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Pathophysiology of orthostatic tremor: a multiple case study (길입성 진전의 병태생리: 다증 증례 연구)

  • Seo, Man-Wook;Lee, Kwang-Woo
    • Annals of Clinical Neurophysiology
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    • v.4 no.1
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    • pp.44-50
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    • 2002
  • Introduction : Orthostatic tremor develops in the legs while standing up with no weakness, pain or imbalance in the leg and the tremor is characteristically not observed when walking. However there have been some confusions about orthostatic tremor in several aspects. For the past ten years, we have observed 4 patients with orthostatic tremor. In each case tests were performed to investigate the following three important areas of inquiry about orthostatic tremor. Firstly, whether this disorder is an independent diagnostic entity or a variant of essential tremor. Secondly, whether the progress of this disorder is specifically related with standing posture. Lastly, the nature of the pathophysiologic mechanism behind the appearance of the tremor when standing after the lapse of a certain latent period and its disappearance upon the commencement of walking. Methods : Our 4 cases of orthostatic tremor were studied clinically, electrophysiologically, and pharmacologically. Electrophysiological tests included tremor spectrum test and electromyography. Results : We observed the presence of this tremor in several other tonic postures, as well as its absence, in a vertically lifted position from all our cases. Our cases registered a variable tremor frequency between 5 and 12 Hz according to the tremor spectrum test and EMG. Furthermore all our 4 cases demonstrated patterns of both synchronous EMG activity and alternating EMG activity at various times in homologous muscles of both legs. Orthostatic tremor was improved significantly with propranolol as well as clonazepam. Conclusions : From the results of our study we drew the following conclusions. It is probable that orthostatic tremor is simply a variant of essential tremor rather than being an independent diagnostic entity and that in most cases its development is specifically related with muscle contraction rather than merely with the act of standing. Furthermore we discovered a clue in the previously described neural control mechanism that the nuclear bag fibers in the muscle spindle have lag time of several seconds in their response to muscle strength and that their baseline does not reset fully in rapidly moving muscle. This neural control mechanism could offer sufficient explanation for the phenomena of tremor appearance when standing and disappearance when walking in orthostatic tremor.

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A Study on the Solidification and Purification of High Purity Aluminium Alternate Stirring Method (정역 회전법에 의한 고순도 알루미늄의 응고 및 정련에 관한 연구)

  • Kim, Wook;Lee, Joung-Ki;Baik, Hong-Koo;Heo, Seong-Gang
    • Journal of Korea Foundry Society
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    • v.12 no.3
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    • pp.220-229
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    • 1992
  • The degree of purification and the macrostructure of high purity aluminium were studied through the alternate stirring method in order to improve the nonuniformity of solute concentration in the unidirectional stirring method. The $2^3$ factorial design was done to examine the effects of experimental factors more qualitatively. In the relatively low stirring speed of 1500 rpm with alternate stirring mode, the uniform solute profile and refined grain structure were obtained due to strong washing effect and turbulent fluid flow. It was induced by the transition of the momentum boundary layer by alternation of the stirrer. It was concluded from this study that the alternate stirring mode was more effective to obtain the uniformity of solute even in the stirring speed of 1500 rpm. But the degree of purification decreased below the critical alternating period. When 2N(99.8wt.%) aluminium was used as the starting material the morphology of solid-liquid showed the cellular shape and the columnar grains were inclined to the direction of rotation. This inclined grain growth resulted from the difference of relative velocities of solid and liquid. The inclined angle was increased as the stirring speed increased and solidification proceeded. In the case of 4N aluminium, there was no inclined grain growth and it was confirmed from the macrostructure and SEM work that the morphology of solid-liquid interface was planar. From the factorial design, it was found that the alternate stirring mode showed poorer purification effect than that of unidirectional stirring mode at low speed(500 rpm). In addition, the factor that had the most significant effect on the degree of purification was the stirring speed.

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Analysis of Acoustic Propagation using Spectral Parabolic Equation Method (스펙트럴 포물선 방정식 법을 이용한 수중음파 전달해석)

  • Kim, Kook-Hyun;Seong, Woo-Jae
    • The Journal of the Acoustical Society of Korea
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    • v.15 no.2
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    • pp.72-78
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    • 1996
  • This thesis deals with a method to solve a two-and-one-half-dimensional ($2\frac12$ D) problem, which means that the ocean environment is two-dimensional whereas the source is fully three-dimensionally propagating, including three-dimensional refraction phenomena and three-dimensional back-scattering, using two-dimensional two-way parabolic equation method combined with Fourier synthesis. Two dimensional two-way parabolic equation method uses Galerkin's method for depth and Crank-Nicolson method and alternating direction for range and provides a solution available to range-dependent problem with wave-field back-scattered from discontinuous interface. Since wavenumber, k, is the function of depth and vertical or horizontal range, we can reduce a dimension of three-dimensional Helmholtz equation by Fourier transforming in the range direction. Thus transformed two-dimensional Helmholtz equation is solved through two-way parabolic equation method. Finally, we can have the $2\frac12$ D solution by inverse Fourier transformation of the spectral solution gained from in the last step. Numerical simulation has been carried out for a canonical ocean environment with stair-step bottom in order to test its accuracy using the present analysis. With this spectral parabolic equation method, we have examined three-dimensional acoustic propagation properties in a specified site in the Korean Straits.

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Clinical Observation on 1 Case of Patient with Bilateral Facial Palsy (양측성 안면신경마비 치험 1례에 관한 고찰)

  • Kim, Min-Jeong;Park, Sang-Dong;Lee, A-Ram;Kim, Kyung-Ho;Jang, Jun-Hyouk;Kim, Kap-Sung
    • Journal of Acupuncture Research
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    • v.19 no.2
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    • pp.238-249
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    • 2002
  • Facial palsy is commonly encountered disease in the clinic but bilateral facial palsy is known as rare disease. Type of facial nerve paralysis include unilateral, recurrent ipsilateral, recurrent alternating and bilateral simultaneous palsies. Among the types, the reported incidence of bilateral simultaneous palsy is 0.3~2% of facial paralysis patients. We experienced I case of patient with bilateral simultaneous facial palsy that was concluded as bilateral bell's palsy. Objective : The purpose of this paper is to report the patient with bilateral facial palsy, who improved by oriental medical treatment. Another purpose is to review the current literature and to differential diagnosis of bilateral facial paralysis. Methods and Results : The patient was treated by acupuncture, herb medication and self-massage on facial muscle for 14 weeks. House-brackmann grading score was improved into I/I (Rt/Lt) from IV/IV. Conclusion : Through reviewing some literatures and reports, It is concluded that bilateral facial palsy was related to many other disorders and more ominous than unilateral facial palsy. therefore, its work-up should include a complete neurologic assesment and thorough evaluation. also, we consider that bilateral Bell's palsy can improve by oriental medical treatments.

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Optimal OPC Position and Fiber Dispersion Coefficients depending on WDM Channel Numbers (WDM 채널수에 따른 최적의 OPC 위치 및 광섬유 분산 계수)

  • Lee, Seong-Real;Chung, Jae-Pil
    • Journal of Advanced Navigation Technology
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    • v.11 no.2
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    • pp.177-186
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    • 2007
  • In this paper, the optimal position offset of optical phase conjugator (OPC) and the optimal dispersion offsets of fiber sections, which are alternating with the method for the symmetry of optical power and chromatic dispersion with respect to OPC, are numerically investigated as afunction of the WDM channel numbers. The WDM channel numbers are assumed to be 8, 12, 16, 20 and 24. The bit-rate of each channel is assumed to be 40 Gbps for all cases. It is confirmed that the optimal position offset of OPC and optimal dispersion offset of fiber section are gradually increased as the WDM channel numbers are gradually increased. But, the optimal dispersion values of fiber sections per OPC position offset of 1 km are independent on WDM channel numbers, because the optimal position offset of OPC and optimal dispersion offset of fiber section are simultaneously increased as the WDM channel numbers are increased. It is also confirmed that the applying of these optimal parameter values is efficient to WDM system with many channels rather than WDM with small channels.

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Characteristics of Nonthermal Plasma Source in Various Liquids

  • Lim, Seung-Ju;Min, Boo-Ki;Taylor, Nathan;Kim, Tae-Gyu;Kim, Hyeong-Seok;Yang, Seon-Pil;Jung, Jin-Yong;Han, Jin-Hyun;Lee, Jong-Yong;Kang, Seung-Oun;Choi, Eun Ha
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.259.1-259.1
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    • 2014
  • Recently non-thermal plasma has been frequently applied to various research fields. The liquid plasma have received much attention lately because of interests in surgical and nanomaterial synthesis applications. Especially, intensive researches have been carried out for non-thermal plasma in liquid by using various electrode configurations and power supplies. We have developed a bioplasma source which could be used in a liquid, in which outer insulator has been covered onto the outer electrode. Also we have also put an insulator between the inner and outer electrode. Based on the surface discharge mode, the nonthermal bioplasma has been generated inside a liquid by using an alternating current voltage generator with peak voltage of 12 kV under driving frequency of 22 KHz. Here the discharge voltage and current have been measured for electrical characteristics. Especially, We have measured discharge and optical characteristics under various liquids of deionized (DI) water, tap water, and saline by using monochromator. We have also observed nitric oxide (NO), hydrogen peroxide (H2O2), and hydroxyl (OH) radical species by optical emission spectroscopy during the operation of bioplasma discharge inside various kinds of DI water, tap water, and saline. Here the temperature has been kept to be $40^{\circ}C$ or less when discharge in liquid has been operated in this experiment. Also we have measured plasma temperature by high speed camera image and density by using either H-alpha or H-beta Stark broadening method.

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Fabrication of an Alternating Multilayer Film of Poly(ethylene-alt-maleic anhydride) and Poly(4-vinyl pyridine) by Layer-by-Layer Self-Assembly Method (Layer-by-Layer 자기조립법에 의한 Poly(ethyiene-alt-maleic anhydride)i Poly(4-vinyl pyrtdine) 다층막 제조)

  • Lee Joon Youl;Hong Sook-Young
    • Polymer(Korea)
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    • v.29 no.4
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    • pp.392-398
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    • 2005
  • Self-assembled multilayer thin films of poly(ethylene-alt-maleic anhydride) (PEMAh) and poly(4-vinyl pyridine) (P4VP) were fabricated by layer-by-layer (LbL) sequential adsorption. Fourier transform infrared (FT-IR) spectroscopic analysis of the self-assembled PEMAh/P4VP multilayer films confirms that the driving forces for the multilayer buildup are the intermolecular hydrogen bonding and electrostatic interactions. The linear increase of absorption peak of P4VP at 256 nm with increasing number of PEMAh/P4VP bilayers indicates that the multilayer buildup is an uniform assembling process. We also investigate the effects of polyelectrolyte concenhation variation of the dipping solution and pH variation of the PEMAh solution on the multilayer film formation. Thickness. adsorbed polyelectrolyte mass and surface roughness of the multilayer films were measured by UV-visible spectroscopy, quartz crystal microbalance (QCM), and atomic force microscopy (AFM), respectively.

Characterization of polysaccharide A-1 from Opuntia ficus-indica and it's protection effect on alcoholic induced hepatic oxidative stress (Opuntia ficus-indica 다당 A-1의 특성 및 알코올유도 간 산화스트레스의 보호 효과)

  • Ryu, Il-Hwan;Kwon, Ji-Wung;Lee, Eoh-Jin;Yun, Young-Gab;Kwon, Tae-Oh
    • Herbal Formula Science
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    • v.17 no.2
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    • pp.163-174
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    • 2009
  • Reactive oxygen species(ROS) can induce hepatotoxicity and trigger apoptosis in the liver. In this study, we investigated the sulfated polysaccharide A-1 from Opuntia ficus-indica against alcoholic oxidative stress in human liver Hep G2 cell. An antioxidant substance A-1 obtained from the enzymatic extract of Opuntia ficus-indica fruit was purified by DEAE-cellulose ion exchange and sephadex G-100 gel permeation chromatography. The purification yield and molecular weight were 14.3% and 1.8 KDa, respectively. The A-1 predominately contained arabinose, galactose, rhamnose and also sulfate group. The structure of A-1 was investigated by periodate oxidation, FT-IR spectroscopy, $^1H$-NMR spectroscopy. The A-1 mainly composed of alternating unit of ${\rightarrow}4$)-$\alpha$-L- Rapp-2-$SO_3^-$-$\alpha$-L-Galp-($1{\rightarrow}$ and branched linkage of $\beta$-D-Arbp- ($5{\rightarrow}$. The antioxidative activity was measured using the SOD, CAT activity and GSH assay, respectively. The expression of Nrf2 protein was analyzed by western blotting. The viable cell count analyzed by autofluorescence. Oxidative stress induced by ethanol(1 M) were dramatically reduced by A-1 treatment. A-1 also prevented cell death induced by oxidative stress. It also increased expression Nrf2 protein level. We concluded that sulfated polysaccharide A-1 from Opuntia ficus-indica effectively protect Hep G2 liver cell from alcoholic oxidative stress.

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Optical reflectance of TiO2/SiO2 multilayer coating flat mirrors (TiO2/SiO2 다층 박막 평판 mirror의 광학적 반사)

  • Lee, Chanku;Lee, Sudae;Joung, Maengsig
    • Journal of Korean Ophthalmic Optics Society
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    • v.7 no.1
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    • pp.75-78
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    • 2002
  • Thirty three layer $TiO_2/SiO_2$ coating mirrors with high reflectance through a 620~820nm wavelength range have been designed and fabricated by electron beam evaporation method. Multilayer films were deposited on glass(BK7) and sequentially. The high reflector design is based on alternating high and low refractive index layers. $n_H$ and $n_L$ such that a "stopband"(or area of high reflectivity) is created that is centered around the design wavelength. ${\lambda}_0$. The measured transmittance spectrum with an incident wavelength at an incident angle of $40^{\circ}{\pm}7^{\circ}$ exhibited a reflectance of 99.9% at the wavelength of 620~820nm but high peak transmittance in the wavelength region from 700 to 740nm.

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A Study of Occurrence and Alternating Current of a Matal Kwan in Korean Ancient Times (한국 고대 금속관의 발생과 그 교류에 관한 연구)

  • 진미희;권영숙
    • Journal of the Korean Society of Clothing and Textiles
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    • v.19 no.2
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    • pp.297-316
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    • 1995
  • The system and symbolizing ideologic meanings of the metallic Kwon in period of the Three-Kingdoms were comsidered by comparing to their cultural path and structal styles throughout the tree and the deer worship ideology. The results of this study are as followings; Firstly, the beginning of the Korean, mostly northern style was originated from metal tools of the Bronze age in BC 6c-7c. The maJ;lufature of the metallic adornment brought the pr-evailing use of metallic objects of craftwork after the supply of ironmongery. Secondly, the cultmal characteristics of the metallic Kwan in the kor-ean Peninsula were influenced f-rom the northern chinese tribes, Momg Go, Hung No, and Sien-pi who were transmitted from the scythian of the southern Russia having a prefenence for gold. Thir-dly, the metallic Kwon of the Kogmgo and the Baekje era was ideologically based on the ar-t of Buddism of the pattern of blazing flame, the carved pattern of flower- of herb, and the honey. sukle which were tramsmitted to china thr-ough the silk noad. Fourthly, the metallic K wam of the silla era consisted of the tree and the antler types in closely nelated to the tree and the deer ideology which were based on the background of shamanism. It should be raid that the metallic Kwan of the silla esa are connected to the type of nor-them ancient K wan. Lasthy, the metallic Kwan-Mo of the Kaja esa was mosthy original type of flower of herb even if kome of these ar-e similiar to the tree adornment type of silla. This type of flower of herb in based on the scythian type with a statue im silveer founded at Alexandnopol in the southern russia.

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