Synthesis of 8-Alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and Evaluation of their Anticonvulsant Properties
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Sun, Xian-Yu
(College of Pharmacy, Yanbian University)
Jin, Yun-Zhe (College of Pharmacy, Yanbian University) Li, Fu-Nan (Key Laboratory of Organism Functional Factors of the Changbai Mountain (Yanbian University), Ministry of Education) Li, Gao (Key Laboratory of Organism Functional Factors of the Changbai Mountain (Yanbian University), Ministry of Education) Chai, Kyu-Yun (Department of Chemistry, Wonkwang University) Quan, Zhe-Shan (Key Laboratory of Organism Functional Factors of the Changbai Mountain (Yanbian University), Ministry of Education) |
1 | Colin, X. and Sauleau, A., Coulon, J. 1,2,4-Triazole mercapto and aminonitriles as potent antifungal agents. Bioorg. Med. Chem. Lett., 13, 2601-2605 (2003) DOI ScienceOn |
2 | Cui, L. J., Xie, Z. F., Piao, H. R., Li, G., Chai, K. Y., and Quan, Z. S. Synthesis and anticonvulsant activity of 1-substituted-7- benzyloxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline. Biol. Pharm. Bull., 28,1216-1220 (2005) DOI ScienceOn |
3 | Gitto, R., Orlando, V., Quartarone, S., De Sarro, G., De Sarro, A., Russo, E., Ferreri, G., and Chimirri, A., Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives. J. Med. Chem., 46, 3758 (2003) DOI ScienceOn |
4 | Quan, Z. S., Wang, J. M., Lee, W. Y., Kwak, K. C., Kang, H. C., and Chai, K. Y., Synthesis of 6-alkyloxyl-3,4-dihydro-2(1H)- quinoliones and their Anticonvulsant Activities. Bull. Kor. Chem. Soc., 26, 1757-1760 (2005) DOI |
5 | Xie, Z. F., Chai, K. Y., Piao, H. R., Kwak, K. C., and Quan, Z. S., Synthesis and anticonvulsant activity of 7-alkoxyl-4,5- dihydro-[1,2,4]triazole[4,3-a]quinolines. Bioorg. Med. Chem. Lett., 15, 4803-4805 (2005) DOI ScienceOn |
6 | Zappala, M., Gitto, R., Bevacqua, F., Quartarone, S., Chimirri, A., Rizzo, M., De Sarro, G., and De Sarro, A., Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H- [1,2,4] triazole [4,5-c] [2,3] benzodiazepin-3(2H)- ones. J. Med. Chem., 43, 4834-4839 (2000) DOI ScienceOn |
7 | Cunha, A. C., Figuerredo, J. M., and Tributino, J. L., Antiplatelet properties of novel N-substituted- phenyl-1,2,3-triazole-4- acylhydrazone derivatives. Bioorg. Med. Chem., 11, 2051- 2059 (2003) DOI ScienceOn |
8 | Ucar, H., Van derpoorten, K., Cacciagurra, S., Spampinato, S., Stables, J. P., Depovere, P., Isa, M., Masereel, B., Delarge, J., and Poupaert, J. H., Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives. J. Med.Chem., 41, 1138-1145 (1998) DOI ScienceOn |
9 | Lazrek, H. B., Taourirte, M., Oulih, T., Barascut, J. l., Imbach, J. L., Pannecouque, C., Witrouw, M., and De Clercq, E. Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides. Nucleosides. Nucleotides. Nucleic. Acids., 20, 1949-1960 (2001) DOI ScienceOn |
10 | Krall, R. J., Penry, J. K., White, B. G., and Kupferberg, H. J., Antiepileptic drug development: II. Anticonvulsant drug screening. Epilepsia, 19, 409-428 (1978) DOI ScienceOn |
11 | Poter, R. J., Cereghino, J. J., Gladding, G. D., Hessie, B. J., Kupferberg, H. J., and Scoville, B., Antiepileptic drug development program. Clev. Clin. J. Med., 51, 293-305 (1984) DOI |
12 | Gulerman, N. N., Dogan, H., N., Rollas, S., Johansson, C., and Celik, C., Synthesis and structure elucidation of some new thioether derivatives of 1,2,4-triazoline-3-thiones and their antimicrobial activities. Farmaco, 56, 953-958 (2001) DOI ScienceOn |
13 | Chimirri, A., Bevacqua, F., Gitto, R., Quartarone, S., Zappala. M., De Sarro, A., Maciocco, L., Biggo, G., and De Sarro, G., Synthesis and anticonvulsant activity of new 11H-triazole [4,5-c][2,3]benzodiazepines. Med. Chem. Res., 9, 203-212 (1999) |
14 | Maria, Z., Rosaria, G., Francesca, B., Silvana, Q., Alba, C., Milena, R., Giovambattista, D. S., and Angela D. S., Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4] Triazole[4,5-c][2,3]benzodiazepin- 3(2H)-ones. J. Med. Chem., 43, 4834-4839 (2000) DOI ScienceOn |
15 | Kane, J. M., Baron, B. M., Dudley, M. W., Sorensen, S. M., Staeger, M. A., and Miller, F. P., 2,4-Dihydro-3H-1,2,4-triazol- 3-ones as anticonvulsant agents. J. Med. Chem., 33, 2772- 2777 (1990) DOI |
16 | Labanauskas, L., Udrenaite, E., Gaidelis, P., and Brukstus, A., Synthesis of 5-(2-,3- and 4-PTZhoxyphenyl)-4H-1,2,4-triazole- 3-thiol derivatives exhibiting anti-inflammatory activity. Farmaco, 59, 255-259 (2004) DOI ScienceOn |
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