• Title/Summary/Keyword: analysis of model

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Deciphering the Genetic Code in the RNA Tie Club: Observations on Multidisciplinary Research and a Common Research Agenda (RNA 타이 클럽의 유전암호 해독 연구: 다학제 협동연구와 공동의 연구의제에 관한 고찰)

  • Kim, Bong-kook
    • Journal of Science and Technology Studies
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    • v.17 no.1
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    • pp.71-115
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    • 2017
  • In 1953, theoretical physicist George Gamow attempted to explain the process of protein synthesis by hypothesizing that the base sequence of DNA encodes a protein's amino acid sequence and, in response, proposed the nucleic acid-protein information transfer model, which he dubbed the "diamond code." After expressing interest in discussing the daring hypothesis, contemporary biologists, including James Watson, Francis Crick, Sydney Brenner, and Gunther Stent, were soon invited to join the RNA Tie Club, an informal research group that would also count biologists and various researchers in physics, mathematics, and computer engineering among its members. In examining the club's formation, growth, and decline in multidisciplinary research on deciphering the genetic code in the 1950s, this paper first investigates whether Gamow's idiosyncratic approach could be adopted as a collaborative research forum among contemporary biologists. Second, it explores how the RNA Tie Club's research agenda could have been expanded to other relevant research topics needing multidisciplinary approach? Third, it asks why and how the RNA Tie Club dissolved in the late 1950s. In answering those questions, this paper shows that analyses on the intersymbol correlation of the overlapping code functioned to integrate diverse approaches, including sequence decoding and statistical analysis, in research on the genetic code. As those analyses reveal, the peculiar approaches of the RNA Tie Club could be regarded as a useful method for biological research. The paper also concludes that the RNA Tie Club dissolved in the late 1950s due to the disappearance of the collaborative research agenda when the overlapping code hypothesis was abandoned.

Identification of a SNP in Cattle HGD Gene with its Effect on Economic Trait in Hanwoo (한우 HGD 유전자내 변이지역과 경제형질간의 연관성 분석)

  • Han, Jung-Min;Kong, Hong Sik
    • Journal of Life Science
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    • v.24 no.11
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    • pp.1168-1173
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    • 2014
  • The homogentisate 1,2-dioxygenase (HGD) gene, which consists of 14 exons and spans approximately 42630bp on Bos taurus autosome 1 (BTA 1), is one of the six enzymes required for catabolism of the aromatic amino acids tyrosine and phenylalanine. It has been reported that BTA1 harbors quantitative trait loci that effect marbling score (MS), carcass weight (CW), and longissimus muscle area (LMA) in cattle. The aim of this study was to identify the single nucleotide polymorphisms (SNPs) in the HGD gene and to analyze their association with economic traits in Korean cattle (Hanwoo). Genetic polymorphisms were screened by direct sequencing, which detected 10 SNPs (T11187C, T11301A, T11398G, G29833A, G34256T, G34257C, T34284C, T42333G, T42348C, and T42468C). Six polymorphic sites were selected for genotyping, and economic traits were analyzed using a general linear model in Korean cattle (n=90). The observed genotype frequencies for G34256T were 0.5843(GG), 0.3708(GT), and 0.0449(TT). In addition, 0.3596(GG), 0.3708(GC), and 0.2697(CC) were observed for the G34257C mutation. Statistical association analysis revealed that G34256T polymorphisms were significantly associated with MS, and G34257C polymorphisms were significantly associated with MS and LMA (p<0.05). Further study is needed in order to use the genetic variant as a marker for marker-assisted selection in Korean cattle.

In-Store's Servicescapes and Consumer's Responses in Restaurant (레스토랑 내부 서비스환경과 소비자반응)

  • Choi, Chul-Jae
    • The Journal of the Korea Contents Association
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    • v.17 no.6
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    • pp.452-469
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    • 2017
  • The purpose of this study is to examine consumer's cognitive, affective and behavioral responses to in-store's servicescapes in restaurant by confirming the effect of service environment factors such as ambient, layout, interior and auditory on perceived service quality and image as cognitive responses, and the effect of perceived service quality and image on affective satisfaction as affective response, and the effect of affective satisfaction on repurchase intention as a behavioral responses. To this end, the research hypothesis was verified by structural equation model analysis using SPSS 21.0 and AMOS 20.0 statistical packages. The results of study are as follows. First, ambient environment, interior environment and auditory environment had significant influence on perceived service quality, but interior environment had no effect. Second, ambient environment and layout environment had a significant influence on the image, while the interior environment and auditory environment had no effect. Third, perceived service quality had a significant effect on emotional satisfaction, but had no effect on image and repurchase intention. Finally, image had a significant effect on emotional satisfaction and repurchase intention. Therefore, the marketing manager of the restaurant will need to plan and implement a service marketing strategy that will increase consumers' visit by enhance the perceived service quality level by improving ambient environment, layout environment and auditory environment, and increase image by improving ambient environment and layout environment.

A Study on the relationship between the entrepreneurial intention influencing factors in one's youth and the entrepreneurial behavior (청년 창업의지의 영향요인과 창업행동 간의 관계)

  • Kim, Jang-Ho;Geum, Yong-Pil
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.7
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    • pp.555-563
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    • 2020
  • This study aimed to distinguish between predisposing factors influencing the entrepreneurial intentions of university and college students who completed an entrepreneurship education course and to empirically determine the relationship between entrepreneurial intention and entrepreneurial behavior. Since company foundation involves uncertainty, potential entrepreneurs are known to fear creating a new company. Entrepreneurship has been confirmed in advanced studies to not only reduce this fear but also positively influence one's entrepreneurial intention. This study presents a research model that connects entrepreneurship, entrepreneurial intention, and entrepreneurial behavior and verifies it via empirical analysis. It was confirmed as a result that entrepreneurial intention is positively influenced by actively engaging with changes of a certain product or service, problem-solving capability, resolving unexpected setbacks during company foundation, and expertise in the business field where the founded company belongs to. It was also confirmed that entrepreneurial intention has a positive influence on entrepreneurial behavior. In the conclusion of this study, importance and necessity of entrepreneurship education are discussed in order to essentially improve entrepreneurial intention and company foundation via entrepreneurship education.

A Multipurpose Design Framework for Hardware-Software Cosimulation of System-on-Chip (시스템-온-칩의 하드웨어-소프트웨어 통합 시뮬레이션을 위한 다목적 설계 프레임워크)

  • Joo, Young-Pyo;Yun, Duk-Young;Kim, Sung-Chan;Ha, Soon-Hoi
    • Journal of KIISE:Computer Systems and Theory
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    • v.35 no.9_10
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    • pp.485-496
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    • 2008
  • As the complexity of SoC (System-on-Chip) design increases dramatically. traditional system performance analysis and verification methods based on RTL (Register Transfer Level) are no more valid for increasing time-to-market pressure. Therefore a new design methodology is desperately required for system verification in early design stages. and hardware software (HW-SW) cosimulation at TLM (Transaction Level Modeling) level has been researched widely for solving this problem. However, most of HW-SW cosimulators support few restricted ion levels only, which makes it difficult to integrate HW-SW cosimulators with different ion levels. To overcome this difficulty, this paper proposes a multipurpose framework for HW SW cosimulation to provide systematic SoC design flow starting from software application design. It supports various design techniques flexibly for each design step, and various HW-SW cosimulators. Since a platform design is possible independently of ion levels and description languages, it allows us to generate simulation models with various ion levels. We verified the proposed framework to model a commercial SoC platform based on an ARM9 processor. It was also proved that this framework could be used for the performance optimization of an MJPEG example up to 44% successfully.

Church's Cognition and Christian Counseling in Luther's Church in Korea (한국 루터교회 평신도의 교회인식과 기독교 상담)

  • Kim, Ock-Jin
    • The Journal of the Korea Contents Association
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    • v.18 no.10
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    • pp.194-202
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    • 2018
  • This study was designed to analyze the impact of Christian counseling for the common faith and religious wellbeing within the Korean Luther Church, and to provide church growth factors based on the results. The study target was based on the survey results of a total of 83 members who were attending layman in the ${\bigcirc}{\bigcirc}{\bigcirc}$ church, which is affiliated with the Korean Lutheran Church. The research tool used NCD questionnaire for church health diagnosis by the Korea Church Growth Institute for the church growth model and the reliability of Cronbach's ${\alpha}$ in this study was 0.91. The collected questionnaire was tested for correlation to verify the relationship between church development and growth, and for multiple recursive analysis to confirm factors affecting church development and growth. The results showed that church's services, programs, and atmosphere were highly correlated with development of church, including counseling. The research showed that the relationship between church services, programs, and friends, including counseling, was highly correlated with spiritual growth and self-growth, while community activities and mutual communication were low. Therefore, for continuous church growth, the importance of community programs in the church is considered necessary.

An Analysis of the Optimal Integration of Korea's Public Pension Schemes (공적연금(公的年金)의 적정급여구조(適正給與構造)에 관한 연구(硏究))

  • Yoo, Il-ho
    • KDI Journal of Economic Policy
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    • v.12 no.4
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    • pp.113-126
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    • 1990
  • With the introduction of the national pension, efficient integration of Korea's four public pension schemes has been discussed. The main point of such discussions is whether to have a progressive scheme or an income-proportional one. Under the assumption of a perfect labor market, it has been proved in the income tax literature that the regressive tax scheme with the 0 % tax rate to the most able person (person earning highest income) is pareto efficient, if there is an incentive problem in the labor supply. In this paper, a life-cycle model with a linear benefit schedule, when there is uncertainty about future earning ability, is studied. It is proved that the second best pension scheme is that having a progressive benefit schedule. This result implies that integration into a progressive pension scheme, like the current national pension, is required not only for efficiency but also for equity.

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Effects of Academic Emotion Regulation and Group Cohesiveness on Learning Satisfaction and Learning Interest in the University Flipped Learning (대학 플립러닝 수업에서 학업적 정서조절과 집단응집성이 학습만족도와 학습흥미도에 미치는 영향)

  • Lee, Jeongmin;Jung, Yeonji;Park, HyeonKyeong;Cho, Boram
    • Journal of The Korean Association of Information Education
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    • v.20 no.4
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    • pp.341-356
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    • 2016
  • The purpose of this study is to investigate the effects of academic emotion regulation and group cohesiveness on learning satisfaction and learning interest in the flipped learning at the university. In order to examine the purpose, this study applied a problem-solving classroom model to the flipped learning. 33 university students participated in the flipped learning activities for 9 weeks, and the data from them were used for multiple regression analysis. The results indicated that learners' academic emotion regulation did not affect learning satisfaction, and subjects' group cohesiveness influenced on learning satisfaction. Second, learners' academic emotion regulation did not affect learning interest, but their group cohesiveness had an impact on learning interest. This research has several implications with regard to suggesting the guidelines and conditions for the design and implementation of the flipped classroom at the university.

A Study on Antecedents of Cognitive and Affective Trust Leading to IT Service Project Performance (IT서비스 프로젝트에 있어서 인지적 신뢰와 정서적 신뢰를 형성하는 요인들에 관한 연구)

  • Yoon, Jungin;Park, Jun-Gi;Lee, Jungwoo
    • Information Systems Review
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    • v.16 no.1
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    • pp.51-71
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    • 2014
  • This study explores the influence of cognitive and affective trust on IT service project performance. Technology and Business expertise are posited as antecedents for cognitive trust which social bonding and relationship conflict as over for affective trust. Communication is posited as the commons antecedent for both kind of trust. A study was administered among IT Project leading in different projects. Analysis of 169 data point in general supports the research model. For building cognitive trust, Communication is formal to be must important while business expertise the second and technical expertise the third. For affective trust, the influence of antecedent are relatively smaller than the case of cognitive trust. For project performance, Cognitive trust seem to have stronger impact as IT may have direct impact as well as indirect impact via affective trust. Findings trust though the impact is smaller than the cognitive trust. In practice, this means to maintain Balanced approach in fostering trust-cognitive and affective.

Application of Multi-Criteria Analysis and GIS to the Coastal Assessment (GIS와 다기준분석법(MCA)을 활용한 연안지역 평가방법 연구)

  • 최희정;윤진숙;황철수
    • Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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    • 2003.04a
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    • pp.510-516
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    • 2003
  • 연안관리 정책을 결정하기 위해서는 다양한 정보의 수집과 이를 체계적으로 관리하고 분석할 수 있는 기법이 필요하다. 특히, 다양한 이해집단과 목적들이 상충하는 지역의 특성을 파악하기 위해서는 환경, 사회, 경제적인 기준 및 의사결정자의 가치체계가 반영될 수 있어야 하며, 선호도가 반영된 요소를 효율적으로 분석할 수 있어야 한다. 이에, 본 연구에서는 공간자료의 처리 및 분석이 용이한 GIS 환경에 다기준 분석법, 그 중에서도 AHP 모형을 결합하는 방법을 다루어 보았다. 분석과정을 살펴보면, 본 연구에서는 지역에 영향을 미치는 사회ㆍ경제적인 지표, 환경 지표를 정하였고, 이런 지표들의 데이터를 GIS라는 도구를 통하여 분석이 용이하도록 변환시켰다. 한편, 이 지역에 영향을 미치는 각 기준들의 중요성을 파악하여 의사결정자의 의견을 반영할 수 있도록 다기준 분석법의 하나인 AHP를 이용하여 가중치를 산정하였다. 다음으로, 다양한 출처의 자료를 표준화하여 GIS의 래스터 자료로 구축한 후, 가중치를 적용한 개별 레이어를 지도대수와 중첩분석을 이용하여 최종 결과 레이어를 생성하였다. 생성된 최종 결과 레이어 상의 공간의 대안인 각 셀 값을 비교ㆍ분석하였다. 이로 인한 결과는 연안의 유한한 자원과 공간의 다양한 이용상태를 관리하기 위한 해안과 육상의 정보를 제공할 수 있다. GIS와 다기준 분석을 통합함으로써 다양한 출처의 공간정보를 분석하고 연안의 현 상태를 밝힐 수 있다. 또한, 이것은 분석 결과가 단순하고 명확하게 설명되어 정책 결정자에게 유용한 정보를 제공할 뿐만 아니라, 이 정보를 이용하여 실질적인 연안관리계획을 수립하는데 도움이 된다.가능성 0.5이상의 면적은 59%를 차지하였다.퇴적이 우세한 것으로 관측되었다.보체계의 구축사업의 시각이 행정정보화, 생활정보화, 산업정보화 등 다양한 분야와 결합하여 보다 큰 시너지 효과와 사용자 중심의 서비스 개선을 창출할 수 있는 기반을 제공할 것을 기대해 본다.. 이상의 결과를 종합해볼 때, ${\beta}$-glucan은 고용량일 때 직접적으로 또는 $IFN-{\gamma}$ 존재시에는 저용량에서도 복강 큰 포식세로를 활성화시킬 뿐 아니라, 탐식효율도 높임으로써 면역기능을 증진 시키는 것으로 나타났고, 그 효과는 crude ${\beta}$-glucan의 추출조건에 따라 달라지는 것을 알 수 있었다.eveloped. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be sim

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