The First Step of Biotechnological Approaches for Alkaloid Biosynthesis in Papaveraceae: In vitro Plant Regenerations

  • Park, Sang-Un (Biology Research Center for Industrial Accelerators (BRCIA), Dongshin Univ.) ;
  • Yu, Chang-Yeon (Division of Appl. Plant Sci., College of Agric. & Life Sci., Kangwon Natl. Univ.) ;
  • Chae, Young-Am (School of Plant Science, Seoul National University)
  • Published : 2004.11.01

Abstract

Alkaloid producing species of plants have long been a major component of the medicinal social and magico-religious aspects of human culture. A diverse array of biological activities has been attributed to different alkaloids including numerous members of benzylisoquinoline family of alkaloids. For biotechnological approaches of alkaloid biosynthesis in poppy family, plant regeneration protocol through somatic embryogenesis or shoot organogenesis is a first step. This paper describes the methods and applications of plant regeneration of poppy family.

Keywords

References

  1. Ahmad N, Gupta S, Husain MM., Heiskanen KM, Mukhtar H (2000) Differential antiproliferative and apoptotic response of sanguinarine for cancer cells versus normal cells. Clin. Cancer Res. 6:1524-8
  2. Alkhimova OG, Kyrylenko TK, Vagyn YV, Heslop HJS (2001) Alkaloid biosynthesis in Papaver spp. cells in culture and during organogenesis. Ukrainskii-Biokhimicheskii-Zhurnal. 73:141-146
  3. Archambault J, Williams RD, Lavoie L, Pepin MF, Chavarie C (1994) Production of somatic embryos in a helical ribbon impeller bioreactor. Biotechnology and Bioengineering 44:930-943 https://doi.org/10.1002/bit.260440809
  4. Brown DC, Thorpe TA (1986) Plant regeneration by organogenesis, in Vasil, I.K. (eds.), Cell Culture and Somatic Cell Genetics of Plants, Vol. 3. Academic Press, New York, 1986, p. 49-65
  5. Brownstein MJ (1993)A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci USA. 90: 5391-5393 https://doi.org/10.1073/pnas.90.12.5391
  6. Calmo]B, Beirith A, Ferreira J, Santos ARS, Filho VC, Tunes RA (2000) Naturally occurring antinociceptive substances from plants. Phytother. Res.14: 401-18 https://doi.org/10.1002/1099-1573(200009)14:6<401::AID-PTR762>3.0.CO;2-H
  7. Cheney RH (1964) Therapeutic potential of Eschscholtziae californicae herba. Quart J Crud Drugs. 3:413-416
  8. Colombo M.L, Bosisio E (1996) Pharmacological Activities of Chelidonium majus L. (Papaveraceae). Pharmacological Research. 33:127-134 https://doi.org/10.1006/phrs.1996.0019
  9. Day KB, Draper J, Smith H (1986). Plant regeneration and thebaine content of plants derived from callus culture of Papaver bracteatum. Plant Cell Rep. 5:471-474 https://doi.org/10.1007/BF00269645
  10. Dzink JL, Socransky SS (1985) Comparative in vitro activity of sanguinarine against oral microbial isolates. Antimicrob Agents Chemother. 27:663-665 https://doi.org/10.1128/AAC.27.4.663
  11. Facchini PJ, Park SU, Bird BA, Samanani N (2000) Biochemistry, molecular biology, and metabolic engineering of benzylisoquinoline alkaloid biosynthesis. Korean J. Plant Tissue Culture 27:269-282
  12. Galewsky S, Nessler CL (1986) Synthesis of morphinane alkaloids during opium poppy somatic embryogenesis. Plant Sci. 45:215-222 https://doi.org/10.1016/0168-9452(86)90142-1
  13. Haberlandt G. (1902) Kulturversuche mit isolierten Pflanzenzellen. Naturwis. 111 :69-92
  14. Hara S, Falk H, Kleinig H (1985) Starch and triacylglycerol metabolism related to somatic embryogenesis in Papaver orientale tissue cultures. Planta 164:303-307 https://doi.org/10.1007/BF00402941
  15. Hahi I., Ghauri EG (1997) Regeneration in cultures of Papaver bracteatum as influenced by growth hormones and temperature. Plant Cell Tissue and Organ Culture 38:81-83
  16. Iwasa K, Moriyasu M, Yamori T, Turuo T, Lee D-U, Wiegrebe W (2001) In vitro cytotoxicity of the protoberberine-type alkaloids. J. Nat. Prod. 64:896-8 https://doi.org/10.1021/np000554f
  17. Iwasa K, Moriyasu M, Tachibana Y, Kim H-S, Wataya Y, Wiegrebe W, Bastow KF, Cosetino LM, Kozuka M, Lee K-H. (2001) Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and antiHIVagents. Bioorg. Med. Chem. 9:2871-84 https://doi.org/10.1016/S0968-0896(01)00154-7
  18. Kamo KK, Kimoto W, Hsu AF, Mahlberg PG., Bills DD (1982) Morphinane alkaloids in cultured tissues and redifferentiated organs of Papaver somniferum. Phytochemistry 21:219-222 https://doi.org/10.1016/0031-9422(82)80047-2
  19. Kang JS, Long PH, Lim HM, Kim YH, Blaschke G (2003) Achiral and chiral determination of benzophenanthridine alkaloids from methanol extracts of Hylomecon species by high performance liquid chromatography. Arch Pharm Res. 26(2):114-9 https://doi.org/10.1007/BF02976654
  20. Kassem MA, Jacquin A (2001) Somatic embryogenesis, rhizogenesis, and morphinan alkaloids production in two species of opium poppy. J. Biomedicine and Biotechnology 1:70-78 https://doi.org/10.1155/S1110724301000237
  21. Kavathekar AK (1974) Studies on origin, development, and dormancy of embryoids of Eschscholtzia califomica. Ph.D. Thesis. University of Delhi
  22. Kavathekar AK, Ganapathy PS (1973) Embryoid differentiation in Eschscholzia califomica. Curr Sci. 42:671-673
  23. Kavathekar AK, Ganapathy PS, Johri BM (1977) Chilling induces development of embryoids into plantlets in Eschscholzia. Z Pflanzenphysiol. 81 :358-363
  24. Kim SW, In DS, Kim TJ, Liu JR (2003) High frequency somatic embryogenesis and plant regeneration in petiole and leaf explant cultures and petiole-derived embryogenic cell suspension cultures of Hylomecon vemalis. plant Cell Tissue and Organ Culture 4:163-167
  25. Kim SW, Min BW, Liu JR (1999) High frequency plant regeneration from immature ovule-derived embryogenic cell suspension cultures of Chelidonium majus var. asiaticum. Plant Cell Tissue and Organ Culture 56:125-129 https://doi.org/10.1023/A:1006210205704
  26. Laurain MD, Gillet MF, Buchon LN, Fliniaux MA, Jacquin DA (1999) Somatic embryogenesis and rhizogenesis of tissue cultures of two genotypes of Papaver somniferum: Relationships to alkaloid production. Planta-Medica. 65:167-170 https://doi.org/10.1055/s-2006-960457
  27. Lazarz SA, Zillis MR, Sink KC (1982) In vitro propagation of Dicentra spectabilis. HortSci. 17:188189
  28. Lee KP, Lee DW (2003) Somatic embryogenesis and plant regeneration from seeds of wild Dicentra spectabilis (L.) LEM. Plant Cell Reports 22:105-109 https://doi.org/10.1007/s00299-003-0642-5
  29. Ma W, Fukushi Y, Tahara S, Osawa T (2000) Fungitoxic alkaloids from Hokkaido Papaveraceae. Fitoterapia, 71:527-34 https://doi.org/10.1016/S0367-326X(00)00193-3
  30. Morteza-Semnani K, Amin Gh, Shidfar MR, Hadizadeh H, Shafiee A (2003) Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum. Fitoterapia 74:493-6 https://doi.org/10.1016/S0367-326X(03)00113-8
  31. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant. 15:473-497 https://doi.org/10.1111/j.1399-3054.1962.tb08052.x
  32. Nessler CL (1982) Somatic embryogenesis in the opium poppy, Papaver somniferum. Physiol Plant. 55:453-458 https://doi.org/10.1111/j.1399-3054.1982.tb04526.x
  33. Nessler CL, Mahlberg PG (1978) Ultrastructure of laticifers in redifferentiated organs on callus from Papaver somniferum (Papaveraceae). Can J Bot. 57:675-685 https://doi.org/10.1139/b79-086
  34. Ovecka M, Bobak M, Erdelsky K, Samaj J, Blehova A, Kristin J (1996) Morphology and conversion ability of somatic embryos in long-term embryogenic callus culture of Papaver somniferum. Biologia Bratislava 51:417-423
  35. Ovecka M, Bobak M, Blehova A, Kristin J (1997) Papaver somniferum regeneration by somatic embryogenesis and shoot organogenesis. Biologia Plantarum Prague 40:321-328 https://doi.org/10.1023/A:1001049526976
  36. Ovecka M, Bobak M (1999) Structural diversity of Papaver somniferum L. cell surfaces in vitro depending on particular steps of plant regeneration and morphogenetic program. Acta Physiologiae Plantarum 21:117-126 https://doi.org/10.1007/s11738-999-0065-1
  37. Ovecka M, Bobak M, Samaj J (2000) A comparative structural analysis of direct and indirect shoot regeneration of Papaver somniferum L. in vitro. Plant Physiology 157:281-289 https://doi.org/10.1016/S0176-1617(00)80049-8
  38. Park SU, Facchini PJ (1999) High-efficiency somatic embryogenesis and plant regeneration in California poppy, Eschscholzia califomica Cham. Plant Cell Reports 19:421-426 https://doi.org/10.1007/s002990050750
  39. Park SU, Facchini PJ (2000) Agrobacterium-mediated stable transformation of opium poppy, Papaver somniferum L., via shoot organogenesis. Plant Physiology 157:207-214 https://doi.org/10.1016/S0176-1617(00)80192-3
  40. Park SU, Facchini PJ (2001) Improved somatic embryogenesisusing embryogenic suspension cultures of California poppy, Eschscholzia californica Cham. In Vitro Cellular and Developmental Biology- Plant. 37:35-39 https://doi.org/10.1007/s11627-001-0007-0
  41. Phillips GC, Hubstenberger JF, Hansen EE (1995) Plant regeneration from callus and cell suspension cultures by somatic embryogenesis. In Gamborg and Phillips (eds.), Plant cell, tissue and organ culture: fundamental methods. Springer-Verlag, Berlin Heidelberg, 1995, p 81-90
  42. Pierik RLM (1987) In vitro culture of higher plants. Martinus Nijhoff, Dordrecht
  43. Rashid A (1988) Cell physiology and genetics of higher plants, vol.I. CRC Press, Boca Raton, FL, p. 1-38,67-103
  44. Ritchie SW, Hodges TK (1993) Cell culture and regeneration of transgenic plants. In: Kung & Wu(ed), Transgenic plants. Vol.1. Academic Press Inc. San Diego, p. 147-178
  45. Sato F, Hashimoto T, Hachiya A, Tamura K-i, Choi K-B, Morishige T (2001) Metabolic engineering of plant alkaloid biosynthesis. PNAS, 98(1):367-72 https://doi.org/10.1073/pnas.011526398
  46. Schuchmann R, Wellmann E (1983) Somatic embryogenesis of tissue cultures of Papaver somniferum and Papaver orientale and its relationship to alkaloid and lipid metabolism. Plant Cell Rep. 2:88-91 https://doi.org/10.1007/BF00270173
  47. Skoog F, Miller CO (1957) Chemical regulation of growth and organ formation in plant tissues cultivated in vitro. Symp. Soc. Exp. Bio. 11:118-130
  48. Staba EJ, Zito S, Amin M (1982) Alkaloid production from Papavertissue cultures. J. Nat. Prod. 45:256-262 https://doi.org/10.1021/np50021a004
  49. Steward FC, Mapes MO, Mears K (1958) Growth and organized development of cultured cells. II. Organization in cultures grown from freely suspended cells. Am.J. Bot. 45:705-708 https://doi.org/10.2307/2439728
  50. Sulaiman IM (1994) Regeneration of plantlets through organogenesis in the Himalayan yellow poppy, Meconopsis paniculata. Plant Cell Tissue and Organ Culture 36:377-380 https://doi.org/10.1007/BF00046097
  51. Sulaiman IM, Babu CR (1993) Plant regeneration through organogenesis of Meconopsis simplicifolia: An endangered ornamental species. Plant Cell Tissue and Organ Culture 34:295-298 https://doi.org/10.1007/BF00029719
  52. Sulaiman IM, Rangaswamy NS, Babu CR (1991) Formation of plantlets through somatic bryogeny in the Himalayan blue poppy, Meconopsis simplicifolia (Papaveraceae). Plant Cell Rep 9:582-585
  53. Thorpe TA (1990) The current status of plant tissue culture. In: Bhojwani, S.S.(ed), Plant tissue culture: Applications and limitations. Elsevier.Amsterdam. p.1-33
  54. Vinterhalter B, Vinterhalter D (2002) Propagation of Chelidonium majus L. by somatic embryogenesis. Biologia Plantarum Prague 45:489-493 https://doi.org/10.1023/A:1022360230668
  55. Wang BH, Lu ZX, Polya GM (1997) Inhibition of eukaryotic protein kinases by isoquinoline and oxazine alkaloids. Planta Medica, 63:494-8 https://doi.org/10.1055/s-2006-957749
  56. WOO JW, Huh GH, Ahn MY, Kim SW, Liu JR (1996) Somatic embryogenesis and plant regeneration in pedicel explant cultures of Chelidonium majus var. asiaticum. Korean J. Plant Tissue Culture 23:363-366
  57. Wright CW, Marshall SJ, Russell PF, Anderson MM, Phillipson JD, Kirby GC, Warhurst DC, Schiff PL (2000) In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J. Nat. Prod. 63:1638-40 https://doi.org/10.1021/np000144r
  58. Xie H, Xu J, Teng R, Li B, Wang D, Yang C (2001) Two new epimeric isopavine N-oxides from Meconopsis horridula var. racemosa. Fitoterapia 72(2):120-3 https://doi.org/10.1016/S0367-326X(00)00266-5
  59. Ye K, Ke Y, Keshava N, Shanks J, Kapp JA, Tekmal RR, Petros J, Joshi HC (1998) Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apotosis in dividing cells. Proceedings of the National Academy of Sciences of the USA, 95:1601-1606 https://doi.org/10.1073/pnas.95.4.1601
  60. YoshikawaT, Furuya, T (1983) Regeneration and in vitro flowering of plants derived from callus cultures of opium poppy (Papaver somniferum). Experientia 39:1031-1033 https://doi.org/10.1007/BF01989788