• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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• pp.890-892
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• 2007

We report the syntheses and characterizations of a novel TTF derivative. To extend the mesogenic core, alkoxy naphthalenic group and short alkyl chains were introduced on either side of TTF unit, which results in asymmetric planar structure. TTF molecule is expected to show many interesting properties.

• Elastomers and Composites
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• 제55권2호
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• pp.137-146
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• 2020

Part 1 provides a theoretical introduction of the hydrolysis mechanism, while Part 2 introduces other types of reaction mechanisms after hydrolysis in elastomer and PA66 composites. We reviewed the condensation reaction, which occurs after hydrolysis in bi-functional alkoxy silane (TESPD & TESPT), and investigated its effects on the mechanical properties of the composites. We also reviewed activators such as zinc soap, which enhances the mechanical properties of silica-silane-filled elastomer composites. The interaction parameter of silica-silane-filled elastomer composites [α_C (alpha C)] were also discussed. The effects of hydrolysis on the mechanical property changes in plastic composites were compared and reviewed.

• 한국막학회:학술대회논문집
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• 한국막학회 2004년도 Proceedings of the second conference of aseanian membrane society
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• pp.170-174
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• 2004

Most of thin film composite reverse osmosis membranes include amide linkages, which are susceptible to chlorine attack resulting in N-chloro derivatives. This study examined a new method based on post-treatment of reverse osmosis membrane with various silane derivatives to improve chlorine resistance. The silane derivatives contain one alkyl group and three alkoxy groups such as trifluoromethyltrimethoxysilane, 3-aminopropylmethoxydiethoxysilane and 3, 3, 3-trifluoropropyltrimethoxysilane. Compared to commercial membranes, silane derivatives coated membranes showed significantly enhanced chlorine durability.

• Bulletin of the Korean Chemical Society
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• 제12권1호
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• pp.57-60
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• 1991

Benzosilacyclobutenes were prepared from the reactions of 1,1-dichlorobenzosilacyclobutene with Grignard reagents or t-butyllithium. In the thermal reactions with alcohols, benzosilacyclobutenes underwent both benzyl-silicon and aryl-silicon bond rupture to yield (dialkyl)alkoxy-o-tolylsilanes and (dialkyl)alkoxybenzylsilanes, respectively. The photochemical reactions, however, produced only the former products via o-silaquinone methides.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.342.2-342.2
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• 2002

The ${\beta}$-turn has been implicated as an important conformation for biological recognition of peptides or proteins. Benzodiazepine classes have been known as one of the non peptide ${\beta}$-turn mimic scaffolds. We have developed an efficient approach for the synthesis and derivatization of a scaffold of hydroxytetrahydrodizepinone class in order to screen compound library in various protein targets for new lead generations as well as for structure activity relationships of the scaffold. (omitted)

• Archives of Pharmacal Research
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• 제29권12호
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• pp.1080-1085
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• 2006

A series of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-one derivatives were synthesized using 7-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and the subcutaneous pentylenetetrazole test (sc-PTZ), and their neurotoxicities were measured by the rotarod neurotoxicity test (Tox). The tests demonstrated that 8-hexyloxy-4,5-dihydro-[1.2.4]triazole[4.3-a]quinoline-1-one (4e) and 8-heptyloxy-4,5-dihydro-[1,2,4]triazole[4, 3-a]quinoline-1-one (4f) were the most potent anticonvulsants, with 4e having $ED_{50}$ values of 17.17 mg/kg and 24.55 mg/kg and protective index ($PI=TD_{50}/ED_{50}$) values of 41.9 and 29.3 in the MES and sc-PTZ tests, respectively, and 4f having $ED_{50}$ values of 19.7 mg/kg and 21.2 mg/kg and PI values of 36.5 and 33.9 in the MES and sc-PTZ tests, respectively. The PI values of 4e and 4f were many fold better than that of the marketed drugs phenytoin, carbamazepine, phenobarbital and valproate, which have PI values in the range of 1.6-8.1 in the MES test and <0.22-5.2 in the sc-PTZ test. Structure-activity relationships were also discussed.

• 공업화학
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• 제25권4호
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• pp.352-356
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• 2014

${\alpha},{\omega}$-Aminopropylpolydimethylsiloxane을 bisphenol-A diglycidyl ether (DGEBA)계 이관능성 에폭시 수지와 반응시켜 polydimethylsiloxane (PDMS)의 양 말단에 에폭시가 도입된 실리콘 변성 에폭시 수지(EMPDMS)를 제조한 다음 alkylesteraminopropyl alkoxy silane (XD 5607)을 반응시켜 PDMS가 도입된 에폭시 hybrid 화합물(EMPDMSH)을 제조하고 이를 FT-IR, $^1H$-NMR 및 $^{29}Si$-NMR로 구조를 확인하였다. EMPDMSH base 수지에 용매를 혼합하여 코팅 액을 제조하였으며, 이를 에폭시/유리 섬유 복합재료로 얻어진 필름에 도포하고 경화시킨 후 base수지 중에 함유된 PDMS의 함량에 따른 물성을 측정하였다. 코팅 면의 접촉각을 측정한 결과 기존의 에폭시 수지로 코팅하여 얻은 코팅 면에 비해 접촉각이 $41^{\circ}$에서 $71^{\circ}$로 약 $30^{\circ}$정도 증가되고 있어 코팅 면에 PDMS가 나타나 있음을 확인할 수 있었다. 또한 접착력 및 표면 평활도 개선효과 측정 결과 에폭시 자체 코팅 액이나 일반적으로 많이 사용되고 있는 아크릴계 코팅 액 보다 5B 등급의 뛰어난 접착력을 나타내었고 평활도 개선 효과도 우수함을 나타내었다.

• 접착 및 계면
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• 제15권4호
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• pp.161-168
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• 2014

페놀과 피리딘 간의 단일 수소결합을 이용하여 새로운 형태의 자기 집합된 원반형 액정을 제조하고 그 액정 특성을 조사하였다. 원반형 구조 설계를 위해 phloroglucinol을 중심부 분자로, 체계적으로 알킬사슬 길이를 변화시킨 trans-4-alkoxy-4'-stilbazole을 주변 물질로 사용하였다. 적외선 분광 분석을 통해 중심부 분자와 주변 물질 사이의 분자간 수소결합이 성공적으로 형성됨을 확인하였고, 또한 수소결합의 안정성이 분자 정렬에 의해 크게 영향을 받음을 확인하였다. 자기 집합된 원반형 액정 복합체는 원반형 메소겐 주위의 알킬 사슬 길이에 따라 다른 액정상들을 나타내었다. 긴 알킬사슬을 함유하는 액정 복합체의 경우 육방형 컬럼상이 나타났으며, 상대적으로 짧은 사슬을 갖는 다른 액정 복합체에서는 네마틱 컬럼상이 형성되었다. 이는 자기 집합된 원반형 액정 복합체의 액정상 구조가 원반형 핵 단위 주변의 알킬사슬 길이에 의해 크게 영향을 받음을 의미하였다.

• Archives of Pharmacal Research
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• 제29권11호
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• pp.969-976
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• 2006

Novel chalcones were found as potent inhibitors of interleukin-5 (II-5). 1-(6-Benzyloxy-2-hydroxyphenyl)-3-(4-hydroxyphenyl)propenone (2a, 78.8% inhibition at $50\;{\mu}M,\;IC_{50}=25.3\;{\mu}M$) was initially identified as a potent inhibitor of IL-5. This activity is comparable to that of budesonide or sophoricoside (1a). The benzyloxy group appears to be critical for the enhancement of the IL-5 inhibitory activity. To identify the role of this hydrophobic moiety, cyclohexyloxy (2d), cyclohexylmethoxy (2c), cyclohexylethoxy (2e), cyclohexylpropoxy (2f), 2-methylpropoxy (2g), 3-methylbutoxy (2h), 4-methylpentoxy (2i), and 2-ethylbutoxy (2j) analogs were prepared and tested for their effects on IL-5 bioactivity. Compounds 2c ($IC_{50}=12.6\;{\mu}M$), 2d ($IC_{50}=12.2\;{\mu}M$), and 2i ($IC_{50}=12.3\;{\mu}M$) exhibited the most potent activity. Considering the cLog P values of 2, the alkoxy group contributes to the cell permeability of 2 for the enhancement of activity, rather than playing a role in ligand motif binding to the receptor. The optimum alkoxy group in ring A of 2 should be one that provides the cLog P of 2 in the range of 4.22 to 4.67.

• 문화기술의 융합
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• 제7권2호
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• pp.389-394
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• 2021

본 연구에서는 알콕시-아민-알루미늄 유도체인 DPHMP-AlH와 프로피오페논, 부티로페논과의 분자구조 및 경계궤도함수의 특성을 알아보았다. 또한, 전이상태의 입체구조 및 열역학적 파라미터를 계산하여 최종 생성물인 (R),(S)-페닐프로판올과 (R),(S)-페닐부탄올의 선택적 환원에 미치는 영향을 조사하였다. 그 결과 입체 분자구조적 안정성을 고려해 볼 때 (S)형 DPHMP-AlH와 알킬페논의 전이상태가 더 안정한 것으로 나타났으며, 이 결과로부터 DPHMP-AlH와 알킬페논의 선택적 환원으로 얻어진 최종 결과물은 (S)-(1)-페닐프로판올과 (S)-(1)-페닐부탄올의 형성이 유리한 것을 확인하였다.