• The Journal of Internal Korean Medicine
• /
• v.38 no.6
• /
• pp.1000-1006
• /
• 2017

Objectives: Head symptoms, such as headache and dizziness, are commonly presented in clinical practice. Although Donguibogam, the representative book of Korean medicine, contains many prescriptions for head symptoms, they are difficult to learn and apply because of the vast numbers. The aim of this study was to simplify and visualize the vast contents of Donguibogam by network analysis. Methods: 127 prescriptions for head symptoms, found in Donguibogam, were entered into a Microsoft office Excel 2013 file. This was used as a database for network analysis using the NetMiner 4 program. Results: Through network analysis, six networks for prescriptions for head symptoms in Donguibogam were established. The first network is similar to the herb composition of Cheongsangsahwa-tang (prescriptions for hwa-yeol syndrome). The second network is similar to the herb composition of Yanghyulgupung-tang (prescriptions for hyul-heo syndrome). The third network is similar to the herb composition of Sangcheongbaekbuja-hwan (prescriptions for dam-eum syndrome). The fourth network is similar to the herb composition of Heukseok-dan (prescriptions for yang-heo syndrome). The fifth network is similar to the herb composition of Boheo-eum (prescriptions for chil-jeong syndrome). The sixth network is similar to the herb composition of Bangpungtongseong-san (prescriptions for hwa-yeol syndrome). Conclusions: The results of the network analysis of 127 prescriptions for head symptoms in Donguibogam suggest that there are five major causes of head symptoms (hwa-yeol, hyul-heo, dam-eum, yang-heo, and chil-jeong), and that it is possible to prescribe Cheongsangsahwa-tang, Bangpungtongseong-san, Yanghyulgupung-tang, Sangcheongbaekbuja-hwan, Heukseok-dan, or Boheo-eum depending on the major causes.

• The Journal of Internal Korean Medicine
• /
• v.42 no.4
• /
• pp.628-644
• /
• 2021

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

• Journal of Sasang Constitutional Medicine
• /
• v.35 no.4
• /
• pp.10-22
• /
• 2023

Objectives The aim of this study is to explore the mechanism of action and target diseases of Sasang constitutional prescriptions using a multiscale interactome approach. Methods The compound and target information of Sasang constitutional prescriptions were retrieved from various databases such as the TM-MC, STITCH, and TTD. Key targets for Sasang constitutional prescriptions were identified by selecting the top 100 targets based on the number of simple paths within the constructed network. Diffusion profiles for Sasang constitutional prescriptions and diseases were calculated based on a biased random walk algorithm. Potential diseases and key mechanisms of Sasang constitutional prescriptions were identified by analyzing diffusion profiles. Results We identified 144 Sasang constitutional prescriptions and their targets, finding 80 herbs with effective biological targets. A cluster analysis based on selecting up to 100 key targets for each prescription revealed a more cohesive grouping of prescriptions according to Sasang constitution. We then predicted potential diseases for 62 Sasang constitutional prescriptions using diffusion profiles calculated on a multiscale interactome. Finally, our analysis of diffusion profiles revealed key targets and biological functions of prescriptions in obesity and diabetes. Conclusions This study demonstrates the effectiveness of a multiscale interactome approach in elucidating the complex mechanisms and potential therapeutic applications of prescriptions in Sasang constitutional medicine.

• Herbal Formula Science
• /
• v.20 no.1
• /
• pp.101-121
• /
• 2012

Objectives : As the understand about historical consumptive part through studying prescriptions in DonguiBogam, we would like to study some modern geriatric and chronic diseases. Methods : We analyzed application frequency of basic prescriptions, symptoms of prescriptions and the pathology analysis against historical comsumptive in DonguiBogam. Results : Through investigation into application frequency of basic prescriptions, symptoms of prescriptions, and two way analysis of Qi blood(yin yang) pathologies and viscera and bowels pathologies, we were able to found mostly used basic prescription, common symptoms, and separate some characteristics pathologies. Conclusions : We expected that this study will can help to give rationale for future study of consumptive caring.

• Journal of Korean Medical classics
• /
• v.34 no.4
• /
• pp.65-78
• /
• 2021

Objectives : This study aims to provide a methodology for effectively searching similar applications of formulas by comparing applications of pre-existing prescriptions and those applied clinically based on the difference in weight ratio of each medicinal. Methods : The clinical application part was substituted by prescriptions from the Donguibogam. Samples of pre-existing prescriptions were taken from the Bangyakhappyeon. The component ratio of Donguibogam prescriptions(Y) and Bangyakhappyeon prescriptions(X1, X2) were calculated and expressed as Y = a×X1 +b×X2 + α. (a,b: numbers, α: the rest) Results : 1. In order to express the component ratio based on arbitrary prescriptions as standard prescription, a system that incorporates a storage sector for pre-existing prescription data, an input sector for arbitrary prescription data, an analysis sector that compares the two, and an output sector that generates analysis results is required. 2. The current study shows that the suggested analysis method allows for two standard prescriptions to an arbitrary prescription. Therefore, it is possible to analyze prescriptions that are combinations of two standard prescriptions. 3. Based on arbitrary prescription(Y) and pre-existing prescription(X1, X2), the combinations could be expressed as Y= a×X1 + b×X2 + α. Through finding the most simple combination, it is possible to search the most similar application to each arbitrary prescription.

• Herbal Formula Science
• /
• v.25 no.2
• /
• pp.303-324
• /
• 2017

Objectives : Consumptive is an unhealthy condition that are caused by lack of blood and essence, and that means also some stages of chronic diseases. The purpose of this study is to analysis 108 Prescriptions of Consumptive part in Dongui Bogam. Methods : The 108 Prescriptions of Consumptive part in Dongui Bogam analysed frequency of basic prescriptions, symptoms of prescriptions and the pathology. Results : Ssangbohwan, Yiuihwan, Gamrihwan were used for tonifying were mostly used as basic prescriptions in whole Consumptive part respectively. There are common symptoms in consumptive part in Dongui Bogam. That symptoms are "tidal fever, night sweating, nocturnal emission, cough, sputum, skinny body, weak pulse, spontaneous sweating, deafness, dim vision and tuberculosis". Qi blood(yin yang) pathologies in prescriptions on consumptive part are "yin deficiency, yin deficiency with effulgent fire, yang qi deficiency, dual damage of qi and blood, non-interaction between fire and water, collapse of yang and exhaustion of yin, less blood". viscera and bowels pathologies in prescriptions on consumptive part are "heart and kidney deficiency, spleen-stomach weakness, spleen and kidney great deficiency, weakness of kidney qi, meridian waste in heart, spleen and kidney, damage in heart and lung". Conclusions : As a result of Study on Analysis all Prescriptions of Consumptive part in Dongui Bogam, We can understand more about basic prescriptions, symptoms of prescriptions and the pathology that are using for curing consumptive. We expected that this study will can help to give rationale for future study of consumptive caring.

• Journal of Korean Medical classics
• /
• v.27 no.4
• /
• pp.121-131
• /
• 2014

Objectives : The objectives of this study is to compare the differences in medical herbs combination of Taepyeonghyeminhwajegukbang, Somunsunmyungronbang and Nansilbijang. Methods : This study was proceeded by using Access 2007 and SQL Server and prescriptions of which herbal configuration could be indicated by weight unit were analysed from 765 prescriptions of Taepyeonghyeminhwajegukbang, 350 prescriptions of Somunsunmyungronbang and 277 prescriptions of Nansilbijang. Results : If more than 80% similarity, it is considered similar prescription. Only 6 Prescriptions of Nansilbijang similar to Prescriptions of Taepyeonghyeminhwajegukbang. And 20 Prescriptions of Somunsunmyungronbang similar to Prescriptions of Taepyeonghyeminhwajegukbang. Conclusions : Configuration patterns of Somunsunmyungronbang and Nansilbijang are different from Taepyeonghyeminhwajegukbang. So We can prove that theory of Somunsunmyungronbang and Nansilbijang are different from Taepyeonghyeminhwajegukbang.

• Herbal Formula Science
• /
• v.19 no.2
• /
• pp.1-10
• /
• 2011

Objectives : Since its enactment in 1987, the 56 standard prescriptions covered by insurance have remained unchanged from its original version. In this study, we tried to discover most frequently used herbal combinations by analyzing prescriptions used in actual clinical settings. Methods : We have built Structured Query Language to analyze herbal combination and progressed this analysis through analyzing the frequencies of medicinal herb combinations in medical prescription slips. Results : We have found out that traditional Korean medical doctors use about 13 herbs in a prescriptions and usually use 253 kinds of herb. And We have found out the most frequently used herbal combination. Conclusions : In this study, We can suggest new method to decide what do we need on insurance prescriptions.

• Herbal Formula Science
• /
• v.11 no.1
• /
• pp.1-18
• /
• 2003

Science of prescriptions is an important part in the education of Korean Oriental Medicine. In spite of that, there is less agreement on measures for improving the education quality of science of prescriptions. Science of prescriptions can be classified into generalities and particulars. This study sought to present contents that must be incorporated into Introduction to Science of Prescriptions to enhance the quality of education by examining both teaching materials being used in colleges of traditional Chinese medicine and those of Korean oriental medicine and the Introduction part of books related with science of prescriptions. And when this study was carried out, training Korean oriental medicine practitioners and researchers and educators of science of prescriptions was taken into account. It is judged that Introduction to Science of Prescriptions needs to be divided into seven chapters and that each chapter requires containing opinions of ancient doctors and references to lay the basis of learning and revised and practical contents in addition to traditional ones. Chapter One Introduction (Conception, History, Disciplinery, Study, How to Learn, Range of Study, How to Study, Academic Activities) Chapter Two Prescriptions and Selection of Treatment Based on the Differential Diagnosis Chapter Three Prescriptions and Therapeutic Methods (Eight Therapeutic Methods, Sixty Four Therapeutic Methods etc.) Chapter Four Classification of Prescriptions Chapter Five Designing and Modification of Prescriptions (Compatibility, Designing, Modification) Chapter Six Preparation Forms of the Prescriptions (Origin, Charicteristics) Chapter Seven Methods of Decocting and Taking Korean Oriental Herbal Medicines Appendix Tables of Apothecaries' Measures and Weights in Current and Ancient Times

• Herbal Formula Science
• /
• v.26 no.2
• /
• pp.147-170
• /
• 2018

Objectivs : This report describes the studies as follows through the research of 163prescribtions in low-chapter from Bangyakhappyun. Methods : Analysis the 163prescribtions of basic prescribtions, therapeutic area, symptoms and pathology. Result : Many prescriptions are contained in the diseases areas such as defecate diseases, women diseases, internal diseases, exogenous febrile diseases. And prescriptions in the low-chapter are used in the areas such as eye, aggregation, mouth and tongue, teeth, hand, back, neck, emergency. Eighty-five basic prescriptions are analyzed from the low-chapter and the ratio of nineteen prescriptions containing Ijintang, Pyeongwisan, Oryungsan, Samultang, Sunggitang, Jichultang are over 60%. The efficacy classifications containing basic prescriptions frequently used are researched in the following order: heat-clearing and fire-purging formulae, digestant formulae, phlegm-dispelling formulae, qi-regulating formulae and blood-activating formulae. And tonifying and replenishing formulae are rarely used. Most of the prescriptions in the low-chapter are used for the excess syndrome and few of them are used for the deficiency syndrome. And six excesses, food damage, phlegm are the major causes of excess syndrome. Conclusions : As s result of study on analysis all prescriptions in low-chapter from Bangyakhappyun. We can understand more about basic prescriptions, symptoms of prescriptions and pathology.