• BMB Reports
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• v.55 no.7
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• pp.348-353
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• 2022

Gastrointestinal cancer is associated with a high mortality rate. Here, we report that the splice variant of NRP/B contributes to tumorigenic activity in highly malignant gastric cancer through dissociation from the tumor repressor, HDAC5. NRP/B mRNA expression is significantly higher in the human gastric cancer tissues than in the normal tissues. Further, high levels of both the NRP/B splice variant and Lgr5, but not the full-length protein, are found in highly tumorigenic gastric tumor cells, but not in non-tumorigenic cells. The loss of NRP/B markedly inhibits cell migration and invasion, which reduces tumor formation in vivo. Importantly, the inhibition of alternative splicing increases the levels of NRP/B-1 mRNA and protein in AGS cells. The ectopic expression of full-length NRP/B exhibits tumor-suppressive activity, whereas NRP/B-2 induces the noninvasive human gastric cancer cells tumorigenesis. The splice variant NRP/B-2 which loses the capacity to interact with tumor repressors promoted oncogenic activity, suggesting that the BTB/POZ domain in the N-terminus has a crucial role in the suppression of gastric cancer. Therefore, the regulation of alternative splicing of the NRP/B gene is a potential novel target for the treatment of gastrointestinal cancer.

• Journal of Distribution Science
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• v.14 no.12
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• pp.43-51
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• 2016

Purpose - The purpose of this paper is to discuss success factors behind ATO distribution channels by examining successful partnerships between producers and alternative trading organizations (ATOs). Research design, data, and methodology - This is a case study, an analytical approach, which illustrates how the partnership between producers and ATOs has strengthened the fair trade and the performance of participants in the trade based on the example of the trading relationship between Beautiful Coffee, an alternative trading organization dealing coffee related products, and the coffee cooperative union (CCU), a coffee producing cooperative in Gulmi, Nepal. Results - Beautiful Coffee in the partnership with HELVETAS empowered small coffee farmers by a successful institutionalization of CCU that consolidated the distribution channel to be more efficient. Also, Beautiful Coffee and its partnership with KOICA have tried to increase productivity and quality of coffee beans. Conclusions - The case of Beautiful Coffee demonstrates that the partnership between producers and alternative trading organizations (ATOs) has benefited the fair trade partners. In other words, Beautiful Coffee's partnerships with a NGO working in the local producing area, HELVETAS, and a government aid agency, KOICA could strengthen the relationship between the producers and the ATO, and thus contributes to the whole distribution channel.

• Journal of Distribution Science
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• v.13 no.8
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• pp.41-48
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• 2015

Purpose - This study's objective is to confirm the effects of the perceived relationship value, alternative attractiveness, and investment size on Korean food service franchisees' commitment, using an investment model. Among the three factors, the study examines which factors enhance or weaken the commitment in the franchising investment model. Research design, data, methodology - The data were collected from 495 franchisees and analyzed by a SEM (Structure Equation Model) using path analysis by SPSS 18.0 and AMOS 18.0. Results - 1) The perceived relationship value has a positive effect on franchisee commitment. 2) The alternative attractiveness has a negative effect on franchisee commitment. 3) The investment size has a positive effect on franchisee commitment. Conclusions - The findings show that the investment model can be adapted to franchising and confirms previous investment model study results. We can assume that the higher the perceived relationship value and the bigger the investment, the stronger the commitment, and the greater the alternative attractiveness, the weaker the commitment. These results offer managerial implications for a franchisor wanting to strengthen franchisee commitment.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.2 s.146
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• pp.197-205
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• 2006

In general, brackets found at tank boundary are design according to the Classification Society Rule. Since much man power is needed in manufacturing the brackets stiffened by flange, it is necessary to suggest alternative designs, of which flanges are removed, through the rigorous structural analysis. In this paper non-linear structural analysis for brackets with and/or without flange have been carried out to examine their structural behavior and ultimate strengths. Alternative designs for brackets are suggested based on the results of ultimate strength analysis so that the alternative brackets have the similar level of strength and stiffness to the original brackets. It has been seen that the structural safety of alternative brackets proposed in this paper are beyond the appropriate level. The primary benefit of replacing the original brackets by the alternatives is the reduction of man power in manufacturing brackets and 10 to 15% weight saving can be expected in additional. This paper ends with some comments about the extension of the present study.

• Journal of Information Processing Systems
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• v.13 no.3
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• pp.559-572
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• 2017

Cyberbullying has been an emerging issue in recent years where research has revealed that users generally spend an increasing amount of time in social networks and forums to keep connected with each other. However, issue arises when cyberbullies are able to reach their victims through these social media platforms. There are different types of cyberbullying and like traditional bullying; it causes victims to feel overly selfconscious, increases their tendency to self-harm and generally affects their mental state negatively. Such situations occur due to security issues such as user anonymity and the lack of content restrictions in some social networks or web forums. In this paper, we highlight the existing solutions, which are Intrusion Prevention System and Intrusion Detection System from a number of researchers. However, even with such solutions, cyberbullying acts still occurs at an alarming rate. As such, we proposed an alternative solution that aims to prevent cyberbullying activities at a younger age, e.g., young children. The application would provide an alternative method to preventing cyberbullying activities among the younger generations in the future.

• Korean Journal of Health Education and Promotion
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• v.20 no.4
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• pp.27-40
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• 2003

Objective： To determine second, third and fourth-year medical students' opinions and knowledge related to complementary and alternative medicine (CAM) in a school with no requirement or elective course on the subject. Study Design： A questionnaire was offered to second, third and fourth-year medical students of the Medical College of Kosin University from August 7th, through August 30th, 2003. Results： Most students had been exposed to CAM therapies, knew that the majority of the South Korean public was using CAM, believed that some CAM interventions were useful, and did not believe CAM therapies were a threat to public health. Only one fifth of the students(22.5％) disagreed that they had to have requirement or elective course on CAM in their curriculum. Most students had insufficient knowledge or understanding of the safety or lack of it for ten of the more common CAM modalities. Most respondents thought these interventions were useful, but would not refer a patient nor dissuade a patient from seeking out such interventions. Conclusion： Medical students in this school self-identified an interest about the clinical usefulness of ten CAM modalities, but did not have sufficient knowledge about the safety for ten of the more common CAM modalities. Including CAM topics in the medical school curriculum would better prepare physicians to respond to patient inquiries about CAM and thereby to fulfill their role as patient advocates.

• Korean Journal of Child Studies
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• v.30 no.6
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• pp.237-248
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• 2009

The reasons to attend Alternative Schools are : to compensate for the discontent over what is locally taught in state schools and to improve the students' satisfaction and social emotional development. In 2006, it was estimated that about a thousand Home Schools were set up. With the studies of Alternative Education and Home Schooling, the issues are : 1) the depth study of curriculum of Alternative Education with a wide range of subjects, 2) the institutionalization of Home Schooling, 3) educational methods for Home Schooling, 4) a research on Home Schooling's effectiveness. Their practical and political issues are : 1) to give the licence to the rest of schools and to formulate Education Law on Home Schooling, 2) to obtain government's financial support to the both sections, 3) to support a system of instructional contents and methods of Home Schooling, and 4) to select, share and popularize the best practices of Home Schooling.

• Journal of the Korean earth science society
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• v.35 no.5
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• pp.385-398
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• 2014

This study investigated students' alternative conceptions of plate boundaries and their conception revision according to the pattern of students' reasoning. Participants were twenty-two 10th grade high school students. All participants were asked to draw the three types of plate boundaries and to explain their drawings. Nine students participated in the reasoning activity. To this end, a semi-structured interview was conducted during which key questions were asked for the students to individually answer. The key questions used in the reasoning activity were created, by utilizing questions used in the previous studies. The findings revealed that the alternative conceptions of plate boundaries were classified into three levels based on established criteria. Students who attempted a variety of reasoning strategies such as causal reasoning, using an analogy, abductive reasoning, data reconstruction and concept combination, revised their alternative conception to a scientific conception after the reasoning activity. On the other hand, some students could not revise their alternative conceptions because they only conducted an incomplete reasoning strategy. The study also found that they were unable to use other reasoning strategies, either.

• The Journal of Korean Academic Society of Nursing Education
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• v.18 no.2
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• pp.188-196
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• 2012

Purpose: The purpose of this study was to identify attitudes of nursing students in terms of complementary and alternative therapies and to find out what curriculums they prefer. Methods: Data was collected through 283 participants from a nursing school by self-report questionnaires that were constructed to include scales. The scales were made as a measurement to search the attitudes of nursing students regarding complementary and alternative therapies. In addition, to find out some of the curriculum that are preferred by them. The data was analyzed using t-test and ANOVA with SPSS/WIN 18.0. Results: Students' attitudes of complementary and alternative therapies were positive. Students' attitudes of complementary and alternative therapies differed depending on factors like one's religion, experiences and education. Some of the curriculum that nursing students wished to be opened related to complementary and alternative therapies turned out to be massage therapy, art therapies that include music and dancing, medication therapy and aroma therapy. Conclusion: In order for nursing students to be able to apply these complementary and alternative therapies at the field after graduation while they are working as a registered nurse, constant effort should be accomplished in establishing complementary and alternative therapies as regular curriculum at University.

• Journal of Science Education
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• v.39 no.2
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• pp.180-208
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• 2015

The purpose of this study was to investigate secondary students' perception of a good secondary science classes. Subjects were 18 secondary students who enrolled in alternative school located in Korea. The instruments of this study was a questionnaire which consisted of 18 items on 4 domains. Also data were collected from in-deep interviews and students' drawing. The results of the study were summarized as follows; First, students explained that good schools have the characteristics of the interesting and respectful atmosphere. Also there are good relationships between teachers and students. Second, they emphasized that good teachers are humanistic teachers. Third, good science classes are based on the constructivism in terms of the education methods. The results suggest that it may be necessary to remodel the merits of the alternative schools to solve the problem of public school. It is important to develop expertise of the science teachers in alternative school through teacher education programs based on the constructivism. Also it is necessary to provide appropriate learning space and various media for effective science teaching and learning in alternative school.