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http://dx.doi.org/10.3831/KPI.2019.22.032

Allium Jesdianum Extract Improve AcetaminophenInduced Hepatic Failure through Inhibition of Oxidative/Nitrosative Stress  

Sohrabinezhad, Zohreh (Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences)
Dastan, Dara (Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences)
Asl, Sara Soleimani (Anatomy Department, School of Medicine, Hamadan University of Medical Sciences)
Nili-Ahmadabadi, Amir (Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences)
Publication Information
Journal of Pharmacopuncture / v.22, no.4, 2019 , pp. 239-247 More about this Journal
Abstract
Objectives: Allium jesdianum (Aj) is a medicinal plant that has highlighted pharmacological features. In this study, the effects of Aj extract were examined on acetaminophen (APAP)-induced hepatic failure in rats. Methods: Methanolic fraction of hydro-alcoholic extract of Aj was obtained by silica gel column chromatography method. Animals were randomly divided into four groups each containing six rats and treated by gavage as follows: the first and second groups received normal saline, the third and fourth groups were received with 50 and 100 mg/kg of Aj extract, respectively. After two consecutive weeks, the groups 2-4 were given a single dose of APAP (2 g/kg). After 48 hours, blood and liver samples were collected for biochemical and histological examinations. Results: The findings of the study demonstrated that APAP caused a significant increase in ALT (P < 0.001), AST (P < 0.001), LDH (P < 0.001), ALP (P < 0.001) serum levels, hepatic lipid peroxidation (LPO; P < 0.001) and nitric oxide (NO; P < 0.001). In this regard, APAP led to the depletion of the total antioxidant capacity (TAC; P < 0.001), glutathione and total thiol groups (TTGs; P < 0.001), and structural change in the liver. In the Aj extract groups, a considerable improvement was found in the hepatic function alongside the histopathologic changes. Conclusion: This investigation indicated that the influential effects of Aj extract in APAP-induced hepatic failure might depend on its effect on improving oxidant/antioxidant balance in hepatic tissue.
Keywords
Allium jesdianum; Oxidative stress; Acetaminophen; Hepatotoxicity;
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