• KSCE Journal of Civil and Environmental Engineering Research
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• v.9 no.2
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• pp.1-10
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• 1989

In this paper, dynamic response of a truss bridge due to constantly moving train loads is analysed. Dynamic response of the bridge is found by the mode superposition method with the solution of the eigenvalue problem by Householder transformation and QL algorithm. To prove the validity of the analysis procedure, the response due to a very slowly moving load is compared with the result from the static analysis program, and the dynamic response is also compared with the result from the direct integration method. Based upon this, the variation of dynamic amplification factors is investigated by changing the train types and speeds, and the result is compared with the code specified impact factor. From this study, it was known that the dynamic amplification factor is not quite different by train types in low speeds but in high speeds it is, and in the case of electric car and U. I. C. loads the factor could exceed the code specified impact factor depending upon the speed.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1015-1018
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• 2016

Background: Overexpression or amplification of human epidermal growth factor receptor-2 (HER2) is associated with grade of malignancy and a poor prognosis in breast cancer (BC). The aim of this study was to evaluate of value of HER2 as a prognostic marker, and to analyze associations with common histopathological parameters in BC cases. Materials and Methods: Between of 2007 to 2014, 260 patients with BC referred to Oncology Clinic provided cancer tissue samples which underwent immunohistochemistry (IHC) for markers. ER and PR positivity was defined as ${\geq}10%$ positive tumor cells with nuclear staining. HER2-positive was defined as either HER2 gene amplification by fluorescent in situ hybridization (FISH) or scored as 3+ by IHC. For HER2 (2+), FISH was performed to determine HER2 positivity. Results: The mean age at diagnosis for the patients with HER2-negative was significantly higher than in HER2-positive cases. Also, there were significant correlations between histological grade, nuclear grade, lymph node metastasis, tumor size, ER status, PR status, p53 overexpression and Ki-67 index with HER2 expression. HER2-negative lesions were of higher grade and more likely to be ER-negative, PR-negative, p53-positive, lymph node metastasis, with a tumor size<2cm and also $Ki-67{\geq}20%$ as compared to the HER2-positive group. Conclusions: Contrary to the results of other studies, HER2-positive tumors in our study had a lower Ki-67 index and were p53-positive. Also, Ki-67 proliferation index ${\geq}20%$ in more studies was associated with p53-positive.Therefore, tumors which are HER2-positive and have a Ki-$67{\geq}20%$ had a more aggressive behavior compared to HER2-positive and Ki-67<20% lesions.

• Structural Engineering and Mechanics
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• v.64 no.5
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• pp.661-670
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• 2017

The dynamic model test of dam-reservoir coupling system for a 203m high gravity dam is performed to investigate effects of reservoir water on dynamic responses of dam during earthquake. The hydrodynamic pressure under condition of full reservoir, natural frequencies and acceleration amplification factors along the dam height under conditions of full and empty reservoir are obtained from the test. The results indicate that the reservoir water have a stronger influence on the dynamic responses of dam. The measured natural frequency of the dam model under full reservoir is 21.7% lower than that of empty reservoir, and the acceleration amplification factor at dam crest under full reservoir is 18% larger than that under empty reservoir. Seismic dynamic analysis of the gravity dams with five different heights is performed with the Fluid-Structure Coupling Model (FSCM). The hydrodynamic pressures from Westergaard formula are overestimated in the lower part of the dam body and underestimated in its upper part to compare with those from the FSCM. The underestimation and overestimation are more significance with the increase of the dam height. The position of the maximum hydrodynamic pressure from the FSCM is raised with the increase of dam height. In view of the above, the Westergaard formula is modified with consideration in the influence of the height of dam, the elasticity of dam on the hydrodynamic pressure. The solutions of modified Westergaard formula are quite coincident with the hydrodynamic pressures in the model test and the previous report.

• Journal of the Korean Society for Railway
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• v.19 no.1
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• pp.67-76
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• 2016

The asphalt-concrete trackbed system has many advantages in terms of maintenance and economics. However, methods to investigate practical use corresponding to the development of the trackbed system must be developed. The primary objective of this study was to evaluate the dynamic performance of the asphalt system in accordance with both the elastic and viscoelastic material characteristics and design thickness of the asphalt trackbed. More specifically, in order to reduce the uncertainty error of the Finite Element(FE) model, a three-dimensional full scale FE model was developed and then the infinite foundation model was considered. Finally, to compare the condition of viscoelastic materials, performance evaluation of the asphalt-concrete trackbed system was used to deal with the dynamic amplification factors; numerical results using isotropic-elastic materials in the FE analysis are presented.

• Analytical Science and Technology
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• v.32 no.4
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• pp.155-162
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• 2019

Analysis techniques using DNA profiling are widely used in various fields including forensic science and new technologies such as the Direct PCR amplification method are being developed continuously in order to acquire the DNA profiles efficiently. However, it has a limits such as non-specific amplification according to the quality of crime scene evidence samples. Especially, split peaks caused by excessive DNA samples are one of the important factors that could cause the debate to allow researchers to interpret the DNA profile results. In this study, we confirmed the occurrence rate of split peaks in each STR (short tandem repeats) locus of the $GlobalFiler^{TM}$ kit and investigated the possibility of improving the split peaks using several PCR additives such as DMSO (dimethylsulfoxide), $MgCl_2$, Betaine and Tween-20. As a result, we could make three groups according to the occurrence rate of split peaks in Direct PCR and it was confirmed that the ratio of split peaks could be reduced by DMSO (87.4 %), $MgCl_2$ (84.5 %) and Betaine (86.1 %), respectively. These results indicate that PCR additives such as DMSO, $MgCl_2$ and Betaine can be improve the split peaks in Direct PCR and thereby facilitate subsequently a successful DNA profile results.

• Journal of Life Science
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• v.19 no.4
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• pp.449-456
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• 2009

Murine Neuro-2a (N2a) cells have been widely used for the investigation of neuronal differentiation, trophic interaction and neurotoxic effects of various compounds and their associated mechanisms. N2a cells have many genomic variations such as gains or losses in DNA copy number, similar to other neuroblastoma cells, and no systematic or high-resolution studies of their genome-wide chromosomal aberrations have been reported. Presently, we conducted a systematic genome-wide determination of chromosomal aberrations in N2a cells using a high-throughput, oligonucleotide array-based comparative genomic hybridization (oaCGH) technique. A hidden Markov Model was employed to assign each genomic oligonucleotide to a DNA copy number state: double loss, single loss, normal, gain, double gain and amplification. Unlike most neuroblastoma cells, Mycn amplification was not observed in N2a cells. In addition, these cells showed gain only in the neuron-derived neurotrophic factor (NF), while other neurotrophic factors such as glial line-derived NF and brain-derived NF presented normal copy numbers. Chromosomes 4, 8, 10, 11 and 15 displayed more than 1000 aberrational oligonucleotides, while chromosomes 3, 17, 18 and 19 displayed less than 20. The largest region of gain was located on chromosome 8 and its size was no less than 26.7 Mb (Chr8:8427841-35162415), while chromosome 4 had the longest region of single deletion, with a size of 15.1 Mb (Chr4:73265785-88374165).

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.459-464
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• 2007

Seismic control performance of MR dampers, which have severe nonlinearity, differs with respect to the dynamic characteristics of an earthquake such as magnitude, frequency and duration. In this study, the effects of excitation characteristics on the equivalent linear system of a building structure with the MR damper are investigated through numerical analysis for artificial ground motions generated from different response spectrums. The equivalent damping ratio of the structure with the MR damper is calculated using Newmark and Hall's equations for ground motion amplification factors. It is found that the equivalent damping ratio of the structure with the MR damper is dependent on the ratio of the maximum friction force of the MR damper over excitation magnitude. Frequency contents of the earthquake ground motion affects the equivalent damping ratio of long-period structures considerably. Also, additional damping effect caused by interaction between the viscousity and friction of the MR damper is observed. Finally, response reduction factors for equivalent linear systems are proposed in order to improve accuracy in the prediction of the actual nonlinear response.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.879-885
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• 2006

Seismic control performance of MR dampers, which have severe nonlinearity, differs with respect to the dynamic characteristics of an earthquake such as magnitude, frequency and duration. In this study, the effects of excitation characteristics on the equivalent linear system of a building structure with the MR damper are investigated through numerical analysis for artificial ground motions generated from different response spectrums. The equivalent damping ratio of the structure with the MR damper is calculated using Newmark and Hall's equations for ground motion amplification factors. It is found that the equivalent damping ratio of the structure with the MR damper is dependent on the ratio of the maximum friction force of the MR damper over excitation magnitude. frequency contents of the earthquake ground motion affects the equivalent damping ratio of long-period structures considerably. Also, additional damping effect caused by interaction between the viscousity and friction of the MR damper is observed. Finally, response reduction factors for equivalent linear systems are proposed in order to improve accuracy in the prediction of the actual nonlinear response.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.3
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• pp.29-38
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• 2009

n the event of an earthquake, additional stresses can occur in the continuous welded rails (CWR) of High-speed railway (HSR) bridges due to relative displacements at expansion joints, and this stress can cause derailment. The amplification of ground motion occurs as a result of site effects, and this is pronounced at the site of a soft surface soil layer and of a rigid surface soil layer over a soft one. As a result, the amplified ground motion leads to an amplified seismic response in HSR bridges. A change in bridge pier height affects the seismic behavior of the bridge. A HSR bridge with gravel ballast tracks will show different dynamic behavior during an earthquake than one with concrete ballast tracks. The seismic responses of HSR bridges and their CWR are analyzed considering the derailment-inducing factors.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.3
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• pp.421-432
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• 2002

In this study the modal characteristics and responses of an asymmetric structure with added viscoelastic dampers were investigated for design parameters such as eccentricity of stiffness and added dampers, the loss factor of the damping materials used. For modal characteristics, variation of the quantities such as natural frequencies, modal damping ratios, modal participation factors, and dynamic amplification factors were observed, and displacements at flexible and stiff edges, and at center of mass were obtained. Based on the results, the problem of the optimum damper distribution to minimize the torsional effects was addressed, and the proposed method for optimum damper distribution was applied to a multi-story structure to verify the applicability Finally the effect of viscous and viscoelastic dampers were compared by varying the loss factor of the viscoelastic material.