, Q.K.Y., Ng, C.F. and To, K.F. (2017) Activation of GPR30 stimulates GTP-binding of Galphai1 protein to sustain activation of Erk1/2 in inhibition of prostate cancer cell growth and modulates metastatic properties. Exp. Cell Res., 350, 199-209.
DOI
|
| 56 |
Cirillo, F., Pellegrino, M., Malivindi, R., Rago, V., Avino, S., Muto, L., Dolce, V., Vivacqua, A., Rigiracciolo, D.C., De Marco, P., Sebastiani, A., Abonante, S., Nakajima, M., Lappano, R. and Maggiolini, M. (2017) GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer. Oncotarget, 8, 106608-106624.
DOI
|
| 57 |
Lappano, R. and Maggiolini, M. (2018) GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs). J. Steroid Biochem. Mol. Biol., 176, 49-56.
DOI
|
| 58 |
Rodriguez, C., Patel, A.V., Calle, E.E., Jacob, E.J. and Thun, M.J. (2001) Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women. JAMA, 285, 1460-1465.
DOI
|
| 59 |
Zhu, C.X., Xiong, W., Wang, M.L., Yang, J., Shi, H.J., Chen, H.Q. and Niu, G. (2018) Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer. J. Int. Med. Res., 46, 723-731.
DOI
|
| 60 |
Liu, H., Yan, Y., Wen, H., Jiang, X., Cao, X., Zhang, G. and Liu, G. (2014) A novel estrogen receptor GPER mediates proliferation induced by 17beta-estradiol and selective GPER agonist G-1 in estrogen receptor alpha (ERalpha)-negative ovarian cancer cells. Cell Biol. Int., 38, 631-638.
DOI
|
| 61 |
Yan, Y., Liu, H., Wen, H., Jiang, X., Cao, X., Zhang, G. and Liu, G. (2013) The novel estrogen receptor GPER regulates the migration and invasion of ovarian cancer cells. Mol. Cell. Biochem., 378, 1-7.
DOI
|
| 62 |
Ignatov, T., Modl, S., Thulig, M., Weissenborn, C., Treeck, O., Ortmann, O., Zenclussen, A., Costa, S.D., Kalinski, T. and Ignatov, A. (2013) GPER-1 acts as a tumor suppressor in ovarian cancer. J. Ovarian Res., 6, 51.
DOI
|
| 63 |
Yan, Y., Jiang, X., Zhao, Y., Wen, H. and Liu, G. (2015) Role of GPER on proliferation, migration and invasion in ligand-independent manner in human ovarian cancer cell line SKOV3. Cell Biochem. Funct., 33, 552-559.
DOI
|
| 64 |
Heublein, S., Mayr, D., Vrekoussis, T., Friese, K., Hofmann, S.S., Jeschke, U. and Lenhard, M. (2013) The G-protein coupled estrogen receptor (GPER/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients. PLoS ONE, 8, e71791.
DOI
|
| 65 |
Zhang, Q., Madden, N.E., Wong, A.S.T., Chow, B.K.C. and Lee, L.T.O. (2017) The role of endocrine G protein-coupled receptors in ovarian cancer progression. Front. Endocrinol. (Lausanne), 8, 66.
|
| 66 |
Skrzypczak, M., Schuler, S., Lattrich, C., Ignatov, A., Ortmann, O. and Treeck, O. (2013) G protein-coupled estrogen receptor (GPER) expression in endometrial adenocarcinoma and effect of agonist G-1 on growth of endometrial adenocarcinoma cell lines. Steroids, 78, 1087-1091.
DOI
|
| 67 |
Smith, H.O., Leslie, K.K., Singh, M., Qualls, C.R., Revankar, C.M., Joste, N.E. and Prossnitz, E.R. (2007) GPR30: a novel indicator of poor survival for endometrial carcinoma. Am. J. Obstet. Gynecol., 196, 386.e1-386.e11.
DOI
|
| 68 |
Jia, B., Gao, Y., Li, M., Shi, J., Peng, Y., Du, X., Klocker, H., Sampson, N., Shen, Y., Liu, M. and Zhang, J. (2016) GPR30 Promotes prostate stromal cell activation via suppression of ERalpha expression and its downstream signaling pathway. Endocrinology, 157, 3023-3035.
DOI
|
| 69 |
Lam, H.M., Ouyang, B., Chen, J., Ying, J., Wang, J., Wu, C.L., Jia, L., Medvedovic, M., Vessella, R.L. and Ho, S.M. (2014) Targeting GPR30 with G-1: a new therapeutic target for castration-resistant prostate cancer. Endocr. Relat. Cancer, 21, 903-914.
DOI
|
webmaster
