• Title/Summary/Keyword: alcoholic stress

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The Paradoxical Coping In Life of Children of Alcoholics (알코올중독자 자녀의 삶에 대한 역설적 대처)

  • Kim Myung Ah
    • Journal of Korean Public Health Nursing
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    • v.17 no.2
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    • pp.299-316
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    • 2003
  • A phenomenological methodology was used to identify the life of children living with alcoholic parents. Nine adolescents participated in the in-depth interviews, done between October and December 2001. The Colaizzi's method was used for data analysis. The results of this study are as follows. One theme and thirteen meanings were identified, The one theme is Paradoxical Coping in Life. The meanings are obsessive behavior as a way to control father's behavior, always on the defensive due to anxiety and tension, being afraid of life alone due to paranoid thoughts, contradictory expectations about father's drinking behavior due to life with chronic tension, stress becoming familiar and life being boring and tendious without stimulation, life that is fake and filled with misinterpretations about reality, affection sought from others due to loneliness, compensatory life within peer group, negative expectation about the future due to negative experiences, controling others to protect ego, denial of real emotion to protect self from hurt, life of regretting self, and strong need for approval from others. The results of this study can provide a foundation for the development of programs for children of alcohol dependent parents.

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Prevalence of Hypertension and Its Risk Factors among Aged 65 and over in Korea (한국노인의 고혈압 유병률과 위험요인)

  • Kim, Hye Ryoung;Son, Hye Gyeong
    • Journal of Korean Biological Nursing Science
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    • v.14 no.4
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    • pp.282-290
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    • 2012
  • Purpose: The purpose of this study was to identify the prevalence of hypertension and its risk factors among community dwelling aged 65 and over in South Korea. Methods: A total of 1,367 subjects from the 2010 Korean National Health and Nutrition Examination Survey (KNHANES) were selected. The data analysis was conducted by SPSS WIN 19.0 using descriptive statistics, ${\chi}^2$-test, and logistic regression analysis. Results: The prevalence of hypertension was found to be 47.70%. Logistic regression analysis shows that hypertension was more prevalent as people became older; in females; in elderly who were not employed as compared to those employed; elderly with diabetes, and obesity as compared to those without these health conditions; as elderly who performed more moderate intensity exercise. While, education, household income, high risk alcoholic drinking, smoking, stress perception, usual activity, and eating out behavior were not associated with prevalence of hypertension in this study. Conclusion: The finding of prevalence of hypertension and its risk factors is expected to promote the screening or prevention strategy for community dwelling aged 65 and over at risk of hypertension in Korea.

Four case of Liver fire.Phlegm-fire Tinnitus treated by Axupuncture Therapy with the Inyeong.the chon spot comparison pulse diagnosis (인영촌구 비교맥진을 통한 간화 담화성 이명환자 침 치료4례)

  • Weon, Young-Ho;So, Woong-Ryong;Lee, Sun-Ho;Kim, Jae-Gwan
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.15 no.2
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    • pp.183-189
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    • 2002
  • Tinnitus is usually due to insufficiency of Kidney-essence, asthenia of the Spleen and Stomach, diseases caused by exogenous pathogenic factor, Liver fire(肝火) by severe stress, Phlegm -fire(痰火) by surfeit of high caloric food and alcoholic liquor. I observed and treated four patients who had been diagnosed with tinnitus of Liver-fire(肝火) and Phlegm-fire(痰火). After I checked the Inyeong(人迎) and the chon spot(寸口), all of their Inyeong were stronger than chon spot. Unbalance of the Inyeong(人迎) and the chon spot(寸口), and symptoms of tinnitus were removed by Acupuncture therapy of three Yang meridians of the hand(手三陽) and three Yang meridians of the foot(足三陽).

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Allium Jesdianum Extract Improve AcetaminophenInduced Hepatic Failure through Inhibition of Oxidative/Nitrosative Stress

  • Sohrabinezhad, Zohreh;Dastan, Dara;Asl, Sara Soleimani;Nili-Ahmadabadi, Amir
    • Journal of Pharmacopuncture
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    • v.22 no.4
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    • pp.239-247
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    • 2019
  • Objectives: Allium jesdianum (Aj) is a medicinal plant that has highlighted pharmacological features. In this study, the effects of Aj extract were examined on acetaminophen (APAP)-induced hepatic failure in rats. Methods: Methanolic fraction of hydro-alcoholic extract of Aj was obtained by silica gel column chromatography method. Animals were randomly divided into four groups each containing six rats and treated by gavage as follows: the first and second groups received normal saline, the third and fourth groups were received with 50 and 100 mg/kg of Aj extract, respectively. After two consecutive weeks, the groups 2-4 were given a single dose of APAP (2 g/kg). After 48 hours, blood and liver samples were collected for biochemical and histological examinations. Results: The findings of the study demonstrated that APAP caused a significant increase in ALT (P < 0.001), AST (P < 0.001), LDH (P < 0.001), ALP (P < 0.001) serum levels, hepatic lipid peroxidation (LPO; P < 0.001) and nitric oxide (NO; P < 0.001). In this regard, APAP led to the depletion of the total antioxidant capacity (TAC; P < 0.001), glutathione and total thiol groups (TTGs; P < 0.001), and structural change in the liver. In the Aj extract groups, a considerable improvement was found in the hepatic function alongside the histopathologic changes. Conclusion: This investigation indicated that the influential effects of Aj extract in APAP-induced hepatic failure might depend on its effect on improving oxidant/antioxidant balance in hepatic tissue.

Anti-oxidative effects of broccoli (Brassica oleracea var. italica) sprout extract in RAW 264.7 cell and cisplatin-induced testicular damage

  • Won-Young Lee;Hyun-Woo Shim;Hyun-Jung Park
    • Journal of Animal Reproduction and Biotechnology
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    • v.38 no.4
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    • pp.189-198
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    • 2023
  • Background: Brassica oleracea var. italica (broccoli), a rich source of antioxidants, can prevent various diseases and improve human health. In this study, we investigated the antioxidative effects of broccoli sprout extract on oxidative stress induced by lipopolysaccharide and cisplatin in cell and organ tissue models. Methods: Antioxidative effect of BSE was evaluated using DPPH and ABTS in RAW 364.7 cells, and effects of BSE on testes were investigated using Cisplatin-induced testicular damage model with an in vitro organ culture system. Results: The DPPH assay showed that the antioxidant activity of the alcoholic broccoli sprout extract was higher than that of the water extract. Additionally, the expression levels of antioxidation-related genes, Nrf2, Gsr, HO-1, and catalase, were significantly increased in broccoli sprout extract-treated RAW 264.7 cells, and the extract suppressed lipopolysaccharide-induced mitochondrial dysfunction. Based on the results in the RAW 264.7 cell culture, the antioxidative effects of the extracts were investigated in a mouse testis fragment culture. The expression of Nrf2, HO-1, and Ddx4 was clearly decreased in cisplatin-treated mouse testis fragments and not in both broccoli sprout extract- and cisplatin-treated mouse testis fragments. In addition, the oxidative marker O-HdG was strongly detected in cisplatin-treated mouse testis fragments, and these signals were reduced by broccoli sprout extract treatment. Conclusions: The results of this study show that broccoli sprout extracts could serve as potential nutraceutical agents as they possess antioxidant effects in the testes.

Relationship between Problematic Drinking Behavior and the Personalities of High School Students (고등학생의 음주문제행동과 성격특성)

  • Cho, Won-Jung;Kim, Gwang-Suk;Seo, Ku-Min;Kwon, In-Sook
    • Research in Community and Public Health Nursing
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    • v.15 no.3
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    • pp.471-482
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    • 2004
  • Purpose: This study intended to identify personality factors and related problematic behaviors of adolescents who drink alcohol in order to provide basic data for developing nursing programs. Methods: The data were collected from October to December 2002 from 1.080 high school students in Seoul. The Revised Cloninger's Tri-dimensional Personality Questionnaire (TPQ) was used to measure their personalities. The alcohol expectancy was measured using the tool revised by Cho (1999) and stress levels were measure using a stress tool revised Cho (1998). The data were analyzed with SPSS Windows using Chi square test. independent t-test. and logistic regression analysis. Results: 1. The percentage of fathers who drank was 79.8%. mothers. 54.3%. and friends. 54.3%. The alcohol expectancy averaged 6.36 while the stress levels were 132.79. 2. It was found that there are significant differences (p<.001) in problematic drinking behaviors according to the following variables: second year high school students among all grade variables, more monthly pocket money for the amount of money variables, the group of students who smoked in the case of the variable related to smoking, spending more time using the Internet for the Internet use variable, and having friends who drink 65.6% for the friend variable. The alcohol expectancy scale of those students who showed problematic drinking behaviors was higher than that of those who did not. There are four family-related stress subscales, and there was a significant difference among them (p<.05). Among the personal characteristics, the group who displayed problematic drinking behaviors seeks new experiences and reward dependence more than the group who did not exhibit those behaviors, and there were significant differences between the two groups (p<.001). 3. When the socio-demographic and drinking-related factors were controlled, the tendency of seeking new experiences increased the risk of problematic behaviors 1.07 times (p<.05). Compared to the non smoking group, the smoking group was found to have a 5.06 time (p<.001) greater risk of displaying problematic drinking behaviors. In comparison with the non drinking group, the drinking group was also found to have a 5.31 time (p<.001) greater risk of exhibiting problematic drinking behaviors. The group with high alcohol expectancy scores was significantly different from the group with the no alcohol expectancy, showing a 1.26 time (p<.00l) greater risk of problematic drinking behaviors. Conclusions: Based on these results, the problematic drinking behaviors were connected with alcohol expectancies, friends and personality types. Therefore, we should develop an alcoholic prevention program for adolescence considering the above results.

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Development of a Simple Evaluation Questionnaire for Screening the Dietary Patterns of Overweight Young Adults (20대 성인의 과체중 식생활 패턴과 간이평가표 개발)

  • 박영숙;이정원
    • Korean Journal of Community Nutrition
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    • v.7 no.5
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    • pp.675-685
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    • 2002
  • A study was performed to develop as a screening tool, the Simple Evaluation Questionnaire for screening Overweight Dietary Patterns in people in their 20's. We used the data from the 20 to 29 year old subjects who participated in the three surveys: the health behavior survey, the dietary habit survey and the food intake survey - as part of the National Health and Nutrition Survey of 1998. The 1,493 adults were classified into two body fatness groups, that of normal (including the underweight) , and the overweight (including the obese) on the basis of their relative body weight (RBW). When comparing general variables between the two groups, significant differences (11 variables) were found in gender, sadness/depression state, stress level, age, number of diseases, age when overweightedness started, maximum body weight, sleep length, presently a smoker, everyday smoking habits, number of alcoholic drinks in the past month, and the number of alcoholic drinks when dunk, as well as snacking frequency and fatty food consumption. There were significant differences between the two groups in the three variables of daily soup/kuk, pan fried fish/meat/poultry and cooked fish paste/ham/dried squid in terms of cooked food intake, and 11 variables of food size, cooked rice, stews, vegetables and kimchi at breakfast, panfried foods and beverage/teas at lunch, cooked rice and stews (liquid) at dinner, cooked fish paste/ham/dried squid at snacks and cooked fishpaste/ham/dried squid at snack between lunch and dinner. In terms of raw food intake, we observed significant differences (8 variables) in daily food intake and grains, grains/vegetables/fishes (shellfish) at breakfast, meat at lunch and milt at snack after dinner. After developing questions with indicators and analyzing the indicators by logistic regression analysis using 34 variables, including these 33, plus eating-out frequency, we chose 10 questions for the simple evaluation of dietary patterns for the overweight category, in order to give each one point each. Among them we assigned an additional point to one question and two points to another question. The average scores of the overweight and normal groups, as shown by the questionnaire developed, were 5.97 $\pm$ 2.36 and 7.36 $\pm$ 2.21, respectively. A score of seven points was selected as the cut-off point. We examined the sensitivity, specificity and positive predictive value of the questionnaire to the results of 49.3%,75.4% and 68.8%, respectively. The total score categorized as an overweight dietary pattern was 30.2%.

Changes in Blood Superoxide Dismutase Activities after Alcohol Withdrawal (주정금단 후 혈중 Superoxide Dismutase 활성도의 변화)

  • Cheon, Jin-Sook;Lee, Kyu-Cheon;Oh, Byoung-Hoon
    • Korean Journal of Biological Psychiatry
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    • v.6 no.2
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    • pp.219-226
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    • 1999
  • Objectives : The aims of this study were to evaluate changes in plasma superoxide dismutase(SOD) activities in alcohol depedence, to find out variables to influence on the SOD activities, and finally to identify the correlation of SOD activities with the alcohol-associated cognitive disorders. Methods : For 24 male alcoholics and 21 healthy male controls, plasma SOD activities were measured by spectrophotometry on 1-2 wks after alcohol withdrawal. Structured interviews and laboratory tests were also performed. Results : 1) Upon comparing SOD activities between controls and alcoholics, the SOD activities were significantly(p<0.01) lower in alcoholics($0.308{\pm}0.140$ units/mL) than in healthy controls($0.313{\pm}0.086$ units/mL). 2) Upon comparing SOD activities according to the presence of alcohol-related cognitive disorders, the SOD activities were significantly(p<0.05) lower in alcoholics with cognitive disorders($0.247{\pm}0.049$ units/mL) than in alcoholics without cognitive disorders($0.317{\pm}0.148$ units/mL). 3) Upon comparing SOD activities according to the presence of alcoholic polyneuropathy or alcohol withdrawal seizure, the SOD activities showed no significant differences between alcoholics with polyneuropathy or epilepsy and those without. 4) Upon analyzing variables influencing on the SOD activities in alcoholics, the SOD activities had the negative correlation with hemoglobin(${\gamma}=-0.433$) and severity of alcohol withdrawal symptoms(${\gamma}=-0.375$). 5) Upon comparing variables according to the presence of alcohol-related cognitive disorders, the occurrence of alcoholic polyneuropathy(p<0.05) and blood phosphorus concentrations(p<0.01) were significantly higher in alcoholics with cognitive disorders than those without. 6) Upon analyzing an association between SOD activities and variables in alcoholics with cognitive disorders, the SOD activities were positively correlated with the onset age(${\gamma}=0.995$), and negatively correlated with the severity of alcohol withdrawal symptoms(${\gamma}=-0.996$). Conclusions : Lower SOD activities in alcohol dependence suggested alcohol-associated cognitive disorders and alcohol withdrawal symptoms might be caused by oxidative stress.

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The Effects of the Makgeolri on the Antioxidative Activity in the Endotoxin LPS-treated Rats (내독소인 LPS로 처치된 흰쥐에 대한 막걸리 항산화 활성효과)

  • Kwon, Ryun-Hee;Chae, Go-Yeon;Ho, Boe-Jin
    • Journal of Food Hygiene and Safety
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    • v.26 no.2
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    • pp.166-170
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    • 2011
  • Modem people have begun to have the nationwide interest in the rice wine called Makgeolri which is one of the traditional Korean alcoholic liquors. This study was performed to investigate the effects of San sung Makgeolri extract (SM) on antioxidation together with the determination of pH and dissolved oxygen (DO) in the progress of fermentation in the lipopolysaccharide(LPS)-treated rats. We examined the levels of SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase) in liver homogenates and the histopathological observations in liver tissue. LPS-treated group markedly decreased the levels of SOD, CAT and GPx. But SM + LPS-treated group significantly increased the levels of them. Furthermore, the antioxidative effects of SM were supported by the histopathological observations in liver tissue which showed severe inflammation and necrosis in LPS-treated group, compared to the attenuated inflammation and necrosis in SM + LPS-treated group. This results suggested that SM could be a candidate of antioxidative material in spite of alcoholic liquors.

A mixture of blackberry leaf and fruit extracts decreases fat deposition in HepG2 cells, modifying the gut microbiome

  • Wu, Xuangao;Jin, Bo Ram;Yang, Hye Jeong;Kim, Min Jung;Park, Sunmin
    • Journal of Applied Biological Chemistry
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    • v.62 no.3
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    • pp.229-237
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    • 2019
  • More effective treatments are needed for non-alcoholic fatty liver disease (NAFLD). We hypothesized that water extracts of blackberry fruits (BF) and leaves (BL) and their combinations (BFL) reduce fat deposition in HepG2 cells and modulate shor-tchain fatty acids (SCFA) and fecal bacteria in vitro. HepG2 cells were treated with BF, BL, BFL1:2, and BFL1:3 for 1 h, and 0.5 mM palmitate was added to the cells. Moreover, low ($30{\mu}g/mL$) and high doses ($90{\mu}g/mL$) of BL and BF were applied to fecal bacteria in vitro, and SCFA was measured by GC. BL, BF, BFL1:2, and BFL1:3 reduced triglyceride deposition in the cells in a dose-dependent manner, and BFL1:2 and BFL1:3 had a stronger effect than BF. The content of malondialdehyde, an index of oxidative stress, was also reduced in BL, BF, and BFL1:2 with increasing superoxide dismutase and glutathione peroxidase activities. The mRNA expression of acetyl CoA carboxylase, fatty acid synthase, and sterol regulatory element-binding protein-1c was reduced in BL, BF, BFL1:2, and BFL1:3 compared to the control, and BFL1:2 had the strongest effect. By contrast, the carnitine palmitolytransferase-1expression, a regulator of fatty acid oxidation, increased mostly in BFL1:2 and BFL1:3. Tumor necrosis factor-${\alpha}$ and interleukin-$1{\beta}$ expression was reduced in BL compared to that in BF and BFL1:2 in HepG2 cells. Interestingly, BL increased propionate production, and BF increased butyrate and propionate production and increased total SCFA content in fecal incubation. BF increased the contents of Bifidobacteriales and Lactobacillales and decreased those of Clostridiales, whereas BL elevated the contents of Bacteroidales and decreased those of Enterobacteriales. In conclusion, BFL1:2 and BFL1:3 may be potential therapeutic candidates for NAFLD.