• 생약학회지
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• 제5권3호
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• pp.159-166
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• 1974

The Yellow needle crystal was isolated from Atractylis Rhizoma, having mp $124{\sim}126^{\circ}C$(decomp.), the chemical composition $C_{16}H_{21}N_{3}O_{6}$, and its m.w. 251. The pharmacological actions of this alkaloid were studied by various psycopharmacological experiments. 1) In order to see the effect of this Atractylis(=At.) alkaloid on gross general behaviors in mice, a behavioral analysis experiment was adapted. The occurrence number of sleep and lying in At. alkaloidal animals with the doses 10mg/kg or 20mg/kg was increased but the number of jumping, exploration, rearing and defecation was significantly decreased than those of placebo. 2) The effect of the At. alkaloid on unlearned emotional behaviors of mice was studied with an open-field method. The At. alkaloidal groups with the doses 20mg/kg or 30mg/kg showed less often the frequency of locomotion than that of placebo. 3) To know the effect of the At. alkaloid on the learning, a standard water maze experiment and conditioned avoidance response were conducted. As compared to placebo control, the aquisition rate of the maze learning in the alkaloidal mice with the dose of 10mg/kg or 20mg/kg was significantly impaired and the speed of swimming was also signficantly delayed. In the conditioned avoidance response, the extinction performances of the alkaloidal rats with doses of 20mg/kg or 30mg/kg did not differ significantly than that of placebo.

• 생약학회지
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• 제8권3호
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• pp.109-113
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• 1977

The alkaloid fraction was separated from the methanol extract of 13 Saudi Arabian plants. The Rf values of the spots appeared on TLC (silicagel G) plates were calculated with each alkaloid fraction. The results are presented in this paper.

• 생약학회지
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• 제32권4호통권127호
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• pp.307-310
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• 2001

In order to investigate alkaloid contents in different Fritillaria species, we analyzed 17 Fritillaria species by HPLC using prederivatization method. The contents of alkaloid $fr.5(11-deoxo-6-oxo-5{\alpha},6-dihydrojervine)$, delavinone and delavine were analyzed and compared.

• 생약학회지
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• 제19권3호
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• pp.177-180
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• 1988

A diterpene alkaloid and a disaccharide were isolated from root of Aconitum uchiyamai, and identified as mesaconitine and sucrose respectively by UV, IR, MS, and NMR data.

• 생약학회지
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• 제15권2호
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• pp.108-113
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• 1984

The structure of tuguaconitine, MP $196{\sim}198^{\circ}C$, a new diterpene alkaloid isolated from the roots of Aconitum sibiricum P., was studied. Its empirical formula is $C_{23}H_{35}NO_7$ and spectroscopic evidence shows that the base contains three methoxyl, three hydroxyl and one N-ethyl groups. The acute toxicities of most of Aconitum species were strong and the acute toxicity of the alkaloid fraction of A. sibiricum was decreased by Glycyrrhizae, black bean or Zingiberis extract.

• Journal of Microbiology and Biotechnology
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• 제10권1호
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• pp.107-110
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• 2000

Elicited cells with methyl jasmonate continued to produce benzophenanthridine alkaloids throughout medium changes in suspension cultures of Eschscholtzia californica. Large increases in alkaloid production were observed by re-elitations with medium changes. The total alkaloid production increased during the successive elicitation steps reaching a maximum level on the 4th elicitation. The highest total alkaloid produced was 250 mg/I, which was 20fold higher than that of the single elicitation and 4-fold higher than that of the normal culture without elicitation. The large increases in alkaloid production in successive re-elicitations with medium changes are believed to be caused by the accumulation of the signal transduction compound, jasmonate.

• 한국약용작물학회지
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• 제12권5호
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• pp.428-435
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• 2004

Alkaloid producing species of plants have long been a major component of the medicinal social and magico-religious aspects of human culture. A diverse array of biological activities has been attributed to different alkaloids including numerous members of benzylisoquinoline family of alkaloids. For biotechnological approaches of alkaloid biosynthesis in poppy family, plant regeneration protocol through somatic embryogenesis or shoot organogenesis is a first step. This paper describes the methods and applications of plant regeneration of poppy family.

• 생약학회지
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• 제25권4호통권99호
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• pp.395-398
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• 1994

A diterpene alkaloid in addition to hypaconitine and mesaconitine was isolated from the tubers of Aconitum napiforme (Ranunculaceae), which is an indigenous plant in Korea. Its structure was elucidated as 8-methoxy 14-benzoyl hypaconine by Physicochemical and spectroscopic data. This compound was isolated from this plant for the first time.

• Bulletin of the Korean Chemical Society
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• 제31권9호
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• pp.2715-2716
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• 2010

• Bulletin of the Korean Chemical Society
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• 제23권1호
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• pp.163-166
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• 2002