• Clinical and Experimental Pediatrics
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• 제56권8호
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• pp.338-342
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• 2013

Purpose: Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children. Methods: We conducted a cross-sectional study comprising 615 Korean children (age, 3 to 6 years). Symptoms of allergic diseases were assessed using the Korean version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire that was modified for preschool children. Comorbidities of allergic diseases were assessed by 'In the last 12 months, has your child had symptoms?'. Results: The prevalence of symptoms of asthma, allergic rhinitis, and atopic dermatitis as recorded using the ISAAC questionnaire, within the last 12 months was 13.8%, 40.7%, and 20.8%, respectively. The symptom rates of allergic conjunctivitis, food allergy, and drug allergy were 14.8%, 10.4%, and 0.8%, respectively. The prevalence of allergic rhinitis in children with asthma was 64.3% and that of asthma in children with allergic rhinitis was 21.6%. The prevalence of rhinitis in children with conjunctivitis was 64.8% and that of conjunctivitis in children with rhinitis was 23.6%. Conclusion: The prevalence of current rhinitis in our preschool children is shown to be higher than that previously reported. Allergic conjunctivitis is closely associated with asthma and allergic rhinitis. However, further studies are warranted to determine the prevalence and effects of these comorbidities on health outcomes in preschool children.

• 한방안이비인후피부과학회지
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• 제18권1호
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• pp.172-182
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• 2005

Objective : The purpose of this study was to know the clinical effect of Hydrotherapy based Ultasonic spa on Atopic Dermatitis and Allergic Rhinitis. Methods : Allery Test(MAST CLA Allergy system, inhalant panel), DITI, Bio Chemistry, Hematology were investigated in 20 patients(Atopic Dermatitis 10, Allergic Rhinitis 10) who visited Department of Ophthalmology & Otolaryngology & Dermatology, Semyung Oriental medicine hospital from November 2004 to January 2005. Results : 1. In atopic dermatitis patients, there was good in 7 cases(70%), excellent in 3 cases(30%). 2. In allergic rhinitis patients there was improved in 5 eases(50%), good in 2 cases(20%), unimproved in 3cases(30%). 3. In conclusion, there was good(doctor and patients ail) in 6(60%), unimproved in 3(30%) Conclusion : Hydrotherapy based Utasonic spa showed useful effect on Atopic Dermatitis and Allergic Rhinitis.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.662-674
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• 2018

Purpose: Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, the effect of allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The aim of this study was to evaluate the levels of ILC subsets in allergic rhinitis (AR) patients in response to house dust mite (HDM)-specific immunotherapy. Methods: We enrolled 37 AR patients undergoing AIT (16 responders and 11 non-responders) for 2 years, 35 HDM AR patients and 28 healthy subjects. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry to identify ILC subsets. Stimulation of ILC2s with recombinant allergen-specific protein was used to determine ILC2's activation (CD69 expression). Results: Responder AIT patients and healthy subjects had a decreased frequency of circulating ILC2s compared to non-responder AIT and AR patients. Conversely, ILC1s from responder AIT patients and healthy subjects showed increased frequency compared to non-responder AIT and AR patients. The frequency of ILC3s natural cytotoxicity receptor $(NCR)^+$ and $NCR^-$ in responder AIT patients was significantly lower compared to AR patients and healthy subjects. The ILC1: ILC2 proportion in responder AIT patients was similar to that of healthy subjects. PBMCs from patients who were responders to AIT had a significantly lower expression of the activation marker CD69 on ILC2s in response to allergen re-stimulation compared to AR patients, but no difference compared to non-responder AIT patients and healthy subjects. Conclusions: We propose that AIT might affect ILC responses. The activation of ILC2s was reduced in AR patients treated with AIT. Our results indicate that a relative ILC1/ILC2 skewed response is a possible key to successful AIT.

• Journal of Dairy Science and Biotechnology
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• 제38권1호
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• pp.19-26
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• 2020

Allergic diseases, including atopic dermatitis, asthma, allergic rhinitis, and food allergies, could be caused by dysbiosis that results in an immune system imbalance. The incidence of allergic diseases has been increasing and they are now one of the most common diseases throughout the world. Recently, probiotics have been suggested as an alternative intervention for the prevention and treatment of allergic diseases. Probiotics are endogenous microflora with functional effects within hosts. They have various clinical and immunological capacities and have recently been considered as a supplement for the treatment and prevention of allergic diseases. Probiotic bacteria modulate immune cells such as Th1, Th2, and regulatory T cells that are correlated with protection against atopic dermatitis, however, safety concerns for the use of probiotics have been raised. Therefore, further research is needed to clarify the efficacy and safety of probiotics in the treatment of allergic diseases.

• Journal of Korean Biological Nursing Science
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• 제15권4호
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• pp.264-271
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• 2013

Purpose: The purpose of this study was to analyze the symptoms of allergic rhinitis among university students and assess their quality of life (QOL) in order to establish an effective program for university students with allergic rhinitis. Methods: The data were collected in May, 2012 in a university school health center. The collected data were analyzed in terms of frequency, percentage and mean for the symptom types and QOL among 131 university students with allergic rhinitis. An independent t-test was conducted to determine differences in QOL according to general and disease related characteristics. Results: Symptoms were reported in the following order: nasal obstruction, rhinorrhea, sneezing, and nasal itching respectively. The mean score of QOL of the participants was 2.24 (5 point). Nasal symptoms such as rhinorrhea (M=3.16) and nasal obstruction (M=3.12) had the highest score and affected QOL badly in the item analysis. QOL differed according to the diagnosis of allergic rhinitis history, skin test reaction, some symptoms and allergens. Conclusion: To establish an effective management program for increasing QOL among university students with allergic rhinitis, symptom management methods for nasal obstruction and rhinorrhea should be included in the program.

• 생명과학회지
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• 제14권5호
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• pp.847-854
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• 2004

알러지는 복합적인 유전적, 환경적 요인에 의해 발병하는 질환이다. 선진국에서 알러지 질환의 수가 증가함에 따라 알러지에 대한 관심이 증가하고 있으며 이에 대한 유전적인 원인에 대한 관심도 증가하고 있다. 알러지에는 천식, 아토피, 비염을 포함한 알러지에 관련된 유전자와 염색체 부위가 밝혀지고 있다. 하지만 이들에 대한 평가 및 확인이 제대로 진행되지 않는 상황이다. 본 연구팀은 알러지를 일으키는 유전적인 요인을 찾고자 하였다. 과학영재학교 138명을 대상으로 하였고 이들 중 약 30%가 천식, 아토피, 비염과 같은 알러지 질환을 앓고 있었다. 본 연구팀은 지금까지 보고된 연구 결과들을 토대로 알러지에 관련된 유전자를 찾았으며 그중 알러지를 일으키는데 관여하는 IL-4와 IL-4Ra를 후보 유전자로 선정하였다. 지금까지 발표된 보고들은 SNP의 발견과 그리고 하나 혹은 두개의 SNP에 초점을 맞추어 발표한 반면, 본 연구팀은 알러지와 관련하여 발표된 IL-4와 IL-4Ra의 SNP를 종합적으로 분석하고자 하였다 과학영재학교 학생들 96명을 머리카락 샘플을 확보하고 이 것으로 9개 의 SNP를 선정 하여 염기서열 분석 및 MALDI-TOF을 이용한 유전자 분석을 진행하였다. 각각의 SNP에 대해 알러지를 가지고 있는 그룹과 정상 그룹간의 약간의 차이들은 있었지만 이것이 알러지를 가지고 있는 사람과 정상인과의 구분을 시켜줄 수 있을 정도는 아니었다. 이러한 결과는 현재 한국에서 널리 행하여지고 있는 유전자 검사에 대한 재고가 필요함을 시사한다.

• Child Health Nursing Research
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• 제18권1호
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• pp.29-35
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• 2012

Purpose: The purpose of this study was to analyze the prevalence of allergic disease among elementary school students in rural and urban areas. Methods: In this study, 1,513 elementary students (1,163 in urban areas, 350 in rural areas) were surveyed. Data were analyzed using frequency, percentage of allergic symptoms and $X^2$ test was used to identify differences in the prevalence of allergic symptoms between urban and rural area students. The SAS program was used in the data analysis. Results: There were significant differences in the prevalence of allergic disease according to whether there was a family member with a prior history of allergy symptoms. 48.7% of surveyed students (49.4% in urban, 46.3% in rural) had allergic symptoms. Allergic rhinitis was the most frequent allergic symptom in both urban and rural students. Conclusion: These results suggest that there is a need to prevent and manage allergies among elementary students. The family history should be considered an important factor when a program for allergy prevention and management is developed. Interventions are needed in both areas, especially for students with allergic rhinitis.

• 대한임상검사과학회지
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• 제51권2호
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• pp.134-144
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• 2019

대사증후군과 알레르기 비염은 중요한 만성질환이다. 본 연구에서는 대사증후군의 각 항목에 따른 알레르기 비염 유병률의 관계를 분석하였다. 제4, 5, 6기 및 제7기 1차년도 국민건강 영양조사 자료를 이용한 것으로(KNHANES IV, V, VI, VII-1) (2007~2016년) 이 자료를 통합하여. 51,854명의 연구대상자를 선정하였다. 연령대는 청장년(19~39세), 중년(40~64세), 노년(65세 이상)으로 분류하였다. 또 대사증후군에 영향을 미치는 일반적인 특성인 근력운동, 걷기운동, 흡연, 음주가 미치는 영향이 있다는 사실에 근거하여 조사하였다. 따라서 본 연구는 연령대 및 근력운동, 걷기운동, 흡연, 음주에 따라서 대사증후군 및 알레르기 비염의 유병률에 미치는 영향을 조사했다. 연구 결과 전 연령대에서 대사증후군이 없는 대상자가 대사증후군이 있는 대상자보다 알레르기 유병률이 높았고, 이는 연령대가 낮을 수록 알레르기 유병률이 높은 것으로 나타났다. 종합해 보면, 이 연구의 결과는 연령별, 일반적 특성별(근력운동, 걷기운동, 흡연, 음주), 대사증후군 또는 대사증후군 각각의 항목별로 알레르기 비염 유병률에 유의한 영향을 미친다는 것을 확인하였다. 본 연구에서 발견된 근거를 바탕으로 대사증후군과 알레르기 비염 유병률의 상관관계를 더 잘 이해하는데 도움이 될 것이다.

• Clinical and Experimental Pediatrics
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• 제50권5호
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• pp.409-415
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• 2007

Allergy skin prick test and intradermal test represent one of the major tools in the diagnosis of IgE-mediated diseases like as atopic asthma, allergic rhinitis, atopic dermatitis, food and drug allergy, and insect bite when properly performed. Skin tests are of particular importance in fields such as allergen standardization, pharmacology, and epidemiology. Even if skin tests seem easy to perform, adequate and proper interpretation requires well-trained physicians who can recognize the numerous factors that may modify the results of skin tests.

• 한국학교ㆍ지역보건교육학회지
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• 제17권3호
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• pp.11-25
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• 2016

Background & Objectives: There were increasing evidence about the relationship between allergy related disease such as asthma, atopic dermatitis and allergic rhinitis and suicide ideation. However little was known about the concrete relatedness between severity and comorbidity of allergy related disease with suicide ideation. The objective of this study was to investigate the cases of the prevalence of suicide ideation among adolescents with allergy related disease such as asthma, atopic dermatitis and allergic rhinitis, and examine the association between allergy related disease and suicidal ideation among adolescents in South Korea. Methods: Data was based on Korean Youth Risk Behavior Web-based Survey(2014) which was a cross-sectional study containing 34,874 Korean middle and high school students who diagnosed with allergy related disease. We used the weights, strata and primary sampling unit information provided by the public use dataset to compute descriptive statistics and logistic regressions. Computations were done with SPSS version 20.0. Results: 19.9%, 15.6%, 13.8% of adolescents who suffered from one, two and three of allergy related diseases respectively reported having been thought of suicide ideation. Socio-demographic factors were adjusted as control variables. Students with greater severity of disease were more likely to have suicide ideation. Odds ratio for students who were absent one to three days from school because of allergies was 1.96(95% CI 1.51-2.46), and odds ratio for those who were absent more than four days from school was 3.60(95% CI 2.46-5.28). Conclusions: Given that adolescents' severity and comorbidity of allergy related disease were clearly associated with suicide ideation, suicide prevention programs for adolescents with allergy related disease should be improved by strategic approaches towards the severity and comorbidity of disease.