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Clinical Assessment of Intracranial Mesenchymal Tumors with Relevant to Non-meningothelial Tumors (두개강내 원발성 간엽성 종양에 대한 임상 고찰)

  • Yi, Hyeong Joong;Kim, Choong Hyun;Bak, Koang Hum;Kim, Young Soo;Kim, Jae Min;Ko, Yong;Oh, Suck Jun;Kim, Kwang Myung
    • Journal of Korean Neurosurgical Society
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    • v.29 no.1
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    • pp.44-50
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    • 2000
  • Objective : A few anecdotal cases of mesenchyme-derived tumors which grow into a cranial cavity have been reported that disclosed a dismal prognosis, due to their critical location, aggressive biological behavior, and high rate of surgical morbidity. The aim of this study is to search clinical factors related to these tumors. Methods : Eight patients who underwent surgical removal of intracranial mesenchymal tumors between January 1993 and December 1997 were studied retrospectively. The tumors included are three chordomas, two chondrosarcomas, two rhabdomyosarcomas, and one hemangiopericytoma. Authors compared clinical features, treatment, and results of our cases with reported cases. The mean follow-up period was 20.5 months. Results : All cases showed nonspecific, location-related clinical findings and arose from sphenopetroclival region. Single stage operation was performed in 4 cases, and skull base approaches in 3 cases. Adjuvant therapies were done in 2 cases. Recurrence was seen in 3 cases(37.5%), and 3 patients died. Interdisciplinary approach with otologic surgeon was done in 2 cases. Conclusion : Recent advancement of refined tactics has made these tumors amenable and provides prolongation of progression-free survival. These are modified skull base approaches, multi-modality treatment options, and inter-disciplinary team approaches. Good results may be expected for these mesenchymal tumors by aggressive resection and adjuvant therapies according to their biological nature.

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Aneurysmal Neck Clipping as the Primary Treatment Option for Both Ruptured and Unruptured Middle Cerebral Artery Aneurysms

  • Choi, Jai Ho;Park, Jung Eon;Kim, Myeong Jin;Kim, Bum Su;Shin, Yong Sam
    • Journal of Korean Neurosurgical Society
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    • v.59 no.3
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    • pp.269-275
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    • 2016
  • Objective : Although middle cerebral artery (MCA) aneurysms are less amenable to coil embolization, an increasing number of studies support favorable endovascular treatment for them. The purpose of this study is to compare the outcomes of two different treatments (surgery versus coiling) and evaluate the benefits of surgical clipping for MCA aneurysms. Methods : Here we retrospectively analyzed the outcomes of 178 ruptured and unruptured MCA aneurysms treated in patients between September 2008 and April 2012. Parameters assessing treatment outcomes include degree of aneurysm occlusion, presence of regrowth, clinical status, and complications. Results : Among 178 MCA aneurysms, 153 were treated surgically. After a mean follow-up of 12 months, the surgery group showed a clinically significant complete occlusion rate (98%) compared with the coiling group (56%) (p<0.001). Follow-up radiologic evaluation showed a higher regrowth rate (four of 16 cases) in the coiling group than in the surgery group (one of 49 cases) (p=0.003). There was no statistically significant difference in favorable clinical outcome rate between the two groups. The procedure-related permanent morbidity and mortality rates were 2% (three of 153 cases) in the surgery group and 0% (0 of 25 cases) in the coiling group. Conclusion : Compared to endovascular treatment, surgical neck clipping for both ruptured and unruptured MCA aneurysms results in a significantly higher complete obliteration rate and less regrowth. Therefore, even in this endovascular era, we still recommend surgical clipping as the primary treatment option for MCA aneurysms rather than coil embolization.

PHARMACOLOGICAL TREATMENT IN PERVASIVE DEVELOPMENTAL DISORDERS (전반적발달장애의 약물치료)

  • Choi, Jin-Sook
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.4 no.1
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    • pp.27-38
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    • 1993
  • Pervasive developmental disorder is one of the most severe clinical disorder in child psychiatry and is associated with deviancies in multiple areas of development. Medication does not cure pervasive developmental disorder and its effectiveness is generally nonspecific. But psychopharmacological treatment can be important for some children with pervasive developmental disorder and can make many young autistics more amenable to behavior modification and education. Haloperidol, the most widely studied antipsychotics, was statistically and clinically superior to placebo, and furthermore, was known to facilitate the positive functioning such as, discrimination learning and imitative communication, without side effects. However, administration of haloperidol is associated with drug related dyskinesia, and it warrants the introduction and use of the other novel drugs. Several biochemical studies suggest that subgroups of children with pervasive developmental disorder show hyperserotonemia and increased endogenous opioid level as compared with controls. Psychopharmacological trials were conducted according to these findings(ex : fenfluramine, naltrexone), with mixed results till now. These and another drugs that have been used in children with pervasive developmental disorder and their effectiveness are reviewed.

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Construction of PANM Database (Protostome DB) for rapid annotation of NGS data in Mollusks

  • Kang, Se Won;Park, So Young;Patnaik, Bharat Bhusan;Hwang, Hee Ju;Kim, Changmu;Kim, Soonok;Lee, Jun Sang;Han, Yeon Soo;Lee, Yong Seok
    • The Korean Journal of Malacology
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    • v.31 no.3
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    • pp.243-247
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    • 2015
  • A stand-alone BLAST server is available that provides a convenient and amenable platform for the analysis of molluscan sequence information especially the EST sequences generated by traditional sequencing methods. However, it is found that the server has limitations in the annotation of molluscan sequences generated using next-generation sequencing (NGS) platforms due to inconsistencies in molluscan sequence available at NCBI. We constructed a web-based interface for a new stand-alone BLAST, called PANM-DB (Protostome DB) for the analysis of molluscan NGS data. The PANM-DB includes the amino acid sequences from the protostome groups-Arthropoda, Nematoda, and Mollusca downloaded from GenBank with the NCBI taxonomy Browser. The sequences were translated into multi-FASTA format and stored in the database by using the formatdb program at NCBI. PANM-DB contains 6% of NCBInr database sequences (as of 24-06-2015), and for an input of 10,000 RNA-seq sequences the processing speed was 15 times faster by using PANM-DB when compared with NCBInr DB. It was also noted that PANM-DB show two times more significant hits with diverse annotation profiles as compared with Mollusks DB. Hence, the construction of PANM-DB is a significant step in the annotation of molluscan sequence information obtained from NGS platforms. The PANM-DB is freely downloadable from the web-based interface (Malacological Society of Korea, http://malacol.or/kr/blast) as compressed file system and can run on any compatible operating system.

A comparative evaluation of fracture resistance of endodontically treated teeth restored with different post core systems - an in-vitro study

  • Makade, Chetana S.;Meshram, Ganesh K.;Warhadpande, Manjusha;Patil, Pravinkumar G.
    • The Journal of Advanced Prosthodontics
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    • v.3 no.2
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    • pp.90-95
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    • 2011
  • PURPOSE. To compare the fracture resistance and the mode of failure of endodontically treated teeth restored with different post-core systems. MATERIALS AND METHODS. Root canal treatment was performed on 40 maxillary incisors and the samples were divided into four groups of 10 each. For three experimental groups post space preparation was done and teeth were restored with cast post-core (Group B), stainless steel post with composite core (Group C) and glass fiber post with composite core using adhesive resin cement (Group D). Control group (A) samples were selected with intact coronal structure. All the samples were prepared for ideal abutment preparation. All the samples were subjected to a load of 0.5 mm/min at $130^{circ}$.until fracture occurred using the universal testing machine. The fracture resistance was measured and the data were analyzed statistically. The fracture above the embedded resin was considered to be favorable and the fracture below the level was considered as unfavorable. The statistical analysis of fracture resistance between different groups was carried out with t-test. For the mode of failure the statistical analysis was carried out by Kruskal-Wallis test and Chi-Square test. RESULTS. For experimental group Vs control group the fracture resistance values showed significant differences (P<.05). For the mode of failure the chi-square value is 16.1610, which means highly significant (P=.0009) statistically. CONCLUSION. Endodontically treated teeth without post core system showed the least fracture resistance demonstrating the need to reinforce the tooth. Stainless steel post with composite core showed the highest fracture resistance among all the experimental groups. Teeth restored with the Glass fiber post showed the most favorable fractures making them more amenable to the re-treatment.

Hierarchical Analysis of Astronomical Space Concepts Based on the Knowledge Space Theory (지식공간론에 기초한 천문학적 공간개념의 위계 분석)

  • Yoon, Ma-Byong;Kim, Hee-Soo
    • Journal of the Korean earth science society
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    • v.31 no.3
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    • pp.259-266
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    • 2010
  • High school students' understanding hierarchy of astronomical concepts and an individual student's knowledge state are analyzed by using the knowledge space theory that allows one to infer an individual's entire knowledge on a subject based on fragmentary information coming from that student's answers. The hierarchy of astronomical space concepts is: spatial position$\ll$spatial reasoning$\ll$spatial variation. In addition, an analysis of assessment materials using the knowledge space theory shows not only the relationship of assessment questions but also the knowledge state of individual students, which the current evaluation method is not able to reveal. Therefore, the assessment analysis of this study using the knowledge space theory becomes critically instrumental in providing information of an instructional differentiation amenable to individual learners for deciding their level of understanding and selecting suitable curriculum.

Diffraction of Electromagnetic Waves by Right Angle Dielectric Wedge (직각 쐐기형 유전분에 의한 전자파 회절)

  • Ju, Chang-Seong;Ra, Jeong-Ung;Sin, Sang-Yeong
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.18 no.5
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    • pp.35-45
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    • 1981
  • An asymptotic solution of electromagnetic waves scattered by a right-angled dielectric wedge for plane wave incidence is obtained. Scattered fields are constructed by waves reflected and refracted from dielectric interfaces (geometric-optical fields) and a cylindrical wave diffracted from the edge. The edge diffracted field is obtained by adding a correction to the edge diffraction of physical optics approximation, where the correction field is calculated by solving a dual series equation amenable to simple numerical calculation. Validity of this result is assured by two limits of relative dielectric constant $\varepsilon$ of the wedge. The total asymptotic field calculated results in a Rawlins' Neumann series solution for small $\varepsilon$, and the edge diffraction pattern is shown to approach that of a perfectly conducting wedge for large $\varepsilon$. Calculated field patterns are presented and the accuracy of physical optics approximation is discussed.

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Evaluation of Virtual Reality Simulation of Dental Caries through Student Questionnaire (학생 설문을 통한 가상현실 치아우식 시뮬레이션의 평가)

  • Kim, Byunggee;Ryu, Jeeheon;Kim, Jaehwan;Kim, Seonmi;Choi, Namki
    • Journal of the korean academy of Pediatric Dentistry
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    • v.47 no.3
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    • pp.293-302
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    • 2020
  • The purpose of this study was to evaluate the applicability of virtual reality simulation after experience of dental caries diagnosis for dental students before exposing to clinical pediatric practice. A pediatric patient model of a five-year-old child with primary dentition was developed and a caries model that is amenable to VR(virtual reality) diagnosis was organized and set-up. The dental student's were allowed to use the simulated model for fifteen minutes and their experiences were evaluated using a self-reported questionnaire to evaluate presence and usability of this application. Overall, virtual presence and appearance area of the simulation were highly scored. The result indicates that the VR model has no significant difference from the actual clinical caries regardless of grade of students, gender and VR experience. If the prototype is continuously advanced, its applicability in dental education will increase.

Characteristics and Distribution of Teleworkable Jobs Based on Physical Working Conditions (재택근무가 가능한 일자리의 특성과 분포: 물리적 근로환경을 중심으로)

  • Choi, Sungwoong
    • Journal of the Economic Geographical Society of Korea
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    • v.23 no.3
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    • pp.276-291
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    • 2020
  • As social distancing is implemented to prevent the spread of COVID-19, there is an increasing number of workers participating in telework. This study aims to classify the feasibility of working at home for occupations and industries based on physical working conditions, and to analyze regional distribution of the teleworkable jobs. And the raw data of the Korea Working Conditions Survey is used to examine working environment and characteristics of jobs. The main findings show that 35% of jobs in South Korea can be done at home, and the occupations that are less amenable to work at home are closely related to the economically vulnerable workers who earn low wages. Furthermore, the regions that are heavily dependent on manufacturing for employment are likely to have a lower share of jobs that can be done at home due to the industrial structure and working conditions.

A Study on the Determinant Attributes for Developing Korean-Style Industrial Tourism (한국형 산업관광 활성화를 위한 선택속성에 대한 연구)

  • Kim, Do Young
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.7 no.4
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    • pp.149-157
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    • 2012
  • This article aims to identify the selection attributes for developing korean-style industrial tourism. Evaluating attributes is the most important stage in consumer decision-making process and culture has a significant influence on this stage. This study is to analyze in the evaluation of selection attributes with the theory of industrial tourism and come up with developing tourism. a survey was conducted to the staff of travel agency in korea. Through factor analysis and multiple regression analysis, authors identified five factors(i.e. business, conveniences, tourism attraction, hospitality, property) were amenable to the industrial tourism, found that the most important attributes had the strongest influence on satisfaction level. According to the results of this study, author suggests that nationality of industrial tourism have an effect on evaluating selection attributes of the korean-style industrial tourism. therefore, nationality could be the basis of target marketing strategy.

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