The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Network Analysis of Herbs that are Frequently Prescribed for Osteoporosis with a Focus on Oasis Platform Research

골다공증 다빈도 처방과 구성 약물의 네트워크 분석 - 오아시스 검색을 중심으로

  • Shin, Seon-mi (Dept. of Korean Internal Medicine, College of Korean Medicine, Semyung University) ;
  • Ko, Heung (Dept. of Korean Internal Medicine, College of Korean Medicine, Semyung University)
  • 신선미 (세명대학교 한의과대학 한방내과학교실) ;
  • 고흥 (세명대학교 한의과대학 한방내과학교실)
  • Received : 2021.09.06
  • Accepted : 2021.09.27
  • Published : 2021.09.30
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Abstract

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

Keywords

Acknowledgement

본 논문은 2021년도 미래창조과학부의 재원으로 한국연구재단 생애 첫 연구사업의 지원을 받아 수행된 연구임(과제번호: 2021R1G1A100854911). 본 논문은 2021년도 교육부의 재원으로 한국연구재단의 지원을 받아 수행된 지자체-대학 협력기반 지역혁신 사업의 결과입니다.

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